Adipose accumulation. Medical search. Frequent questions

We studied the effect of bilberry ( Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). (nih.gov)
5 μg/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. (nih.gov)
Hepatic magnetic resonance spectroscopy (MRS) and two-step hyperinsulinemic euglycemic clamps incorporating stable isotopes with concomitant adipose tissue microdialysis were used to evaluate carbohydrate and lipid flux. (whiterose.ac.uk)
Adipose tissue lipid mobilization was decreased by dutasteride. (whiterose.ac.uk)
Conclusions: Dual-SRD5A inhibition with dutasteride is associated with increased intrahepatic lipid accumulation. (whiterose.ac.uk)
Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning of white adipose tissues. (dtu.dk)
A) In normoxia conditions, adipocytes differentiate with an increase of PPARγ2 expression and increase of lipid accumulation (B) In hypoxic conditions (mimetic), adipocytes do not express PPARγ2 but with increased lipid accumulation. (atlasofscience.org)
Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line. (atlasofscience.org)
Furthermore, isoproterenol-induced hepatic unwanted fat accumulation seemed to reveal systems intrinsic to liver organ since acipimox, an inhibitor of adipose tissues lipolysis, didn't alter hepatic lipid amounts. (baxkyardgardener.com)
Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (WC, cm) and triglycerides (TGs, mmol/l): (WC-65) ×TG (men) and (WC-58) ×TG (women). (biomedcentral.com)
Lipid accumulation should be defined and measured specifically in those contexts where accumulation may represent a physiologic danger [ 6 , 7 ]. (biomedcentral.com)
These contexts might be described as lipid over accumulation [ 8 ]. (biomedcentral.com)
Kahn described a simple index for estimating lipid over accumulation among adults - designated the "lipid accumulation product" (LAP) - based on a combination of two measurements that are safe and inexpensive to obtain. (biomedcentral.com)
If LAP is better correlated than BMI with cardiovascular risk factors, this finding would support the notion that the over accumulation of lipid carries worse cardiovascular consequences than the less specific over accumulation of weight [ 9 ]. (biomedcentral.com)
Hepatic lipid accumulation was also significantly reduced in caffeine treatment larvae. (biomedcentral.com)
Because of the advantage of transparent body in juvenile period suitable for identifying lipid accumulation in liver by whole-mount oil red O staining, in present study we attempted to determine whether juvenile zebrafish can be used as a model for diet-induced NAFLD. (biomedcentral.com)
the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
Indeed, WAT remodeling eventually associated with a limited capacity to adequately expand might induce lipid spill over and this triglyceride accumulation in other depots such as liver or muscle. (springer.com)
However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
We observed that human hepatocytes exhibited excessive lipid accumulation. (wur.nl)
In diet-induced obese mice, HILPDA deficiency in macrophages markedly reduced lipid accumulation in macrophages yet it did not alter any measured inflammatory or metabolic parameters. (wur.nl)
Treatment with the ATGL inhibitor Atglistatin rescued lipid accumulation inside lipid droplets in HILPDA-deficient macrophages. (wur.nl)
This research questions the contribution of lipid droplet accumulation in adipose tissue macrophages in obesityinduced inflammation and metabolic disfunction. (wur.nl)
Hilpda overexpression in turn induces triglyceride accumulation inside lipid droplets. (wur.nl)
Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)
A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)

Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. (nih.gov)
In addition, we investigated the relationship of ATMc and subcutaneous adipose tissue expression of genes potentially involved in attraction of macrophages into adipose tissue. (bioinbrief.com)
Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
HIIT increased the AOPP level in subcutaneous adipose tissue. (hindawi.com)
In this thesis, MR-based methods for in vivo FAC measurements were compared and validated against FAC quantification gas chromatography analysis of subcutaneous adipose tissue (Paper III). (lu.se)

Compared to littermate wildtype mice, TG mice selectively reduced inguinal white adipose tissue (iWAT) mass and fat cell size, whereas the epididymal (eWAT) fat depot remained unchanged. (dtu.dk)
It is characterized by an excessive increase of white adipose tissue. (atlasofscience.org)
Fig. 1b, c ) or the pancreas and the white adipose tissue (WAT) that are infiltrated with MAC1-possitve macrophages expressing YFP (Fig. 1d ). (nature.com)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)
Since the discovery that adipocytes may secrete a variety of bioactive molecules (hormones, chemokines, and cytokines), an endocrine and paracrine role for white adipose tissue (WAT) in the regulation of energy balance and other physiological processes has been established, particularly with regard to brain and muscle. (unige.ch)

