• Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. (techscience.com)
  • Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
  • Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
  • We examined the correlation between nuclear deformation and cell functions such as cell proliferation, transfection and extracellular matrix protein type I collagen production. (cdc.gov)
  • Extracellular matrix is a fibrillar network composed of structural (collagens) and adhesion (fibronectin) proteins crucial for tissue architecture and biological pathway Histol Histopathol 27:1515-1528, 2012 . (springer.com)
  • GO and KEGG analyses showed that the upregulated DEGs were mainly enriched in the extracellular matrix (ECM) organization of the biological process (BP), the collagen-containing ECM of cellular component (CC), and the ECM structural constituent of molecular function (MF). (hindawi.com)
  • As an example, we have fabricated fibrous materials that have varied mechanical properties and fiber densities when mechanically loaded due to the chemical adhesion between fibers, similar to natural extracellular matrix (see Figure). (upenn.edu)
  • Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. (wikipedia.org)
  • Bones contain a matrix of collagen proteins, which are piezoelectric materials that accumulate small electrical charges when subjected to mechanical stresses, leading to stimulation and deposition of intracellular calcium during fracture healing [ 13 ]. (hindawi.com)
  • These proteins are vital to normal platelet adhesion and hemostatic function. (nottingham.ac.uk)
  • This fibrillar network is composed of many structural proteins, such as collagens, and adhesion proteins, including fibronectin and proteoglycans (perlecan, decorin) [ 13 , 14 ]. (springer.com)
  • In the present study, we investigated the role of Src family tyrosine kinases in the initial adhesion events of human platelets to collagen and cross-linked CRP. (reading.ac.uk)
  • Although PP2 prevented activation of Syk and PLCgamma2 in collagen-adherent platelets, tyrosine phosphorylation of several unidentified protein bands persisted, as did autophosphorylation of pp125(FAK). (reading.ac.uk)
  • Conclusions - These findings indicate that activation of Src-tyrosine kinases Syk and PLCgamma2 is not required for the initial stable attachment of human platelets to collagen and for FAK autophosphorylation. (reading.ac.uk)
  • This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
  • The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
  • Platelet adhesion (ie, of platelets to exposed vascular subendothelium) requires von Willebrand factor (VWF) and the platelet glycoprotein Ib/IX complex. (msdmanuals.com)
  • Platelet aggregation tests assess the ability of platelets to clump in response to the addition of various activators (eg, collagen, epinephrine , ADP, ristocetin). (msdmanuals.com)
  • The binding of different collagen receptor integrins to citrullinated collagen was studied by CHO cell lines, each overexpressing 1 of the 4 human collagen receptors on the cell surface, and with solid-phase binding assays, using the recombinant human integrin α1I, α2I, α10I, and α11I domains. (abo.fi)
  • Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
  • ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)
  • Adhesion receptors of the immune system. (bdbiosciences.com)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
  • Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
  • Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
  • This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
  • This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
  • Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
  • Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
  • Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
  • Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. (thieme-connect.com)
  • Context: Adhesion G protein-coupled receptor (GPCR)-G1 (ADGRG1) is the most abundant GPCR in human pancreatic islets, but its role in islet function is unclear. (lu.se)
  • In normal breast epithelium, Wnt-5a is important for cell-ECM adhesion and activation of the collagen receptor DDR1. (lu.se)
  • Mesh implantation induced collagen I and III deposition, but in smaller amounts in NOS2(-/-) mice. (unifesp.br)
  • NO deficiency results in a prolonged inflammatory reaction to the mesh implant, and reduced collagen deposition may contribute to an increased incidence of visceral adhesions. (unifesp.br)
