• Their studies show that this tissue actively takes up the metabolic substrate glucose when adults are exposed to cold. (scienceblogs.com)
  • Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk," Journal of Clinical Endocrinology and Metabolism , vol. 88, no. 11, pp. 5163-5168, 2003. (hindawi.com)
  • Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications. (jci.org)
  • The National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focusing on the role of the adipose tissue niche in the development, maintenance and remodeling of different adipose tissue depots in healthy individuals, and how the extracellular matrix and cellular components of the niche are modified during the develop of diabetes, in the overfed state, and following other metabolic stressors. (nih.gov)
  • Brown adipose tissue (BAT) has emerged as a promising target to counteract obesity and its associated metabolic disorders. (bioportfolio.com)
  • Adipose tissue (AT) dysfunction is a commonly observed feature of metabolic dysfunction in obesity and diabetes. (bioportfolio.com)
  • The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity as. (bioportfolio.com)
  • There is compelling evidence with regard to the importance of the nervous system in the regulation of adipose tissue mass, either brown or white, by acting on the metabolic pathways and on the plasticity (proliferation, differentiation, transdifferentiation, apoptosis) of these tissues. (biomedsearch.com)
  • Normal adipose tissue development is critical for maintaining a healthy metabolic state. (uniklinikum-leipzig.de)
  • Analyzing these samples, we assess alterations in gene expression, adipose tissue composition, metabolic function and the capacity of adipose progenitor cells to differentiate and proliferate. (uniklinikum-leipzig.de)
  • In addition to its lipid-storing capacity, adipose tissue is a highly active endocrine and metabolic organ. (aacrjournals.org)
  • It is clear that centrally mediated circadian rhythms play an important role in human health and our results provide initial information about how appropriate sunlight exposure to subcutaneous white adipose tissue (scWAT) might act as a peripheral circadian sensor that contributes to metabolic health. (patreon.com)
  • Henriette Frikke-Schmidt, Ph.D., from the University of Michigan in Ann Arbor, and colleagues examined how altered physiology of adipose tissue may contribute to the metabolic effects of bariatric surgery. (medicalxpress.com)
  • Our findings represent an important step forward in the understanding of how adipose tissue links to the development of metabolic disease", comments Professor Peter Arner, one of the principal investigators at Karolinska Institutet along with Hui Gao, Niklas Mejhert and Mikael Rydén. (medicalxpress.com)
  • IMPORTANCE Although the lungs are the port of entry and the predominant site of TB disease manifestation, we and others have demonstrated that M. tuberculosis also persists in adipose tissue of aerosol-infected animals and directly or indirectly alters adipose tissue physiology, which in turn alters whole-body immuno-metabolic homeostasis. (asm.org)
  • This novel concept is expanded as the role of adipose tissue in maintaining body homeostasis and the modulation of inflammatory and metabolic responses is discussed. (indigo.ca)
  • Collectively, we expect this work highlight the power of biomaterial drug delivery to the adipose tissue as a platform for treating obesity and type 2 diabetes and to aid in the development of new treatments for diabetes, the most common metabolic disorder in the United States. (aiche.org)
  • The team of researchers demonstrated a relationship between the metabolic activation of the tissue and changes in oxygenated and deoxygenated hemoglobin (red blood pigment), measured by means of multispectral optoacoustic tomography (MSOT). (phys.org)
  • The study demonstrated a direct relationship between the metabolic activation of the brown adipose tissue measured using hemoglobin gradients as an intrinsic biomarker of tissue metabolism and its calorie consumption after stimulation. (phys.org)
  • Overall we expect MSOT to become a key tool in measuring metabolic parameters in tissue, using portable and safe MSOT technology," says Prof. Ntziachristos. (phys.org)
