Adipose tissue inflammation. Medical search. Frequent questions

Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
In this study, we examined the expression pattern of IL-1Ra and showed that it is highly expressed not only in liver and spleen, but also in white adipose tissue (WAT), where it is upregulated in obesity. (diabetesjournals.org)
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. (elifesciences.org)

In this thesis, two behaviorally distinct macrophage pools are identified in subcutaneous adipose tissue of subjects with obesity. (oulu.fi)
We recently showed that the severity of histological liver lesions related to obesity increases with the amount of macrophage accumulation in visceral adipose tissue (VAT), while no association was found with the subcutaneous adipose tissue (SAT). In the abdominal region, SAT is anatomically divided into two layers, i.e. superficial (sSAT) and deep (dSAT). (nih.gov)
This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy, and inflammation. (medscape.com)
Association between erosive esophagitis, FDG activity and anthropometric evaluation, including body mass index (BMI), waist circumference, visceral and subcutaneous adipose tissue volumes were analyzed. (who.int)
heartburn="" positively="" oesophagus="" .262="" using="" multivariate="" regression="" analyses="" age="" .027="" total="" cholesterol="" level="" .003="" alcohol="" drinking="" .03="" subcutaneous="" adipose="" tissue="" bmi="" waist="" circumference="" were="" independently="" associated="" respective="" locations. (who.int)

Thus, the aim of the present study is to evaluate the effects of moderate aerobic exercise on visceral adipose tissue (VAT) of female LDL-receptor knockout ovariectomized mice. (thieme-connect.de)
obesity="" markers="" both="" visceral="" general="" are="" independent="" determinants="" inflammation. (who.int)
Diagnosis of metabolic a 24hour dietary recall for 3 days (2 which originates from excess visceral syndrome was based on World Health workdays and 1 holiday) by a trained adipose tissue [2]. (who.int)

In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)
However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)
As senior investigator Dr. Noyan Gokce told Reuters Health, "Our data demonstrate that obese subjects exhibit varying degrees of inflammation in their fat tissue, and increased inflammatory activity in fat was associated with systemic metabolic abnormalities including insulin resistance. (massagemag.com)
These macrophages were also highly imbued by known pro-inflammatory proteins, NLRP3 inflammasome and Caspase-1 which are associated with type 2 diabetes and insulin resistance in adipose tissue. (oulu.fi)
Under pathological conditions including hypertension and hyperlipidemia, increased levels of pro-inflammatory immunocytes in perivascular adipose tissue (PVAT), "whitening" of brown adipose tissue, and oxidative stress could promote the development of PVAT inflammation. (magtechjournal.com)
PVAT inflammation could induce various crucial stages of atherosclerosis by disturbing secretion of inflammatory and anti-inflammatory adipokines, inhibiting PVAT cell autophagy, and activating angiogenesis in arterial adventitia, thereby promoting the onset and progression of atherosclerosis. (magtechjournal.com)
The accumulation of sub-dermal adipose tissue and, consequently, increased pro-inflammatory cytokine release could affect the dermal fibroblast physiology. (buckingham.ac.uk)
Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice. (google.com)
In addition to total body fat, the regional distribution and inflammatory status of enlarged adipose tissue are strongly associated with metabolic co-morbidities of obesity. (nih.gov)
The accumulation in adipose tissue of macrophages in an inflammatory state is a hallmark of obesity-induced insulin resistance. (edu.au)
In summary, we demonstrated that WAT is one of the most important sources of IL-1Ra quantitatively, suggesting that this tissue could represent a novel target for anti-inflammatory treatment. (diabetesjournals.org)
Background Pericoronary adipose tissue (PCAT) may influence plaque development through inflammatory mechanisms. (reprievetrial.org)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Conclusion Rheumatoid AAT is highly reactive tissue which upon stimulation secretes considerable amounts of proinflammatory (IL-6, IL-8, TNF) and anti-inflammatory (IL-1Ra) cytokines and classical adipokines. (bmj.com)
Recent studies have indicated that adipose tissue plays a major role in the secretion of inflammatory factors, which have been called adipo-cytokines or adipokines. (europa.eu)
Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)
A diet high in sugar may affect chronic inflammation by increasing inflammatory markers in the blood, according to a 2018 systematic review of several studies. (medicalnewstoday.com)
In addition, excessive sugar consumption may increase inflammatory markers in children and lead to chronic inflammation, according to a 2018 study . (medicalnewstoday.com)
Trans fats may increase inflammatory markers and the risk of chronic inflammation, which can lead to diseases such as diabetes and cardiovascular disease. (medicalnewstoday.com)
Chronic inflammation is also linked with inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, which may increase the risk of colon cancer. (medicalnewstoday.com)
In their research, the scientists identified how "checkpoint proteins" and immune cells alter inflammatory cells within the fat tissue to cause obesity. (sciencedaily.com)
Production of the latter relates positively to adipose tissue mass and through its actions on immune function exerts a pro-inflammatory influence. (lww.com)
Since obesity is also associated with increased inflammatory immune cell numbers in fat tissue, they tested whether numbers of particular subsets of immune cells called M1 and M2 macrophages are different in the fat tissues of offspring whose mothers were fed a low protein diet. (usda.gov)
It is currently unknown whether maternal LP diet-induced offspring obesity is associated with changes in M1, M1b, or M2 cell numbers and expression of inflammatory factors in fat tissue. (usda.gov)
Additionally, the researchers noted that the anti-inflammatory properties of the pecans were observed to reduce levels of low-grade inflammation that can lead to chronic inflammation and the development of a range of diseases. (worldhealth.net)
He mentioned how obesity induced inflammation can result in low-grade chronic systemic inflammation as there is no pathogen to resolve, and how inflammatory cells exacerbate disease by causing insulin resistance. (lu.se)

Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
Obesity is associated with adipose and vascular remodelling, an inadequate blood supply leading to hypoxia and systemic inflammation. (buckingham.ac.uk)
The result is increased inflammation without a pathogen or injury that inflicted damage, which is referred to as sterile inflammation or chronic systemic inflammation. (internationalnursingconference.com)
Her research is focused on clarifying biological links between systemic inflammation and chronic diseases specifically effects of adipokines, leptin & adiponectin, which are inflammation regulators. (internationalnursingconference.com)
Systemic inflammation contributes to the development of multiple organ dysfunction, the major cause of mortality in patients with septic shock. (europa.eu)
Systemic inflammation is a consequence of activation of the innate immune system. (europa.eu)
For the present proposal we will test the hypothesis, that adipose tissue is one of the links between systemic inflammation causing insulin resistance in critically ill patients and low-grade inflammation causing insulin resistance in obesity. (europa.eu)
Increasingly, evidence implicates localized inflammation in adipose tissue , which in turn stimulates systemic low-grade inflammation, as a primary force contributing to the development of these diseases. (medscape.com)
30 kg/m2, triglycerides 150 Germany) and height was measured dicators of systemic inflammation [3]. (who.int)
The next speaker, Mario Kratz (Fred Hutchinson Cancer Research Center) continued by presenting some research about the impact of total dairy intake and dairy fat on biomarkers of systemic inflammation . (lu.se)
He specifically focused on results about fasting plasma hsCRP, IL-6, TNFalpha and adiponectin, biomarkers which have previously been strongly linked to systemic inflammation. (lu.se)
2010 found a consistent reduction in biomarkers of systemic inflammation on a low-fat milk intervention compared to a soy drink control among 20 participants, without any differentiating effects on body weight or composition. (lu.se)
2014. Among 112 men and women with elevated hsCRP, both the control and dairy diet decreased biomarkers of systemic inflammation. (lu.se)

