• Results An analysis of granulocyte and monocyte chemotactic activity and phagocytic activity revealed significantly higher levels of phagocytic activity in calves administered HMB than in the control group, expressed in terms of the percentage of phagocytising cells and mean fluorescence intensity (MFI). (researchsquare.com)
  • CXCL16/CXCR6 pathway-related protein expression, P2X7R protein expression and the expression of monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-α (TNF-α), and CD68 were detected by immunohistochemical and immunofluorescence staining. (medsci.org)
  • In addition, we found monocyte chemoattractant protein-1(MCP-1) levels significantly increased, whereas intercellular adhesion molecule-1(ICAM-1) significantly decreased, and microglial marker (Iba1) did not change in the treatment group compared to the control. (biomedcentral.com)
  • The response was measured by assessing Cluster of differentiation 54 (CD54), Cluster of differentiation 62E (CD62E), Monocyte chemotactic protein-1 (MCP-1) expression and von Willebrand factor (vWF) release, at 6 and 24 h after stimulation. (iiarjournals.org)
  • CD54 known also as intercellular adhesion molecule-1 (ICAM-1) is an adhesion molecule crucial in inflammatory process by controlling monocyte endothelium interactions. (iiarjournals.org)
  • Monocyte chemotactic protein-1 (MCP-1) is the most important chemotactant protein contributing to the accumulation of mononuclear leucocytes after vessel injury ( 22 ). (iiarjournals.org)
  • out there in PMC 2015 January 01.FeigPageIn addition, mRNA concentrations of quite a few well-known proteins implicated in atherothrombosis, including vascular cell adhesion protein-1 (VCAM-1), monocyte chemotactic protein 1 (MCP-1) and tissue factor, are decreased in foam cells throughout regression. (squalene-epoxidase.com)
  • Additionally, HT reduced cytokine (interleukin 1 beta (IL- 1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α)) levels in serum, pancreas and colon tissue and chemokine release (monocyte chemotactic protein-1 (MCP1/CCL2)) in pancreas and colon tissue. (unime.it)
  • Fasting blood samples collected at 0, 4, and 8 wk were analyzed for concentrations of monocyte chemotactic protein-1 (MCP-1), IL-6, and soluble intercellular adhesion molecule-1 (sICAM-1) and for cardiovascular risk factors. (elsevierpure.com)
  • Many processes associated with the oxidation of LDL, increase expression of prothrombotic factors, adhesion molecules, proinflammatory cytokines and chemotactic factors are involved in the pathophysiology of atherosclerosis. (usp.br)
  • Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
  • This leads to increased antigen presentation and increased expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. (smpdb.ca)
  • Of these, 1,386 had data on serum proinflammatory cytokines and adhesion molecules. (bvsalud.org)
  • Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. (smpdb.ca)
  • Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. (thermofisher.com)
  • Cell adhesion molecules, such as integrins, have been extensively characterized with respect to their contribution to cell migration in vitro and genetic evidence now supports a role for these receptors in certain instances in vivo as well. (johnshopkins.edu)
  • 2 , 3 Bone engineering involves the delivery of cells or biologic molecules such as growth factors to a defect site for tissue regeneration. (allenpress.com)
  • HT was able to reduce the serum hallmarks of pancreatitis (amylase and lipase), histological damage score in both pancreas and colon tissue, inflammatory cells recruitment (mast cells) in both injured tissues, intrapancreatic trypsin activity and overexpression of the adhesion molecules (Intercellular Adhesion Molecule-1 (ICAM-1) and P-selectin) in colon. (unime.it)
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
  • Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
  • The defective chemotactic response to IL-8 does not appear to be due to impaired chemoattractant receptor function, as the number of IL-8 receptors and chemoattractant-induced calcium influx, actin polymerization, and release of gelatinase B were comparable to those of wild- type PMNs. (elsevierpure.com)
  • The physiopathological process of ACS is the atherosclerosis, the build-up of an atherosclerotic plaque starts at lesion-prone areas in large- and medium-sized arteries where the endothelium is dysfunctional, induced by cardiovascular risk factors like chronic smoking, hypertension, and permeation of macromolecules such as lipoproteins to the intima layer [ 6 , 7 ]. (hindawi.com)
  • Infants with this disorder may have an elevated serum immunoglobulin E level with reduced serum immunoglobulin G and immunoglobulin A levels and diminished neutrophil chemotactic activity. (medscape.com)
  • Chemoattractant-induced adhesion of G-CSFR-deficient PMNs was significantly impaired, suggesting a defect in β2-integrin activation. (elsevierpure.com)
  • The study evaluates the ability of osteoprogenitors treated with platelet-derived growth factor BB (PDGF-BB) delivered on vinyl styrene microbeads (VSM) to regenerate rat calvarial critical-size defects (CSDs). (allenpress.com)
  • Platelet-derived growth factor BB (PDGF-BB) is the most potent mitogenic and chemotactic member of PDGFs. (allenpress.com)
  • The membrane-bound form of CXCL16 binds and internalizes oxidative low-density lipoprotein (oxLDL) and promotes adhesion of cells expressing its cognate receptor, CXCR6 [ 6 , 7 ] . (medsci.org)
  • We first investigated the influence of microglia or ATP, a microglial chemotactic factor, on MBEC barrier integrity. (portlandpress.com)
  • TNF, tumour necrosis factor. (docksci.com)
  • The COL4A1-VEGFD fusion leads to production of mature VEGFD after proteolytic processing, which may act as an autocrine growth factor for tumour cells. (cusabio.com)
  • This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
  • His studies deal with areas such as Plasminogen activator, Tissue plasminogen activator and Cell adhesion as well as Molecular biology. (research.com)
