SymmetricLipomaTumorsLipedemaReduction of adiposeAdiposalgiaMadelung'sLipomas and LipomatosisDolorosaSyndromeDisordersFamilial multipleSoft-tissueLiposuctionAdipocytesHereditaryAbnormalDepositionConnective tissueBiopsyTumorAccumulationMalignantSuperficialDepositsAdjacent tissuesTumourOrgansMultipleDiseaseSubcutaneous fat tissueMusculatureStem CellsObeseMetabolismLiverDeeplyPleomorphicHumansGenesDistinguishFibrousBodyGene
Symmetric7
- Multiple symmetric lipomatosis represents a group of similar syndromes characterized by the excessive growth of subcutaneous fat, often in the periphery of the body in areas such as the arms, legs, shoulders, and neck (picture the Michelin man). (scienceblogs.com)
- For a given BMI, multiple symmetric lipomatosis patients are reported to carry 50% more fat tissue than healthy individuals. (scienceblogs.com)
- Multiple benign symmetric lipomatosis (Madelung s disease, Launois Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. (endocrine-abstracts.org)
- Multiple symmetric lipomatosis (MSL) is a rare disease also known as Madelung's disease, Launois-Bensaude syndrome, and benign symmetric lipomatosis. (hindawi.com)
- Multiple symmetric lipomatosis (MSL) is a rare disease characterized by the growth of uncapsulated masses of adipose tissue. (lipomaboard.com)
- Also called multiple symmetric lipomatosis, Madelung's disease causes lipomas to grow around the neck and shoulders. (askdrmakkar.com)
- Madelung's Disease , also known as Multiple Symmetric Lipomatosis (MSL) , is another Rare Adipose Disorder. (blogspot.com)
Lipoma16
- Lipoma is a benign tumor most frequently found in almost all anatomical sites that have adipose tissue in their structure. (springer.com)
- As lipoblastoma arises from embryonic adipose tissue, it is additionally nomenclated as "embryonic lipoma or foetal or embryonal lipoblastoma" [1]. (lupinepublishers.com)
- Non-resected lipoblastoma generally matures into lipoma with prominent fibrous tissue septa [4]. (lupinepublishers.com)
- As in other types of tumors, the exact cause of a lipoma is not known and, although it is sometimes related to a genetic origin , it has only been shown that genetic inheritance is correctly involved with the development of hereditary multiple lipomatosis syndrome, in which the tumors can be both superficial and deep. (fastlyheal.com)
- Another treatment for this benign tumor is liposuction , a technique that consists of the aspiration and suction of the excess fatty tissue that makes up the lipoma, through a small incision and with the help of a syringe. (fastlyheal.com)
- White adipose tissue (WAT) cells in a lipoma have a large single lipid vacuole, whereas brown adipose tissue (BAT) cells in a hibernoma contain multiple small lipid vacuoles. (biomedcentral.com)
- Wen (lipoma, fatty tumor, atheroma) is a benign tumor of adipose tissue that occurs most often under the skin of the scalp, back, face. (goodshapetips.com)
- Lipoma (wen) can develop in any organ containing adipose tissue. (goodshapetips.com)
- A large lipoma can compress surrounding tissues and organs, causing pain and disrupting their function. (goodshapetips.com)
- Pain in the wen area can also occur in those rare cases when nerve tissue is part of the lipoma. (goodshapetips.com)
- Lipoma treatment is surgical removal along with the connective tissue capsule, which eliminates the possibility of recurrence. (goodshapetips.com)
- Lipoma is a benign (non-malignant or non-cancerous) tumour of adipose tissue (fat). (askdrmakkar.com)
- Even though lipoma can be confirmed by clinical examination with its texture, freely movable nature, slippery edges and lack of attachment to adjacent tissues, confirmation may be necessary with biopsy and histo-pathological reports, to rule out other complications or diseases. (askdrmakkar.com)
- CT, MRI and soft tissue radiographs can give an idea about lipoma. (askdrmakkar.com)
- Cholesterol level is often found to be within normal limits, even though lipoma is supposed to be a tumour of fatty tissue (deposition of fat). (askdrmakkar.com)
- A lipoma is a benign tumor made up of adipose cells (adipocytes or fat cells). (chirurgie-esthetique-vincent-masson.com)
Tumors6