We highlight the rationale for pharmacological targeting of the perivascular and epicardial adipose tissue or associated signaling pathways as potential disease modifying approaches in cardiometabolic syndromes. (silverchair.com)
This study assessed the link between local inflammation in adjacent epicardial adipose tissue (EAT) and coronary arterial atherosclerosis in fresh cadavers. (tokushima-u.ac.jp)

There are three dominant contributors to the pathogenesis of dysfunctional adipose tissue (AT) in obesity: unresolved inflammation, inappropriate extracellular matrix (ECM) remodeling and insufficient angiogenic potential. (wustl.edu)

In obese subjects, this remodeling is often pathological, characterized by excessive inflammation and fibrosis. (wikipedia.org)
The high prevalence of vitamin D deficiency in obese subjects [ 3 ] suggests that adipose tissue (AT) has a major role in the body distribution of vitamin D, but the causal relationship between obesity and low levels of circulating 25(OH)D has not been completely elucidated yet. (medscape.com)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
The researchers found that 50 of the subjects had an inflamed adipose phenotype characterized by tissue macrophage accumulation in crown-like structures. (massagemag.com)
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)

Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
3) Vascular dysfunction within adipose tissue leads to inflammation and metabolic dysfunction. (bu.edu)
Consumption of a high-fat Western diet (HFWD) contributes to obesity, disrupted adipose endocrine function, and development of metabolic dysfunction (MetDys). (cdc.gov)

Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation. (google.com)
Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. (elsevierpure.com)
Manipulating ERα in vivo increases Phd3 transcription and reduces HIF-1 activity, while addition of PHD3 ameliorates adipose tissue fibrosis and inflammation. (elsevierpure.com)

Because adipose inflammation was linked to impaired arterial endothelial function, Dr. Gokce pointed out, "that may identify obese individuals at increased cardiovascular risk. (massagemag.com)
1]Saxton SN, Withers SB, Heagerty AM. Perivascular adipose tissue anticontractile function is mediated by both endothelial and neuronal nitric oxide synthase isoforms[J]. J Vasc Res, 2022, 59:288-302. (magtechjournal.com)
Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism[J]. Vascul Pharmacol, 2019, 115:55-63. (magtechjournal.com)
In the maturation phase, myofibroblast numbers are reduced by apoptosis, allowing for infiltration by endothelial cells (for blood vessels) and cardiomyocytes (heart tissue cells). (wikipedia.org)
Cardiovascular (CV) risk factors such as hypercholesterolemia, hyperglycaemia, obesity, hypertension, smoking, and aging promote vascular inflammation and endothelial activation [ 7 - 9 ]. (hindawi.com)
5 , - , 9 This loose connective tissue is composed of extracellular matrix and various types of cells: fat cells-named adipocytes, and the non-fat cells of the stromal vascular fraction that contains preadipocytes, capillary endothelial cells, infiltrating leucocytes and multipotent stem cells. (bmj.com)
ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
The projects involve genetic, physiological and clinical studies that focus on the central theme of defining how obesity and insulin resistance lead to biochemical changes in endothelial cell that impair function and promote inflammation. (bu.edu)
Also, CRP is produced by cells in the vascular wall such as endothelial cells, smooth muscle cells, and also by adipose tissue. (medscape.com)

Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
Adipose tissue macrophages were quantified by immunohistochemistry using HAM56 antibody in subjects scored for liver histopathology. (nih.gov)
These data show distinct gene signature and macrophage abundance in the two compartments of SAT, with dSAT more closely related to VAT than to sSAT in terms of inflammation and relation with the severity of liver diseases in morbid obesity. (nih.gov)
When challenged with a high-fat diet, mice that received β1-/- bone marrow displayed enhanced adipose tissue macrophage inflammation and liver insulin resistance compared with animals that received WT bone marrow. (edu.au)
An interdisciplinary collaborative study published in MDPI suggests that the daily consumption of pecans may help to prevent obesity as well as reduce inflammation that leads to associated health issues such as diabetes and fatty liver disease. (worldhealth.net)
confirming that pecans modulate adipose tissues lipolysis and mitochondrial oxidative metabolism in the liver and skeletal muscle. (worldhealth.net)
CRP is an acute-phase reactant synthesized by the liver in response to cytokines released by damaged tissue. (medscape.com)

ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)

NEW YORK (Reuters Health) - Certain obese people demonstrate potentially harmful proinflammatory changes in their adipose tissue, researchers report in the September issue of Arteriosclerosis, Thrombosis, and Vascular Biology. (massagemag.com)
Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling[J]. Nat Commun, 2022, 13:5117. (magtechjournal.com)
Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice[J]. Cardiovasc Diabetol, 2019, 18:83. (magtechjournal.com)

Of these, only the macrophages associated with pyroptotic adipocyte deaths decreased after laparoscopic Roux-en-Y gastric bypass for obesity. (oulu.fi)
Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta[J]. Adipocyte, 2021, 10:412-423. (magtechjournal.com)

For example, both inflammation and inadequate angiogenic remodeling can drive fibrosis, which can in turn promote migration of immune cells into adipose depots and impede further angiogenesis. (wustl.edu)
Here we untangle some of these intricacies to highlight the contributions of inflammation, angiogenesis, and the ECM to both "healthy" and "unhealthy" AT expansion. (wustl.edu)

Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)
Macrophages repair wounds and remodel tissue by producing extracellular matrix and proteases to modify that specific matrix. (wikipedia.org)

Research progress on the mechanism of perivascular adipose tissue inflammation promoting atherosclerosis[J]. Basic & Clinical Medicine, 2023, 43(4): 685-689. (magtechjournal.com)
A new function for perivascular adipose tissue (PVAT): assistance of arterial stress relaxation[J]. Sci Rep, 2020, 10:1807. (magtechjournal.com)
Exercise improves endethelial function associated with alleviated inflammation and oxidative stress of perivascular adipose tissue in type 2 diabetic mice[J]. Oxid Med Cell Longev, 2020, 2020:8830537. (magtechjournal.com)
Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis[J]. Br J Pharmacol, 2017, 174:4055-4069. (magtechjournal.com)
GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-κB signalling pathway[J]. J Int Med Res, 2021, 49:300060521992981. (magtechjournal.com)
Pathological conversion of mouse perivascular adipose tissue by Notch activation[J]. Arterioscler Thromb Vasc Biol, 2020, 40:2227-2243. (magtechjournal.com)
The particular importance of epicardial and perivascular adipose pools emerged as main modulators of the physiology or pathology of heart and blood vessels. (silverchair.com)
New cardiac CT techniques can assess coronary artery inflammation by imaging perivascular fat, and this may represent an important step forward in identifying the 'residual risk' that is not detected by plaque or ischaemia imaging. (bmj.com)
Coronary artery disease risk assessment that incorporates clinical factors, plaque characteristics and perivascular inflammation offers a more comprehensive individualised approach to quantify and stratify coronary artery disease risk, with potential healthcare benefits for prevention, diagnosis and treatment recommendations. (bmj.com)

Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. (nih.gov)

In collaboration with our academic and industrial partners, studies are performed to investigate the links and the cross-talk between adipose tissue and the brain, also to understand the links between fat mass expansion and oxidative stress and inflammation in nerve cells, as well as investigating the potential preventive and protective effects of plant-based medicines. (buckingham.ac.uk)

The comorbidities related to obesity are increasingly viewed as a result of low-grade inflammation characterizing the state of excess adiposity. (oulu.fi)
Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. (frontiersin.org)
Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)
Lymph stasis and inflammation result in excess formation of adipose tissue, which makes removal of the deposited subcutaneous fat necessary to eliminate the excess volume. (lu.se)

The signalling pathways for several key adipose metabolites are mediated through GPCRs expressed both on the adipocytes themselves and on infiltrating macrophages . (bvsalud.org)