  • Co-author Professor Martin Klingenspor from the Chair for Molecular Nutritional Medicine says, "The higher metabolic demand of the brown adipose tissue is supplied by increased blood circulation and oxygen utilization, which can be made visible in the tissue and the venous outflow by MSOT. (phys.org)
  • In the obesity/metabolic syndrome rat model, we observed that circulating sFlt-1 levels and sFlt-1 expression in adipose tissue were also inversely correlated with body weight. (ahajournals.org)
  • Introduction: Cell sheets consisting of adipose -derived stem cells (ADSCs) have been reported to be effective for wound healing. (nii.ac.jp)
  • The researchers used the new lab-on-a-chip to study how adult stem cells in adipose tissue develop into mature fat cells, conducting their investigations outside the body. (medindia.net)
  • Factors such as insulin and blood sugar levels influence whether or not adult stem cells in adipose tissue will develop into mature adipose cell. (medindia.net)
  • In contrast to embryonic stem cells, when adult stem cells divide, their offspring are only able to develop at the same site and in certain tissue types. (medindia.net)
  • This enabled adipose-derived adult stem cells to be successfully converted into mature fat cells within the experiments, and the corresponding signalling pathway mTORC1 was also decoded. (medindia.net)
  • Stem cell researchers led by Dr Adam Reid, present a review of the current literature on the suitability of adipose-derived stem cells in peripheral nerve repair. (medindia.net)
  • The use of stem cells for cell-based tissue engineering and regeneration strategies represents a promising alternative for smooth muscle repair. (pnas.org)
  • In this study, the capacity of processed lipoaspirate (PLA) and adipose-derived stem cells to differentiate into phenotypic and functional smooth muscle cells was evaluated. (pnas.org)
  • Several groups have suggested the use of bone marrow-derived cells ( 3 - 5 ) and embryonic stem cells to repair smooth muscle tissues ( 6 , 7 ) because of their stem cell-like properties. (pnas.org)
  • Adipose stem cells (ASC), a pluripotent clonal population derived from PLA cells, have shown higher differentiation capacity when compared to PLA cells ( 8 ). (pnas.org)
  • As stem cells can be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves, their use in medical therapies has been proposed. (patientslikeme.com)
  • However, the relatively low abundance, small tissue volume, difficult accessibility, and disease-related malfunction of bone marrow-derived stem cells hamper their clinical usefulness. (ahajournals.org)
  • Numerous studies have provided evidence that stromal cells derived from the adipose tissue (adipose tissue-derived stromal cells [ADSCs]) contain a population of adult multipotent mesenchymal stem cells and endothelial progenitor cells that can differentiate into several lineages, including endothelial cells, smooth muscle cells, and cardiomyocytes. (ahajournals.org)
  • The similarities between stem cells extracted from the bone marrow and the adipose tissue suggest the potential for the adipose tissue to act as an alternative, and perhaps preferable, cell source for repairing damaged tissues, such as the ischemic or infarcted heart. (ahajournals.org)
  • Adipose tissue may represent an ideal source of autologous stem cells, because it is easy to obtain with minimal patient discomfort, but yet capable of yielding cell numbers substantial enough to obviate extensive expansion in culture. (ahajournals.org)
  • 23-26 There is much confusion in the literature when using terms describing multipotent stem cells from the adipose tissue stroma. (ahajournals.org)
  • We refer here to the term adipose tissue-derived stromal cells (ADSCs), which identifies a plastic-adherent cell population that includes vascular (pericytes and endothelial progenitor cells)/adipocyte progenitor cells (preadipocytes) and adult multipotent mesenchymal stem cells (MSCs), besides circulating blood cells, fibroblasts, endothelial cells, smooth muscle cells, and immune cells, such as macrophages and lymphocytes 27 ( Figure 1 ). (ahajournals.org)
  • The relative abundance and easy access to adipose tissue has raised great interest among researchers using these cells as a source of mesenchymal stem cells (MSCs) in equine medicine. (scielo.br)
  • There are positive results related to the use of adipose-derived mesenchymal stem cells (AdMSCs) in disorders such as tendinitis (Del Bue et al . (scielo.br)
