Loading...
  • fatty
  • Elbaz A, Wu X, Rivas D, Gimble JM, Duque G (2009) Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. (springer.com)
  • CD137 and TMEM26), (3) glucose and fatty acid uptake, and (4) basal and cAMP-stimulated oxygen consumption rate compared to white adipocyte control. (springer.com)
  • Direct effect refers to adipocyte or fatty infiltration of the atrial and ventricular myocardium itself, possibly causing increased dispersion of normal myocardial electrical signals and fibrotic substrate of adipocytes that promote reentry or adipocytes serving as a direct source of aberrant signals. (frontiersin.org)
  • In conclusion, we have shown that the development of adipocyte-induced VSMC alterations is linked to diet fatty acid composition and the degree of metabolic alterations. (scirp.org)
  • Coe NR, Simpson MA, Bernlohr DA (1999) Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels. (springer.com)
  • gene expression
  • Our results showed that exposure of h ASC to human BMP7 was associated with significant escalation of (1) UCP1 gene expression, a signature gene of brown adipocytes, (2) beige specific marker gene expression (i.e. (springer.com)
  • Global gene expression analysis of mESC-derived adipocytes showed that lack of menin downregulated the expression of many differentially methylated genes including the tumor suppressor long noncoding RNA Meg3 but upregulated gene expression from the prolactin gene family locus. (hindawi.com)
  • To characterize changes in gene expression profile during human mature adipocyte dedifferentiation in ceiling culture. (hindawi.com)
  • cells
  • In this study, we hypothesized that pre-exposure of the stromal vascular (SV) fraction of primary human adipogenic precursor cells ( h ASC) to BMP7 would convert metabolically active brown adipocytes. (springer.com)
  • Adipocytes derived from Men1-KO mESCs or after menin knockdown in 3T3-L1 cells showed a 1.5-1.7-fold increase in fat-cell size. (hindawi.com)
  • Akoum, S. , Cloutier, I. and Tanguay, J. (2013) Adipocytes modulate vascular smooth muscle cells migration potential through their secretions. (scirp.org)
  • Over the course of several days, confluent 3T3-L1 cells can be converted to adipocytes in the presence of an adipogenic cocktail. (springer.com)
  • With this review we will provide a working model indicating a close interaction in between bacterial translocation, activation of the adipocytes, and subsequent direction of the infiltrating immune cells. (frontiersin.org)
  • The size of adipocytes varies according to their lipid content and is linked to the function of the cells, with larger adipocytes usually being more active with regard to their metabolic activity and adipokine production ( 2 ). (frontiersin.org)
  • Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. (osti.gov)
  • Immortalized human mesenchymal stem cells were used to study adipocyte development. (osti.gov)
  • The aim of this study was to assess both glycerol permeability and metabolism in undifferentiated 3T3-L1 cells (UDCs) as well as in untreated (CTL-DCs) versus lipopolysaccharide (LPS-DCs)-treated differentiated 3T3-L1 adipocytes. (mdpi.com)
  • proteins
  • Dedifferentiation is associated with downregulation of transcripts encoding proteins involved in mature adipocyte functions and upregulation of genes involved in matrix remodeling, cellular development, and cell cycle. (hindawi.com)
  • activation
  • Xbp1s is a key molecule involved in adipocyte uridine biosynthesis and release by activation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD), the rate-limiting enzyme for UMP biosynthesis. (nih.gov)
  • What is Inducing Adipocyte Activation? (frontiersin.org)
  • metabolic activity
  • By confirming the cellular identity and metabolic activity, this BMP7-induced human beige adipocytes from h ASC should aid in the discovery and assessment of bioactive molecules to promote adaptive thermogenesis. (springer.com)
  • cell
  • Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell (adipocyte) proliferation and function. (hindawi.com)
  • control
  • No such studies have been performed perhaps due to the limitation of procuring normal adipocytes that can serve as a matched control for the abnormal adipocytes in the lipoma. (hindawi.com)