Adiponectin receptor expression. Medical search. Frequent questions

The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin. (diabetesjournals.org)
AdipoR1 mRNA expression was positively correlated with in vivo insulin and C-peptide concentrations, first-phase insulin secretion, and plasma triglyceride and cholesterol concentrations before and after adjustment for sex, age, waist-to-hip ratio, and body fat. (diabetesjournals.org)
In multivariate linear regression models, mRNA expression of AdipoR1, but not AdipoR2, was a determinant of first-phase insulin secretion independent of insulin sensitivity and body fat. (diabetesjournals.org)
Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene. (wikipedia.org)
Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. (wikipedia.org)
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. (wikipedia.org)
Adiponectin (ADIPOQ) is a member adipocytokines, and its actions are supported by two receptors, ADIPOQ receptor 1 and -2, respectively (ADIPOR1 and -R2). (unipg.it)
Our study was performed to evaluate the ADIPOR1 presence and location and its gene expression in reproductive tissues of the male ram, during its non-breading season. (unipg.it)
Two receptors ubiquitously expressed, AdipoR1 and AdipoR2, are involved in its action which. (unina.it)
Results: Expression levels of AdipoR1 were lower in advanced plaques as well as in their respective adjacent regions than in healthy arteries (p = 0.020 and p = 0.001 respectively). (unina.it)
In both cell types, expression of AdipoR1 was not affected by the co-culture with THP-1. (unina.it)
On the maternal side adiponectin and adipor1 are increased. (uni-halle.de)
In the blastocyst adipor1 was increased in the whole blastocyst while adiponectin was only increased in the trophoblast and no adiponectin was detectable in the embryoblast. (uni-halle.de)
mRNA levels of Adiponectin in WHT ( A ). Immunoblot results ( B ) and protein expression of Adiponectin ( C ). mRNA expression of the Adiponectin receptors AdipoR1 ( D ), AdipoR2 ( E ) and T-cadherin ( F ). The transcripts were analyzed by qPCR. (aging-us.com)
Based on crystal structure of AdipoR1, we designed AdipoR1's peptide agonists using protein-peptide docking simulation and screened their receptor binding abilities and biological functions via surface plasmon resonance (SPR) and biological analysis. (phoenixpeptide.com)
The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. (elsevierpure.com)
Molecular dynamics simulations revealed that a Tyr-Pro molecule was stably positioned in the two potential binding pockets (sites 1 and 2) of the seven-transmembrane receptor, AdipoR1, anchored in a virtual 1-palmitoyl-2-oleoyl-phosphatidylcholine membrane. (elsevierpure.com)
Adiponectin (APN) is the most abundant adipocytokine primarily secreted by adipose tissues and regulates various physiological processes via its receptors (AdipoR1, AdipoR2, and T-cadherin) [ 16 ]. (biomedcentral.com)

Discovery of a novel potent peptide agonist to adiponectin receptor 1. (phoenixpeptide.com)
A potent peptide as adiponectin receptor 1 agonist to against fibrosis. (phoenixpeptide.com)
BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. (jci.org)
In BV2 cells, the APN receptor agonist AdipoRon alleviated the mitochondrial deficits and aging markers induced by rotenone or antimycin A. HDAC1 antagonism by Compound 60 (Cpd 60) improved mitochondrial dysfunction and age-related inflammation, as validated in D-galactose-treated APN KO mice. (biomedcentral.com)

After its secretion by adipocytes, adiponectin oligomerizes in three forms: trimers of low molecular weight (LMW), hexamers of medium molecular weight (MMW), and multimers of high molecular weight (HMW) [ 8 ]. (hindawi.com)
2003 Reduced circulating adiponectin in obesity likely derives from decreased adiponectin expression and secretion which may result from mitochondrial dysfunction or aberrantly increased inflammation hypoxia or endoplasmic reticulum stress (Ye and Scherer 2013 Far less is known about why serum adiponectin increases in lean states. (mdm2-inhibitors.com)
2011 most studies in mice and humans find that prolonged CR or extensive weight loss increases serum adiponectin without affecting adiponectin expression or secretion from WAT (Behre et al. (mdm2-inhibitors.com)
2011 Thus in lean states such as CR or AN the paradoxical increase in serum adiponectin can occur without greater expression or secretion from WAT or decreased adiponectin clearance. (mdm2-inhibitors.com)
This striking increase P7C3-A20 strongly suggests that during CR MAT exists in an amount that has clear potential to exert systemic effects through secretion of endocrine factors such as adiponectin. (mdm2-inhibitors.com)
Table 1 MAT WAT BMD and serum adiponectin in subjects with Anorexia Nervosa and healthy controls The relative expression and secretion of adiponectin is greater from MAT than from WAT The ability of MAT to express or secrete adiponectin has not been addressed. (mdm2-inhibitors.com)
Increased HO-1 expression and HO-1 activity is associated with an increase in adiponectin secretion that prevent differentiation and enlargement of adipocytes resulting in the stimulation of nitric oxide (NO) bioavailability and improved endothelial function and glucose tolerance. (nymc.edu)

