AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
AdipogenesisAdipocytesPPAR gammaCCAAT-Enhancer-Binding Protein-alphaCell DifferentiationCCAAT-Enhancer-Binding Protein-betaAdipose TissueAdipose Tissue, WhiteAdipocytes, WhiteAzo CompoundsAdipocytes, Brown3T3 CellsMesenchymal Stromal CellsReceptors, Cytoplasmic and NuclearThiazolidinedionesGene Expression RegulationObesityOsteogenesisTranscription FactorsCCAAT-Enhancer-Binding ProteinsAnti-Obesity AgentsFatty Acid-Binding ProteinsLipid MetabolismCCAAT-Enhancer-Binding Protein-deltaSubcutaneous FatGene Knockdown TechniquesCells, CulturedMice, ObeseRNA, Small InterferingMice, Inbred C57BLSignal TransductionInsulinRNA, MessengerReverse Transcriptase Polymerase Chain ReactionEndrinFibroblastsLipodystrophy1-Methyl-3-isobutylxanthineWnt ProteinsDexamethasoneOsteoblastsAdiposityGraves OphthalmopathyMice, KnockoutStem CellsLipogenesisAdipose Tissue, BrownRNA InterferenceCell LineStromal CellsOrbitNuclear Receptor Subfamily 1, Group D, Member 1Down-Regulationbeta CateninChromatin ImmunoprecipitationIntercellular Signaling Peptides and ProteinsNIH 3T3 CellsTrialkyltin CompoundsBlotting, Western
AdipocytesPPARPharmacological InhibitionDifferentiationLipidInhibit adipogenesisAngiogenesisPreadipocytesRegulationInhibitsDecreased peroxisomeInsulin resistanceObesity and its associatedMechanismAdipocyteVitroSuppressionDefectsAdipose tissueCellsBoneInflammatoryGene expressionMechanismsAccumulationCrucialInvestigateRolesEffectsFormationFoundExpressionBackgroundEffectDevelopmentNegativeImportanceSpecific
Adipocytes8
PPAR4
  • Transcription factors, peroxis proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding proteins (C/EBPs) are main regulators of adipogenesis. (wikipedia.org)
  • PPARγ is a member of the nuclear-receptor superfamily and is the master regulator of adipogenesis. (wikipedia.org)
  • Dietary fatty acids (FA) and their derivatives are described as PPARγ ligands that trigger physiological responses such as adipogenesis and adipokine secretion. (biomedcentral.com)
  • A recent in vitro study indicates that IGOB131, a novel seed extract of the traditional West African food plant Irvingia gabonensis , favorably impacts adipogenesis through a variety of critical metabolic pathways including PPAR gamma, leptin, adiponectin, and glycerol-3 phosphate dehydrogenase. (biomedcentral.com)
Pharmacological Inhibition3
  • Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling. (sdu.dk)
  • Within this research, we dealt with the MEK162 metabolic outcomes and potential healing influence of pseudohypoxia by hereditary and pharmacological inhibition of the main oxygen-sensing enzyme PHD2 in adipose tissues. (bioskinrevive.com)
  • and pharmacological inhibition of VEGFR2 signaling we found provocative reciprocal regulation of adipogenesis and angiogenesis, suggesting a novel strategy to treat obesity related diseases including cancer. (harvard.edu)
Differentiation5
  • The inhibition was diminished when the addition of EA was delayed to days 2-four of differentiation. (gplmedicine.org)
  • At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. (biomedcentral.com)
  • Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation. (integratedpainandrehab.com)
  • Overexpression of miR-135a-5p impairs the expressions of adipogenic marker genes as well as lipid droplet accumulation and triglyceride content, indicating the importance of miR-135a-5p for adipogenic differentiation and adipogenesis. (endocrinology-journals.org)
  • Our findings demonstrate that miR-135a-5p suppresses 3T3-L1 preadipocyte differentiation and adipogenesis through the activation of canonical Wnt/β-catenin signaling by directly targeting Apc . (endocrinology-journals.org)
Lipid3
  • 6,7,4'-THIF significantly suppressed MDI-induced lipid accumulation in the early stage of adipogenesis, attributable to a suppression of cell proliferation and the induction of cell cycle arrest. (oregonstate.edu)
  • However, when obesity and inflammation are sustained, these adaptive homeostatic mechanisms fail, leading to WAT dysfunction characterised by impaired secretion of adipokines, abnormal lipid storage and adipogenesis, exacerbated fibrosis deposition and insulin resistance. (springer.com)
  • Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
Inhibit adipogenesis3
  • Additionally, pentagalloylglucose and tannin acids inhibit adipogenesis and counteract obesity [ 8 - 10 ]. (hindawi.com)
  • Tropical fruits contain different quantities and mixtures of different phytochemicals (chemicals found naturally in plants), some of which have been shown to inhibit adipogenesis. (chemistryworld.com)
  • As mango is rich in phytochemicals and popular in both developed and developing countries, the researchers at the University of Queensland chose to study the ability of three varieties of mangoes to inhibit adipogenesis. (chemistryworld.com)
Angiogenesis2
  • Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)
  • Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)
Preadipocytes7
  • Firstly, proliferating preadipocytes arrest growth usually by contact inhibition. (wikipedia.org)
  • A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K. (oregonstate.edu)
