Adhesin of escherichia coli. Medical search. Frequent questions

Enterohaemorrhagic Escherichia coli O157 : H7 is a bacterial pathogen that can cause haemorrhagic colitis and haemolytic uremic syndrome. (hw.ac.uk)
Therefore, many commercial producers of beef products screen for E. coli O157:H7 before shipment. (nih.gov)
Both E. coli O157:H7 and non-O157:H7 serotypes can cause human disease and among non-O157 infections, up to 70% of human infections are attributed to six non-O157 STEC serogroups (O26, O45, O103, O111, O121, and O145) ( Bosilevac and Koohmaraie, 2012 ). (frontiersin.org)
In this study, the molecular basis of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium flagella binding to epithelial cell cultures was investigated. (ed.ac.uk)
Motor mutants of E. coli O157:H7 and S. Typhimurium caused reduced haemolysis compared to wild-type, indicating that membrane disruption was in part due to flagella rotation. (ed.ac.uk)
Flagella from E. coli O157 (H7), EPEC O127 (H6) and S. Typhimurium (P1 and P2 flagella) were shown to bind to purified intracellular components of the actin cytoskeleton and directly increase in vitro actin polymerization rates. (ed.ac.uk)
We propose that flagella interactions with host cell membranes and cytoskeletal components may help prime intimate attachment and invasion for E. coli O157:H7 and S. Typhimurium, respectively. (ed.ac.uk)
Due to the appearance of the highly virulent strain of E. coli of serotype O157:H7 in the US and Canada in the 1980's, and subsequently in other Latin American countries, there is an increase need for accurate testing for this and other pathogenic E. coli strains, substantially enhancing detection of virulent strains and, therefore, facilitating identification of sporadic E. coli infections and outbreaks. (eurekaselect.com)
However, a significant risk exists that infections caused by highly virulent E. coli isolates, such as the enterohemorrhagic E. coli O157:H7, develop into serious and potentially lifethreatening complications, such as hemolytic uremic syndrome. (eurekaselect.com)

The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
Whole genome sequencing was performed on colony isolates from one of these donor/recipient pairs and demonstrated that clbB+ E. coli strains present in the recipient after FMT were identical to a strain present in the donor, confirming strain transmission. (jci.org)
We isolated and whole-genome sequenced up to five colonies of faecal E. coli from 66 asymptomatic children aged three-to-five years in rural Gambia (n = 88 isolates from 21 positive stools). (peerj.com)
Several isolates encode putative virulence factors commonly found in Enteropathogenic and Enteroaggregative E. coli, and 53% of the isolates encode resistance to three or more classes of antimicrobials. (peerj.com)
These factors were evaluated in various phylogenetic groups (phylotypes) of E. coli isolates. (biomedcentral.com)
The ability of extended spectrum β-lactamases (ESBLs) production in E. coli isolates was detected using the combined disc diffusion method. (biomedcentral.com)
This study's results confirmed an explosion of antibiotic resistance amongst E. coli isolates from UTI against β-lactams and fluoroquinolones. (biomedcentral.com)
However, despite this staggering statistic, very few studies have investigated the relationship between biofilm production and host factors such age group and hospitalization status, and non-host factors, including recurrence of UTI, phylogenetic group distribution, and antibiotic susceptibility, among urinary E. coli isolates from reproductive age women. (clinmedjournals.org)

The presence of fecal organisms in beef products suggests a failure of sanitary controls during processing and the more prevalent relatives of E. coli O157, Shiga toxin-producing Escherichia coli, enteropathogenic E. coli, and enterohemorrhagic E. coli, serve as more sensitive indicators of contamination than O157 strains alone. (nih.gov)
In addition, factors underlying the emergence of enteroaggregative and atypical enteropathogenic E. coli strains associated with persistent diarrhea are unknown. (eurekaselect.com)
Protection of rabbits against enteropathogenic Escherichia coli (EPEC) using an intimin null mutant. (sciensano.be)