In addition, data from in vitro studies on lung cells were consistent with an anti-inflammatory function of adiponectin [ 11 , 12 ], and adiponectin-deficient mouse models develop lung function impairment and systemic inflammation [ 13 , 14 ]. (hindawi.com)
Under normal circumstances adiponectin presents anti-inflammatory, pro-apoptotic and anti-proliferative effects (Booth et al . (scielo.br)
ABSTRACT Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. (diabetesjournals.org)
The mediators of the specific weight effect on the kidney appear to be an obesity-related inflammation, aggravated by a lowered anti-inflammatory adiponectin level, an increased oxidative stress and advanced glycation, and an enhanced TGF-beta expression, all of which might constitute promising therapeutic targets. (hindawi.com)

Expression of AdipoR2 mRNA clearly associated only with plasma triglyceride concentrations. (diabetesjournals.org)
The presence of THP-1 decreased AdipoR2 expression in Smooth Muscle Cells (p = 0.040), whereas a not statistically significant decrease was observed in Endothelial Cells. (unina.it)

In obesity a mechanism of adiponectin resistance was demonstrated. (unina.it)
In non-obesity-related inflammatory disorders, adiponectin levels are increased [ 9 - 11 ]. (hindawi.com)
BEVILACQUA, F. The potential role of leptin and adiponectin in obesity: a comparative review. (scielo.br)
Low adiponectin levels may play an important role in the development of colon and other obesity-related malignancies. (nuthealth.org)
No previous studies have directly investigated the mechanistic effects of adiponectin on colon cancer in the settings of obesity, a high-fat diet and/or adiponectin deficiency. (nuthealth.org)
Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). (diabetesjournals.org)
0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. (diabetesjournals.org)
Obesity (2009) Lifestyle changes such as weight loss and regular physical At present, adiponectin may be the most important and promis- activity are recognized as effective nonpharmacological inter- ing adipocytokine for obtaining a better understanding of the link ventions with beneficial effects on metabolic and cardio vascular between obesity and metabolic and cardiovascular disease (1,2). (hmamedicalclinic.com)
Circulating levels of adiponectin may be In the present study, we hypothesized that a twice-weekly the link between visceral obesity and certain related metabolic PRT would be particularly useful in the context of a weight- abnormalities which contribute to the development of insulin loss diet in adult obese women, increasing the visceral fat resistance, type 2 diabetes and atherosclerosis (3,8,9). (hmamedicalclinic.com)
The study included 56 individuals with obesity, of whom 30 individuals underwent Roux-en-Y gastric bypass surgery (RYGB) and twenty-six underwent sleeve gastrectomy (SG). (biomedcentral.com)
For example, deletion of HO-2, increased obesity and decreased EET can be rescued by pharmacological upregulation of HO-1, signifying the role of both HO-1/-2 in adipocyte/vascular protection by regulating the EET-adiponectin-pAMPK signaling pathway. (nymc.edu)
Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. (hindawi.com)

Introduction: Adiponectin is a protein secreted by the adipose tissue with pleiotropic effects on metabolism. (unina.it)
Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. (hindawi.com)
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. (nature.com)
Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
The antidiabetic thiazolidinediones (TZDs) also promote MAT expansion and hyperadiponectinemia, even without increasing adiponectin expression in white adipose tissue (WAT). (frontiersin.org)
To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. (diabetesjournals.org)
Adiponectin has been shown to be secreted principal y visceral fat in older men (11) and women (12), improving by visceral adipose tissue (VAT), the size of this visceral fat depot insulin sensitivity (11). (hmamedicalclinic.com)
Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)

Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
ADP-1 induced an interaction between APPL1 and the small GTPase Rab5 resulting in AMPK phosphorylation, in turn leading to phosphorylation of p38MAP kinase, acetyl coenzyme-A carboxylase, and peroxisome proliferator-activated receptor alpha. (phoenixpeptide.com)
In contrast expression of peroxisome proliferator-activated receptor-γ (PPARγ) was similar. (mdm2-inhibitors.com)
Mitochondrial biogenesis and oxidative metabolism are controlled by Peroxisome Proliferator-Activated Receptor gamma coactivator 1-alpha (PGC-1α), originally described as a coactivator of PPAR-γ that modulated thermogenesis. (nymc.edu)

and d) impaired expression of PPAR γ receptors. (isciii.es)
There were significant positive correlations between SCD1 and peroxisomal proliferator-activated receptor γ (PPARγ) as well as other PPARγ-responsive genes, including lipin-β, AGPAT2, RBP4, adiponectin receptors, CD68, and MCP1. (uky.edu)
SCD1 is closely linked to PPARγ expression in humans, and is increased by PPARγ agonists. (uky.edu)
The change in expression of some downstream PPARγ targets after SCD1 knockdown suggests that PPARγ up-regulation of SCD1 leads to increased lipogenesis and potentiation of adiponectin signaling. (uky.edu)

Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
Among adipokines, leptin and adiponectin are the most abundantly secreted peptides [ 11 ]. (plos.org)

Adipose tissues were taken for histopathologic examination as well as determination of gene expression for leptin, leptin receptors, adiponectin, and visfatin. (nih.gov)
Conversely, adipogenic differentiation was greater in hydrogels containing MPCs from diabetic rats as compared to those derived from lean rats, as evidenced by an increase in lipid accumulation and adipogenic gene expression. (cheric.org)
In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. (jci.org)
Stearoyl-Coenzyme A Desaturase 1 Gene Expression Increases After Piogl" by Aiwei Yao-Borengasser, Negah Rassouli et al. (uky.edu)
In contrast, histone deacetylases promote gene expression in the mitochondrial stress response, immunity, and metabolism. (biomedcentral.com)

In vitro, it was found that adiponectin directly controls malignant potential (cell proliferation, adhesion, invasion and colony formation) and regulates metabolic (AMPK/S6), inflammatory (STAT3/VEGF) and cell cycle (p21/p27/p53/cyclins) signalling pathways in both mouse MCA38 and human HT29, HCT116 and LoVo colon cancer cell lines in a LKB1-dependent way. (nuthealth.org)
We found that adiponectin expression in CV of C57BL/6J mice was similar to that in inguinal WAT (iWAT) P7C3-A20 gonadal WAT (gWAT) and perirenal WAT (pWAT) (Fig 1B). (mdm2-inhibitors.com)

It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1. (wikipedia.org)

In this study, we examined whether AdipoR mRNA expression in human myotubes correlates with in vivo measures of insulin sensitivity. (diabetesjournals.org)
The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
Increased circulating adiponectin and insulin sensitivity are usually observed after body fat loss induced by a weight‑loss diet. (hmamedicalclinic.com)
Therefore, the purpose of this study was to ascertain the effects of combined 16‑week PRT and weight‑loss diet on circulating adiponectin and insulin sensitivity index. (hmamedicalclinic.com)
WL resulted in an expected increase in circulating levels of adiponectin ( P = 0.07) and insulin sensitivity. (hmamedicalclinic.com)
This study was designed to better characterize SCD1 gene and protein expression in humans with varying insulin sensitivity. (uky.edu)

Adiponectin treatment also suppressed angiogenesis assessed by CD31 staining and VEGFb and VEGFd mRNA expression in tumours obtained from mice fed a high-fat diet and from adiponectin-deficient mice. (nuthealth.org)

However, at present both the effect being an important correlate of plasma adiponectin levels (5). (hmamedicalclinic.com)

adiponectin oligomeric profiles were analysed by western blot. (hindawi.com)

Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls. (hindawi.com)
However, rosiglitazone significantly increased adiponectin protein expression in WAT, suggesting that WAT contributes to hyperadiponectinemia in this context. (frontiersin.org)
Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states. (mdm2-inhibitors.com)
AN subjects had significantly higher MAT of the L4 vertebrae femoral metaphysis and femoral diaphysis and increased total and P7C3-A20 HMW serum adiponectin despite decreased total fat mass (Table 1). (mdm2-inhibitors.com)

A local adiponectin-resistance could be a main cause of the lack of atheroprotective effects mediated by adiponectin. (unina.it)

Adipocytes were treated with pioglitazone, and SCD1 expression was attenuated with small interfering RNA (siRNA) to examine other adipocyte genes. (uky.edu)
In addition, they also interfere with the expression of regulator genes, CHOP , ATF4 , and XBP , which further alters lipid metabolism and autophagy. (medscape.com)

Objective: To investigate the effects of adiponectin on the growth of colorectal cancer in adiponectin-deficient or wild-type-C57BL/6 mice fed a low-fat or high-fat diet. (nuthealth.org)
Adiponectin immunohistochemical expression in colorectal cancer and its correlation with histological grade and tumor microvessel density. (unime.it)

