Adhesion myoblast. Medical search. Frequent questions

In vitro TNFa induces proliferation and migration but suppresses differentiation of myoblasts. (cdc.gov)
For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)
The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
Stephane Koenig ABSTRACT Ca 2+ signaling plays a key role during human myoblast differentiation. (biologists.com)
Among Ca 2+ -sensitive pathways, calcineurin is essential for myoblast differentiation and muscle regeneration. (biologists.com)
Our results showed that miR-195 and miR-497 were upregulated during muscle development and myoblast differentiation. (biologists.com)
Using synchronized cultures of C2C12 myoblasts to model these divergent programs, we show that p8 (also known as Nupr1 ), a G1-induced gene, negatively regulates the cell cycle and promotes myogenic differentiation. (biologists.com)
In keeping with its appearance pattern Cdo has important assignments in myogenesis and neurogenesis12 13 In myoblasts Cdo promotes differentiation as an element of multiprotein complexes offering the cell adhesion substances N-cadherin as well as the carefully related proteins Boc and Neogenin14-16. (cell-metabolism.com)
Protein tyrosine phosphatases (PTPs) are critical regulators of cellular phosphorylation functioning in processes such as cell growth, differentiation, and adhesion. (umn.edu)
This in accordance with recent data presented by researchers at Icagen Inc., demonstrating that the laminin-521 cell culture matrix maintains the differentiation potential of mouse and human satellite cell-derived myoblasts, even during long-term culture expansion (Penton, 2016). (biolamina.com)

MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
Myoblasts from TNFR1 and TNFR2 deficient mice demonstrated that TNFa induced gene expression in primary myoblasts is dependent on both receptors. (cdc.gov)
C2C12 cells, primary myoblasts and myotubes. (sun.ac.za)

This activation appears to be specific to osteoblasts, since progression to a myoblast phenotype results in no change in reporter gene activity. (umn.edu)

Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts. (southernbiotech.com)

during which it mediates myoblast fusion. (biologists.com)

The inhibition of NCAM-mediated adhesion produced by Fab fragments can be compensated for by addition of wheat germ agglutinin, but only with membranes whose NCAM has low levels of polysialic acid. (rupress.org)

This response may be related to myoblast migration or fusion activities. (cdc.gov)
This applies a tensile signal to the actin-binding domain (ABD) of α-catenin, which provides a clutch to promote lateral adhesion growth and inhibit the lamellipodial activity necessary for migration. (ibecbarcelona.eu)
2009). Within TEMs, tetraspanins can modulate the features of linked protein, controlling many physical and pathological procedures thus, such as fertilization, cell adhesion, motility, growth breach and transendothelial migration (Barreiro et al. (healthweblognews.info)
2004), and can regulate cell adhesion (Masellis-Smith and Shaw, 1994), migration (Anton et al. (healthweblognews.info)
Here we show that vascular edhesion protein-1 (VAP-1) is required for proper cell migration, adhesion, contractility and clonogenic behaviour. (mechanochemistry.org)

CD44 primarily functions as an adhesion molecule. (southernbiotech.com)

When the cells were cultured on soft tissue culture dishes that resemble the stiffness of muscle fibers, both patient cell lines displayed an elevated level of stress fibers and focal adhesions, and the cells spread further than WT myoblasts in these conditions. (fu-berlin.de)

Through the recombinant synthesis of extracellular matrix proteins, the roles of immobilized adhesion, proliferative and differentiative cues are evaluated. (units.it)

Materials and methods Cell culture Myoblasts were isolated from neonatal C57 mice by enzymatic dissociation of hindlimb musculature and purified by selective trypsinization and differential adhesion using procedures reviewed and approved by Georgia Institute of Technology's IACUC and in compliance with the Guide for Care and Use of Laboratory Animals. (academicediting.org)

Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced. (stemcellsciencenews.com)
CD9 also interacts with additional proteins, including additional tetraspanins, a subset of integrins, additional adhesion substances, membrane proteases, choline receptors and G proteins (Le Naour et al. (healthweblognews.info)