- Adiposis dolorosa is a condition characterized by painful folds of fatty (adipose) tissue or the growth of multiple noncancerous (benign) fatty tumors called lipomas. (medlineplus.gov)
- Lipomas are the most common soft-tissue tumors formed with adipose tissue. (davinciplastic.com)
- Tumors affecting the skin or the tissue just under the skin are the most commonly seen tumors in dogs. (merckvetmanual.com)
- Malignant tumors can invade surrounding tissue and spread to distant organs. (merckvetmanual.com)
- This study presents 65 cases with soft tissue tumors. (medicaljournal-ias.org)
- A review of the histopathologic findings of Dercum disease (adiposis dolorosa) showed no consistent histologic abnormality in the adipose tissue that might distinguish these tumors from common sporadic lipomas. (medscape.com)
Lipedema8
- Subcutaneous Adipose Tissue Diseases: Dercum Disease, Lipedema, Familial Multiple Lipomatosis and Madelung Disease. (wikipedia.org)
- In my practice, I see many people with lipedema, familial multiple lipomatosis (FML), Madelung's disease and Dercum's disease (adiposis dolorosa). (tillysmidt.nl)
- So what is going on in lipedema at the level of the tissue? (tillysmidt.nl)
- Lipedema is a chronic disorder of the adipose tissue that affects mainly women, characterised by symmetrical, excessive fatty tissue on the legs and pain. (biomedcentral.com)
- An important factor in the pathophysiology of lipedema is the increased capillary permeability, which leads to orthostatic edema and seems to be responsible for the increased tissue sensitivity in response to touch and pressure. (biomedcentral.com)
- There is a clear difference between regular fat and lipedema body fat tissue that accumulates with lipedema that can be observed by the trained eye. (lipedema.net)
- For example, fat tissue found in the leg will not significantly decrease with diet and exercise in those with lipedema as opposed to someone with obesity. (lipedema.net)
- Lipedema is associated with the hormone-dependent subcutaneous fat tissue. (lipedema.net)
Reduction of adipose2
- 4] Soon thereafter, numerous pilot studies reported reduction of adipose tissues with these injections. (jcadonline.com)
- Through the experimental treatment of mammals with the peptide adipotide protocol, a weight loss of around 11 percent can be achieved, which mainly affects the reduction of adipose tissue, mainly on the abdomen and waist. (peptidesforresearch.com)
Adiposalgia1
- Adiposis dolorosa is most commonly known as Dercum disease, but it is also known as Ander syndrome, morbus Dercum, adipose tissue rheumatism, adiposalgia, or lipomatosis dolorosa. (medscape.com)
Madelung's2
- Multiple symmetrical lipomatosis, or Madelung's disease, is a rare disease of unknown etiology. (hindawi.com)
- Madelung's disease (aka multiple symmetrical lipomatosis. (lipomaboard.com)
Lipomas and Lipomatosis1
- In addition, obesity leads to increased production of white fat cells, which in turn can cause lipomas and lipomatosis. (peptidesforresearch.com)
Dolorosa3
- In people with adiposis dolorosa, abnormal fatty tissue or lipomas can occur anywhere on the body but are most often found on the torso, buttocks, and upper parts of the arms and legs. (medlineplus.gov)
- Researchers have also suggested that adiposis dolorosa could be an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body's own tissues and organs. (medlineplus.gov)
- Dercum's Disease , sometimes known as Adiposis Dolorosa or Painful Fat Disorder, is a Rare Adipose Disorder (RAD) . (blogspot.com)
Syndrome3
- In other words, its was located in either the submuscular or subfascial plane.Lipomatosis was diagnosed in seven cases and lipodystrophic syndrome in five cases. (medicaljournal-ias.org)
- Pathogenetic insights from quantification of the cerebriform connective tissue nevus in Proteus syndrome. (medscape.com)
- Ehlers-Danlos Syndrome is a "group of hereditary connective tissue disorders characterized by defects of the major structural protein in the body (collagen). (blogspot.com)
Disorders4
- [ 4 ] Dercum disease is a subcutaneous adipose tissue disease that involves the adipose tissue and its fascia (ie, adipofascial disorders). (medscape.com)
- Rare adipose disorders (RADs) masquerading as obesity. (medlineplus.gov)