  • Within their niche, adipose-derived stem cells (ADSCs) are essential for homeostasis as well as for regeneration. (mdpi.com)
  • To investigate related risks, this study analyses the radiation response of adult stem cells isolated from the adipose tissue of the female breast. (mdpi.com)
  • And the title of my presentation is 'Stem Cells from Adipose Tissue. (hstalks.com)
  • Adipose tissue-derived stem cells are a powerful tool for in vitro study of adult stem cell biology. (wiley.com)
  • Fatty acids are taken up by muscle and cardiac tissue as a fuel source, and glycerol is taken up by the liver for gluconeogenesis. (wikipedia.org)
  • RESULTS Adipose tissue recovery during the dynamic phase of catch-up fat is accompanied by increased adipocyte number with smaller diameter, increased expression of genes for adipogenesis and de novo lipogenesis, increased fatty acid synthase activity, increased proportion of saturated fatty acids in triglyceride (storage) fraction but not in phospholipid (membrane) fraction, and no impairment in insulin signaling. (gu.se)
  • The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. (bioportfolio.com)
  • The overriding control of how Much gets deposited in the tissue as triglyceride and how much spills over into blood as albumin-bound fatty acids (NEFA) is exerted by the rate of glyceride synthesis. (diva-portal.org)
  • Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. (sciencemag.org)
  • Mobilization of stored fat is mediated by lipolytic enzymes, which degrade adipose TGs and release nonesterified fatty acids (FAs) into the circulation. (sciencemag.org)
  • Whereas white adipose tissue can provide lipids as substrates for other tissues according to the needs of the organism, brown adipose tissue will use fatty acids for heat production. (biomedsearch.com)
  • Paracrine interactions between adipose and lymphoid tissues are enhanced by diets rich in n-6 fatty acids and attentuated by fish oils. (open.ac.uk)
  • Fatty acids were assessed by gas-liquid chromatography in adipose tissue samples collected from all subjects. (ahajournals.org)
  • For the first time, positive relationships are reported between the proportion of n-6 polyunsaturated fatty acids (PUFA) in adipose tissue and adiponectin concentration and expression. (biomedsearch.com)
  • Electrical stimulation of nerves to isolated rat and rabbit adipose tissue in vitro causes production of free fatty acids. (sciencemag.org)
  • The release of free fatty acids results in the recruitment of macrophages into the adipose tissue . (biology-online.org)
  • To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and Israel. (unboundmedicine.com)
  • Adipose tissue levels of fatty acids were determined by capillary gas chromatography. (unboundmedicine.com)
  • Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. (nih.gov)
  • A gene that is responsible for the development of harmful adipose tissue in humans, thereby raising the risk of insulin resistance and type 2 diabetes, has been identified. (medindia.net)
  • Insulin resistance - a condition characterised by reduced cellular response to the hormone insulin that is released when the blood glucose levels rise after a meal - is an important causal factor underlying the increased risk of diabetes in individuals with hypertrophic adipose tissue. (medicalxpress.com)
  • The fact that adiponectin expression was decreased in omental adipose tissue relative to subcutaneous adipose tissue in overweight children suggests that a risk of insulin resistance may be present in childhood, which allows such resistance to develop after a relatively short duration of overweight. (aappublications.org)
  • However, its main function is to be a reserve of lipids, which can be oxidised to meet the energy needs of the body and to protect it from excess glucose by storing triglycerides produced by the liver from sugars, although some evidence suggests that most lipid synthesis from carbohydrates occurs in the adipose tissue itself. (wikipedia.org)
  • Adipose Tissue: Lipids and the Intercellular Matrix. (waterstones.com)
  • Human fat tissue contains about 87% lipids. (bionity.com)
  • We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). (jci.org)