He suggested that these results are due to components of the diet that address the underlying cause of inflammation , such as unsaturated fatty acids, phenolics and fiber that may for example diminish damage of adipose tissue depots. (lu.se)

The hormones released from adipose tissue are referred to as adipokines and include leptin, adiponectin, resistin, and vistatin. (internationalnursingconference.com)
These adipokines influence many bodily functions including appetite, insulin sensitivity, inflammation, immunity, and fatty acid oxidation to name a few. (internationalnursingconference.com)
Adipose tissue continues to produce adipokines but the levels of adipokines have changed. (internationalnursingconference.com)
Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)

This scenario is further complicated by the altered molecular phenotype featuring AT in obesity-induced inflammation and insulin resistance. (medscape.com)

Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)

Inhibition of the sodium-glucose co-transporter SGLT2 by canagliflozin ameliorates diet-induced obesity by increasing intra-adipose sympathetic innervation [J]. Br J Pharmacol, 2021, 178:1756-1771. (magtechjournal.com)

AD-MSC were isolated by collagenase treatment from adipose tissue from healthy individuals subjected to abdominal lipectomy surgery. (karger.com)

Phenotypic changes in T cell and macrophage subtypes in perivasuclar adipose tissue precede high-fat diet-induced hypertension [J]. Front Physiol, 2021, 12:616055. (magtechjournal.com)

As an example he brought up PREDIMED, a large Spanish primary prevention trial which showed significant reductions in several biomarkers of inflammation for those following the Mediterranean Diet. (lu.se)
Another similar study (randomised cross-over design) found no difference in biomarkers of inflammation between dairy foods and the control (fruit juice and granola) among the 37 participants. (lu.se)

The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. (frontiersin.org)
In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)
Here, we reveal a role for AMPK β1 in protecting macrophages from inflammation under high lipid exposure. (edu.au)
Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. (tokushima-u.ac.jp)
Population studies show a strong association between indices of inflammation, and abnormal lipid and carbohydrate metabolism, obesity and atherosclerosis. (lww.com)

4 5 Adipose tissue is an active endocrine organ, heterogeneous with respect to embryonic origin, body distribution and function. (bmj.com)

In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)
There is now a growing appreciation that various metabolites released from adipose tissue serve as key signalling mediators, influencing this interaction with inflammation . (bvsalud.org)

Senescent T cell induces brown adipose tissue "whitening" via secreting IFN-γ[J]. Front Cell Dev Biol, 2021, 637424. (magtechjournal.com)
A myocardial infarction induces tissue remodeling of the heart in a three-phase process: inflammation, proliferation, and maturation. (wikipedia.org)

Adipocytes are the main constituent cells of adipose tissue. (frontiersin.org)

β1-/- macrophages displayed increased levels of diacylglycerol and markers of inflammation, effects that were reproduced in WT macrophages by inhibiting fatty acid oxidation and, conversely, prevented by pharmacological activation of AMPK β1-containing complexes. (edu.au)

However, the metabolic role and possible consequences of adipose tissue as a secretory organ in critically ill patients has not been investigated to date. (europa.eu)
To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls. (europa.eu)

which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). (medlineplus.gov)
We know that fat tissue can release hormones and regulate metabolism in different organs in the body. (lu.se)
They found that genes that are involved in inflammation were up-regulated and that genes involved in the fat and glucose metabolism were down-regulated in those who had diabetes. (lu.se)

Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
Recent studies on diseases which involve insulin insensitivity (e.g. obesity, type 2 diabetes and atherosclerosis) also show increased cytokine production and markers of inflammation. (lww.com)

Inflammation is one of Sina Hospital, Tabriz from April 2007 tional intake data were collected using the features of metabolic syndrome, to April 2008. (who.int)

However, dysregulation of adipose tissue occurs when these hormones are produced in discordance with normal values and effects are seen in processes throughout the body. (internationalnursingconference.com)