Alawi MA, Tamimi S, Jaghabir M. Storage of organochlorine pesticides in human adipose tissues of Jordanian males and females. (comprehensivephysiology.com)
Nevertheless, PAI-1 and Compact disc11c appearance are indie predictors of insulin actions, indicating a feasible function for adipose tissues macrophage activation. (bioinbrief.com)
Adipose tissues is an initial site of obesity-induced irritation and a complicated organ formulated with adipocytes aswell as connective tissues matrix, nerve tissues, stromal vascular cells, and immune system cells. (bioinbrief.com)
A cardinal feature of obesity-induced irritation in adipose tissues may be the recruitment of immune system cells, macrophages (5 specifically,6). (bioinbrief.com)
However the adipocyte may be the determining cell of adipose tissues and does donate to the creation of inflammatory substances (7), it would appear that macrophages donate to the inflammatory indicators that are induced by weight problems (5 significantly,8C11). (bioinbrief.com)
Among the inflammatory elements whose expression is certainly upregulated in adipose tissues using the starting point of weight problems, some have already been implicated in recruitment of macrophages to adipose tissues, including chemokines, BIX 02189 ic50 while some seem to be derived mainly from adipose tissues macrophages (ATMs). (bioinbrief.com)
Research in rodents suggest that ATMs are bone tissue marrowCderived cells recruited to adipose tissues during intervals of positive energy stability and raising adiposity (5). (bioinbrief.com)
Specifically, the adhesion molecule intercellular adhesion molecule 1 (ICAM1) is certainly essential in the recruitment of monocytes to sites of irritation (14), its soluble plasma concentrations have already been found to become positively connected with adiposity (15,16), and in prior microarray research in mice adipose tissues appearance was correlated with body mass (5). (bioinbrief.com)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. (cambridge.org)
This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx. (cambridge.org)
Exipure was created to combat the root cause for obesity in women and men: low brown adipose tissues levels. (ipsnews.net)
This formula will help your body produce more brown adipose tissues, which can be used to burn more fats naturally. (ipsnews.net)
Many scientists finally agree that obesity is caused by low brown adipose tissues, according to a 2021 study. (ipsnews.net)
This ingredient increases the amount of brown adipose tissues (BAT) which helps fat cells shrink. (ipsnews.net)

The influx of macrophages and accumulation of T-cells and myofibroblast were quantified in orbital connective tissue. (frontiersin.org)
OBJECTIVE In severely obese individuals and patients with diabetes, accumulation and activation of macrophages in adipose tissue has been implicated in the development of obesity-associated complications, including insulin resistance. (bioinbrief.com)
adipose tissue expression of plasminogen activator inhibitor type-1 (PAI-1) and CD11 antigen-like family member C (CD11c), markers produced by macrophages, were negatively correlated with adjusted glucose disposal rate (= ?0.28, = 0.05 and = ?0.31, = 0.03). (bioinbrief.com)
Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect ( Er1 F/− ) triggers Golgi dispersal, dilation of endoplasmic reticulum, autophagy and exosome biogenesis leading to the secretion of extracellular vesicles (EVs) in vivo and ex vivo. (nature.com)
Indeed the visceral WAT which is more inflamed with higher accumulation of macrophages [ 7 ] has more detrimental effects than the subcutaneous WAT [ 11 ]. (springer.com)
We studied the function of HILDPA in adipose tissue macrophages (ATM) in the context of obesity-induced inflammation and in hepatocytes during non-alcoholic steatohepatitis (NASH). (wur.nl)
CONCLUSION: The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes. (unige.ch)

In obesity, adipocytes become very large and the vasculature of adipose tissue is unable to grow along to provide oxygen to adipocytes, leading to local adipose tissue hypoxia. (atlasofscience.org)
In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)