  • 1 , 2 In contrast to the notorious WAT that stores energy as lipids, brown adipose tissue (BAT) dissipates energy directly as heat by uncoupling oxidative phosphorylation from adenosine triphosphate (ATP) production through the action of brown adipocyte-specific uncoupling protein 1 (UCP1). (nature.com)
  • Because these lipids have a chain of carbon atoms, there will be a density difference with the surrounding soft tissue such as the abdominal muscle. (bruker.com)
  • When the tissue is active, high amounts of lipids and glucose are combusted in the tissue. (nih.gov)
  • Adipose tissue consists of more than 99% of storage lipids, mainly triglycerides that are stored within the cell in so-called lipid droplets. (tu-dresden.de)
  • Oguri Y, Kajimura S. Cellular heterogeneity in brown adipose tissue. (harvard.edu)
  • Analysis of the long-term effects of dexamethasone treatment in mice revealed that Foxa3 ablation protects mice specifically against fat accretion but not against other pathological side effects elicited by this synthetic GC in tissues such as liver, muscle, and spleen. (pnas.org)
  • Bone marrow transplant studies and quantitation of macrophage number in adipose tissue from macrophage-deficient (Csf1op/op) mice suggest that these F4/80+ cells are CSF-1 dependent, bone marrow-derived adipose tissue macrophages. (jci.org)
  • In the late 1970s it was proposed, primarily on the basis of studies on rats and mice, that reduced expenditure on adaptive heat production (thermogenesis) associated with a specialized fat tissue-brown adipose tissue (BAT)-is central to the development of obesity. (diabetesjournals.org)
  • Using this novel technique in mice, the researchers were able to study the function of the neurons that innervate the adipose tissue, and saw that their elimination results in mice pounding up very quickly. (news-medical.net)
  • Ines Mahu, PhD student in Domingos' laboratory and author of this study, describes their results: 'We were able to eliminate neurons from the adipose tissue of mice, without affecting the brain. (news-medical.net)
  • In the adipose tissue of obese mice and humans, OSM expression is significantly induced. (pbrc.edu)
  • ATGL is highly expressed in adipose tissue of mice and humans. (sciencemag.org)
  • However, the nonobese phenotype of HSL knock-out (HSL-KO) mice ( 7 - 9 ) and the accumulation of diglycerides (DGs) in their adipose tissue ( 10 ) suggest that there may be one or more additional lipases in adipose tissue that preferentially hydrolyzes the first ester bond of the TG molecule. (sciencemag.org)
  • It turned out that these mice developed adipose hypertrophy and displayed increased lipid mobilisation from fat cells . (medicalxpress.com)
  • Our results confirm the presence of M. tuberculosis in fat tissue after aerosol infection of mice and show that loss of fat cells is associated with an increase in pulmonary M. tuberculosis burden and pathology. (asm.org)
  • In high-fat diet (HFD)-fed obese mice, it has been shown that infiltration of macrophages into adipose tissue coincides with the occurrence of hyperinsulinemia, an indirect measure of IR. (ahajournals.org)
  • CCR2 −/− mice exhibited a reduction in adipose tissue macrophage content which was associated with an improvement, but not complete restoration of systemic glucose homeostasis and insulin sensitivity, suggesting that other inflammatory cells may play a role in this context. (ahajournals.org)
  • A recent study in mice reported mainly CD8-positive lymphocyte infiltration in hypoxic areas within the adipose tissue. (ahajournals.org)
  • The therapeutic efficacy of resveratrol scaffolds was tested by implant into the epididymal adipose tissue of mice receiving a 60% fat diet, which results in significant weight gain and glucose intolerance. (aiche.org)
  • The truncated ANGPTL4 was found to be associated with adipocyte differentiation in mice, however, only the native form was detected in adipose tissues in human (Mandard et al. (thefreelibrary.com)
  • This month's issue will focus on the quantification of adipose tissue in vivo in mice or rats using the SkyScan 1278 microCT system. (bruker.com)
  • Plasma decay and tissue uptake of wild-type 125 I-HDL tracer were similar in both genotypes of recipient mice, suggesting that adipocyte ABCA1 deficiency reduces plasma HDL concentrations solely by reducing nascent HDL particle formation. (ahajournals.org)