  • Our objective was to determine the effects of 6,7,4'-THIF on adipogenesis in 3T3-L1 preadipocytes and elucidate the mechanisms of action involved. (oregonstate.edu)
  • Adipogenesis was stimulated in 3T3-L1 preadipocytes. (oregonstate.edu)
  • Our results suggest that 6,7,4'-THIF suppresses adipogenesis in 3T3-L1 preadipocytes by directly targeting PI3K. (oregonstate.edu)
  • However, the effect of EA on preadipocytes adipogenesis and its mechanism haven't been elucidated. (gplmedicine.org)
  • The present research was designed to examine the impact of EA on adipogenesis in 3T3-L1 preadipocytes and underlying mechanism of action involved. (gplmedicine.org)
Regulation2
  • Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
  • Through the regulation of NNMT activity, modulation of methylation patterns, reduction in fat accumulation, the potential for weight management, impact on metabolic health, and potential applications in obesity management, these supplements offer a multifaceted approach to suppressing adipogenesis. (aclassblogs.com)
Inhibits1
Decreased peroxisome1
  • We observed that 6,7,4'-THIF, but not daidzein, inhibited MDI-induced adipogenesis significantly at 40 and 80 μM, associated with decreased peroxisome proliferator-activated receptor-γ and C/EBP-α protein expression. (oregonstate.edu)
Insulin resistance2
  • Here we highlight a second strategy for reducing insulin resistance, the inhibition of 11beta-hydroxysteroid dehydrogenases (11beta-HSD)1, an enzyme which activates glucocorticoid. (pharmiweb.com)
  • Excessive adipogenesis is linked to metabolic disorders like insulin resistance and type-2 diabetes. (aclassblogs.com)
Obesity and its associated1
  • The fight against adipogenesis, a key contributor to obesity and its associated health risks, is a critical goal in achieving better health and well-being. (aclassblogs.com)
Mechanism2
Adipocyte3
  • Adipogenesis plays a critical role in controlling adipocyte cell number, body weight, and metabolic profile in a homeostatic state. (diabetesjournals.org)
  • The treatment with leptin or mdvi-1 (Drp1 inhibitor) significantly increased abnormal biogenesis, improved fusion-to-fission balance and attenuated mitochondrial dysfunction, and adipogenesis, thus inducing white-to-beige adipocyte transdifferentiation. (authorea.com)
  • When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)
Vitro2
Suppression1
Defects1
  • This consequently decreases the expression of mTOR, results in decreased activities of the mTOR complex 1 pathway, and leads to defects in adipogenesis. (diabetesjournals.org)
Adipose tissue2
  • Excessive adipogenesis leads to the accumulation of fat within adipose tissue. (aclassblogs.com)
  • The expression of 10 adipogenesis-regulated miRNAs were studied using real-time qPCR and then we selected 5 miRNAs, that showed robust expression, were profiled in subcutaneous adipose tissue obtained from 20 humans with a range of body mass indices (BMI, range = 21-48, and all samples have U133+2 Affymetrix profiles provided). (biomedcentral.com)
Cells3
  • A cautionary side to this research is that such inhibition of adipogenesis may mean larger adipose cells, which can result in the development of type 2 diabetes. (chemistryworld.com)
  • Improved HIF-1 activation may donate to the pathological adjustments within adipose cells in weight problems (1C5) partly through inhibition of peroxisome proliferator-activated receptor -2Creliant adipogenesis (18). (bioskinrevive.com)
  • Researchers found that "Piceatannol actually alters the timing of gene expressions, gene functions, and insulin action during adipogenesis, the process in which early-stage fat cells become mature fat cells. (integratedpainandrehab.com)
Bone1
  • It has been shown that the inhibition of CTSB can limit bone metastasis in breast cancer, making it an important anti-cancer drug target. (biolegend.com)
Inflammatory1
  • EETs exhibit potent biological effects including adipogenesis, vasodilatation and inhibition of the inflammatory response. (nymc.edu)
Gene expression1
  • NNMT inhibitors have been linked to changes in DNA methylation patterns, which can influence the gene expression related to adipogenesis. (aclassblogs.com)
Mechanisms1
  • This article will delve into the mechanisms and potential benefits of NNMT inhibitor-infused supplements like 5 amino 1mq in suppressing adipogenesis. (aclassblogs.com)
Accumulation1
Crucial2
Investigate1
Roles1
  • The roles of CTSB in autophagy, adipogenesis, and cholesterol absorption in the intestine have also been studied. (biolegend.com)
Effects1
  • In addition, inhibition of APC with siRNA exhibits the same effects as overexpression of miR-135a-5p. (endocrinology-journals.org)
Formation1
  • In this pursuit, innovative approaches to controlling adipogenesis, the process of fat cell formation, have gained attention. (aclassblogs.com)
Found1
Expression1
Background1
Effect1
  • It was identified that the insulin sensitizing effect of chemical constituents from Radix Paeoniae Rubra is modulated by the inhibition of protein-tyrosine phosphatase 1B [ 6 ]. (hindawi.com)
Development1
Negative1
Importance1
Specific1
  • Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of duck adipogenesis. (biomedcentral.com)