  • Lung tissues were collected on day 21, and HE and Masson staining were performed to assess morphological changes and collagen deposition in the lungs. (researchsquare.com)
  • Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (rcsb.org)
  • We, herein, engineered nanotopographies of various shapes (gratings and pillars) and dimensions (feature size, spacing and height), and thoroughly investigated cell spreading, focal adhesion organization and nuclear deformation of human primary fibroblasts as the model cell grown on the nanotopographies. (cdc.gov)
  • It was found that the nanoscale gratings and pillars could facilitate focal adhesion elongation by providing anchoring sites, and the nanogratings could orient focal adhesions and nuclei along the nanograting direction, depending on not only the feature size but also the spacing of the nanogratings. (cdc.gov)
  • DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. (hindawi.com)
  • In a normal wall of arteries, collagen type IV acts to inhibit smooth muscle cell proliferation. (wikipedia.org)
  • Given that the integrins regulate cell metabolism, proliferation, and migration, we suggest that collagen citrullination modifies the pathogenesis of RA. (abo.fi)
  • Further, we demonstrated that cell proliferation, transfection, and type I collagen production were strongly associated with the nuclear volume, indicating that the nucleus serves as a critical mechanosensor for cell regulation. (cdc.gov)
  • Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
  • Beneficial effects of collagen type III on β-cell function via activation of the cAMP/protein kinase A pathway, suppression of RhoA and caspase-3 activity, increased β-cell viability, and proliferation were abolished when ADGRG1 was downregulated in β-cells. (lu.se)
  • Cultured MSCs were seeded and grown onto fabricated silicone-based composites containing collagen and CNT fibers. (hindawi.com)
  • Adhesions are comprised of strong but small (sometimes microscopic) bands of collagen fibers. (clearpassage.com)
  • During fibrosis, collagen fibers become denser and aligned. (upenn.edu)
  • Engineered fibrous matrices now respond to mechanical loading to densify and align fibers through inter-fiber adhesion. (upenn.edu)
  • After 15 days tissues around the mesh implant were collected, and inflammatory markers (the cytokine interleukin 1 beta (IL-1 beta) and NO) and tissue remodeling (collagen and metalloproteinases (MMP) 2 and 9) were analyzed. (unifesp.br)
  • Lung tissues were collected on day 21 to detect pathological changes and the expression of collagen content and regulator of G protein signaling 2(RGS2). (researchsquare.com)
  • Collagens are crucial for the ECM architecture and particularly collagen I, III and VI are key components in animal tissues. (springer.com)
  • An inhibition assay of Candida albicans adhesion to gelatin-immobilized membranes was compared with that to intact type I collagen-immobilized membranes using an arginine-glycine-aspartic acid (RGD) containing peptide. (elsevierpure.com)
  • Platelet adhesion to collagen and collagen-related peptide under flow. (reading.ac.uk)
  • This is a peptide inhibitor of collagen fibrillar matrix assembly. (eurogentec.com)
  • With serogroup A, capsular hyaluronic acid (HA) promotes adhesion to elicited turkey air sac macrophages (TASM). (usda.gov)
  • Collectively, these data indicate that P. multocida adhesion to TPBM is promoted by capsular hyaluronic acid and can be upregulated by maturation on ECL matrix or following hyaluronidase treatment. (usda.gov)
  • Collagen Nutraceuticals, an established nutraceuticals player, is launching a cosmetic grade hyaluronic acid (HA) aimed at a variety of skin and hair care formulations, primarily as a means of retaining moisture. (cosmeticsdesign-europe.com)
  • Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. (wikipedia.org)
  • Accordingly, it was demonstrated that protein expression of collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGFβ mediated stimulation of mRNA. (wikipedia.org)
  • As compared with a protein-free membrane, gelatin and collagen significantly enhanced the adherence of C albicans. (elsevierpure.com)
  • The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. (nih.gov)
  • In contrast, the strong inhibition of platelet adhesion by GPVI-Fc in combination with GPIIb/IIIa inhibitors could be harmful. (thieme-connect.com)
