Adipocyte protein fatty acid binding proteins. Medical search. Frequent questions

aP2 is also called fatty acid binding protein 4 (FABP4). (wikipedia.org)
Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. (wikipedia.org)
FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser. (wikipedia.org)
The protein that the researchers wanted to target was fatty acid-binding protein 4 (fabp4). (medicalnewstoday.com)
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. (harvard.edu)

To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R) reporter. (diabetesjournals.org)
Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
Adiponectin, adipocyte fatty acid binding protein (AFABP), and epidermal fatty acid binding protein (EFABP) - proteins newly identified in human breast milk. (cskb.cz)
It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. (wikipedia.org)
It is expressed most abundantly in keratinocytes but is also found in differentiated adipocytes, macrophages and stratified epithelia of epidermis and tongue. (rndsystems.com)

Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
Through unknown mechanisms, insulin activates the sterol regulatory element-binding protein (SREBP1c) transcription factor to promote hepatic lipogenesis. (harvard.edu)

Adipose tissue plays an important role in metabolism through its storage and release of triglycerides, peptide hormones (adipokines) and other proteins, and in the case of brown fat, for its role in thermogenesis ( 1 ). (diabetesjournals.org)
Conversely, brown adipose tissue (BAT) and browning of WAT represent potential therapeutic approaches, since dysfunctional white adipocyte-induced lipid overspill can be halted by BAT/browning-mediated oxidative anti-lipotoxic effects. (springer.com)
There is also evidence that the deleterious effects mediated by dysfunctional white adipocyte-induced lipid overspill can be halted by the pro-oxidative anti-lipotoxic effects mediated by brown adipose tissue (BAT) activation. (springer.com)
Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. (harvard.edu)
Once acted on by LPL, which is attached to the luminal side of the capillary endothelium adjacent to muscle and adipose tissue, chylomicrons release TGs as monoglycerides and free fatty acids. (medscape.com)
Adipose tissue uses free fatty acids and monoglycerides to resynthesize TGs that are stored for future energy needs. (medscape.com)
An overall aim of our research is to study the regulation and function of protein phosphorylation cascades with relevance to type 2 diabetes, with a particular focus on adipose tissue, since this tissue is involved in the pathogenesis of diabetes. (lu.se)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
The transcription factor GATA2 regulates differentiation of brown adipocytes. (harvard.edu)
IFABP and the binding thermodynamics (Richieri growth and differentiation (Glatz & van der et al. (lu.se)
Risperidone promotes adipocyte differentiation and lipid accumulation through Oil Red O staining and reverse transcription-polymerase chain reaction (RT-PCR). (frontiersin.org)
In addition, risperidone influences adipocyte metabolism, differentiation, and lipid accumulation-related functions through transcriptome analysis. (frontiersin.org)

Significant amounts of this protein are present in white fat and plasma, and scientists believe that it plays a role in sugar and insulin metabolism. (medicalnewstoday.com)
The physiological role of FABP's within the cell remains unclear but a targeting role for the protein would provide an attractive mechanism for ligand (fatty acid) transfer to membrane sites for further metabolism and requires an interaction between the FABP and the membrane. (soton.ac.uk)
The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. (harvard.edu)
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. (harvard.edu)

Making use of a short peptide that specifically docks with white adipocytes, the team was able to deliver the CRISPRi components to 99% of cells in a cell culture model. (medicalnewstoday.com)
UCP-1-expressing multilocular adipocytes, termed 'beige' or 'brite' (brown-in-white) adipocytes, can also be found interspersed among white adipocytes within SAT under conditions requiring increased heat production (e.g. chronic cold exposure). (springer.com)

Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
Protein phosphorylation is a signalling mechanism that regulates most aspects of cellular life, and protein kinases, which carry out this post-translational modification, constitute the largest family of enzymes encoded by the human genome. (lu.se)

Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
In the capillaries of adipose and muscle tissue, apoprotein C-II (apo C-II) on the chylomicron activates endothelial lipoprotein lipase (LPL) to convert 90% of chylomicron triglyceride to fatty acids and glycerol, which are taken up by adipocytes and muscle cells for energy use or storage. (msdmanuals.com)

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease worldwide, it causes chronic hepatitis, which leads to cirrhosis and hepatocellular carcinoma. (scirp.org)
We aimed to assess the value of liver fatty acid binding protein (L-FABP) in the diagnosis of non-alcoholic fatty liver disease in comparison to ultrasonography. (scirp.org)
Ninty subjects were enrolled in this study who attended the Hepatology, Gastroenterology and Internal medicine clinics in Benha University Hospitals between January 2017 and January 2018 and divided into group I included 70 consecutive patients with non-alcoholic fatty liver disease who were diagnosed by ultrasound with or without elevated liver enzymes and group II included 20 healthy control subjects without NAFLD (by ultrasound) with normal liver enzymes. (scirp.org)
They also noted lower blood glucose levels, less inflammation , and improved biomarkers of nonalcoholic fatty liver disease. (medicalnewstoday.com)
Liver fatty acid binding protein (LFABP) belongs to a family of small (14kDa) intracellular lipid-binding proteins, which have a characteristic β-barrel structure. (soton.ac.uk)
Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease (NAFLD). (wjgnet.com)
When the chylomicrons are reduced in TG content, they become remnants that are rapidly cleared by the liver (apoprotein E binds to the LDL receptor [LDL-R]). At this time, apoprotein C-II is passed to high-density lipoprotein (HDL) particles in the circulation. (medscape.com)

Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. (korea.ac.kr)
Lysine residues in the α-helical region of adipocyte and heart FABP had previously been identified as important for interactions between these proteins and the phospholipid interface. (soton.ac.uk)
Mouse FABP5, also named Keratinocyte lipid-binding protein (KLBP) and Mal-1, is a member of the intracellular FABP family. (rndsystems.com)
Aim: Adipocyte fatty acid-binding protein (A-FABP) is a plasma biomarker recently associated with the obesity. (ac.ir)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. (harvard.edu)

Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)
Karasek D, Vaverkova H, Frysak Z, Orsag J, Novotny D, Halenka M, Slavik L. Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)
Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. (harvard.edu)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. (harvard.edu)

Intracellular and extracellular interactions with proteins enables the functional and mechanistic diversity of lipids. (harvard.edu)
However, these lipids can be transported throughout the bloodstream as lipoproteins when packaged with phospholipids and proteins (apoproteins). (medscape.com)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome. (wikipedia.org)
The role of adipocyte XBP1 in metabolic regulation during lactation. (harvard.edu)
Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. (harvard.edu)

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. (harvard.edu)
Initial digestion of dietary triglycerides takes place with pancreatic lipase, which hydrolyzes one fatty acid chain at a time to form 2 free fatty acid (FFA) chains and one 2-monoglyceride (2MG) compound per each triglyceride. (medscape.com)

Triglycerides primarily store energy in adipocytes and muscle cells. (msdmanuals.com)

Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. (rndsystems.com)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)

The most likely explanation for ligand release is that interaction of LFABF with an anionic membrane interface induces a rapid conformational change, reducing the affinity of DAUDA for the protein. (soton.ac.uk)
As an alternative, adipocytes can use TGs in membrane synthesis, which is similar to muscle. (medscape.com)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)

1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)

The effect of strength and endurance exercises-induced cardiac release proteins on its health is no clear. (ac.ir)

Apoprotein B-48 is a chylomicron structural protein. (medscape.com)

Risperidone increases adipocyte lipid accumulation by plausibly inhibiting long-chain fatty acid β-oxidation through targeting MAPK14 and MAPK8. (frontiersin.org)

DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)

Monoglycerides, FFAs, and free cholesterol are then solubilized in the intestine by bile acid micelles, which shuttle them to intestinal villi for absorption. (msdmanuals.com)

Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)

Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

1993), as well uptake and translocation of long-chain fatty acids as NMR solution structures (Hodsdon et al. (lu.se)

Measuring the levels of angiogenesis-related proteins may provide prognostic information concerning disease processes and could also be used to monitor therapeutic efficacy during clinical development. (q2labsolutions.com)
Rules-Based Medicine's AngiogenesisMAP® quantifies nearly 60 proteins involved in angiogenesis to help researchers better understand disease mechanisms and therapeutic interventions. (q2labsolutions.com)

a single fatty acid molecule with high af®nity in Cistola et al. (lu.se)

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. (gentaur.com)
Unlike traditional CRISPR , which seeks to alter the genetic code permanently, CRISPRi interferes with gene expression by inhibiting the production of proteins. (medicalnewstoday.com)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin-6, are implicated in NAFLD. (wjgnet.com)

Increased knowledge about protein kinase signalling is thus needed to prevent and treat these diseases. (lu.se)
Presently, our main project evolves around the AMP-activated protein kinase (AMPK) family, which consists of AMPK and another 12 related kinases, of which we are particularly interested in the salt-inducible kinases (SIK) 1-3. (lu.se)

Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. (rndsystems.com)

In this paper, he explains that adipocytes are difficult cells to target with such gene editing tools. (medicalnewstoday.com)
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. (diabetesjournals.org)

These fatty acid chains can be saturated or unsaturated, and the chemical composition of each chain is different. (medscape.com)

Cholesterol is a ubiquitous constituent of cell membranes, steroids, bile acids, and signaling molecules. (msdmanuals.com)

Among these, 41 studies were ex- in the release of higher amounts of fatty challenge to Arab governments due to cluded because the samples were not acids into the circulation. (who.int)

PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods. (ecust.edu.cn)

Anatomy19

Organisms11

Diseases6

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes39

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

FABP45

Adiponectin5

Macrophages2

Sterol regulat2

Adipose tissue8

Differentiation5

Metabolism4

White adipocytes2

Phosphorylation2

Glycerol2

Liver7

FABP4

Hypertrophy1

Hepatic1

Endothelial3

Regulates2

Lipids4

Metabolic3

Lipase2

Triglycerides1

Retinoic1

Mechanism1

Membrane3

Signaling pathway1

Intracellular lipid1

Cardiac1

Chylomicron1

Oxidation1

Glucose1

Intestinal1

Cellular2

Synthesis1

Translocation1

Angiogenesis2

Molecule1

Genetic3

NAFLD1

Kinase2

Molecular1

Carrier protein1

Gene2

Chains1

Cell1

Circulation1

Function1