The first step in the colonization of the human urinary tract by pathogenic Escherichia coli is the mannose-sensitive binding of FimH, the adhesin present at the tip of type 1 pili, to the bladder epithelium. (rcsb.org)
Our structure/function analysis demonstrated that the binding of the monosaccharide alpha-D-mannose is the primary bladder cell receptor for uropathogenic E. coli and that this event requires a highly conserved FimH binding pocket. (rcsb.org)
The residues in the FimH mannose-binding pocket were sequenced and found to be invariant in over 200 uropathogenic strains of E. coli. (rcsb.org)
Only enterohaemorrhagic E. coli (EHEC) possess a sequence variation within the mannose-binding pocket of FimH, suggesting a naturally occurring mechanism of attenuation in EHEC bacteria that would prevent them from being targeted to the urinary tract. (rcsb.org)
The best characterized bacterial adhesin is the type 1 fimbrial FimH adhesin. (wikipedia.org)
The effectiveness of anti-adhesin antibodies is illustrated by studies with FimH, the adhesin of uropathogenic Escherichia coli (UPEC). (wikipedia.org)
n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, a virulence factor of E. coli. (univ-lille.fr)
These studies are devoted to the structure/functional analysis of allelic variations of the E. coli type 1 fimbrial adhesin, FimH protein. (washington.edu)

Pathogenic Escherichia coli strains on raw or insufficiently cooked foods are of public health concern as serious disease may result from their ingestion. (nih.gov)
Alfredo G. Torres , " Pathogenic Escherichia coli in Latin America ", Bentham Science Publishers (2010). (eurekaselect.com)
The emergence and evolution of pathogenic Escherichia coli strains associated with diarrheal diseases have become a topic of active investigation in recent years due to the emergence of more virulent strains and the association of new serotypes with disease. (eurekaselect.com)

The high-affinity interaction of LF with pore-forming outer-membrane proteins (OMPs) of Gram-negative enterics, including Escherichia coli , is critical for the antimicrobial outcome of LF (Gado et al. (ift.org)
Dimeric and Trimeric Fusion Proteins Generated with Fimbrial Adhesins of Uropathogenic Escherichia coli . (bvsalud.org)
Another group of adhesins that contributes to UPEC-mediated UTI is autotransporter (AT) proteins. (pasteur.fr)

We report a previously undescribed phenomenon of epithelial cell "rolling-shedding" colonization, in which the detached epithelial cells reattach to the underlying cell line through a layer of adherent Dr+ E. coli. (mostwiedzy.pl)
Thus, APN mediates the attachment of F4(+) E. coli to intestinal epithelial cells. (k-state.edu)
On a valency-corrected basis, HM-based glycopolymers are, respectively, 10(2) and 10(6) times more potent than HM and d-mannose for their capacity to disrupt the binding of adherent-invasive E. coli to T84 intestinal epithelial cells. (univ-lille.fr)

Most fimbria of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wikipedia.org)
Intracellular events, such as blocking of microbial attachment factors such as fimbriae (hairlike structures) and other adhesins (putative receptors), have been observed (Naidu and Bidlack, 1998). (ift.org)
P-fimbriae plays major role in bacterial adherence to the uroepithelium through the Galα1-4Gal-binding PapG adhesin. (microbiologyresearch.org)
Analysis of the variability of S fimbriae expression in an Escherichia coli pathogen. (uni-wuerzburg.de)
Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. (wakehealth.edu)
While very elegant work has been done to describe the genes which are responsible for encoding the AAF/1 fimbriae in some EAggEc strains, it is not possible at present to implicate AAF/1 as the fimbrial adhesin which is present in all or even the majority of EAggEc strains. (usda.gov)
They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). (childrensmercy.org)
Goluszko P, Moseley SL, Truong LD, Kaul A, Williford JR, Selvarangan R, Nowicki S, Nowicki B. Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. (childrensmercy.org)
The first project is directed towards understanding the mechanism of bacterial adhesion to host cells mediated by the most common kind of bacterial adhesins known - type 1, or mannose-sensitive, fimbriae. (washington.edu)
Some of these variations result in adaptive changes of the receptor-specificity of type 1 fimbriae that lead to an increased tissue tropism and, consecutively, virulence of uropathogenic and meningitis-associated E. coli. (washington.edu)

