AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth CareGeographicals
Adipose TissueInsulinAdipose Tissue, BrownAdipose Tissue, WhiteReceptor, InsulinInsulin ResistanceAdipocytesSubcutaneous FatObesityLipolysisGlucoseIntra-Abdominal FatLeptin3T3-L1 CellsMice, ObeseInsulin Receptor Substrate ProteinsHypoglycemic AgentsAdipogenesisFatty Acids, NonesterifiedSubcutaneous Fat, AbdominalBody WeightLipid MetabolismAdiponectinThermogenesisFatty AcidsGlucose Tolerance TestLiverTriglyceridesBlood GlucoseDietary FatsAdipokinesDiet, High-FatMuscle, SkeletalInsulin, Long-ActingAdiposityOmentumDiabetes Mellitus, Type 2Glucose Clamp TechniqueRNA, MessengerLipoprotein LipaseAdipocytes, WhiteInsulin AntibodiesBody CompositionMice, Inbred C57BLGlycerolEnergy MetabolismInsulin AntagonistsLipidsIslets of LangerhansMitochondrial ProteinsHyperinsulinismFastingGlucose Transporter Type 4Gene Expression RegulationAdipocytes, BrownPPAR gammaPanniculitisEpididymisVisceraInsulin LisproAbdomenInflammationRats, ZuckerEatingAbdominal FatThiazolidinedionesLipogenesisLipid MobilizationCold TemperatureSignal TransductionBody Fat DistributionInsulin Infusion SystemsMice, KnockoutGlucose IntoleranceLipodystrophyRats, WistarDietBody Mass IndexCells, CulturedResistinSterol EsteraseGlucagonInsulin-Secreting CellsGene ExpressionInsulin AspartBody Temperature RegulationInsulin, IsophaneHyperglycemiaFatty LiverIon ChannelsInsulin, Regular, PorkSubcutaneous TissueButtocksHomeostasisReverse Transcriptase Polymerase Chain ReactionC-PeptideTime FactorsDiabetes Mellitus, ExperimentalMonosaccharide Transport Proteins11-beta-Hydroxysteroid Dehydrogenase Type 1
ResistanceSensitivitySkeletalVisceralBlood GlucoseType 2 diabetSubcutaneousWhite adiposTarget tissuesMetabolismAdiponectinHomeostasisTriglyceridesPancreaticDiabetesFattyLipogenesisAdipocyteAccumulationObese animalsTriglyceride levelsBrown adiposPostprandialUptake of glucoseReceptorSerumAbdominalAcuteDiagnosed insulin-dependentRegulateHyperinsulinemicMechanismsPPARIntakePancreasDepositionHyperinsulinemiaContributesResistantMetabolic diseaseChronicFibrosis
Resistance72
Sensitivity29
  • The increase in plasma adiponectin is strongly associated with a decrease in hepatic fat content and improvements in hepatic and peripheral insulin sensitivity. (nih.gov)
  • A vegan diet improves diet quality, leading to decreased weight and improved insulin sensitivity, according to a new study by the Physicians Committee for Responsible Medicine published in the Journal of the Academy of Nutrition and Dietetics . (news-medical.net)
  • The vegan group also experienced improvements in insulin sensitivity. (news-medical.net)
  • 2022) Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight, Body Composition, and Insulin Sensitivity in Overweight Adults: A Randomized Clinical Trial. (news-medical.net)
  • White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)
  • Does Coffee Decrease Insulin Sensitivity? (marksdailyapple.com)
  • That said, both caffeine and coffee have been shown to exert negative effects on insulin sensitivity. (marksdailyapple.com)
  • But insulin sensitivity, the efficiency with which your body handles incoming glucose? (marksdailyapple.com)
  • Of course, an increase in free fatty acids shooting around your body causes a subsequent - and necessary - drop in insulin sensitivity to allow you to actually burn the fat. (marksdailyapple.com)
  • Despite all the clinical trials showing that acute intakes of caffeine and coffee tend to reduce insulin sensitivity, the overwhelming majority of the observational literature finds that coffee is linked to lower body weight and protection from type 2 diabetes . (marksdailyapple.com)
  • 0.001) and negatively correlated with BMI and insulin sensitivity. (diabetesjournals.org)
  • The post-surgical change in SAT %Tregs positively correlated with the change in insulin sensitivity (M value) by hyperinsulinemic-euglycemic clamp (p=0.003, r=+0.797), so that those subjects with the greatest decline in Tregs had the largest decline in insulin sensitivity. (diabetesjournals.org)
  • Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity. (jci.org)
  • The hallmarks of impaired insulin sensitivity in these three tissues are decreased insulin-stimulated glucose uptake into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue. (jci.org)
  • Several, albeit not all, studies suggested that the consumption of the Paleolithic diet might improve glucose tolerance, decrease insulin secretion, and increase insulin sensitivity. (mdpi.com)
  • The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. (endocrine-abstracts.org)
