In order to support the comprehensive classification of Leukocyte Adhesion Deficiency-I (LAD-I) severity by simultaneous screening of CD11a/CD18, this study assessed clinical, laboratory, and genetic findings along with outcomes of 69 LAD-I patients during the last 15 years. (nih.gov)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
In association with CD18, the CD11a/CD18 complex forms LFA-1. (biolegend.com)
CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). (biolegend.com)
CD4, LFA-1 (CD11a/CD18), and CD28 were critical in the adhesion response. (ox.ac.uk)
The interaction of CD54 and the corresponding ligand CD11a/CD18 expressed on γδ T cells is responsible for triggering effector function in γδ T cells. (aacrjournals.org)
CD18 non-covalently associates with CD11a, CD11b or CD11c. (angioproteomie.com)
Human CD50 is an adhesion molecule that interacts with LFA-1 (CD18/CD11a) and provides a costimulatory signal for T cells which is thought to be essential for initiation of immune responses. (biosave.com)
It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). (betalifesci.com)
In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer CD11a/CD18 (Leu-CAMa, LFA-1) and its ligand CD54 (ICAM-1). (csb-bioenergetics.nl)
It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. (nih.gov)
Background: CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). (icbinhibitor.com)
The dissociation rates were calculated under low force conditions for ICAM-1 interactions with both β 2 -integrins, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), together and separately by using functional blocking antibodies on PMNs. (psu.edu)
Li R, Nortamo P, Valmu L , Tolvanen M, Huuskonen J, Kantor C and Gahmberg C G (1993) A peptide from ICAM-2 binds to the Leu-kocyte Integrin CD11a/CD18 and inhibits endot-helial cell adhesion. (leenavalmu.fi)
Vermot-Desroches C, Wijdenes J, Valmu L , Roy C, Pigott R, Nortamo P and Gahmberg C G (1995) A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. (leenavalmu.fi)
CD11b10
Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2). (wikipedia.org)
Macrophage-1 antigen (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. (wikipedia.org)
CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. (biolegend.com)
In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins. (ox.ac.uk)
The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between ≥ ≥ ≥ cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). (cytekbio.com)
integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). (cytekbio.com)
The increased adherence of activated heterophils can be partially blocked by either anti-alpha M (CD11b) or anti-beta 2 (CD18) antibodies in a dose dependent manner. (tamu.edu)
However, antibodies to the Mac-1 complex (CD11b/CD18) block only the adherence of SE-ILK-stimulated heterophils. (tamu.edu)
Thus, the CD11b/CD18 heterodimer is apparently up regulated in response to the injected SE-ILK and plays a major role in the adherence of activated heterophils. (tamu.edu)
Integrins12
CR3 belongs to a family of cell surface receptors known as integrins (because they share this particular β chain, they are referred to as β2-integrins), which are extremely widely distributed throughout nature and which generally are important in cellular adhesion, migration, phagocytosis and other cell-cell interactions in a variety of cells and circumstances. (wikipedia.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. (ox.ac.uk)
Integrins are the major adhesion receptors of leukocytes and platelets. (ox.ac.uk)
Subjects with leukocyte adhesion deficiency-1 (LAD-I) do not express beta2 integrins because of mutations in the gene specifying the beta2 subunit, and they suffer recurrent bacterial infections. (ox.ac.uk)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus alpha 4 beta 1 and alpha-V containing integrins. (rndsystems.com)
Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
The interactions between melanoma cells and PMNs are mediated by the β 2 -integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. (psu.edu)
It was concluded that the small number of constitutively expressed active β 2 -integrins on PMNs are sufficient to bind to ICAM-1 expressed on melanoma cells and that the intrinsic dissociation rate for these adhesion molecules appear to be more dependent on what method is used to determine them than on what cells express them. (psu.edu)
Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. (leenavalmu.fi)
Valmu L , Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. (leenavalmu.fi)
Antibody4
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
This increase in neutrophil adhesion caused by CD66 antibodies was blocked by a CD18 antibody and associated with up-regalation of CD11/CD18 on the neutrophil surface. (umn.edu)
This increase in neutrophil adhesion required physiological extracellular calcium concentrations at or near the time of CD66 antibody binding to the neutrophil. (umn.edu)
The data suggest that CD66, CD66b, CD66c, and CD66d antibody binding to the neutrophil surface triggers a transient activation signal that requires extracellular calcium and regulates the adhesive activity of CD11/CD18. (umn.edu)
CD113
Physicians' awareness of LAD-I considering delayed separation of umbilical cord marked neutrophilic leukocytosis, and variability in CD11 and CD18 expression levels, and genetic analysis leads to early diagnosis and defining disease severity. (nih.gov)
We examined the mechanism of adherence within the avian heterophil system using an in vitro bovine serum albumin (BSA) matrix in which neutrophil adherence is primarily CD11/CD18 integrin mediated in mammalian systems. (tamu.edu)
Valmu L , Autero M, Siljander P, Patarroyo M and Gahmberg C G (1991) Phosphorylation of the ß-subunit of CD11/CD18 in-tegrins by protein kinase C correlates with leukocyte adhesion. (leenavalmu.fi)
