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  • isoforms
  • Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. (nih.gov)
  • Integrin α3β1 interacts with laminin-5 and -10/11 more specifically than the other isoforms. (amsbio.com)
  • Nicotinic Acetylcho
  • Nicotinic acetylcholine receptors (AChRs) are clustered at high density in the postsynaptic membranes of skeletal neuromuscular junctions and cholinergic interneuronal synapses. (jneurosci.org)
  • and rapsyn for nicotinic acetylcholine receptors (AChRs) at the skeletal neuromuscular junction. (jneurosci.org)
  • proliferation
  • The nuclear receptor NR4A2 was observed to induce cell proliferation via MTT assay and reduce cell apoptosis via FACS assay. (jcancer.org)
  • A total of 120 compounds were acquired and tested in cell culture-based assays for inhibition of ovarian tumor cell adhesion and proliferation. (aacrjournals.org)
  • The role that σ receptors play in cancer is not clear, although it is frequently up-regulated in human cancer cells and tissues and σ receptors inhibit proliferation in carcinoma and melanoma cell lines, induce apoptosis in colon and mammary carcinoma cell lines, and reduce cellular adhesion in mammary carcinoma cell lines. (aacrjournals.org)
  • The role that σ1 receptors play in cancer is not clear (for review, see ref. 16 ), although it is frequently up-regulated in human cancer cells and tissues ( 7 , 16 , 17 ) and σ receptors inhibit proliferation in carcinoma and melanoma cell lines, induce apoptosis in colon and mammary carcinoma cell lines, and reduce cellular adhesion in mammary carcinoma cell lines (for review, see ref. 16 ). (aacrjournals.org)
  • fibrinogen
  • Moreover, the expression of fibrinogen receptors at the surfaces of conidia seemed to be related to the maturation of the conidia. (asm.org)
  • Compounds of the formula ##STR1## in which R1, X and Y have the meanings defined herein, and their salts, inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and tumors. (google.com.au)
  • 18. A method of inhibiting the binding of fibrinogen, fibrinectin or von Willebrand factor to a fibrinogen receptor comprising administering a compound according to claim 1. (google.com.au)
  • signal transduction
  • In-depth analysis of the GPR97 signaling cascade revealed a possible switch from basal Gαs/cAMP-mediated signal transduction to a Gαi-induced reduction in cAMP levels upon mutation-induced activation of the receptor, in combination with an increase in downstream effectors of Gβγ, such as SRE and NF-κB. (frontiersin.org)
  • regulation
  • The findings of this study provide a biological basis for the potential therapeutic applications of lipid raft cholesterol regulation in cancer therapy using σ receptor drugs. (aacrjournals.org)
  • morphogenesis
  • The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. (nih.gov)
  • mediates
  • These findings support that Notch signaling mediates cervical cancer cell growth suppression with the involvement of nuclear receptor NR4A2. (jcancer.org)
  • peptides
  • subsequent studies showed that the σ receptors were able to bind a variety of pharmacologically effective drugs, including benzomorphans, neuroleptics, antidepressants, cocaine, peptides related to neuropeptide Y, and neurosteroids (for review, see ref. 3 ), although intriguingly no known natural specific ligand(s) have been discovered. (aacrjournals.org)
  • Functionally
  • Acetylcholine, the neurotransmitter of skeletal neuromuscular junctions (NMJs), activates two structurally and functionally distinct types of receptors: nicotinic (nAChR) and muscarinic (mAChR). (jneurosci.org)