  • We have here reviewed the medical literature describing molecular and functional characterization, differentiation, potential role, and results obtained so far using ADSCs in tissue repair, with a particular focus on the role for ADSCs in cardiovascular repair and regeneration. (ahajournals.org)
  • We further identify regulators of normal and disturbed adipose tissue function and subsequently perform functional characterization by looking at their role for adipocyte differentiation in vitro (cell lines and primary predadipocytes) and in vivo by using the zebrafish (Danio rerio) as a model for obesity and associated diseases (Landgraf K, 2017). (uniklinikum-leipzig.de)
  • Various tissue-derived products are used to regenerate, repair, or otherwise treat diseased or damaged tissues and organs. (google.ca)
  • White adipose surrounds the internal organs. (wisegeek.com)
  • Smooth muscle is a major component of human tissues and is essential for the normal function of a multitude of organs including the intestine, urinary tract and the vascular system. (pnas.org)
  • The multilineage capacity of PLA cells and ASC makes them promising candidates for reconstruction of human smooth muscle related tissues and organs. (pnas.org)
  • Cell harvesting procedures from these organs are painful and costly, and frequently associated with the risk of donor-site tissue morbidity. (ahajournals.org)
  • ANGPTL4 mRNA is expressed in many organs and tissues, highly in WAT, placenta, liver, muscle (Feingold et al. (thefreelibrary.com)
  • Ulrich's study analyzed the effects of fat on breast, colorectal, esophageal, endometrial, prostate, and ear-nose-throat cancer, taking into consideration the proximity of adipose tissue relative to the organs. (healthcanal.com)
  • The products can comprise a decellularized adipose extracellular tissue matrix and a reduced lipid content. (google.ca)
  • In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development. (jci.org)
  • PKA phosphorylates two important proteins with established functions in lipolysis: HSL, an enzyme that catabolizes adipose tissue TGs, and perilipin A, an abundant structural protein located on the surface of lipid droplets. (sciencemag.org)
  • differences from the lean state that impair muscle function in- Results: Body mass decreased in the RT+CR group but not in the RT cluding greater lipid accumulation around [subcutaneous adipose group. (scribd.com)
  • Individuals with large fat cells had markedly lower EBF1 expression in their adipose tissue, displayed altered lipid mobilisation and were insulin resistant. (medicalxpress.com)
  • Free from residual lipid, cellular fragments and DNA content, Leneva retains key matrix proteins including Collagen IV and Collagen VI, and is injected where native fat already exists to provide soft tissue augmentation and cell attachment and remodeling. (businesswire.com)
  • Shotgun lipidomics technology enables to identify a vast number of lipid molecules and study their roles in biological systems, and it can be applied to cell cultures, fluids and tissues. (tu-dresden.de)
  • It responded to high-fat diet by altering its lipid composition and shifting towards that of white adipose tissue", explains Dr. Michal Grzybek, who is first author of the study. (tu-dresden.de)
  • This new and validated protocol wants to facilitate the systematic molecular profiling of adipose tissue by providing high reproducibility and linear dynamic range for all lipid classes. (tu-dresden.de)
  • In the abdominopelvic cavity, a layer of adipose tissue is present that lines the parietal peritoneum. (enotes.com)
  • In Adipose Tissue Protocols, Gérard Ailhaud and a team of laboratory experts and clinicians describe in step-by-step detail the major techniques needed for the study of adipose tissue and cells. (springer.com)
  • Dr Blüher has a specific research focus in the study of adipose tissue function, including regulation of adipose tissue cellularity and adipokine secretion. (scribd.com)
  • Many of us were taught that the function of adipose tissue was simply for storing energy and providing padding to important structures. (hstalks.com)
  • The formation of adipose tissue appears to be controlled in part by the adipose gene . (wikipedia.org)
  • Adipocytokine gene expression was assessed in the transplanted adipose tissues, and the thoracic aorta was harvested to quantify atherosclerotic lesions by Oil-Red O staining and to assess vasorelaxation by wire myography. (springer.com)