The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. (nih.gov)

Skeletal muscle progenitors (satellite cells), murine cell line and immortalized human myoblasts are studied in vitro to identify, in a controlled environment, the pathways regulating the regenerative potential of the skeletal muscle. (units.it)

DNA array or real-time PCR techniques were used to evaluate gene expression induced by TNFa in myoblast cultures. (cdc.gov)

Binding of the chemokine CXCL12α to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility. (univ-grenoble-alpes.fr)

These cells displayed deformed nuclei and had defects in mechanosensitive responses similar to myoblasts from a second patient with congenital muscular dystrophy who lacks aminoacid K32 in A-type lamins (LMNA-ΔK32). (fu-berlin.de)

We propose that NCAM-mediated adhesion promotes contact between cell membranes to allow the transmission of an otherwise NCAM-independent signal. (rupress.org)

Highly efficient cell adhesion on beads functionalized with clustered peptide ligands. (univ-grenoble-alpes.fr)

In addition, NCAM's polysialic acid moiety appears to influence the ability of cells to transmit this signal, even in the presence of an alternative adhesion mechanism. (rupress.org)
Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding sites on the target glycoproteins. (silverchair.com)

The founder cells, characterised by the expression of genes encoding putative transcription factors such as S59 or vestigial , fuse with neighbouring myoblasts to form syncytial precursors of individual muscles. (biologists.com)
Good for adhesion cells or cells requiring stronger cell-matrix interactions. (thewellbio.com)

MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
In this study, we found that the expression of CaD gradually increased as differentiation of C2C12 myoblasts progressed. (biologists.com)
This study reports the in vitro compatibility of muscle cells (C2C12 mouse myoblast cell line) with the transparent poly(vinyl alcohol) (PVA) hydrogels and the results are explained on the basis of surface wettability, crystallinity, and nanoscale elastic stiffness property. (iisc.ac.in)
The treatment of IO in C2C12 myoblasts led to increased myogenic differentiation and alleviation of dexamethasone-induced myotube atrophy. (ijbs.com)
Molecular analyzes revealed that in contrast to cellulose acetate scaffold, annatto-loaded cellulose acetate scaffold favor a proliferative state of C2C12 mouse skeletal myoblasts. (authorea.com)
The expression levels of Atrogin-1 and MHC1b were examined by RT-PCR in C2C12 myoblasts, and the expression levels of Atrogin-1, muscle atrophy F-box (MAFbx), muscle RING-finger protein-1 (MuRF-1), and myosin heavy chain-7 were investigated by immunoblotting. (kosfaj.org)

In vitro TNFa induces proliferation and migration but suppresses differentiation of myoblasts. (cdc.gov)
However, the cellular signaling pathways controlling the proliferation and differentiation of myoblasts are not fully understood. (rupress.org)

A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. (mcw.edu)
12. Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion. (nih.gov)
During embryonic muscle growth and regeneration in mature muscle, singly nucleated myoblasts fuse to each other to form myotubes. (silverchair.com)
We now show that the related protein myoferlin is highly expressed in myoblasts undergoing fusion, and is expressed at the site of myoblasts fusing to myotubes. (silverchair.com)
Myoferlin null myoblasts undergo initial fusion events, but they form large myotubes less efficiently in vitro, consistent with a defect in a later stage of myogenesis. (silverchair.com)
These data support a role for myoferlin in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes. (silverchair.com)
Muscle differentiation requires the transition from motile myoblasts to sessile myotubes and the assembly of a highly regular contractile apparatus. (ox.ac.uk)

They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation. (lookformedical.com)

16. Palmdelphin promotes myoblast differentiation and muscle regeneration. (nih.gov)
The Myoblast Proliferation Pathway has been researched in relation to Regeneration, Cell Proliferation, Myoblast Differentiation, Cell Cycle, Cell Growth. (novusbio.com)
Skeletal muscle stem cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced muscle regeneration. (rupress.org)
Furthermore, DEX impairs the proliferation activity and regeneration capacity of myoblasts and enhances their apoptosis [ 12 ]. (biomedcentral.com)