Interestingly, only in the active group adiponectin levels were inversely correlated with forced expiratory volume (FEV) 1% decrease/year and FEV1% decrease. (hindawi.com)

Moreover, adiponectin levels negatively correlated with lipid profiles. (hindawi.com)
PIs also have a high affinity for the catalytic site of HIV-1 protease, which shares a 60% sequence homology with 2 proteins involved in lipid metabolism, cytoplasmic retinoic acid-binding protein type 1 (CRABP-1), and low-density lipoprotein receptor-related protein (LDLR-RP). (medscape.com)

Figure 6: Proinflammatory gene and protein expression in human macrophages and rat and human isolated islets treated with AEA, IL-1β or high glucose. (nature.com)
Adiponectin protein expression was obtained by Western blot analysis and quantified with Image Lab 6.1 software. (aging-us.com)

Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. (phoenixpeptide.com)
To our knowledge this is the first report on identification of a short peptidefrom adiponectin with positive effects on glucose or fatty acid metabolism. (phoenixpeptide.com)
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
Overweight youth are more susceptible to metabolic disorders, since the accumulation of body fat, especially in the abdominal region, generates an increase in fatty acids circulating in the bloodstream, which consequently impairs insulin signaling and leads to a reduction in sensitivity of receptors and tissue response to cellular actions that are mediated by this hormone 1,3,4 . (bvsalud.org)

of PRT on circulating adiponectin and the physiological role Moreover, it is known that an excess of abdominal adipose tis- of adiponectin on the improvement of metabolic and cardio- sue is a better predictor of the development of insulin resistance, vascular risk factors with either body or fat mass loss are as yet type 2 diabetes and cardiovascular disease than the total amount incompletely understood (1,13). (hmamedicalclinic.com)
This could yield highly favorable changes in circulating anthropometric variables adiponectin and, as a result, to the metabolic and cardio- Height of the barefoot subjects was measured to the nearest 0.1 cm. vascular risk. (hmamedicalclinic.com)
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. (mdm2-inhibitors.com)
indeed circulating adiponectin is low in obese insulin-resistant individuals and in other adverse metabolic states (Ye and Scherer 2013 Conversely serum adiponectin increases in lean insulin-sensitive states such as with calorie restriction (CR) in animals and anorexia nervosa (AN) in humans (Combs et al. (mdm2-inhibitors.com)
This rat strain has the same hypertensive background as SHR but also a genetic mutation in the leptin receptor gene, which leads to hyperphagia with an attendant wide range of metabolic abnormalities, that is, high body weight, hyperglycemia, hyperlipidemia, and hyperinsulinemia. (hindawi.com)

MAT content was assessed by osmium tetroxide staining and adipocyte marker expression. (frontiersin.org)
EETs upregulate HO-1-adiponectin-AKT signaling and play essential roles in the regulation of adipocyte differentiation, indicating the existence of a crosstalk between HO-1 and EETs. (nymc.edu)

Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)
Accordingly, adiponectin-mimetic molecules possess significant pharmacological potential. (phoenixpeptide.com)

In the development and progression of lung cancer, a pathogenic role of adiponectin was defined by both in vivo and in vitro studies [ 15 , 16 ]. (hindawi.com)
Adiponectin is able to influence the glucose metabolism in the rabbit blastocyst in vitro. (uni-halle.de)
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. (nuthealth.org)

We evaluated the hepatic expression of VDR along with that of vitamin D 25-hydroxylases in patients with nonalcoholic steatohepatitis (NASH) or chronic hepatitis C (CHC) and its relationship with hepatic histological features and serum 25(OH)D(3) levels. (nih.gov)
This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity. (hindawi.com)
In view of the absence of reports regarding adiponectin levels in dogs and the occurrence of malignant neoplasms, the present study aimed to compare the serum levels of adiponectin in clinically normal bitches and in those with a diagnosis of mammary carcinoma. (scielo.br)
This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin levels and some clinical and hormonal parameters. (who.int)
There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. (who.int)
However, there was no correlation between serum adiponectin and proteinuria or estradiol and progesterone levels. (who.int)
Adiponectin treatment decreased serum insulin levels in mice on a high-fat-diet and increased serum-interleukin (IL)-12 levels in adiponectin-deficient mice. (nuthealth.org)
In the studies that were included in our analysis, changes of adiponectin levels (when present) were also evaluated. (plos.org)
Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk. (diabetesjournals.org)
The change in CEC correlated with the change in apo A-I (r = 0.39, p = 0.02) and adiponectin levels (r = 0.35, p = 0.03). (biomedcentral.com)
Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels. (hindawi.com)