After 6 weeks, blood, liver, and adipose tissue were collected for determination of plasma lipids and lipoproteins, tissue cholesterol concentrations, inflammatory cytokines and expression of genes regulating hepatic cholesterol and triglyceride metabolism. (uconn.edu)
Extra fat accumulation in liver organ (hepatic steatosis) predisposes to hepatic useful and structural impairment and general metabolic risk. (baxkyardgardener.com)
Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD. (c3m-nice.fr)
This study investigated the contribution of osteopontin/secreted phosphoprotein 1 (SPP1) to T-cell regulation in initiation of obesity-driven adipose tissue (AT) inflammation and macrophage infiltration and the subsequent impact on insulin resistance (IR) and metabolic-associated fatty liver disease (MAFLD) development. (c3m-nice.fr)
It is estimated that approximately 20-30 % of adults and 3-10 % of children in western countries suffer from excessive fat accumulation in the liver [ 1 ]. (biomedcentral.com)
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. (mdpi.com)
These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glycogen synthase activity and glycogen synthesis rate. (jci.org)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)
Accumulation of triacylglycerol in skeletal muscles and in liver is associated with insulin resistance. (cambridge.org)
Viral DNA was isolated from brain, lung, liver, muscle, and adipose tissue of monkeys 7 months after initial infection, long after the active virus has disappeared from blood and feces ( 3 ). (cdc.gov)
Water/fat imaging has the possibility of measuring both the adipose tissue volume in depots designated for fat storage and the fat and adipose tissue within organs or body parts such as the liver or skeletal muscle. (lu.se)

Hypoxia was reported to occur in adipose tissue in obese mice and humans. (atlasofscience.org)
Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. (harvard.edu)
were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
Infection with human adenovirus 36 (Adv 36) has been reported to cause a large accumulation of fat in 4 animals (chickens, mice, rats, and monkeys) ( 1 - 3 ). (cdc.gov)

Launch The metabolic symptoms comprises several related disorders including weight problems, insulin level of resistance, type 2 diabetes, and coronary disease (Ford administration of isoproterenol to youthful and previous rodents, and overexpression buy AP1903 of 1- and 2-ARs in hepatocytes from youthful animals, increased unwanted fat accumulation, whereas unwanted fat articles of hepatocytes from previous rodents was decreased by 1- and 2-AR selective antagonists. (baxkyardgardener.com)
Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). (mdpi.com)
Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model. (ox.ac.uk)
CONCLUSIONS/INTERPRETATION: Elevated NEFA levels represent a powerful, self-sufficient promoter of cardiac TG accumulation and are a downregulator of myocardial glucose uptake, indicating that the focus of treatment should be to 'normalise' adipose tissue function to lower the risk of cardiac TG accumulation and myocardial insulin resistance. (ox.ac.uk)
Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)

However, HIIT was more efficient than MICT in the skeletal muscle, whereas MICT was more efficient in epididymal adipose tissue. (hindawi.com)
For example, the fat accumulation in skeletal muscle of patients with lymphedema was estimated using water/fat imaging in Paper II. (lu.se)

Incubation of conditioned medium with antimonocyte chemoattractant protein-1 antibodies prevented triglyceride accumulation. (unige.ch)
Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved. (unige.ch)

In this thesis, the FAC of the subcutaneous and visceral adipose tissue of Iraqi- and Swedish-born men was measured and compared using the MRI-based method (Paper IV). (lu.se)
However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)

The high cholesterol diet resulted in accumulation of cholesterol and inflammation in the adipose tissue, which was not prevented by Moringa treatment. (uconn.edu)
We conclude that ML protect against hepatic steatosis by affecting genes involved in synthesis and uptake of hepatic lipids resulting in lower concentrations of cholesterol and triglycerides and reduced inflammation, however, plasma lipids and adipose tissue cholesterol and inflammation were not affected significantly by ML consumption. (uconn.edu)
Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. (greenmedinfo.com)
In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)

Pet and human research of obese and diabetic subjects show that adipose tissue macrophage content (ATMc) correlates with degree of adiposity (5,6,8,9,12). (bioinbrief.com)

