• We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)
  • In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. (frontiersin.org)
  • Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)
  • Next, we summarize various cytokines produced by adipocytes that regulate the survival, activation and differentiation of B cells. (frontiersin.org)
  • 1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. (wikipedia.org)
  • decreased the mRNA expression of CPT1β (a gene associated with fatty acid oxidation) and increased the mRNA expression of FADS1 and FADS2 (genes associated with n-3 LCPUFA synthesis), compared with the LSO diet. (biomedcentral.com)
  • Gene methylation might lead to distinct mRNA isoforms. (cams.cn)
  • miRNAs control gene expression by binding to the complementary sites in the 3' untranslated regions (3' UTRs) of target mRNAs and triggering either translational inhibition or mRNA degradation by a molecular mechanism which is a subject of intense investigation [ 6 - 9 ]. (biomedcentral.com)
  • Current models posit that nuclear speckles (NSs) serve as reservoirs of splicing factors and facilitate posttranscriptional mRNA processing. (bvsalud.org)
  • Importantly, enhanced splicing of the IEGs ZFP36 and FOS is accompanied by relocalization of the corresponding nuclear mRNA foci to NSs. (bvsalud.org)
  • In particular, ribotoxic stress causes targeted excision of retained introns from pre-mRNAs of immediate early genes (IEGs), whose transcription is induced during the stress response. (bvsalud.org)
  • Human genetic variants that introduce an AG into the intronic region between the branchpoint (BP) and the canonical splice acceptor site (ACC) of protein-coding genes can disrupt pre-mRNA splicing. (bvsalud.org)
  • To investigate the processes involved, we studied the rumen bacterial communities and measured the mRNA expression of genes related to lipid metabolism in Longissimus dorsi . (biomedcentral.com)
  • Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
  • NS reorganization relies on the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway and coincides with splicing activation of both pre-existing and newly synthesized pre-mRNAs. (bvsalud.org)
  • Following our observation that erythrosine B (FD&C Red No. 3) is a relatively potent inhibitor of the TNF-R-TNFα and CD40-CD154 protein-protein interactions, we investigated whether this inhibitory activity extends to any other protein-protein interactions (PPI) as well as whether any other approved food colors posses. (shengsci.com)
  • Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. (cams.cn)
  • Methods Circulating (n = 179) and hepatic expression (n = 95) of ghrelin and LEAP-2 were measured in patients with severe obesity and available liver pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). (unav.edu)
  • It is likely that the intronic miRNAs are processed from the same primary transcript as the precursor mRNAs and thus, their expression levels are regulated by the expression of the host mRNA [ 39 ]. (biomedcentral.com)
  • In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
  • However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
  • Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)
  • Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
  • Additionally, maternal nutrition during gestation is closely associated with offspring growth and development in animals, which likely affects mRNA transcription, hormone secretion, antibodies, permeability of the placenta, breast milk composition, maternal parenting behavior and so on [ 4 ]. (animbiosci.org)
  • MicroRNAs (miRNAs) are short, noncoding RNA molecules of 18-24 nucleotides that regulate gene expression through posttranscriptional modification of target mRNA through binding at the 3′ untranslated region. (diabetesjournals.org)
  • mRNA microarray was conducted 72 h after MCAo using brain tissue from normal rats (normal group) and the sham and MSC groups. (molcells.org)
  • Meanwhile, follistatin mRNA levels could be up-regulated by local production of activin but the opposite was true for dopaminergic activation with dopamine (DA) or its agonist apomorphine. (frontiersin.org)
  • We demonstrated that the diagnostic algorithms of FD including a diagnostic apoB levels require correction, taking into account the characteristics of the distribution of apoB levels in the population. (preprints.org)
  • NOVA1 and NOVA2, the two members of the NOVA family of alternative splicing factors, bind YCAY clusters of pre-mRNAs and assemble spliceosomes to induce the maintenance/removal of introns and exons, thus governing the development of mRNAs. (nih.gov)
  • In grass carp pituitary cells, follistatin co-treatment was found to revert activin inhibition on GH mRNA expression. (frontiersin.org)
  • Furthermore, activation of D1 receptor by the D1-specific agonist SKF77434 was also effective in blocking follistatin mRNA expression induced by activin and GH treatment both in carp pituitary cells as well as in carp somatotrophs enriched by density gradient centrifugation. (frontiersin.org)
  • Purpose: Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. (bvsalud.org)
  • Activity of NOVAs accounts for up to 700 alternative splicing events per cell, taking place both in the nucleus (co-transcription of mRNAs) and in the cytoplasm. (nih.gov)
  • In this study there was detected a high prevalence of FD: 1 in 151. (preprints.org)
  • In the present study, we performed transcriptome analyses with mRNA microarray in a rodent stroke model to investigate the therapeutic mechanisms of IV-MSC in cerebral ischemia. (molcells.org)