- Lipodystrophy encompasses a heterogeneous group of disorders associated with whole body or partial lack of adipose tissue, which can be inherited (genetic-origin) or acquired. (scienceblogs.com)
- Studies of rare disorders affecting the amount and distribution of body fat provide opportunities to define previously unidentified genes and biological pathways involved in appetite regulation, adipose tissue biology, and energy homeostasis, and to provide novel insights into the myriad of mechanisms potentially contributing to obesity and its adverse consequences. (nih.gov)
Familial multiple1
- Also called familial multiple lipomatosis, this disorder is inherited (passed down through families). (askdrmakkar.com)
Soft-tissue8
- Lipoblastoma arises as a gradually progressive, painless, superficial, subcutaneous, soft tissue nodule or a well circumscribed mass wherein an estimated 75% tumefaction appear upon the left side. (lupinepublishers.com)
- UCP1 has also been found in other tissues (e.g. smooth muscle) but whether it is expressed in non-adipose benign and malignant soft tissue tumours is unknown. (biomedcentral.com)
- Immunohistochemical staining of normal (axillary) BAT and subcutaneous/abdominal white adipose tissue (WAT) as well as a wide range of benign and malignant primary soft tissue tumours (n = 171) was performed using a rabbit polyclonal antibody to UCP1. (biomedcentral.com)
- UCP1 expression in a few non-adipose soft tissue sarcomas may possibly reflect origin of tumour cells from a common mesenchymal stem cell precursor and/or developmental pathway. (biomedcentral.com)
- Benign and malignant tumours of adipose differentiation represent a large category of soft tissue tumours, many of which are frequently encountered in diagnostic pathology [ 1 ]. (biomedcentral.com)
- In addition, as UCP1 has been reported in other cell types, we have examined whether UCP1 is expressed in a wide range of non-adipose benign and malignant soft tissue tumours. (biomedcentral.com)
- We have also determined whether tumour markers other than UCP1 can be used to distinguish hibernoma from other adipose/non-adipose soft tissue tumours. (biomedcentral.com)
- Lipomas are the most common soft-tissue tumor. (medscape.com)
Liposuction4
- Although it was not difficult to resect the lipomas in superficially located cases, it is believed that liposuction is not a proper treatment for the lipomas seen in the syndromic lipomatosis cases. (medicaljournal-ias.org)
- Tumescent liposuction was developed by dermatologist Jeffrey Klein in 1987 and has since become the gold standard among techniques for subcutaneous adipose tissue removal. (jcadonline.com)
- Patients may benefit from surgical removal of abnormally propagated adipose tissue by liposuction. (biomedcentral.com)
- the amount of aspirated adipose tissue is lower than that obtained from liposuction). (drberbecarzeca.ro)
Adipocytes3
- Currently, the emerging theory of why obesity is associated with metabolic disease risk suggests that it is not the excess amount of fat that results in problems - but rather, it is the inability of the fat tissue (specifically subcutaneous) to expand enough via the development of numerous, healthy adipocytes or fat cells to store all the excess calories being ingested (more details on that here ). (scienceblogs.com)
- Lipoblastoma is an exceptional, benign, lobulated, mesenchymal neoplasm arising from embryonal adipose tissue cells or lipoblasts or immature adipocytes. (lupinepublishers.com)
- It is formed from the abnormal production of adipocytes , which are the cells of adipose tissue, the one that stores fat and protects internal organs. (fastlyheal.com)
Hereditary1
- There is a hereditary form of the disease, transmitted from generation to generation and characterized by multiple lipomas that appear already at a young age - familial lipomatosis. (goodshapetips.com)
Abnormal2
- We postulate that these abnormal adipose tissue deposits were caused by Adv 36 infection. (cdc.gov)
- It is characterized by an abnormal accumulation of painful adipose tissue, primarily in the legs. (lipedema.net)
Deposition1
- which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). (medlineplus.gov)
Connective tissue1
- Connective tissue nevus is required. (medscape.com)
Biopsy2