Receptor4
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. (sigmaaldrich.com)
Differences in cell adhesion molecules and leukocyte adhesion were ablated when disrupting sympathetic nerves, demonstrating their critical role in this process and the importance of ß2-adrenergic receptor signaling. (bvsalud.org)
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion. (uni-luebeck.de)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
Molecules2
Our data suggest a link between antigen-induced T cell adhesion and late responses and also suggest that signals mediated by TCR and CD4 coengagement may induce a greater activation and/or recruitment of molecules involved in T cell adhesion. (ox.ac.uk)
Differential expression of adhesion molecules by chicken heterophils activated in vivo with Salmonella enteritidis-immune lymphokines. (tamu.edu)
Subunit3
The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. (bvsalud.org)
The beta subunit is the CD18 ANTIGEN. (bvsalud.org)
CD18 is a 90-95 kD type I transmembrane protein also known as integrin ß2 subunit, LFA-1 ß subunit, and ß2 integrin. (angioproteomie.com)
Molecule8
The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
Sasaki M, Elrod JW, Jordan P, Itoh M, Joh T, Minagar A, Alexander JS: CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion. (exbio.cz)
Intercellular adhesion molecule 2 (ICAM-2, CD12), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. (betalifesci.com)
As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. (betalifesci.com)
ICAM-4 (Intercellular Adhesion Molecule 4), also known as Landsteiner-Wiener Glycoprotein and CD242, is a 42 kDa member of the ICAM family, Ig superfamily of proteins. (rndsystems.com)
Receptors4
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
These approaches were complemented with genetic, surgical, and pharmacological ablation of sympathetic nerves or adrenergic receptors to assess their relevance for rhythmic leukocyte adhesion. (bvsalud.org)
Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. (betalifesci.com)
They have been implicated in integrin-mediated cellular adhesion and as signalling receptors on T-cells. (ouhsc.edu)
Humans1
First, humans are generally tolerant to their own antigens. (coek.info)
CD541
The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. (exbio.cz)
Antibodies2
To examine their potential role in neutrophil signaling, the effects on neutrophil adhesion to human umbilical vein endothelial cells of a panel of well characterized CD66 mAbs was tested, CD66a, CD66b, CD66c, and CD66d antibodies each increased neutrophil adhesion to human umbilical vein endothelial cell monolayers. (umn.edu)
The incubation of CD66 antibodies with neutrophils in the absence of calcium for 10 min before repletion of calcium resulted in no increase in neutrophil adhesion. (umn.edu)
Differentiation1
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. (ouhsc.edu)
Integrin-mediated1
Notably, transfection of the subjects' lymphocytes with KINDLIN3 complementary DNA but not CALDAGGEF1 cDNA reverses the LAD-III defect, restoring integrin-mediated adhesion and migration. (ox.ac.uk)
ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. (sigmaaldrich.com)
Valmu L , Hilden T J, van Willigen G and Gahmberg C G (1999) Characterization of b2 (CD18) integrin phosphorylation in phorbol ester activated T lymphocytes. (leenavalmu.fi)
CD11c1
La subunidad alfa es el ANTÍGENO CD11c, un antígeno de superficie que se expresa en algunas células mieloides. (bvsalud.org)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.When cells are added to ICAM2-coated plates (12.5 ug/mL, 100 uL/well), approximately 50 % - 60 % will adhere specifically. (betalifesci.com)
Vascular1
Although enhanced numbers of leukocytes have been linked to an increased risk of cardiovascular complications, the role that rhythmic leukocyte adhesion plays in different vascular beds has not been studied. (bvsalud.org)
Cells3
For instance, while both CR3 and CR4 are involved in adhesion, migration and proliferation of B cells, they are involved in enhancing complement-dependent cytotoxicity in NK cells. (wikipedia.org)
CD18 and associated a chains function in adhesion and signaling in hematopoietic cells. (angioproteomie.com)
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
CD473
Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Phagocytosis1
Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency. (ox.ac.uk)
Migration1
Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion. (uchicago.edu)
Neutrophils1
In neutrophils these proteins are activation antigens in that their surface expression is increased following stimulation. (umn.edu)
Proteins1
The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
Cell6
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Induction of T cell adhesion by antigen stimulation and modulation by the coreceptor CD4. (ox.ac.uk)
T cell adhesion induced after physiological stimulation by antigen was investigated using murine T cell hybridomas specific for a tetanus toxin peptide. (ox.ac.uk)
This assay allowed us to study the relationship between T cell adhesion and later activation responses using tetanus toxin peptide and alanine monosubstituted analogs. (ox.ac.uk)
We show that the degree of peptide-induced T cell adhesion correlated with the magnitude of late functional responses. (ox.ac.uk)
The enhancing role of CD4 was further demonstrated by reduced levels of T cell adhesion and late responses of CD4- T cell hybridomas. (ox.ac.uk)
The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. (shengsci.com)
Immune2
because it combines 'immune and 'adhesion' functions. (coek.info)
The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
Severe3
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. (icbinhibitor.com)