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  • cells
  • May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. (mybiosource.com)
  • tumor
  • Infection with hyphae, but not with conidia, stimulated endothelial cells to synthesize E-selectin, vascular cell adhesion molecule 1 (VCAM-1), interleukin 8, and tumor necrosis factor alpha (TNF-alpha) in vitro. (nih.gov)
  • Leukocyte rolling velocities in cremaster muscle venules were increased significantly in ICAM-1-deficient mice during both trauma- and tumor necrosis factor alpha-induced inflammation, but rolling leukocyte flux was not reduced. (duke.edu)
  • Elimination of ICAM-1 expression in L-selectin-deficient mice resulted in a sharp reduction in the flux of rolling leukocytes during tumor necrosis factor alpha-induced inflammation. (duke.edu)
  • We then tested the hypothesis that carvedilol may reduce tumor necrosis factor-α (TNF-α)-induced intracellular ROS production, redox-sensitive transcription pathway activation, and adhesion molecules expression, resulting in the inhibition of endothelial adhesiveness to human MNCs in vitro-an early sign of atherogenesis. (ahajournals.org)
  • cell
  • Hynes RO 1992 Integrins: versatility, modulation, and signaling in cell adhesion. (springer.com)
  • This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. (mybiosource.com)
  • The adhesion of cells to each other and to the proteins of the extracellular matrix provides a stable environment for cell growth, differentiation, and migration. (bmj.com)
  • There is, therefore, increasing interest in the receptors that determine these processes-cell adhesion molecules. (bmj.com)
  • As their name suggests they mediate the adhesion of cells to each other and to surrounding substrates, "integrating" the cell with its environment. (bmj.com)
  • We generated vascular cell adhesion molecule (VCAM)-1 "knock-in" mice and Cre recombinase transgenic mice to delete the VCAM-1 gene ( vcam-1 ) in whole mice, thereby overcoming the embryonic lethality seen with conventional vcam-1 -deficient mice. (rupress.org)
  • This phenomenon is the result of a complex interplay among blood flow, cell adhesion and molecular vascular biology factors. (springer.com)
  • IMMUNOGLOBULIN SUPERFAMILY
  • Three main groups of adhesion molecules have been implicated in cardiovascular pathology: integrins, selectins, and members of the immunoglobulin superfamily. (bmj.com)
  • The β 2 integrins are expressed solely by white cells and principally interact with members of the immunoglobulin superfamily promoting leucocyte adhesion and infiltration. (bmj.com)
  • Schematic representations of integrin (left), immunoglobulin superfamily (centre), and selectin (right) adhesion molecule structures. (bmj.com)
  • interactions
  • May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. (mybiosource.com)
  • Adhesive interactions, however, are also involved in the pathogenesis of cardiovascular disease, regulating thrombus formation, facilitating leucocyte infiltration, mediating the migration and proliferation of smooth muscle cells, and enabling the deposition of fibrotic tissue. (bmj.com)
  • Integrins
  • 2 The most widely distributed integrins belong to the β 1 subfamily, which mainly influence the adhesion of cells to extracellular matrix proteins such as fibronectin, collagens, and laminin (table 1 ). (bmj.com)
  • They induce relatively weak and transient adhesion allowing the cells to roll along the vascular wall after which they will disengage or, following the triggering of other adhesion receptors such as integrins, become more securely bound. (bmj.com)
  • rolling in vivo
  • 1995 Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. (springer.com)
  • Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses. (duke.edu)
  • 1995
  • Kubes P, Jutila M, Payne D. 1995 Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. (springer.com)
  • selectins
  • Unlike other adhesion receptors, selectins bind to carbohydrates and glycopeptides rather than protein ligands (table 2 ). (bmj.com)
  • cellular
  • 11 In this study, we investigated whether stable analogs of native LXA4 and aspirin-triggered 15-epi-LXA4 are active within the microenvironment of human whole blood, and studied the cellular mechanisms that account for their novel inhibitory actions in leukocyte trafficking. (springer.com)
  • In conjunction with fine-tuning of the diaryl substituents, we discovered a novel series of potent, nonpeptide inhibitors of LFA-1/ICAM-1 interaction, exemplified by A-286982 (28h), which has IC(50) values of 44 and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively. (sigmaaldrich.com)
  • 2002). Temporal stability of acute stress-induced changes in leukocyte subsets and cellular adhesion molecules in older adults. (springer.com)
  • platelets
  • A. Papayianni, C.N. Serhan, M.L. Phillips, H.G. Rennke, and H.R. Brady, Transcellular biosynthesis of lipoxin A 4 during adhesion of platelets and neutrophils in experimental immunecomplex glomerulonephritis. (springer.com)
  • novel
  • Etzioni A, Frydman M, Pollack S, Avidor I, Phillips ML, Pualsom JC, Gershoni-Baruch R 1992 Severe recurrent infections due to a novel adhesion molecule defect. (springer.com)