Here, we report an efficient gene editing strategy based on direct delivery of Cas9 and gRNA into Uropathogenic E. coli (UPEC) isolate. (microbiologyresearch.org)
Uropathogenic Escherichia coli (UPEC) is responsible for the majority of urinary tract infections (UTI). (pasteur.fr)
One recently characterized AT protein of UPEC is UpaH, a large adhesin-involved-in-diffuse-adherence (AIDA-I)-type AT protein that contributes to biofilm formation and bladder colonization. (pasteur.fr)
Urinary tract infections (UTIs), mostly caused by uropathogenic E. coli (UPEC), are important human infections. (clinmedjournals.org)
Uropathogenic E. coli (UPEC) are endowed with several virulence associated factors (VFs) that enable the organism to attach, invade, and injure the host. (clinmedjournals.org)

Southern blot analysis of the S fimbrial adhesin (sfa) determinants of normal and hyper-fimbriated strains revealed no marked difference in the gene structure. (uni-wuerzburg.de)

During 2005-2008, about 971,389 samples from several commercial beef production plants were tested using a rapid screening method based on the polymerase chain reaction to determine if they were presumptively positive for bacterial cells carrying Salmonella or Shiga toxin-producing E. coli-specific genes. (nih.gov)
Shiga toxin (Stx) is the main virulence factor of Shiga toxin-producing Escherichia coli (STEC), and ruminants are the main reservoir of STEC. (frontiersin.org)
They include shiga toxin which is produced by Shigella dysenteriae and a variety of shiga-like toxins that are produced by pathologic strains of Escherichia coli such as Escherichia coli o157. (lecturio.com)
Shiga toxin-producing Escherichia coli strains LAA-positive are important cause of human infection. (biomedcentral.com)
Shiga toxin-producing Escherichia coli (STEC) are important pathogens responsible for foodborne diseases. (biomedcentral.com)

This basic structure is conserved across type 1 fimbrial adhesins though recent studies have shown that in vitro induced mutations can lead to the addition of C-terminal domain specificity resulting in a bacterial adhesion with dual bending sites and related binding phenotypes. (wikipedia.org)

In this study, we established a dynamic micromodel of urinary tract infection to analyze the impact of UT-segment-specific urinary outflow on the persistence of E. coli colonization. (mostwiedzy.pl)
Expression of these adhesins at different phases during infection play the most important role in adhesion based virulence. (wikipedia.org)
This has led to the exploration of adhesin activity interruption as a method of bacterial infection treatment. (wikipedia.org)
Additionally, Adhesins are attractive vaccine candidates because they are often essential to infection and are surface-located, making them readily accessible to antibodies. (wikipedia.org)
Diarrheagenic Escherichia coli ( E. coli ) species are a diverse group of pathogens classified into 5 major pathotypes that can cause intestinal infection and diarrhea. (lecturio.com)
Outbreak studies indicate that most patients with an intestinal E. coli infection develop mild, uncomplicated diarrhea. (eurekaselect.com)
Little is known about the genomic diversity of Escherichia coli in healthy children from sub-Saharan Africa, even though this is pertinent to understanding bacterial evolution and ecology and their role in infection. (peerj.com)

UTI, although treatable, is now becoming increasingly tough to control because of rampant antimicrobial resistance in the Enterobacteriaceae family, particularly inEscherichia coli. (microbiologyresearch.org)
Antimicrobial resistant strains of Escherichia coli ( E. coli ) are a common cause of UTI which were identified as a treatment challenge. (biomedcentral.com)

Biochemical characteristic of biofilm of uropathogenic Escherichia coli Dr+ strains. (mostwiedzy.pl)
The uropathogenic Escherichia coli wiJd. (uni-wuerzburg.de)
Hyper-Sfimbriated variants could be The uropathogenic Escherichia coli wiJd. (uni-wuerzburg.de)

We found that the adherence of Dr+ E. coli to bladder T24 transitional cells and type IV collagen is maximal at lowest shear stress and is reduced by any increase in flow velocity. (mostwiedzy.pl)
Adhesins are cell-surface components or appendages of bacteria that facilitate adhesion or adherence to other cells or to surfaces, usually in the host they are infecting or living in. (wikipedia.org)
To effectively achieve adherence to host surfaces, many bacteria produce multiple adherence factors called adhesins. (wikipedia.org)

Afa, afimbrial adhesin. (cdc.gov)