- Biopsy of adipose tissue identified human adenovirus 36 (Adv 36) DNA. (cdc.gov)
- A veterinarian can perform a fine needle aspiration of cells or a biopsy (which removes a small amount of tissue from a tumor) for evaluation. (merckvetmanual.com)
Tumor5
- If malignancy is suspected, tissue surrounding the tumor will also be removed to increase the chance that none of the tumor cells are left behind. (merckvetmanual.com)
- To evaluate the prognostic value and oncogenic function of GXYLT2 in diverse cancer types, we analyzed sequencing data from public databases on 33 tumor tissues and their corresponding normal tissues. (bvsalud.org)
- Mostly a single tumor is formed, but in 7% of cases it is possible that multiple of them arise, which is known as lipomatosis. (fastlyheal.com)
- However, to achieve an accurate diagnosis, especially if there are doubts about the characteristics of the subcutaneous lump, the doctor through the puncture takes a sample of the tumor tissue to analyze the cells. (fastlyheal.com)
- The latter is done by microscopically evaluating the edge of the resected tissue (the "margins") to see whether tumor cells are present. (msdvetmanual.com)
Accumulation1
- In contrast, lipoblastomatosis is a poorly defined, non-encapsulated, multi-centric, infiltrative, generally deep- seated neoplasm composed of an accumulation of foetal adipose tissue. (lupinepublishers.com)
Malignant3
- Because of its histological characteristics, abundance of connective and secondary changes/atrophy, fibrolipoma may appear as infiltrating adjacent tissues and may cause doubts of differential diagnosis with malignant infiltrating lesions. (springer.com)
- In specific subtypes of benign and malignant adipose tumours there may be lipoblasts and/or atypical adipose cells with large or small, single or multiple, fat vacuoles as well as cells with pleomorphic or spindle-shaped nuclei [ 1 ]. (biomedcentral.com)
- In this study, we have sought to determine whether UCP1 is expressed in specific benign and malignant adipose tumour subtypes. (biomedcentral.com)
Superficial1
- The emphasis was on the knowledge of the existence of submuscular and subfascial lipomas so that no surgical time was wasted on the superficial adipose tissue to look for the mass. (medicaljournal-ias.org)
Deposits3
- It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and in the upper body. (hindawi.com)
- Other fat deposits in the body will be impacted by weight loss instead of the hormone-dependent subcutaneous fat tissue in the body. (lipedema.net)
- Then spillover of fat leads to ectopic fat deposits in various tissues such as the liver, heart, skeletal muscle, and pancreas as well [1]. (mathewsopenaccess.com)
Adjacent tissues1
- Fibrolipoma excision, like that described in this report, sometimes may be laborious, because fibrous bands appear to be focally infiltrating adjacent tissues, giving rise to some doubts about the nature of the lesion. (springer.com)
Tumour5
- Essentially comprised of immature, persistent, embryonic adipose tissue which proliferates rapidly within the post natal period, lipoblastoma can configure an enlarged tumefaction wherein the variable tumour magnitude can extend up to 25 centimetres [3,4]. (lupinepublishers.com)
- As a lobulated, mesenchymal neoplasm comprised of embryonal or foetal adipose tissue, lipoblastoma, characteristically demonstrates a benign biological behaviour, preliminary discernment, male predominance and brisk tumour evolution. (lupinepublishers.com)
- BAT and hibernomas were also stained by immunohistochemistry with monoclonal and polyclonal antibodies to adipose/non-adipose tumour markers in order to characterise the immunophenotype of BAT cells. (biomedcentral.com)
- UCP1 was not expressed in WAT or other adipose tumours with the exception a few tumour cells in pleomorphic liposarcoma. (biomedcentral.com)
- UCP1 was variably expressed by tumour cells in a few non-adipose sarcomas including leiomyosarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, synovial sarcoma and clear cell sarcoma. (biomedcentral.com)
Organs1
- Our organs, such as the liver and kidneys, require fat tissue for proper metabolic functioning. (lipedema.net)
Multiple3
- Massive adipose tissue depositions in the abdomen and thorax sufficient to interfere with respiration developed in a patient with multiple medical problems. (cdc.gov)