  • Metformin creates increased insulin sensitivity by assisting the body in using the blood sugar already present. (livestrong.com)
  • Improved glucose tolerance of Lou/C rats was not related to increased insulin output but was related to improved insulin sensitivity/responsiveness in the liver and in skeletal muscles. (unige.ch)
  • The Lou/C rat is a valuable model of spontaneous food restriction with associated improved insulin sensitivity. (unige.ch)
  • It may provide the link between inflammation and insulin sensitivity. (lww.com)
  • Figure 1: Normal Insulin Action: In individuals with normal insulin sensitivity, the pancreatic β-cells release insulin in response to increased circulating glucose levels (as seen in the postprandial state). (endotext.org)
  • Also, in these pets, BAPN ameliorates the disruptions in the adipose cells manifestation of adiponectin, blood sugar transporter 4 (GLUT4), buy 76584-70-8 suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4, all protein mixed up in control of insulin level of sensitivity. (exposed-skin-care.net)
  • In this study we evaluated whether epicardial adipose tissue is related to insulin sensitivity and glucose metabolism in obese subjects. (qxmd.com)
  • Each subject underwent a transthoracic echocardiogram to evaluate epicardial adipose tissue thickness, a euglycemic hyperinsulinemic clamp to estimate insulin sensitivity, and an oral glucose tolerance test to evaluate glucose tolerance. (qxmd.com)
  • 2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
  • When activated, PPAR-γ up-regulates the transcription of genes mainly involved in fatty acid metabolism and triglyceride storage, promoting adipogenesis and lipids uptake to the adipose tissue [ 17 , 18 ] improving whole body insulin sensitivity. (biomedcentral.com)
  • Rosiglitazone, a member of the thiazolidinedione class of antidiabetic agents, improves glycemic control by improving insulin sensitivity. (globalrph.com)
  • In animal models, the antidiabetic activity of rosiglitazone was shown to be mediated by increased sensitivity to insulin's action in the liver, muscle, and adipose tissues. (globalrph.com)
  • [ 28 ] In fact, the predictive power of TCF7L2 variants disappears with lifestyle modifications or metformin treatment, although improved insulin sensitivity resulting from these changes directly opposes the pathologic influence of TCF7L2 variants. (medscape.com)
Skeletal7
  • When certain tissues that are sensitive to insulin, such as skeletal muscle, develop triglyceride deposits, cellular functions are altered, one of which is insulin signaling. (wikipedia.org)
  • We discuss how pathways that "sense" nutrients within skeletal muscle are readily able to regulate insulin action. (jci.org)
  • This was achieved by performing glucose and insulin tolerance tests, euglycemic hyperinsulinemic clamps, and characterization of intracellular insulin signaling in skeletal muscle. (unige.ch)
  • Mice, because of this ANK2 variation develop decreased insulin secretion when young but it is compensated for by the uptake of glucose into adipose tissue and skeletal muscle. (acsh.org)
  • We also tested if these CpG sites exhibit altered DNA methylation in human pancreatic islets, liver, adipose tissue, and skeletal muscle from diabetic vs. non-diabetic subjects. (lu.se)
  • DNA methylation at the PHOSPHO1 locus cg02650017 in blood correlated positively with HDL levels, and was decreased in skeletal muscle from diabetic vs. non-diabetic monozygotic twins. (lu.se)
  • PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. (globalrph.com)
Visceral6
Blood Glucose4
Type 2 diabet6
  • A type 2 diabetes treatment has been found to also have 'off-label' benefits for glucose control in the liver and in fatty cells known as adipose. (sciencedaily.com)
  • A 65-year-old woman with new-onset type 2 diabetes and an A1C level of 8 percent wants to know if she can control her diabetes without taking medications or insulin. (aafp.org)
  • 3 Although some patients may be highly motivated to pursue lifestyle interventions to avoid the use of insulin or medications, others may see lifestyle changes as a burden that adds to the complexities of managing type 2 diabetes. (aafp.org)
  • Recent studies on diseases which involve insulin insensitivity (e.g. obesity, type 2 diabetes and atherosclerosis) also show increased cytokine production and markers of inflammation. (lww.com)
  • It has long been established that obese individuals are typically insulin resistant and predisposed to such disorders as type 2 diabetes, atherosclerotic cardiovascular disease, NAFLD and certain cancers. (bu.edu)
  • In animal models of diabetes, pioglitazone reduces the hyperglycemia, hyperinsulinemia, and hypertriglyceridemia characteristic of insulin-resistant states such as type 2 diabetes. (globalrph.com)