This is because your body lacks brown adipose tissue. (ipsnews.net)
Exipure has been designed to target the root cause (lack BAT-brown adipose tissue) and speed up your metabolism. (ipsnews.net)
Dense mitochondria, which primarily work to shrink and lose fat 24×7 , give the brown adipose tissue its brown color. (ipsnews.net)
It has been shown to increase the brown adipose tissue to aid in fat loss. (ipsnews.net)
Holy basil, a herb, helps to detoxify cells and improve the composition of brown adipose tissue. (ipsnews.net)

CELLIPEX Silhouette Concentrate is an exceptional, concentrated product, that employs a rich mix of natural bio-activators, of the lipolysis process to trigger the breakdown of cellulite, and localized accumulations of fat. (cholley.com)
It contains phyto extracts and caffeine whose combined action stimulates the adrenaline receptors of the adipose cells, initiating the lipolysis process. (cholley.com)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)

The substance does not indicate a significant potential for accumulation, when taking into account the predicted behaviour concerning absorption and metabolism. (europa.eu)

This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. (nih.gov)
Adipose tissue is a metabolic and endocrine organ, and its adipocytes have the ability to synthesize and secrete extracellular vesicles (EVs), thus allowing intercellular communication. (usp.br)

In the paper that we published we evaluated the impact of the oxygen decrease (hypoxia) in adipose tissue by treating adipocytes with hypoxia mimetics, cobalt chloride and deferoxamine. (atlasofscience.org)
Hypoxia blocks the differentiation of adipocytes but increases the accumulation of lipids by these cells. (atlasofscience.org)

Biopsy of adipose tissue identified human adenovirus 36 (Adv 36) DNA. (cdc.gov)

The accumulation of fat in the buttocks and lower limbs occurs almost exclusively in females. (medscape.com)

The excess accumulation of fat within the intermuscular and intramuscular compartments has not been demonstrated in any previous study of lymphedema. (lu.se)

For many years, adipose tissue has been mainly considered as an inert reservoir for storing triglycerides. (unige.ch)

Perivascular adipose tissue surrounds blood vessels and regulates cardiovascular physiology. (jove.com)

Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)

Berardinelli-Seip congenital lipodystrophy type 2, the severest form of human lipodystrophy with an almost complete loss of adipose tissue, is due to loss-of-function mutations in the BSCL2/SEIPIN gene. (medscape.com)

The relationship between the accumulation of adipose tissue within the different depots and organs of the body, and the risk of developing numerous diseases, has been investigated and established. (lu.se)

We show that a population of multipotent progenitors can be derived successfully from perivascular adipose tissue from patients with cardiovascular disease. (jove.com)

This protocol is used to answer key questions related to the function of human adipose progenitors in the vascular microenvironment. (jove.com)

When the open reading frame 1 early region 4 gene was transferred to a retrovirus and inserted into preadipocytes in vitro, the gene was capable of inducing the enzymes and enhancing fat accumulation ( 13 ). (cdc.gov)

Environmental hazard expresses the inherent, environmentally harmful characteristics of the pharmaceutical substance, such as resistance to degradation (P = persistence), ability to accumulate in adipose tissue (B = bioaccumulation), and its toxicity to aquatic organisms (T = toxicity). (janusinfo.se)

Massive adipose tissue depositions in the abdomen and thorax sufficient to interfere with respiration developed in a patient with multiple medical problems. (cdc.gov)

In addition, ectopic fat accumulation in the muscle promotes ROS production in this tissue [ 18 ]. (hindawi.com)

The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
Obtain a 500 milligram piece of Human Perivascular Adipose Tissue or PVAT from the operating room as described in the text protocol. (jove.com)

Anatomy45

Organisms18

Diseases18

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes70

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science3

Health Care3

Lipid26

Subcutaneous adipose tissue5

White Adipos6

Tissues15

Macrophages7

Local adipose tissue hypoxia2

Liver12

Mice4

Insulin7

Skeletal2

Triglyceride2

Visceral2

Inflammation4

Macrophage1

Brown adipos5

Lipolysis2

Excessive1

Metabolism1

Metabolic2

Adipocytes2

Biopsy1

Buttocks1

Excess1

Triglycerides1

Blood vessels1

Tissue expression1

Lipodystrophy1

Depots1

Cardiovascular1

Vascular1

Enzymes1

Resistance1

Abdomen1

Muscle1

Human2