Adipocyte protein. Medical search. Frequent questions

Alteration by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of CCAAT/enhancer binding protein correlates with suppression of adipocyte differentiation in 3T3-L1 cells. (aspetjournals.org)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds elicit multiple effects on the function of adipose tissue and adipogenic cell lines, including the suppression of adipocyte differentiation. (aspetjournals.org)
Analysis of mRNA for three isoforms of the CCAAT/enhancer binding protein (C/EBP) revealed that TCDD (5 nM) selectively inhibited the induction of C/EBP alpha mRNA but did not block the induction of C/EBP beta and C/EBP delta in response to differentiation inducers. (aspetjournals.org)
Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. (nih.gov)
Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. (nih.gov)
Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition. (nih.gov)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al. (nih.gov)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)
Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
2010. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). . (oregonstate.edu)
In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. (frontiersin.org)
Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)
Next, we summarize various cytokines produced by adipocytes that regulate the survival, activation and differentiation of B cells. (frontiersin.org)
Results: Adipsin gene expression was significantly elevated in GO tissue and increased after the stimulation of IGF-1 and CD40L, as well as adipocyte differentiation in GO cells. (bvsalud.org)
Adipsin suppression also attenuated adipocyte differentiation. (bvsalud.org)
The evaluation of the osteoblastic differentiation can be verified through immunohistochemical markers such as bone morphogenetic protein- 2 (BMP-2). (bvsalud.org)
This evaluation of osteoblastic differentiation is commonly evaluated through different protein markers, among them bone morphogenetic protein-2 (BMP-2). (bvsalud.org)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Inactivation of TCF7L2 protein attained by removing the high-mobility group (HMG)-box DNA binding domain in mature adipocytes in vivo leads to whole-body glucose intolerance and hepatic insulin resistance. (medscape.com)
Specifically, we want to understand the very early changes in insulin signalling and glucose transport in mature adipocytes, and how this is related to cell size. (lu.se)

Obesity can be viewed as a state of long-term lipid disequilibrium that is marked by massive adipocyte hypertrophy and is a major risk factor for developing insulin resistance and type 2 diabetes. (jci.org)

GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. (nih.gov)
Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. (korea.ac.kr)
Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity. (diabetesjournals.org)
However, it is still unclear if adipocytes from other depots, such as intramuscular adipocytes, also emerging in the context of obesity and aging ( 6 ) can influence skeletal muscle metabolism, function, and mass. (diabetesjournals.org)
Importantly, NR1D1 action in adipocytes is critical to the development of obesity-related WAT pathology and insulin resistance. (elifesciences.org)
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. (uib.no)
Deletion of AQP7 in mice leads to development of obesity and adipocyte hypertrophy, suggesting an important role in human metabolism. (lu.se)

Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
PKA: a portrait of protein kinase dynamics. (nature.com)
Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. (lu.se)
AICAR, an activator of AMP-activated protein kinase, significantly increased FA release, in accordance with increased expression of ATGL, even in the absence of CGI-58. (indexindex.com)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
On the other hand, interestingly, one of the key downstream insulin signaling molecules, protein kinase-B (PKB, or Akt) and its phosphorylation (pAkt) were significantly increased for cyclically stretched adipocytes relative to unstretched control. (unl.edu)
Moreover, cyclic stretch upregulated the phosphorylation of 5'-AMP-activated protein kinase (pAMPK). (unl.edu)
The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
We previously had seen that after cAMP-dependent protein kinase A, or PKA, activation, a major hyperphosphorylated protein migrates as a 65-67 kDa protein on SDS-PAGE. (asbmb.org)

Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. (nih.gov)
We found 65 miRNAs regulated during in vitro adipogenesis in primary adipocytes. (biomedcentral.com)
When comparing primary adipocyte profiles, with those of cell lines reported in the literature, we found a high degree of difference in 'adipogenesis' regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. (biomedcentral.com)
[ 17 , 18 ] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)
Adipsin protein production was analyzed in primary cultured orbital fibroblasts under insulin growth factor (IGF)-1, CD40 ligand (CD40L) stimulation, and adipogenesis. (bvsalud.org)

The CNS also directly regulates adipocyte metabolism, as we have shown here by examining central action of the orexigenic hormone ghrelin. (jci.org)

In white adipocytes, mRNA expression of various fat storage-promoting enzymes such as lipoprotein lipase, acetyl-CoA carboxylase α, fatty acid synthase, and stearoyl-CoA desaturase-1 was markedly increased, while that of the rate-limiting step in fat oxidation, carnitine palmitoyl transferase-1α, was decreased. (jci.org)
UCP-1-expressing multilocular adipocytes, termed 'beige' or 'brite' (brown-in-white) adipocytes, can also be found interspersed among white adipocytes within SAT under conditions requiring increased heat production (e.g. chronic cold exposure). (springer.com)