  • Crystal structure shows that residues implicated in cell binding, inhibition of cell spreading and disassembly of focal adhesions cluster on one face of SPARC, while a collagen binding epitope and an N-glycosylation site are opposite this face (6). (rndsystems.com)
  • Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
  • It impairs platelet adhesion via a defect in the glycoprotein Ib/IX complex that binds endothelial VWF. (msdmanuals.com)
  • Collagen content was measured by Sircol method, and fibrosis marker levels were detected by PCR and Western Blot. (researchsquare.com)
  • We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. (actapress.com)
  • abstract = "Citrullinated collagen II (CII) is a well-known autoantigen in rheumatoid arthritis (RA). (abo.fi)
  • Objective: Investigate how ADGRG1 expression and activation by its ligand, collagen III, impacts β-cell function in normal and type 2 diabetic (T2D) islets. (lu.se)
  • The rationale for using NaOCl is that it facilitates the infiltration of adhesive resins into an etched dentin substrate, creating the bond without collagen fibrils and hybrid layer 11-13 . (bvsalud.org)
  • In this study, we examined the effects of FAK point mutations at tyrosine residues (Y397, Y925, Y861, and Y576/7) on osteogenic differentiation of human mesenchymal stem cells exposed to collagen I and cyclic tensile strain. (techscience.com)
  • To study whether citrullination of CII could affect cellular functions, we measured the adhesion of 3 different cell types (human Saos2 osteosarcoma cells, human synovial fibroblasts, and rat mesenchymal stem cells) with impedance-based technology. (abo.fi)
  • The collagen-induced activation of DDR1, which also is Src-dependent, appears to be mediated by the PCP pathway. (lu.se)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. (wikipedia.org)
  • COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S domain at its center, and a non-collagenous 1 (NC1) domain at its C-terminal. (wikipedia.org)
  • In humans, a novel mutation of the COL4A1 gene coding for collagen type IV was found to be associated with autosomal dominant congenital cataract in a Chinese family. (wikipedia.org)
  • This report of a new mutation in the COL4A1 gene is the first report of a non-syndromic autosomal dominant congenital cataract that highlights an important role for collagen type IV in the physiological and optical properties of the lens. (wikipedia.org)
  • This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). (nih.gov)
  • Coating of glass slides with Entactin-Collagen IV-Laminin attachment (ECL) matrix further enhanced the adhesion of P. multocida. (usda.gov)
  • Taken together, these studies suggest that Gα12 activation promotes glomerular injury without podocyte depletion through a novel mechanism regulating collagen (α)IV expression, and supports the notion that glomerular damage may accrue through persistent GPCR activation in podocytes. (medscape.com)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
  • Adhesions can cause infertility or pain as they constrict the reproductive organs in adhesive "straitjackets," decreasing the chance for implantation or causing a miscarriage. (clearpassage.com)
  • At a microscopic level, tiny but powerful cross-links form to create adhesions that can cause infertility as they constrict the reproductive organs in adhesive "straitjackets," decreasing the chance for implantation or causing a miscarriage. (clearpassage.com)
  • Although nanotopography has been shown to be a potent modulator of cell behavior, it is unclear how the nanotopographical cue, through focal adhesions, affects the nucleus, eventually influencing cell phenotype and function. (cdc.gov)
  • It was found that pulsed current significantly increased osteodifferentiation on silicone-collagen films without CNTs. (hindawi.com)
  • Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis. (nih.gov)
  • Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens. (nih.gov)
  • These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)
  • Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (nih.gov)
  • A substantial reduction in the amount and quality of collagen leads to age-related deterioration of the elasticity and firmness of the skin. (dovepress.com)
  • The diagnosis of unexplained infertility is often due to adhesions - small yet powerful internal scars that do not appear in medical diagnostic tests. (clearpassage.com)
  • The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
  • When we dissolve or detach the underlying chemical bonds, adhesions appear to pull apart, like clearing the run in a sweater. (clearpassage.com)