8. Creatine kinase B is necessary to limit myoblast fusion during myogenesis. (nih.gov)
Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage. (lookformedical.com)

This striking cytoskeletal remodelling is coordinated with a transformation of focal adhesion-like cell-matrix contacts into costameres. (ox.ac.uk)
We also revealed how different proteins mutated in centronuclear myopathies (myotubularin-MTM1, and amphiphysin-BIN1) control focal adhesion (Lionello et al. (igbmc.fr)
The percentage of cells in parallel … Shape 10 Actin filaments and focal adhesion staining of MSCs on extended vs. unstretched areas. (bibf1120.com)

14. Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. (nih.gov)
Binding of the chemokine CXCL12α to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility. (univ-grenoble-alpes.fr)

4. SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion. (nih.gov)
17. Phosphocreatine as an energy source for actin cytoskeletal rearrangements during myoblast fusion. (nih.gov)
Disruption of the ECM, integrins, or their cytoskeletal adaptors affects integrin-mediated adhesion. (silverchair.com)

1. Nap1-mediated actin remodeling is essential for mammalian myoblast fusion. (nih.gov)
9. Signaling mechanisms in mammalian myoblast fusion. (nih.gov)

Synthetic polymers scaffolds often need to be coated with extracellular matrix (ECM) proteins to improve cell adhesion. (authorea.com)

CD66a, CD66b, CD66c, and CD66d antibodies each increase neutrophil adhesion to human umbilical vein endothelial cell monolayers. (biomedcentral.com)
To examine potential interactions of CEACAMs in neutrophil signaling, the effects on neutrophil adhesion to human umbilical vein endothelial cells of a set of CD66 mAbs was tested following desensitization to stimulation by various combinations of these mAbs. (biomedcentral.com)

Previously, we found that changes in Capn3 expression were linearly correlated with the degree of muscular atrophy following reversible sciatic nerve injury and that knockdown of Capn3 gene expression promoted myoblast differentiation. (nih.gov)
KLF4 knockdown promoted myoblast proliferation and inhibited myoblast fusion, while its overexpression showed opposite results. (biomed.news)

Furthermore, in the L6 myoblast differentiation model in vitro, Capn3 gene expression was shown to be positively associated with the level of Mef2a by qRT-PCR, western-blotting, and immunocytochemistry. (nih.gov)
In vitro, KLF4 was highly expressed in proliferating myoblasts and early differentiated cells. (biomed.news)

13. Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion. (nih.gov)
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). (nih.gov)
Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). (nih.gov)

The difference in cell viability as well as adhesion of cultured myoblast cells on the investigated hydrogel substrates were discussed in reference to the difference in the nanoscale elastic properties, crystallinity, and surface wettability. (iisc.ac.in)

3. Live imaging provides new insights on dynamic F-actin filopodia and differential endocytosis during myoblast fusion in Drosophila. (nih.gov)
10. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. (nih.gov)
11. RhoE controls myoblast alignment prior fusion through RhoA and ROCK. (nih.gov)
15. An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. (nih.gov)
18. Myomaker is a membrane activator of myoblast fusion and muscle formation. (nih.gov)
19. A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion. (nih.gov)
20. Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila. (nih.gov)
Myoblast fusion requires the alignment and fusion of two apposed lipid bilayers. (silverchair.com)
Muscle fibers can contract, are syncytia from the fusion of myoblasts, can have several hundred nuclei, measure up to 30cm in human, and account for nearly half of the dried body weight. (igbmc.fr)
Genetic studies of the fruit fly Drosophila have revealed several genes that are required for the formation of multinucleated muscle cells by fusion of myoblasts [3] . (wikidoc.org)
Some of the key proteins are important for cell adhesion between myocytes and some are involved in adhesion-dependent cell-to-cell signal transduction that allows for a cascade of cell fusion events. (wikidoc.org)