  • In the current study, researchers identified a gene, EBF1, which according to these new findings drive the development of the unhealthy adipose tissue . (medicalxpress.com)
  • This is the first time someone has identified a gene which may cause malfunctioning adipose tissue in man. (medicalxpress.com)
  • mRNA expression of ovine angiopoietin-like protein 4 gene in adipose tissues. (thefreelibrary.com)
  • apM1 gene expression, restricted to the adipocyte fraction of adipose tissue, decreased spontaneously when adipose explants were cultured in basal medium for 24 h while the expression of other adipose genes barely changed (PPARgamma, GAPDH) or increased (PAI-1). (unboundmedicine.com)
  • Despite association with low bone density and skeletal fractures, marrow adipose tissue (MAT) remains poorly understood. (frontiersin.org)
  • Increased marrow adipose tissue (MAT) is associated with states of impaired bone formation ( 1 , 2 ) and dysfunctional hematopoiesis ( 3 - 5 ), although its physiological role remains unclear. (frontiersin.org)
  • Marrow Adipose Tissue in Adolescent Girls with Obesity. (bioportfolio.com)
  • The aim of this study was to compare the expression levels of the genes that encode adiponectin and PPARγ in subcutaneous and omental adipose tissue in children in relation to age and anthropometric variables. (aappublications.org)
  • 001). In overweight children, the median adiponectin mRNA level was lower in omental adipose tissue (odds ratio: 0.51 [95% confidence interval: 0.1-2. compared with subcutaneous adipose tissue (odds ratio: 1.29 [95% confidence interval: 0.16-5. ( P = .032) but not in normal-weight children ( P = .54), and the difference remained significant after adjustment for age ( P = .045). (aappublications.org)
  • Objectives: Our objective was to determine gender-specific responses to periapical tooth lesions (PA) on the composition of omental adipose tissue in the rat. (umich.edu)
  • Schwartze JT, Landgraf K, Spielau U, Rockstroh D, Löffler D, Kratzsch J, Kiess W, Körner A: Adipocyte C1QTNF5 expression is BMI-dependently related to early adipose tissue dysfunction and systemic CTRP5 serum levels in obese children. (uniklinikum-leipzig.de)
  • Recent human and animal studies suggest that by altering rates of adipocyte differentiation and proliferation, differences in the composition of dietary fat may also contribute to adipose tissue development. (cambridge.org)
  • Linnea Pearson (University of Alaska, Fairbanks) presented her work completed with Drs. Mike Hammill (Maurice Lamontagne Institute, Mont-Joli, QC, Canada) and Jennifer Burns (University of Alaska, Anchorage), entitled "Brown Adipose Tissue and Non-shivering Thermogenesis Aid Harp Seals ( Pagophilus groenlandicus ) but not hooded seals ( Cystophora cristata ) or Weddell Seals ( Leptonychotes weddelli ) at birth. (scienceblogs.com)
  • Another mechanism is through nonshivering thermogenesis regulated by brown fat (i.e. adipose). (scienceblogs.com)
  • This model is characterized by glucose redistribution from skeletal muscle to adipose tissue during catch-up fat that results solely from suppressed thermogenesis (i.e., without hyperphagia). (gu.se)
  • Brown adipose tissue (BAT) is an important source of thermogenesis which is nearly exclusively dependent on its sympathetic nervous system (SNS) innervation. (jneurosci.org)
  • Brown adipose tissue expends energy through sympathetic nervous system-mediated non-shivering thermogenesis, where uncoupling protein 1 (UCP1) is the key player. (diva-portal.org)
  • In thermoregulatory thermogenesis, brown adipose tissue is essential for classical nonshivering thermogenesis (this phenomenon does not exist in the absence of functional brown adipose tissue), as well as for the cold acclimation-recruited norepinephrine-induced thermogenesis. (nih.gov)
  • Heat production from brown adipose tissue is activated whenever the organism is in need of extra heat, e.g., postnatally, during entry into a febrile state, and during arousal from hibernation, and the rate of thermogenesis is centrally controlled via a pathway initiated in the hypothalamus. (nih.gov)
  • The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings. (nih.gov)
  • Thyroid hormones, obesity and brown adipose tissue thermogenesis]. (nih.gov)