Subcutaneous2
  • A transcriptomic research revealed a rise in LOX manifestation in subcutaneous white adipose cells from obese topics, but its pathophysiological relevance continues to be unclear (Henegar et al. (exposed-skin-care.net)
  • This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy, and inflammation. (medscape.com)
White adipos5
Target tissues3
  • Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
  • Once in circulation, hormones affect function of the target tissues, which may be another endocrine gland or an end organ. (msdmanuals.com)
  • result from disruptions of the endocrine glands and/or their target tissues. (msdmanuals.com)
Metabolism9
  • Prolonged IV insulin administration can induce laminitis, possibly due to its effects on blood flow to the foot, changes of glucose metabolism and secondary matrix metalloproteinase activation, or altered cell function within the foot. (wikipedia.org)
  • The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
  • These results highlight a role for adipose tissue Tregs in human metabolism. (diabetesjournals.org)
  • Therefore, the aim of this meta-analysis was to compare the effect of the Paleolithic diet with other types of diets on glucose and insulin homeostasis in subjects with altered glucose metabolism. (mdpi.com)
  • Dysregulation of the enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistant states, however longitudinal changes in glucocorticoid metabolism over time have not been investigated. (endocrine-abstracts.org)
  • More and more evidences ( 6 - 8 ) show that miRNAs are involved in the regulation of glucose metabolism, insulin synthesis and secretion, which are the core links in the development of T2D. (researchsquare.com)
  • It decreases insulin levels and increases one's metabolism. (outlookindia.com)
  • Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. (globalrph.com)
  • [ 21 , 22 ] Indeed, dysregulation of glucose metabolism, decreased processing of proinsulin, and elevated levels of gastric inhibitory peptide and glycated hemoglobin (HbA1c) can be observed before the onset of T2DM in normoglycemic individuals with TCF7L2 polymorphisms. (medscape.com)
Adiponectin6
  • Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
  • Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
  • Furthermore, in white adipose cells from obese pets, BAPN avoided the downregulation of adiponectin and blood sugar transporter 4 (GLUT4), aswell as the upsurge in suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4 (DPP4) amounts, triggered from the HFD. (exposed-skin-care.net)
  • Also, in the TNF-induced insulin-resistant 3T3-L1 adipocyte model, BAPN avoided the downregulation of adiponectin and GLUT4 as well as the upsurge in SOCS3 amounts, and therefore normalised insulin-stimulated blood sugar uptake. (exposed-skin-care.net)
  • Finally, BAPN also normalises the insulin-stimulated blood sugar uptake and proteins degrees of GLUT4, adiponectin and SOCS3 buy 76584-70-8 in the TNF-induced insulin-resistant 3T3-L1 adipocyte model. (exposed-skin-care.net)
  • Epicardial adipose tissue has been recently recognized as a source of bioactive molecules as well as free fatty acids, adiponectin, and inflammatory cytokines. (qxmd.com)
Homeostasis5
  • Uncoupling protein 1 (UCP1), which is predominantly expressed in the brown adipose tissue, also plays an important role in energy homeostasis [ 7 ]. (hindawi.com)
  • BAPN also ameliorated the upsurge in collagen content material that was seen in adipose cells from obese pets and improved many metabolic guidelines C it ameliorated blood sugar and insulin amounts, reduced homeostasis model evaluation (HOMA) index and decreased plasma triglyceride amounts. (exposed-skin-care.net)
  • The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • Changes in circulating levels of hormones produced by these endocrine glands are detected by the hypothalamus, which then increases or decreases its stimulation of the pituitary to maintain homeostasis. (msdmanuals.com)
Triglycerides1
  • PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
Pancreatic5
  • Previous studies on the pathogenesis of T2D mainly focused on pancreatic β-cells function and insulin secretion regulation. (researchsquare.com)
  • Rab proteins are known to be important participants in insulin secretion by pancreatic β cells. (researchsquare.com)
  • In our previous study ( 16 ) , we found that Rab35 is closely related to the insulin secretion in pancreatic β cells, and Rab35 might be the target of miR-720 in pancreatic β cells. (researchsquare.com)