The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated proteins such as perilipin, hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and its activator protein, CGI-58. (indexindex.com)
Here, we describe the cellular origin and physiological significance of micro LDs (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key lipolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. (indexindex.com)
These results suggest that, besides on the surface of pre-existing central LDs, LD-associated proteins are actively involved in lipolysis on mLDs that are formed by FA re-esterification. (indexindex.com)
Previously the upregulation of esterification and downregulation of lipolysis in small rat adipocytes upon incubation with exosomes and microvesicles (EMVs) released from large adipocytes and harbouring the glycosylphosphatidylinositol (GPI)-anchored proteins, Gce1 and CD73, transcripts specific for FSP27 and GPAT3, and microRNAs, miR-16 and miR-222 was demonstrated. (ac.ke)
Inhibition of EMV release by tPCPA and BIX01294 was not caused by apoptosis but accompanied by upregulation of the H2O2-induced stimulation of lipid synthesis and downregulation of lipolysis in large (but not small) primary and differentiated rat and human adipocytes. (ac.ke)
β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism. (ku.dk)
We have used pharmacological inhibitors and a direct activator of lipolysis to acutely modulate the activity of lipases, thereby enabling us to uncover lipolysis-dependent signaling pathways downstream of β-adrenergic signaling in cultured brown adipocytes. (ku.dk)
Importantly, however, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs. (ku.dk)
Our results demonstrate that lipolysis generates important metabolic signals that exert profound pleiotropic effects on transcription and function of cultured brown adipocytes. (ku.dk)
The aquaglyceroporin AQP7 is expressed in adipocytes where it regulates glycerol efflux as it translocate to the plasma membrane during lipolysis as a result of catecholamine stimulation. (lu.se)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
This phenotype is associated with increased subcutaneous adipose tissue mass, adipocyte hypertrophy, and inflammation. (medscape.com)

Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARγ ligands regulate lipid metabolism and insulin sensitivity in adipocytes. (jci.org)
Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. (medlineplus.gov)
We knew little about the intracellular architecture of neutral lipid metabolism and the nature and localization of the proteins that regulate LD assembly and maintenance. (asbmb.org)
We wanted to study these fundamental processes and identify the adipocyte proteins that regulate neutral lipid metabolism in response to fasting and feeding. (asbmb.org)
When we fractionated the phosphate-loaded adipocytes, this phosphoprotein localized exclusively to the fat cake, sparking our interest in learning more about its potential role in adipocyte metabolism. (asbmb.org)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
Further, we aim to create a systems biology understanding of changes in both adipose tissue composition, adipocyte size, and cellular insulin responsiveness, and explore their impact on whole-body metabolism using mathematical modelling. (lu.se)

More than 95% of all radiolabeled phosphate that was incorporated into cellular proteins after the PKA stimulation went into PLIN1, making it the predominant PKA substrate in adipocytes. (asbmb.org)

Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)

We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
Since it is known that adipokines such as leptin and adiponectin can instigate their insulin signaling sensitizing effect via AMPK and Akt, we propose a mechanism that mechanical stretching of adipocytes may induce the secretion of insulin sensitizing adipokines like leptin and/or adiponectin, which in turn activates AMPK and Akt phosphorylation and, ultimately, improves insulin signaling in the adipose tissue. (unl.edu)
To home in on the phosphorylation/dephosphorylation mechanisms, we loaded rat adipocytes with phosphorus-32-labeled inorganic phosphate and incubated them with varying concentrations of the beta-adrenoreceptor agonist isoproterenol in the absence and presence of insulin. (asbmb.org)

If the capacity of the adipocyte to store lipids is exceeded, it can no longer regulate the release of FFAs into the circulation, which ultimately leads to the abnormal accumulation of lipid in nonadipose depots. (jci.org)
Uncoupling Protein 1 (UCP-1) in the inner membrane of brown-fat mitochondria uncouples electron transport from ATP production, allowing energy dissipation, thus helping to regulate body temperature [ 3 ]. (biomedcentral.com)
Adipocytes can regulate adaptive immunity, which is involved with various metabolic diseases. (frontiersin.org)
Since there have been many reports on the regulation of metabolic diseases through adaptive immunity ( 9 - 11 ), we focus on how adipocytes regulate adaptive immunity in this review. (frontiersin.org)

To investigate the role of RBP4 in BAT, brown adipocyte-specific human RPB4 transgenic mice (UCP1-hRBP4 mice) were generated. (snu.ac.kr)

3T3-L1 adipocytes (L1) were stimulated by TNF-α to examine S100B secretion. (nih.gov)
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo. (mpg.de)
Silencing of adipsin suppressed IGF-1-induced IL-6, IL-8, COX2, ICAM-1, CCL2 gene expression, and IL-6 protein secretion. (bvsalud.org)

Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. (nature.com)
One LD-associated protein is perilipin 1, or PLIN1 . (asbmb.org)
Andrew Greenberg and colleagues identified perilipin as a major protein associated with lipid droplets. (asbmb.org)
Perilipin (stained red) binds to the surface of lipid droplets (green) and functions as a dynamic scaffolding protein that controls entry and exit of lipids from the droplets. (asbmb.org)
In immunocytochemical studies in differentiated adipocytes, we saw anti-perilipin immunoreactivity in well-defined ringlike patterns around both large and small intracellular lipid droplets. (asbmb.org)

Future studies should also focus on identifying the molecular triggers of this adipocyte-skeletal muscle cross talk. (diabetesjournals.org)
Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
Our research is focused on exploring the molecular mechanisms regulating adipocyte function, both normal and in the insulin-resistant state, using experimental cell biology methods and sophisticated microscopy techniques at a single cell level. (lu.se)

Immunoblot analysis with specific antibodies to each C/EBP isoform demonstrated that the levels of C/EBP delta and C/EBP beta protein were rapidly induced (by day 1) and then abrogated by day 4 and 8, respectively, in solvent-treated (control) cells. (aspetjournals.org)
In TCDD-treated cells, however, the levels of C/EBP beta and C/EBP delta protein persisted at these time points. (aspetjournals.org)
Time-lapse imaging of GFP-tagged LD-associated proteins and immunocytochemical analyses showed that particulate structures carrying LD-associated proteins emerged throughout the cells upon lipolytic stimulation, but not when FA re-esterification was blocked. (indexindex.com)
The transfer of proteins and nucleic acids from donor to acceptor cells via small membrane vesicles has been implicated with (patho)physiological consequences. (ac.ke)
In this study, with the assumption that adipose tissue can be mechanically responsive (as is the case for well-known musculoskeletal tissues), we hypothesized that mechanical loading applied to the adipose tissue and its component cells, such as adipocytes, may play a role in the exercise control of insulin sensitivity. (unl.edu)
Using a combination of three-dimensional coculture and conditioned media experiments, they showed that the secretome of inflamed human visceral adipocytes induces atrophy in human skeletal muscle cells. (diabetesjournals.org)
In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)
This review describes how adipocytes participate in adaptive immunity from the perspective of T cells and B cells, and discusses their role in the pathogenesis of various diseases. (frontiersin.org)
Adipocytes are the main constituent cells of adipose tissue. (frontiersin.org)
Recently, an increasing number of studies have shown that adipocytes have immunological functions capable of recruiting and activating immune cells. (frontiersin.org)
Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
Moreover, like other nucleated cells, adipocytes express MHC class I molecules. (frontiersin.org)
However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)
Andrew Greenberg, his late mentor Constantine Londos and colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases discovered PLIN1, an abundant protein in fat cells and the first protein identified on the LD surface. (asbmb.org)
Triglycerides primarily store energy in adipocytes and muscle cells. (msdmanuals.com)
In the capillaries of adipose and muscle tissue, apoprotein C-II (apo C-II) on the chylomicron activates endothelial lipoprotein lipase (LPL) to convert 90% of chylomicron triglyceride to fatty acids and glycerol, which are taken up by adipocytes and muscle cells for energy use or storage. (msdmanuals.com)

Regulation of glycerol efflux in adipocytes. (lu.se)
Regulation of mLDs and LD-associated proteins may be an attractive therapeutic target against lipid-associated metabolic diseases. (indexindex.com)
Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)
These findings argue for regulation of the release of EMVs harbouring specific GPI-anchored proteins, transcripts and microRNAs from rat and human adipocytes by histone H3 methylation at lysines 4 and 9 in interdependent fashion. (ac.ke)
Studies in mouse indicate the 80 aa SMAF1 protein is involved in adipocyte tissue function or regulation. (nih.gov)
Abstract title:Regulation of de novo lipogenesis through the control of nuclear SREBP-1c protein stability. (csh-asia.org)

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. (wikipedia.org)
Daily Intake of Protein from Cod Residual Material Lowers Serum Concentrations of Nonesterified Fatty Acids in Overweight Healthy Adults: A Randomized Double-Blind Pilot Study. (uib.no)
during fasting, adipocytes release fatty acids into circulation. (asbmb.org)
2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)

Thus the EMV-mediated transfer of lipogenic and anti-lipolytic information between large and small adipocytes in response to certain physiological and pharmacological stimuli seems to be controlled by epigenetic mechanisms. (ac.ke)
Our overall aim is to identify the mechanisms that cause adipocyte dysfunction. (lu.se)
Our research will together with others' provide a novel understanding of the mechanisms underlying the early stages of impaired adipocyte function. (lu.se)

Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. (lu.se)