This increase in neutrophil adhesion caused by CD66 antibodies is blocked by CD18 mAbs and is associated with upregulation of CD11/CD18 on the neutrophil surface. (biomedcentral.com)

Myoblasts from TNFR1 and TNFR2 deficient mice demonstrated that TNFa induced gene expression in primary myoblasts is dependent on both receptors. (cdc.gov)

Furthermore, TNFa induces moderate induction of Pax-7, a mediator of myoblast proliferation. (cdc.gov)
As cellulose acetate nanofibers is a low-cost cellulose-derived material, that induces cell adhesion and proliferation, we investigated its use associated with a bioactive annatto extract, a food-dye and potential meat preservative, as scaffolds for cultivated meat. (authorea.com)

In muscle growth, singly nucleated myoblasts can also fuse to existing large,syncytial myofibers as a mechanism of increasing muscle mass without increasing myofiber number. (silverchair.com)
In the final stage of muscle fiber development, the cell membranes of attached myoblasts open up and fuse together, forming one large, unified cell. (weizmann-usa.org)

DNA array or real-time PCR techniques were used to evaluate gene expression induced by TNFa in myoblast cultures. (cdc.gov)

For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)

7. Myoblast structure affects subsequent skeletal myotube morphology and sarcomere assembly. (nih.gov)

6. Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts. (nih.gov)
Integrin-mediated adhesion between the ECM and the cytoskeleton is crucial for tissue interactions during development. (silverchair.com)

Our observations point to an important function for Zasp in the assembly of integrin adhesion sites both in cell culture and in tissues. (silverchair.com)
In tissues, small adhesion sites mature during development into stable hemiadherens junctions that connect epithelia to the basement membrane and into myotendinous junctions that connect the tips of striated muscles to the ECM. (silverchair.com)

The Myoblast Proliferation Pathway complements our catalog of research reagents including antibodies and ELISA kits against IGF1, MYOG, MYOD1, MSTN, FGF2. (novusbio.com)
We have 2567 products for the study of the Myoblast Proliferation Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)

Disease and disorder research has been conducted in relation to the Myoblast Proliferation Pathway and Hypertrophy, Muscular Dystrophy, Dystrophy, Muscular Atrophy, Muscle Injury. (novusbio.com)

Integrins often localize in highly organized structures, such as focal adhesions in tissue culture and myotendinous junctions in muscles. (silverchair.com)

The study of the Myoblast Proliferation Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)

In addition the pre-stretched surface demonstrated an ability to promote early myoblast differentiation of the MSC. (bibf1120.com)

An important result has been that both elastic stiffness and surface wettability synergistically influence myoblast viability/adhesion on PVA hydrogels. (iisc.ac.in)

We demonstrate that Janus kinase 1 (JAK1) is required for myoblast proliferation and that it also functions as a checkpoint to prevent myoblasts from premature differentiation. (rupress.org)

The process in which a relatively unspecialized cell acquires specialized features of a myoblast. (mcw.edu)

Anatomy44

Organisms10

Diseases9

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes46

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science4

Differentiation10

Primary myoblasts3

Phenotype1

Proliferation and migration1

Mediates1

Inhibition1

Migration5

Molecule1

Focal1

Proliferative1

Selective1

Receptors2

Lamellipodial1

Pathways1

Cultures1

Extracellular1

Responses1

Promotes1

Peptide1

Mechanism2

Cells2

C2C126

Differentiation of myoblasts2

Myotubes7

Skeletal myoblasts1

Regeneration4

Myogenesis2

Focal adhesion3

Facilitates2

Cytoskeletal3

Mammalian2

Extracellular matrix1

Endothelial2

Knockdown2

Vitro2

Regulation3

Substrates1

Fusion11

Neutrophil1

Mice1

Induces2

Fuse2

Gene expression1

Expression1

Affects1

Cytoskeleton2

Tissues2

Antibodies2

Injury1

Highly1

Found1

Early1

Important1

Functions1

Features1