Loading...
  • interaction
  • In conjunction with fine-tuning of the diaryl substituents, we discovered a novel series of potent, nonpeptide inhibitors of LFA-1/ICAM-1 interaction, exemplified by A-286982 (28h), which has IC(50) values of 44 and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively. (sigmaaldrich.com)
  • accumulation
  • Leukocyte trafficking from bloodstream to tissue is important for the continuous surveillance for foreign antigens as well as for rapid leukocyte accumulation at sites of inflammatory response or tissue injury. (springer.com)
  • Leukocyte accumulation in the vessel wall is a hallmark of early atherosclerosis and plaque progression. (ahajournals.org)
  • inflammation
  • Implicated in Note Entity Recruiting blood leukocytes to the site of inflammation Note E-selectin. (picsearch.com)
  • Given that TLRs and sphingosine-1-phosphate (S1P) are key players in inflammation, we explored the potential interplay between TLRs and S1P in the adhesion/inflammatory pathways in primary human endothelial cells. (jimmunol.org)
  • Prostratin and bryostatin-1 could thus be considered as potent regulators of BBB permeability and inflammation that influence leukocyte transport across the BBB. (jimmunol.org)
  • mechanisms
  • Taken together, these results demonstrate that hypoxia induces leukocyte β 2 integrin expression and function by transcriptional mechanisms dependent upon HIF-1. (pnas.org)
  • cytokine
  • Conclusion: These novel data demonstrate that cytokine-induced firm leukocyte adhesion in the mouse aorta and femoral artery is LFA-1-dependent in vivo, which may implicate an important role for this β(2)-integrin leukocyte extravasation. (lu.se)
  • firm adhesion
  • Material and Methods: Intravital fluorescence microscopy was used to study leukocyte firm adhesion in the mouse aorta and femoral artery in response to combined local challenge with TNF-alpha and IL-1beta. (lu.se)
  • ligand
  • E-Selectin interacts with leukocyte sialyl-Lewis x as a ligand and has been recently shown to be expressed in human atherosclerotic lesions. (ahajournals.org)
  • adherent
  • Their adherent-leukocyte densities were changed from 9.17 ± 1.45 cells/100 μm in DM group to 4.71 ± 0.43 cells/100 μm in DM + AAday2 group and to 2.15 ± 0.31 cells/100 μm in DM + AA6wk group, respectively. (nih.gov)
  • significantly
  • Interestingly, the number of leukocyte adhesion was decreased significantly by both intervals of AA supplementation. (nih.gov)
  • Angiotensin II (10 −7 mol/L) increased leukocyte adhesion significantly to 67% of the maximal effect by tumor necrosis factor-α at a wall shear stress of 2 dyne/cm 2 . (ahajournals.org)
  • The AT 1 -receptor antagonist DUP 753 significantly reduced E-selectin-dependent adhesion, whereas the AT 2 -receptor antagonist PD 123177 had no inhibitory effect. (ahajournals.org)
  • recurrent
  • This disease is characterized by recurrent bacterial infections, impaired wound formation, and other aberrations of adhesion-dependent functions. (clinicaltrials.gov)
  • U937
  • Initial experiments revealed that exposure of the promonocytic cell line U937 to hypoxia resulted in increased adhesion to activated endothelia. (pnas.org)
  • shear
  • The technique enables studying vascular adhesion under shear flow with differing intraluminal pressures up to 200 mmHg thus mimic-ing the pathophysiological conditions of high blood pressure. (jove.com)