  • [ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
  • Finally, TCF7L2 polymorphisms have been associated with impaired insulin secretion, glucose production, and glucose tolerance via direct effects on pancreatic islet beta cells. (medscape.com)
Diabetes5
  • This is similar to type II diabetes in humans, where the action of insulin is impaired, despite often elevated concentrations. (wikipedia.org)
  • It is characterized by hyperglycemia and defective production and/or secretion of insulin and complications in the heart, kidney, and neural system leading to death, which have drawn notable attention to the management of diabetes. (frontiersin.org)
  • Diabetes decreased adipose tissue LPL activity partially by decreasing immunoreactive LPL protein and the steady-state levels of LPL mRNA, but primarily by reducing the catalytic activity of LPL. (jci.org)
  • Thus, diabetes and insulin treatment regulate LPL expression pretranslationally, translationally, and post-translationally, with tissue-specific differences apparent in the mechanisms involved. (jci.org)
  • Insulin treatment may prevent disorders of the growth hormone axis and allow normal growth in children with diabetes [ 11 - 13 ]. (hindawi.com)
Fatty2
Lipogenesis2
  • An experiment was conducted to evaluate the effects of dietary levels of chromium in the form of chromium picolinate on growth performance, nutrient utilizability, carcass composition, serum traits, and in vitro lipolysis and lipogenesis in adipose tissues of Arbor Acre broiler chicks. (eurekamag.com)
  • The in vitro lipolysis and lipogenesis in adipose tissues were significantly influenced by dietary addition of chromium (p lt 0.05). (eurekamag.com)
Adipocyte5
  • Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
  • There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
  • In obese rats, the inhibition of LOX activity through -aminopropionitrile (BAPN, a particular inhibitor of LOX activity) decreases adipose cells fibrosis, partly corrects the adipocyte-size distribution design (moving it toward smaller sized sizes) and attenuates the upsurge in bodyweight and extra fat mass. (exposed-skin-care.net)
  • In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling increases in proinflammatory ART markers and decreases in anti-inflammatory ART markers, and preceding adipose tissue macrophage (ATM) accumulation and proinflammatory M1 polarization. (nih.gov)
  • These investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM MHCII, escalates its progression. (nih.gov)
Accumulation1
  • It is also possible that IR occurs when adipocytes are overwhelmed, leading to the accumulation of lipid within other tissues. (wikipedia.org)
Obese animals2
Triglyceride levels2
  • This Cochrane review provides strong evidence that exercise programs ranging in duration from eight weeks to one year reduce A1C levels by approximately 0.6 percent, as well as reducing adipose tissue and triglyceride levels. (aafp.org)
  • Furthermore, the level of DNA methylation at the ABCG1 locus cg06500161 in blood DNA correlated positively with BMI, HbA1c, fasting insulin, and triglyceride levels, and was increased in adipose tissue and blood from the diabetic twin among monozygotic twin pairs discordant for T2D. (lu.se)
Brown adipos2
  • Finally, rosiglitazone upregulated uncoupling protein 1 in brown adipose tissue (BAT), but this protein was undetectable in tibiae, suggesting that MAT is unlikely to share thermogenic properties of BAT. (frontiersin.org)
  • Grains of Paradise: Brown adipose tissue (BAT) may be burned using this plant from the ginger family. (outlookindia.com)
Postprandial2
Uptake of glucose1
Receptor2
  • In the latter tissue, this was accompanied by improved insulin signaling, as suggested by higher activation of the insulin receptor and of the Akt/protein kinase B pathway. (unige.ch)
  • In the inguinal adipose depot, expression of uncoupling protein-1 was detected in Lou/C but not in Wistar rats, in keeping with a higher expression of peroxisome proliferator-activated receptor-gamma coactivator-1 in these animals. (unige.ch)
Serum1
Abdominal2
Acute2
  • Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
  • Both chronic and acute insulin normalized LPL activity and immunoreactive LPL protein, while only chronic insulin corrected the levels of LPL mRNA. (jci.org)
Diagnosed insulin-dependent1
  • The use of insulin regimens in patients with newly diagnosed insulin-dependent DM has substantially improved final height prognosis. (hindawi.com)
Regulate5
  • It is possible adipokines and cytokines made in adipose tissue down-regulate insulin pathways. (wikipedia.org)
  • This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. (nih.gov)
