• type IV colla
  • The latter procedure consists of exposing cryostat sections to specific antisera against type IV collagen (localized in the lamina densa or basal lamina), against laminin (localized in the lower portion of the lamina lucida), and against bullous pemphigoid antigen (localized in the upper portion of the lamina lucida in the vicinity of the hemidesmosomes). (dermaamin.com)
  • Type IV collagen is the major component of BM, provides structural framework of all BMs and interacts with cell surface receptors including integrins and discoidin domain receptors (DDRs). (sciencepublishinggroup.com)
  • Here we demonstrate that native type IV collagen induces Akt2 and FAK activation through a DDR1, PI3K and epidermal growth factor receptor (EGFR)-dependent pathway in MDA-MB-231 breast cancer cells. (sciencepublishinggroup.com)
  • In addition, cell migration induced by native type IV collagen requires PI3K, Akt2 and EGFR activity, whereas collagen IV also induces NFκB-DNA binding activity through a DDR1, PI3K, Akt2 and EGFR-dependent pathway. (sciencepublishinggroup.com)