F4(+) enterotoxigenic Escherichia coli (ETEC) strains cause diarrheal disease in neonatal and post-weaned piglets. (k-state.edu)
2012. Identification of Coli Surface Antigen 23, a Novel Adhesin of Enterotoxigenic Escherichia coli . (umd.edu)
Such studies are needed to understand the increasingly recognized diversity of enterotoxigenic E. coli, a leading cause of pediatric and travelers' diarrhea. (eurekaselect.com)
We sought to determine whether putative procarcinogenic bacteria (enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, and Escherichia coli harboring the colibactin toxin) could be durably transmitted from donors to patients during FMT.METHODS Stool samples were collected from 11 pediatric rCDI patients and their respective FMT donors prior to FMT as well as from the patients at 2-10 weeks, 10-20 weeks, and 6 months after FMT. (jci.org)

Investigating the role of epithelial surface architecture, we showed that the presence of budding cells-a model microarchitectural obstacle-promotes colonization of the urinary tract by E. coli. (mostwiedzy.pl)
In the primary reservoir host, cattle, the terminal rectum is the principal site of E. coli O157 colonization. (hw.ac.uk)
Our data demonstrate that the H7 flagellum acts as an adhesin to bovine intestinal epithelium and its involvement in this crucial initiating step for colonization indicates that H7 flagella could be an important target in intervention strategies. (hw.ac.uk)

Many bacterial pathogens are able to express an array of different adhesins. (wikipedia.org)
The second project is focused on identification of the 'selection footprints' of nucleotide polymorphisms that affect various types of genes encoding different adhesins of E. coli, Shigella and Salmonella strains. (washington.edu)

Thus, resident E. coli in these children may constitute reservoirs of virulence- and resistance-associated genes. (peerj.com)
Genes encoded in LAA contribute to the adhesion phenotype though the expression of STEC adhesins is a coordinated event that depends not only the strain but also on the environment as well as its genetic background. (biomedcentral.com)

Pathogenic properties of Escherichia coli strains isolated from diarrheic commercial rabbits. (sciensano.be)

As a pathogen, E. coli are the most frequent causes of bacterial infections, including urinary tract infections, diarrheal disease, and other clinical infections such as neonatal meningitis, pneumonia and bacteremia. (eurekaselect.com)

Numerous studies have shown that inhibiting a single adhesin in this coordinated effort can often be enough to make a pathogenic bacterium non-virulent. (wikipedia.org)
Escherichia coli Escherichia coli The gram-negative bacterium Escherichia coli is a key component of the human gut microbiota. (lecturio.com)
Under an extremely high magnification of 44, 818X, twice that of PHIL 10574 and 10575, this scanning electron microscopic (SEM) image revealed some of the morphologic details displayed by a single Gram-negative, rod-shaped, Escherichia coli bacterium. (lecturio.com)

In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. (wikipedia.org)
The bacterial adhesion consists primarily of an intramembranous structural protein which provides a scaffold upon which several extracellular adhesins may be attached. (wikipedia.org)
What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin. (wakehealth.edu)

This adhesin is responsible for D-mannose sensitive adhesion. (wikipedia.org)

Of the E. coli O157-positive samples, 14% were also Salmonella positive. (nih.gov)

Antibiotics are reserved for severe or persistent infections and are contraindicated with enterohemorrhagic E. coli because of the risk of hemolytic uremic syndrome. (lecturio.com)

The Enteroaggregative Escherichia coli (EAggEc) are a complex group of bacterial organisms which have a distinctive phenotype and a strong association with persistent diarrheal disease in children in the developing world and in patients infected with the Human Immunodeficiency Virus (HIV). (usda.gov)
Not all patients colonized with Enteroaggregative Escherichia coli are symptomatic. (usda.gov)

Bacterial adhesins provide species and tissue tropism. (wikipedia.org)
Also, this study adds significantly to the number of commensal E. coli genomes, a group that has been traditionally underrepresented in the sequencing of this species. (peerj.com)
Although clinical microbiology typically relies on single-colony picks (which has the potential to underestimate species diversity and transmission events), within-host diversity of E. coli in the gut is crucial to our understanding of inter-strain competition and co-operation and also for accurate diagnosis and epidemiological analyses. (peerj.com)

Adhesion and bacterial adhesins are also a potential target for prophylaxis or treatment of bacterial infections. (wikipedia.org)

A large number of bacterial adhesins with individual receptor specificities have been identified. (wikipedia.org)
adhesin, called intimin, and a translocated receptor (Tir) of prokaryote origin. (sciensano.be)
Nowicki B, Selvarangan R, Nowicki S. Family of Escherichia coli Dr adhesins: decay-accelerating factor receptor recognition and invasiveness. (childrensmercy.org)