Hyperinsulinemic1
  • Hepatic magnetic resonance spectroscopy (MRS) and two-step hyperinsulinemic euglycemic clamps incorporating stable isotopes with concomitant adipose tissue microdialysis were used to evaluate carbohydrate and lipid flux. (whiterose.ac.uk)
Mechanisms4
  • Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
  • In the current experiments the mechanisms involved in the regulation of LPL have been examined in control rats, streptozocin-induced diabetic rats, and diabetic rats treated chronically or with a single injection of insulin. (jci.org)
  • Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
  • Glucose enters nervous tissue by non-insulin dependent transport mechanisms. (vin.com)
PPAR1
  • Activation of PPARγ nuclear receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. (globalrph.com)
Intake11
  • Decreased weight was most associated with increased intake of legumes and decreased intake of meat, fish, and poultry. (news-medical.net)
  • Increased intake of whole fruit was associated with a decrease in body weight. (news-medical.net)
  • Decreased egg intake was correlated with decreased weight. (news-medical.net)
  • Decreased high-fat dairy intake was associated with decreased weight and fat mass. (news-medical.net)
  • Reductions in the combined intake of total meat, fish, and poultry were associated with weight loss and a decrease in fat mass. (news-medical.net)
  • Decreases in intake of added animal fats were associated with decreases in weight and fat mass. (news-medical.net)
  • Decreased intake of added oils also correlated with decreases in weight and fat mass. (news-medical.net)
  • First, I discuss the interaction between coffee intake and insulin . (marksdailyapple.com)
  • Characteristic of a Standard American Diet (SAD) and Western lifestyle is a decrease in physical exercise (sedentary lifestyle) as well as an increase in energy intake in the form of increased dietary sugars and processed foods. (ndnr.com)
  • Pregnant and lactating female mice fed a diet high in fat and sugar (HFHS) commonly consumed by human populations showed decreased food, calorie, and protein intake but increased adiposity at the expense of lean mass. (bvsalud.org)
  • We are not prepared for excess dietary energy, our main defenses being decreased food intake and increased energy expenditure, largely enhanced metabolic activity and thermogenesis. (medscape.com)
Pancreas2
Deposition3
  • This situation leads to fat deposition in other tissues. (cambridge.org)
  • The 'adipose tissue expandability model' identifies the limited capacity and dysfunctionality of WAT, preventing its expansion and accommodation of surplus of energy, as key determinants for the onset and progression of obesity-associated metabolopathologies as a result of ectopic deposition of toxic lipid species in metabolic organs (i.e. muscle or liver [also known as lipotoxic insult]) [ 7 ]. (springer.com)
  • High cortisol levels lead to high insulin and blood sugar levels in the body, which results in easy fat deposition in the chest area. (larrybeinhart.com)
Hyperinsulinemia1
  • Horses with EMS will have an increased insulin response after they are given oral sugars, which will cause a subsequent rise in blood insulin levels, or hyperinsulinemia. (wikipedia.org)
Contributes1
Resistant4
  • Glucocorticoid (GC) production rates are elevated in obese, insulin resistant individuals. (endocrine-abstracts.org)
  • Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)
  • It is our goal to establish an ARC focused on understanding the relationship between metabolic disorders and Adipose Tissue Biology by studying adipose tissues from insulin sensitive and insulin resistant patients obtained during and after Bariatric Surgery. (bu.edu)
  • T2DM has become a source total of 122 studies were considered phied, becoming more resistant to the of suffering to both patients and their for the article and were reviewed in antilipolytic effects of insulin, resulting caregivers. (who.int)
Metabolic disease1
  • hence, the global burden of obesity and metabolic disease has motivated extensive study of these tissues ( 2 ). (frontiersin.org)
Chronic3
Fibrosis2
  • Consequently, our data offer proof that LOX takes on a pathologically relevant part in the metabolic dysfunction induced by weight problems and emphasise the eye of book pharmacological interventions that focus on adipose cells fibrosis and LOX activity for the medical management of the disease. (exposed-skin-care.net)
  • Lately, fibrosis continues to be recognised as an essential participant in adipose cells dysfunction in weight problems. (exposed-skin-care.net)