Consumption of kefir made with traditional microorganisms resulted in greater improvements in LDL cholesterol and plasma markers of inflammation. (greenmedinfo.com)
Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. (medscape.com)

This situation leads to fat deposition in other tissues. (cambridge.org)

Circulating cytokines can act on the brain to induce local inflammation and production of cytokines which can contribute to cognitive decline and dementia. (buckingham.ac.uk)
Tissue explants were treated with proinflammatory cytokines relevant to RA pathogenesis (interleukin 1β (IL-1β), tumour necrosis factor (TNF), interferon γ, IL-15, IL-17, IL-23). (bmj.com)
1 In RA, numerous cytokines play a fundamental role in inflammation and joint destruction and are thought to originate primarily from synoviocytes and leucocytes that massively infiltrate synovial tissue. (bmj.com)

Conclusion Among PWH in REPRIEVE, a large primary cardiovascular disease prevention cohort, increased PCAT density independently associated with prevalence and severity of coronary plaque, linking increased coronary inflammation to CAD in PWH. (reprievetrial.org)

Adipose tissue macrophages (ATM) are implicated in adipose tissue inflammation and obesity-related insulin resistance. (usda.gov)

Background: The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). (tokushima-u.ac.jp)

Chronic inflammation occurs in diseases such as asthma, rheumatoid arthritis, and type 2 diabetes. (medicalnewstoday.com)
The question the researchers posed was whether epigenetic* changes in the DNA lead to changes in the fat tissue that in turn can lead to the development of type 2 diabetes. (lu.se)

In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)

On microscopic level, this associates with the infiltration of immune cells, particularly macrophages, into adipose tissue. (oulu.fi)
Scientists have just identified how specific immune cells can work together in fat to cause inflammation that leads to weight gain and obesity. (sciencedaily.com)

Their work pinpoints new avenues to exploit the regulation of that inflammation in fat tissue, thereby suggesting new ways to manage obesity [Wednesday 9th March 2022]. (sciencedaily.com)

We assessed PCAT density, as a measure of pericoronary inflammation, in relationship to coronary plaque among people with HIV (PWH) and to a matched control population. (reprievetrial.org)
This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV. (tokushima-u.ac.jp)
However, coronary artery disease risk is also driven by biological processes, such as inflammation, that are not fully reflected by severity of stenosis, myocardial ischaemia or by coronary plaque features. (bmj.com)

By contrast, aerobic exercise can produce beneficial cardiac tissue remodeling in those suffering from left ventricular hypertrophy. (wikipedia.org)

Occupational silica-inhalation leads to chronic lung inflammation, progressive fibrosis, and significant respiratory morbidity and mortality. (cdc.gov)

Anatomy43

Organisms13

Diseases34

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology2

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture2

Health Care4

Geographicals1

White adipos4

Subcutaneous adipose5

Visceral3

Inflammatory26

Systemic13

Epicardial adipose tissue2

Dysfunctional adipose tissue1

Obese subjects2

Accumulation6

Dysfunction3

Fibrosis and inflammation3

Endothelial9

Liver7

Abstract1

Vascular3

Adipocyte2

Angiogenesis2

Extracellular matrix3

Perivascular9

Dysbiosis and Inflammation1

Oxidative stress and inflammation1

Excess5

Pathways1

Depots1

Adipokines4

Phenotype1

Mesenchymal2

Ameliorates diet-induced obesity1

Abdominal1

Diet-induced1

Biomarkers2

Lipid5

Endocrine1

Metabolites2

Induces2

Adipocytes1

Inhibiting fatty acid oxid1

Secretory organ2

Metabolism3

Atherosclerosis2

Metabolic syndrome1

Dysregulation1

Markers2

Deposition1

Cytokines3

Cardiovascular disease1

Obesity-related1

Blood vessels1

Type 2 diabet2

Expansion1

Immune cells2

20221

Coronary3

Hypertrophy1

Leads to chronic1