Diarrheagenic strains of E. coli can be classified into 5 key "pathotypes," each of which has unique virulence factors Virulence factors Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. (lecturio.com)
Bacterial virulence factors in stool DNA extracts and stool cultures were measured by quantitative PCR: Bacteroides fragilis toxin (bft), Fusobacterium adhesin A (fadA), and Escherichia coli colibactin (clbB).RESULTS Four of 11 patients demonstrated sustained acquisition of a procarcinogenic bacteria. (jci.org)

At least six different categories of pathogenic E. coli causing enteric infections have been identified and further characterized. (eurekaselect.com)
In Latin America, as well as many other developing countries, diarrheal infections caused by E. coli remain an important cause de infant morbidity - mortality. (eurekaselect.com)

This function is mediated primarily by fimbrial adhesins, which mediate specific attachment to host cell receptors. (pasteur.fr)

Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia coli. (expasy.org)

The relative contribution of recombination events in the generation of new categories of pathogenic E. coli varies among the E. coli population, and it is represented by the wide variety of mobile elements found in different diarrheal strains (e.g. pathogenicity islands, phages, transposons, pathoadaptive mutations, etc). (eurekaselect.com)

Escherichia coli are Gram-negative bacteria found as normal commensal flora in the gastrointestinal tract. (eurekaselect.com)
Oral therapy with an empirically chosen antibiotic that is effective against gram-negative aerobic coliform bacteria (eg, Escherichia coli ) is the principal treatment intervention in patients with cystitis. (medscape.com)

Most strains of E. coli are avirulent, but occasionally they escape the GI tract, infecting the urinary tract and other sites. (lecturio.com)

In most UTI cases, E. coli is the causative pathogen, with over 80-90% of uncomplicated UTIs caused by this organism [ 3 ]. (clinmedjournals.org)

Work with E. coli stems from observations of human acquired immunity. (wikipedia.org)

Understanding the population structure of pathogenic E. coli is important, since it impacts the effectiveness of molecular epidemiological studies. (eurekaselect.com)
However, the molecular mechanisms underlying how cells use this adhesin (a hypothetical fusogen) to recognize kin and transition towards a multicellular lifestyle remain largely unexplored. (nature.com)

Yet, most of what we know about E. coli stems from the investigation of laboratory strains, which fail to capture the ecology and evolution of this key organism "in the wild" ( Hobman, Penn & Pallen, 2007 ). (peerj.com)

Naoise McGarry, Stephen Smith, Escherichia coli serum resistance : roles for cell number and Haemolysin. (tcd.ie)

The study of adhesins as a point of exploitation for vaccines comes from early studies which indicated that an important component of protective immunity against certain bacteria came from an ability to prevent adhesin binding. (wikipedia.org)

Once Dr+ E. coli bound to host cells or collagen, they did not detach even in the presence of elevated shear stress or of chloramphenicol, a competitive inhibitor of binding. (mostwiedzy.pl)
It was demonstrated by itrtmunofluorescence microscopy that in noimal (wild-type) and hyperS- fimbriated E. coli populaiions non-fimbriated cells also · exist, and that the percentage of Sfinibrlated and non-fimbriated bacteria was roughly identica1 in either population. (uni-wuerzburg.de)

Anatomy8

Organisms26

Diseases7

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes84

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Health Care4

O157:H79

Isolates8

Enteropathogenic3

FimH8

Pathogenic Escherichia3

Proteins3

Epithelial Cells3

Fimbriae10

UPEC5

Fimbrial adhesin1

Shiga5

Type 1 fimbrial1

Infection7

Antimicrobial2

Uropathogenic Escherichia3

Adherence3

Afimbrial adhesin1

Enterotoxigenic4

Colonization3

Different adhesins2

Genes2

Strains isolated1

Including urinary tract infe1

Bacterium3

Protein3

Mannose-sensitive1

Salmonella1

Enterohemorrhagic1

Enteroaggregative2

Species3

Adhesion1

Receptor3

Virulence factors2

Infections2

Attachment1

Determinants1

Diarrheal1

Gram-negative2

Urinary tract1

Causative1

Acquired immunity1

Molecular2

Organism1

Resistance1

Vaccines1

Cells2