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  • LAMA2
  • Mutations in the human laminin α 2 ( LAMA2 ) gene result in the most common form of congenital muscular dystrophy (MDC1A). (pnas.org)
  • Here we show that the degenerative muscle phenotype in the zebrafish dystrophic mutant, candyfloss ( caf ) results from mutations in the laminin α 2 ( lama2 ) gene. (pnas.org)
  • The incidence of CMDs has been estimated to be approximately one in 21,500 ( 2 ), with laminin α2- (LAMA2) deficient CMD (MDC1A) accounting for ≈40-50% of the CMD cases in European countries ( 3 ). (pnas.org)
  • inhibition
  • The lack of inhibition of adhesion to vWF as a single molecule may be explained by assuming that this adhesion is determined by interaction of nonactivated GPIb with vWF that has been changed in conformation by adsorption. (ahajournals.org)
  • dependent
  • VCL coated to a coverslip caused a concentration-dependent adhesion that was blocked by antibodies against GPIb, which block interaction with vWF. (ahajournals.org)
  • VCL may be of value in preventing adhesion and thrombus formation under conditions in which these processes are dependent on vWF. (ahajournals.org)
  • At the C-terminal end of the beta sheet is a conserved metal binding site that has been called the metal ion-dependent adhesion site, or MIDAS motif. (sdbonline.org)