  • Corticotropin releasing factor increases in brown adipose tissue thermogenesis and heart rate through dorsomedial hypothalamus and medullary raphe pallidus. (nih.gov)
  • Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. (nih.gov)
  • Glucocorticoids (GCs) are widely prescribed anti-inflammatory agents, but their chronic use leads to undesirable side effects such as excessive expansion of adipose tissue. (pnas.org)
  • Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals. (jci.org)
  • According to research published online in The FASEB Journal , repeated irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that ultimately reduces the efficiency of radiotherapy in breast cancer patients. (news-medical.net)
  • This research was based on a recent discovery that there is an inflammatory interaction between breast tumors and adipose tissue. (news-medical.net)
  • Contrary to prior belief that the adipose tissue plays a role only in energy storage, it is in fact a large endocrine and secretory organ that produces a multitude of pro-inflammatory cytokines and adipokines, resulting in various downstream effects ( 8 ). (frontiersin.org)
  • Diet-induced obesity is associated with the loss of tissue homeostasis and development of type 1 inflammatory responses in VAT, characterized by IFN-γ. (nih.gov)
  • Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity," Circulation , vol. 128, no. 1, pp. 9-18, 2013. (hindawi.com)
  • Perivascular adipose tissue (PVAT) surrounds the arterial adventitia and plays an important role in vascular homeostasis. (springer.com)
  • Here, using adipose tissue transplantation, we tested the hypothesis that expansion of PVAT can also remotely exacerbate vascular disease. (springer.com)
  • Periadventitial adipose tissue plays a critical role in vascular remodeling. (springer.com)
  • We propose that adipose tissue dysfunction has a prominent role in cancer pathogenesis and progression. (aacrjournals.org)
  • In this article, we investigated the association between M. tuberculosis infection, adipose tissue, and TB disease progression using a transgenic inducible "fatless" model system, the FAT-ATTAC (fat apoptosis through targeted activation of caspase 8) mouse. (asm.org)
  • Adipose tissue - more specifically brown adipose tissue - was first identified by the Swiss naturalist Conrad Gessner in 1551. (wikipedia.org)
  • Dr. Symonds presented data showing that the temperature of the brown adipose tissue in children's bodies actually increased in response to placing their hands or feet into cool water. (scienceblogs.com)
  • Figure 2 from the research paper ("Functional Imaging of Brown Adipose Tissue", Heart Metab. (scienceblogs.com)
  • The other kind of adipose tissue is brown adipose tissue. (wikipedia.org)
  • Brown adipose tissue (BAT) is known to function in the dissipation of chemical energy in response to cold or excess feeding, and also has the capacity to modulate energy balance. (nih.gov)
  • Brown adipose tissue also generates heat, which keeps the body at a stable temperature. (wisegeek.com)
  • Brown adipose tissue (BAT) was first discovered several hundreds of years ago ( 1 ). (diabetesjournals.org)
  • A Novel PET Probe for Brown Adipose Tissue Imaging in Rodents. (bioportfolio.com)
  • brown adipose tissue ( brown fat tissue ) brown fat . (thefreedictionary.com)
  • Brown adipose tissue dissipates energy in the form of heat. (nature.com)
  • Recent development in targeting brown adipose tissues for th. (lww.com)
  • PPARa is not involved in the regulation of muscle-associated genesin brown adipose tissue. (diva-portal.org)
  • We were able to observe that brown adipose tissue exhibited a distinct lipidomic profile. (tu-dresden.de)
  • Brown adipose tissue has played a key role in prevention research since its presence was first documented in adults. (phys.org)
  • A team at the Technical University Munich (TUM) and the Helmholtz Zentrum München has now visualized the activity of brown adipose tissue without injecting substances. (phys.org)
  • In the cold, brown adipose tissue acts like a heat generator, and its activity has a positive effect on energy balance. (phys.org)
  • Therefore, scientists are researching the factors keeping brown adipose tissue active. (phys.org)
  • Until now, it has only been possible to measure the heat output of brown adipose tissue by means of invasive methods. (phys.org)