- Adv 36 DNA persists in multiple tissues of infected animals for long periods after initial infection ( 3 ). (cdc.gov)
- Cases of lipomatosis (multiple lipomas) have been described. (chirurgie-esthetique-vincent-masson.com)
Disease1
- This disease, almost exclusively affecting females, is characterised by a symmetrical bilateral increase of the adipose tissue in the upper and/or lower extremities. (biomedcentral.com)
Subcutaneous fat tissue3
- All of the above examples would seem to suggest that if obese and metabolically unhealthy individuals could somehow develop more subcutaneous fat tissue, they could theoretically become healthier. (scienceblogs.com)
- The third type of adipose fat tissue is called subcutaneous fat tissue and is found between your skin and muscle tissue. (lipedema.net)
- Even less active in regards to metabolism is hormone-dependent subcutaneous fat tissue that develops in females around the age of puberty. (lipedema.net)
Musculature2
- Individuals who suffer from a condition called lipodystrophy, have little to no fat tissue (they look extremely athletic, with defined musculature) but display many of the metabolic symptoms thought to be exclusive to obese individuals. (scienceblogs.com)
- Blepharoplasty is a plastic surgery operation, which aims to improve the appearance of the periocular region by removing the tegument / musculature or excess adipose tissue. (drberbecarzeca.ro)
Stem Cells2
- The grafting of adipose tissue in the infraorbital area also has regenerative effects due to the presence of stem cells in adipose tissue. (drberbecarzeca.ro)
- The addition of stem cells provided by the adipose tissue and the enriched stem cell (PRP) plasma will ensure a faster recovery and better skin quality in the infraorbital region. (drberbecarzeca.ro)
Obese1
- At the same time, an obese patient may not require any treatment because of excellent adipose tissue quality (meda sara). (carakasamhitaonline.com)
Metabolism1
- The adipose tissue not only functions as an insulating layer which prevents heat loss but also acts as a reservoir and source of energy release with fat metabolism. (askdrmakkar.com)
Liver1
- Viral DNA was isolated from brain, lung, liver, muscle, and adipose tissue of monkeys 7 months after initial infection, long after the active virus has disappeared from blood and feces ( 3 ). (cdc.gov)
Deeply1
- Fat can penetrate deeply in the surrounding tissues, involving vessels, nerves, and muscles and compressing trachea and esophagus. (hindawi.com)
Pleomorphic1
- UCP1 is strongly expressed in BAT but not WAT and is found in all hibernomas and a few pleomorphic liposarcomas but not in other adipose tumours. (biomedcentral.com)
Humans1
- Humans are usually covered with adipose tissue as a blanket which gives beauty and keeps the body warm and soft. (askdrmakkar.com)
Genes1
- One of their essential functions is their interaction with specific DNA regions, facilitating the transfer of genetic information encoded in amino acid sequences to regulate particular genes within specific tissues. (peptidesforresearch.com)
Distinguish1
- We suppose that one of the reasons for these inconsistent results is due to the intricate structure of the pancreas, since it is difficult to distinguish intra-pancreas fat from fat tissue outside the pancreas by computed tomography (CT) or magnetic resonance imaging (MRI) studies. (mathewsopenaccess.com)
Fibrous1
- Intraoperatively, the excision was more laborious at some points because fibrous bands appeared to be focally infiltrating surrounding tissues, and the neoformation was hard to detach (giving rise to some doubts about the nature of the lesion). (springer.com)
Body2
- Sarata means the optimum quality of body tissues. (carakasamhitaonline.com)
- Collagen helps hold together, strengthen, and provide elasticity to body tissues. (blogspot.com)
Gene3
- The virus DNA apparently continues to alter gene expression chronically in tissues. (cdc.gov)
- An assay measuring the expression of lacZ shows the tissue where the gene is expressed. (mousephenotype.org)
- Short active peptides play pivotal roles as tissue-specific gene expression and DNA methylation modulators. (peptidesforresearch.com)