More specifically, retinol-binding protein 4 (RBP4), which is a retinol carrier protein in the serum, is well known for its effects in the adipose tissues. (snu.ac.kr)
Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)
Karasek D, Vaverkova H, Frysak Z, Orsag J, Novotny D, Halenka M, Slavik L. Relationship between serum adipocyte fatty acid-binding protein and endothelial/hemostatic markers in dyslipidemic subjects. (nel.edu)

Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
These data identify OLR1 as a novel PPARγ target gene in adipocytes. (jci.org)

PLIN1 mainly acts as a dynamic scaffold for proteins involved in the storage and hydrolysis of neutral lipids in LDs. (asbmb.org)

In addition to their main functions, adipocytes have endocrine functions and can secrete a variety of adipokines such as leptin, adiponectin, and resistin ( 2 - 4 ). (frontiersin.org)
The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. (bvsalud.org)

As a proof-ofconcept test, we applied cyclic stretch loading to the adipocyte model, differentiated adipocytes from 3T3-L1 preadipocytes, and evaluated stretch-induced activation of key insulin signaling molecules. (unl.edu)

In brown adipocytes, central ghrelin infusion resulted in lowered expression of the thermogenesis-related mitochondrial uncoupling proteins 1 and 3. (jci.org)

This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)

Learn how Dr. Abbott and her team are 3D printing adipocytes into the intramuscular space to improve the flavor and texture of cultivated meat products. (gfi.org)

Thus, adipocytes may produce peptide and/or lipid factors that are secreted into the systemic bloodstream and negatively influence skeletal muscle mass. (diabetesjournals.org)

We investigated the role of S100B in the interaction between adipocytes and macrophages using a cell-culture model. (nih.gov)
Thus, S100B as an adipokine may play a role in the interaction between adipocytes and macrophages to establish a vicious paracrine loop. (nih.gov)

The IAFNS Innovation Showcase will feature a session describing career pathways for food and nutrition scientists in the alternative protein field. (gfi.org)

However, RBP4 expression in BAT is significantly increased along with uncoupling protein 1 when thermogenesis is activated. (snu.ac.kr)

Interestingly, this effect is more potent with visceral than with subcutaneous adipocytes. (diabetesjournals.org)

Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)

However, rosiglitazone significantly increased adiponectin protein expression in WAT, suggesting that WAT contributes to hyperadiponectinemia in this context. (frontiersin.org)

Purpose: Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. (bvsalud.org)

This underlying mechanism may involve a reduced activation of protein synthesis signaling in response to anabolic signals, such as insulin, amino acids, and insulin-like growth factors, rather than to increased atrophy signaling. (diabetesjournals.org)

FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser. (wikipedia.org)

Together, these findings are indicative of how glycerol release is controlled in adipocytes, and may pave the way for the future design of drugs against human metabolic pathologies. (lu.se)
Here the release of EMVs from large (but not small) primary and differentiated and human rat adipocytes in response to palmitate, H2O2 and the anti-diabetic sulfonylurea, glimepiride, is shown to be significantly reduced upon inhibition of histone H3 lysine9 methyltransferase G9a by trans-2-phenylcyclopropylamine (tPCPA) and histone H3 lysine4 demethylase LSD1 by BIX01294. (ac.ke)

Therefore, adipocyte-speci﫿c remain in adipose tissues. (deepdyve.com)

Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)
In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)

Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome. (wikipedia.org)
Adipocyte NR1D1 does not drive an anticipatory daily rhythm in WAT lipogenesis, but rather modulates WAT activity in response to alterations in metabolic state. (elifesciences.org)

The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. (nih.gov)

Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes. (frontiersin.org)
These include lead's ability to inhibit or mimic the actions of calcium (which can affect calcium-dependent or related processes) and to interact with proteins (including those with sulfhydryl, amine, phosphate, and carboxyl groups) [ATSDR 2010]. (cdc.gov)

Anatomy9

Organisms2

Diseases2

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes8

Differentiation20

Mature adipocytes3

Developing insulin resistance1

Obesity7

Kinase11

Adipogenesis5

Regulates adipocyte1

White adipocytes2

Lipolysis10

Hypertrophy2

Metabolism8

Substrate in adipocytes1

Obese1

Phosphorylation3

Regulate4

Brown adipocyte1

Secretion3

Perilipin5

Molecular3

Cells17

Regulation6

Fatty acids4

Mechanisms3

Glycerol efflux1

Serum3

PPAR2

Scaffold1

Leptin2

Signaling molecules1

Mitochondrial1

Glucose uptake3

Intramuscular1

Skeletal1

Macrophages2

Pathways1

Thermogenesis1

Subcutaneous1

Lipid storage3

Adiponectin1

Cytokines1

Mechanism1

MeSH1

Human2

Adipose tissues1

Significantly2

Metabolic2

Inflammation1

Processes2