Adiponectin is an abundant serum adipokine composing up to 0.05% of total circulating protein [ 7 ]. (hindawi.com)

Oligomeric states of adiponectin appear to determine its biological activity. (phoenixpeptide.com)

In addition, they create a large production of reactive oxygen species, which leads to the production of cytokines, macrophage recruitment, and inhibition of glucose transport 4 (GLUT-4), along with a deficiency in insulin signaling and the hormones leptin and adiponectin. (medscape.com)

2006 Indeed adiponectin expression in WAT decreases in human subjects with AN (Dolezalova et al. (mdm2-inhibitors.com)
Increased HO-1 expression provides protection for stem cell function and decreases adiposity. (nymc.edu)

Figure 3: Macrophage content and Nlrp3 expression in islets of lean and diabetic rats. (nature.com)

Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)

The underlying molecular mechanism may be related to reduction of systemic inflammation, alleviating insulin resistance and modulation of adipokine expression. (nih.gov)

Under diabetic conditions adiponectin could be relevant for the coverage of the glucose uptake instead of the missing insulin. (uni-halle.de)

Circulating adiponectin was determined by ELISA. (frontiersin.org)
Notably, this was also the only group in which tibial adiponectin expression was lower than in WT mice, suggesting a close association between MAT adiponectin production and circulating adiponectin. (frontiersin.org)
In conclusion, in obese women a 16‑week combined PRT and weight‑loss diet is accompanied by significant improvements in different cardiovascular risk factors in spite of a significant decrease of circulating adiponectin. (hmamedicalclinic.com)
2013 In striking contrast to WAT MAT markedly increases during CR in animals including humans (Devlin 2011 Thus in this manuscript we investigate the hypothesis that MAT is a source of circulating adiponectin in states of leanness. (mdm2-inhibitors.com)

Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. (jci.org)

Unlike other SGAs, such as clozapine and olanzapine, risperidone is a derivative of benzisoxazole with multiple receptor antagonist properties, making it more effective against negative symptoms and more beneficial on both affective symptoms and cognitive impairments ( 11 ). (frontiersin.org)
Upon activation, the IL-1 receptor antagonist (IL-1Ra)/IL-1β ratio was higher in AAT than in SM cultures. (bmj.com)

Also, SPR and virtual screening techniques utilized in this study may potentially be applied to other peptide-drug screening processes against membrane receptor proteins. (phoenixpeptide.com)

Because of limitations in production of biologically active adiponectin, adiponectin-mimetic AdipoRs' agonists have been suggested as alternative ways to expand the opportunity to develop anti-diabetic agents. (phoenixpeptide.com)
Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis? (jci.org)

Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. (phoenixpeptide.com)

Investigate the expression of adiponectin receptors in Barretts Oesophagus and oesophageal carcinoma. (uea.ac.uk)

The adiponectin system represents a safety net under diabetic conditions to assure the further development of the embryo. (uni-halle.de)

Aim: To verify if adiponectin-resistance occurs in human atherosclerotic plaques. (unina.it)
Conclusions: We demonstrated a decreased expression of adiponectin receptors in initial and advanced plaques, suggesting a mechanism of adiponectin-resistance during atherosclerotic process. (unina.it)
Endocannabinoids contribute to insulin resistance through activation of peripheral CB 1 receptors (CB 1 Rs) and also promote beta cell failure. (nature.com)

Tyr-Pro induces glucose transporter 4 (Glut4) expression in the plasma membrane, along with adenosine monophosphate-activated protein kinase (AMPK) activation. (elsevierpure.com)

Conclusion: These new mechanistic and pathophysiology studies provide evidence for an important role of adiponectin in colon cancer. (nuthealth.org)

AdipoR118

Agonist4

Secretion7

Anti-inflammatory5

AdipoR22

Obesity12

Adipose tissue8

Peroxisome prolifer5

PPAR4

Adipokines2

Gene expression5

Found that adiponectin2

AdipoQ1

Insulin sensitivity6

MRNA expression1

Plasma adiponectin1

Analysed by western blot1

Significantly5

Atheroprotective effects1

Genes2

Colorectal cancer2

Inversely correlated1

Lipid2

Protein expression2

Fatty6

Metabolic5

Adipocyte2

Molecules2

Vitro3

Levels12

0.051

Oligomeric1

Deficiency1

Decreases2

Rats1

Phosphorylation1

Inflammation1

Glucose uptake1

Circulating4

Antidiabetic1

Antagonist2

Membrane receptor1

Agonists2

Cardiovascular1

Investigate1

Diabetic1

Resistance3

AMPK1

Conclusion1