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  • high
  • MBS025616 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the High Molecular Weight Adiponectin (HMW ADNP) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • effect
  • Coexpression of CCAAT/enhancer-binding protein (C/EBP)α increased luciferase activity of the Pro-Int1-Luc construct ∼75-fold but had no effect on the constructs containing the proximal adiponectin promoter alone. (diabetesjournals.org)
  • coronary heart d
  • In a risk prediction model including variables of the UK Prospective Diabetes Study coronary heart disease risk engine urinary adiponectin, but not the albumin excretion rate, added significant value for the prediction of increased IMT ( P = 0.007). (diabetesjournals.org)
  • whereas low-circulating adiponectin was significantly associated with increased primary CVD risk in apparently healthy men ( 8 ), subsequent studies in high-risk populations, as well as patients with prevalent coronary heart disease (CHD), failed to confirm this association ( 9 , 10 ). (diabetesjournals.org)
  • mediates
  • Thus, adiponectin mediates protective effects in obesity-related metabolic and vascular disease presumably by its anti-inflammatory actions and protects the heart against ischemia-reperfusion injury through its ability to suppress myocardial inflammation and apoptosis [ 23 ]. (hindawi.com)
  • Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment? (wikipedia.org)
  • adipokine
  • Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - than WAT", suggesting an endocrine function for this depot, akin, but different, from that of WAT. (wikipedia.org)
  • concentrations
  • There is an association between adiponectin concentrations and insulin sensitivity. (diabetesjournals.org)
  • Circulating adiponectin concentrations increase during caloric restriction in animals and humans, such as in patients with anorexia nervosa. (wikipedia.org)
  • Adiponectin is secreted into the bloodstream where it accounts for approximately 0.01% of all plasma protein at around 5-10 μg/mL (mg/L). In adults, plasma concentrations are higher in females than males, and are reduced in diabetics compared to non-diabetics. (wikipedia.org)
  • Obesity
  • Given that the levels of adiponectin vary in different inflammatory diseases as discussed above, these data suggest that the metabolic consequences observed in obesity may be related to an imbalance of pro- and anti-inflammatory cytokines. (hindawi.com)
  • Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. (prospecbio.com)
  • Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and a panoply of other conditions. (wikipedia.org)
  • high-molecular weight
  • The adiponectin monomer (30 kDa) has a structure consisting of a globular head and a collagenous tail, and this monomer is able to multimerize to form several stable complexes of low-, medium-, and high-molecular weight. (hindawi.com)
  • High-molecular-weight adiponectin was further found to be associated with a lower risk of diabetes with similar magnitude of association as total adiponectin. (wikipedia.org)
  • However, coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin. (wikipedia.org)
  • trimers
  • Adiponectin is a secreted protein of 244 amino acids that belongs to a protein family possessing a collagen-like domain through which they form homo-trimers, which further combine to make oligomeric complexes (Tsao et al, 2002). (prospecbio.com)
  • secretion
  • Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes. (abcam.com)
  • endothelial
  • RESULTS A homogenous staining of adiponectin was found on the endothelial surface of glomerular capillaries and intrarenal arterioles in nondiabetic kidneys, whereas staining was decreased in diabetic nephropathy. (diabetesjournals.org)
  • Ouchi et al (1999) have determined that adiponectin suppresses TNF induced adhesion of monocytes to aortic endothelial cells and also suppresses the expression of vascular cell adhesion molecule 1 (VCAM-1), selectin E, and intercellular adhesion molecule 1 (ICAM-1 (CD54)) in these cells. (prospecbio.com)
  • cardiovascular
  • In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena. (springer.com)
  • WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects on metabolic and cardiovascular endpoints. (wikipedia.org)
  • Diabetes Care
  • 1 ) in this issue of Diabetes Care regarding adiponectin in youth. (diabetesjournals.org)
  • 1 ) recently published an article in Diabetes Care that claims adiponectin is present in the cord blood of the offspring of diabetic and nondiabetic pregnant mothers and that its level does not correlate with their birth weight and skinfold thickness. (diabetesjournals.org)