  • Therefore, the present study aimed to evaluate the influence of HMB on the chemotactic activity (MIGRATEST® kit), phagocytic activity (PHAGOTEST® kit) and oxidative burst (BURSTTEST® kit) of monocytes and granulocytes in the peripheral blood of calves by flow cytometry. (researchsquare.com)
  • Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. (elsevierpure.com)
  • Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1, Bsp, and Opn and upregulate transcription. (wikipedia.org)
  • Endothelial dysfunction refers to a state where endothelial cells lose the ability to produce bioactive nitric oxide and increase their expression of vasoconstrictor, pro-inflammatory and pro-thrombotic factors. (bu.edu)
  • In parallel, we discovered elevated cyclooxygenase-2 (COX2) expression levels in the treated group, which might be a positive factor for synaptic activity. (biomedcentral.com)
  • His primary area of study in Platelet is in the field of Von Willebrand factor. (research.com)
  • ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. (research.com)
  • His Von Willebrand factor study combines topics in areas such as Thrombotic thrombocytopenic purpura and Platelet membrane glycoprotein. (research.com)
  • His scientific interests lie mostly in Platelet, Von Willebrand factor, Cell biology, Endothelial stem cell and Molecular biology. (research.com)
  • His Von Willebrand factor study integrates concerns from other disciplines, such as Biophysics, Thrombotic thrombocytopenic purpura and Platelet membrane glycoprotein. (research.com)
  • Platelet, Von Willebrand factor, Biophysics, Biochemistry and Molecular biology are his primary areas of study. (research.com)
  • Conclusion HMB stimulates non-specific cell-mediated immunity, which is a very important consideration in newborn calves that are exposed to adverse environmental factors in the first weeks of their life. (researchsquare.com)
  • 2-4 The pathogenesis, factors, and cell types involved in this process are largely unknown. (bmj.com)
  • 5 Richter et al 6 reported elevated mast cell numbers in association with increased transforming growth factor-β immunoreactivity in radiation induced enteropathy in rats, which is characterised by intestinal wall fibrosis, serosal thickening, and chronic ulceration. (bmj.com)
  • However, liver cirrhosis and intestinal stricture formation are not common in mast cell disease, indicating that besides mast cells additional factors or specific stimulation of mast cells may be necessary to induce severe fibrosis. (bmj.com)
  • His Endothelial stem cell study combines topics in areas such as Adhesion, Granulocyte and Shear stress. (research.com)
  • Larry V. McIntire mainly focuses on Biophysics, Platelet, Cell biology, Endothelial stem cell and Adhesion. (research.com)
  • His Cell biology research integrates issues from Complementary DNA, Microarray analysis techniques, Integrin and Cell adhesion. (research.com)
  • The chemotactic guidance factor encoded by the Caenorhabditis elegans unc-6 locus, whose mammalian homolog is Netrin, is perhaps the best known of the cell migration guidance factors. (johnshopkins.edu)
  • Local inflammation induces the differentiation of bronchial fibroblasts into α-smooth muscle actin (α-SMA) positive myofibroblasts and increases their longevity ( 5 ) through paracrine (for example TGFβ-dependent) and cell adhesion-dependent mechanisms ( 3 , 6 , 7 ). (spandidos-publications.com)
  • A growth factor produced by the cell that stimulates the same cell to grow. (unboundmedicine.com)
  • It facilitates relaxation of vascular smooth muscle and inhibition of adhesion and aggregation of platelets. (unboundmedicine.com)
  • ABBR: AHF Coagulation factor VIII, a glycoprotein clotting factor essential for the formation of blood thromboplastin. (unboundmedicine.com)
  • HT decreased lipid peroxidation and oxidative stress (superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST) activity) by enhancing the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) in both injured tissues. (unime.it)
  • To compare the differences of vitreous protein profiles in PDR patients before and after a complete anti-vascular endothelial growth factor (VEGF) loading dose with ranibizumab treatment. (frontiersin.org)
  • Several studies have shown that vascular endothelial growth factor (VEGF) is a crucial causative factor of PDR ( 6 , 7 ). (frontiersin.org)
  • They include agents like vascular endothelial growth factor (VEGF) and blood vessel fibroblastic growth factor (bFGF). (unboundmedicine.com)
  • and high-molecular-weight kininogen, also called Fitzgerald , Flaujeac , or Williams factor , or contact activation cofactor . (unboundmedicine.com)
  • Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98. (thermofisher.com)
  • 1 Autografts contain living cells and osteoinductive factors. (allenpress.com)
  • The pretreatment of osteoblastic cells with PDGF-BB before transplantation into osseous defects is investigated in the present study to further investigate the role of this growth factor in bone regeneration. (allenpress.com)
  • In contrast to NA HBFs, which formed A549‑impenetrable lateral barriers, α‑SMA+ AS HBFs actively infiltrated A549 monolayers and secreted chemotactic factors that arrested A549 cells within AS HBF/A549 contact zone. (spandidos-publications.com)
  • 6 It has been shown that these microbeads are capable of delivering transforming growth factor-β (TGF-β) to rat calvarial critical-size defects. (allenpress.com)
  • Manipulation of some of these factors can improve healing in experimental wounds. (docksci.com)
  • These factors are active in healing wounds, chronic inflammatory conditions, retrolental fibroplasia, and malignant tumors, which require new blood vessels for continued growth. (unboundmedicine.com)
  • Laser light is believed to influence the inflammatory process, a major factor during early events in the restenosis cascade ( 10 - 12 ). (iiarjournals.org)
  • BHR, but factors such as airway remodeling also influence the potential of a chemical to induce respiratory allergy. (cdc.gov)
  • genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
  • C0s, En, An, Pn patients may present with a transient reflux in the GSV that occurs at the end of day. (phlebolymphology.org)