Adhesin genes. Medical search. Frequent questions

Recently, core photosystem II (PSII) genes were identified in cyanophages and proposed to function in photosynthesis and in increasing viral fitness by supplementing the host production of these proteins. (nih.gov)
Potentially, the seven proteins encoded by the viral genes are sufficient to form an intact monomeric PSI complex. (nih.gov)
Outer membrane adhesin OpcA protein family consists of several Neisseria species specific outer membrane proteins. (wikipedia.org)
We conclude that whether peptidoglycan binding proteins do not appear to be major adhesins, most of the choline-binding proteins interact with host proteins (elastin and C reactive proteins are the major Cbp partners). (biomedcentral.com)
These genes encode proteins involved in DNA replication and cell cycle/proliferation that contribute to major pathways responsible for suppression of colorectal carcinogenesis pathways. (iiarjournals.org)
Conclusion: SCFAs inhibited the expression of genes encoding proteins involved in DNA replication and cell cycle/proliferation of human colorectal cancer cells and exerted antiproliferative activity via different pathways. (iiarjournals.org)
To understand these unique modifications, we used a large-scale gene knockout strategy combined with functional screens to identify proteins exported into parasite-infected erythrocytes and involved in remodeling these cells. (gla.ac.uk)
Eight genes were identified encoding proteins required for export of the parasite adhesin PfEMP1 and assembly of knobs that function as physical platforms to anchor the adhesin. (gla.ac.uk)
All were found to be located within putative open reading frames and included homologues of hemoglobin-binding proteins of Neisseria, a glycosyltransferase (lgtC gene product) of Neisseria, and an adhesin of Yersinia. (jcvi.org)
The gene network of ADHD included 599 genes/proteins and 148,978 interactions, while that of dyslexia included 167 genes/proteins and 27,083 interactions. (biomedcentral.com)
When the ANDSystem and GeneCards data were combined, a total of 213 genes/proteins for ADHD and dyslexia were found. (biomedcentral.com)
gene to additional surface proteins such as M-like proteins and other adhesins. (cdc.gov)
In addition, we found putative virulence genes involved in lipooligosaccharide synthesis, adhesins and bacteriotoxic proteins . (bvsalud.org)

Like many bacteria, Enterococcus faecalis encodes a number of adhesins involved in colonization or infection of different niches. (nih.gov)
IMPORTANCE Most bacteria express multiple adhesins that contribute to surface attachment and colonization. (nih.gov)
Certain Bordetella bacteria exist in two phases - Bvg+ is characterized by the expression of virulence genes and respiratory tract colonization, while the Bvg- phase is adapted for ex vivo growth when virulence genes are silenced. (the-scientist.com)
The bacteria also produce multiple adhesins. (medscape.com)
Using DNA extracted from bacteria in the dental plaque of mother/child pairs, a sequence of the S. mutans spaP gene was amplified using PCR. (bvsalud.org)
An association was found between experience of caries in the children and the presence of bacteria carrying the spaP+ gene. (bvsalud.org)

While very elegant work has been done to describe the genes which are responsible for encoding the AAF/1 fimbriae in some EAggEc strains, it is not possible at present to implicate AAF/1 as the fimbrial adhesin which is present in all or even the majority of EAggEc strains. (usda.gov)
Southern blot analysis of the S fimbrial adhesin (sfa) determinants of normal and hyper-fimbriated strains revealed no marked difference in the gene structure. (uni-wuerzburg.de)

No combinations of the seven genes were either more or less likely to cause disease than others with the same number of virulence-associated genes. (ox.ac.uk)

Two well-studied E. faecalis adhesins, aggregation substance (AS) and endocarditis- and biofilm-associated pili (Ebp), both contribute to biofilm formation on abiotic surfaces and in endocarditis, suggesting that they may be expressed at the same time. (nih.gov)
Here, we examined two well-characterized adhesins in Enterococcus faecalis , aggregation substance and endocarditis- and biofilm-associated pili, and found that they exhibit distinct functional contributions depending on the growth stage of the bacterial community. (nih.gov)
Pili interfere with aggregation substance-mediated clumping and plasmid transfer under planktonic conditions, whereas the two adhesins structurally complement one another during biofilm development. (nih.gov)
We identified several features that render it an opportunistic human pathogen, We found genes involved in anaerobic growth and the pgaABCD operon encoding the biofilm adhesin poly-β-1,6-N-acetyl-D-glucosamin. (ku.dk)
In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. (embrapa.br)
Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. (embrapa.br)
Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development. (embrapa.br)
Using RNA-seq and comparative real-time quantitative RT-PCR, we observed the difference in gene expression between the hicAB mutant and the parent strain, which was associated with biofilm formation. (bvsalud.org)
Our data indicate that the HicAB type II T-A system has a key role in biofilm formation by ExPEC, which may be associated with outer membrane protein (OMP) gene expression. (bvsalud.org)

Alice: Genomic comparisons and phylogenetic analysis of mastitis‑related staphylococci with a focus on adhesion, bioflm, and related regulatory genes. (embrapa.br)
Transcripts binning to the genomes of Fe(III)-reducers Anaeromyxobacter , Geobacter , and Pelosinus indicated significant differences in extracellular electron transport (e.g., multiheme cytochrome c , multicopper oxidase, and type-IV pilin gene expression), adhesion/contact (e.g. (biomedcentral.com)
Additionally, it was revealed that the most relevant genes are involved in biological processes related to signal transduction, positive regulation of transcription from RNA polymerase II promoters, chemical synaptic transmission, response to drugs, ion transmembrane transport, nervous system development, cell adhesion, and neuron migration. (biomedcentral.com)

Virulence genotype analysis revealed that strain CR1 lacked hemolytic phospholipase C and D, three genes for LPS biosynthesis and had reduced antibiotic resistance genes when compared with clinical strains. (frontiersin.org)
Furthermore, the genome contains a range of antibiotic resistance genes coding efflux pump systems and antibiotic modifying enzymes. (ku.dk)

We recently showed that in vitro expression of the intimin adhesin and the type III secretion system encoded on the LEE pathogenicity island is positively regulated by autoinducer molecules expressed by normal flora E. coli strains, i.e., quorum sensing. (usda.gov)
The low and nonpathogenic strains did not contain the genes tps B2 and pfh A2. (biomedcentral.com)
A deletion of four bases was observed in the pfh A gene in the low pathogenic strain, and an insertion of 37 kb of phage DNA was observed in the nonpathogenic strains. (biomedcentral.com)
The HP strains can cause necrotic bronchopneumonia, fibrinous pleuritis and pericarditis in pigs and can be identified by PCR amplification of the gene pfh A2. (biomedcentral.com)
These genes were further analyzed by sequencing, and the strains were compared by MLST of seven housekeeping genes ( adk , aroA , deoD , gdhA , g6pD , mdh , and pgi ). (biomedcentral.com)

CusabioAlternative Name(s): Accessory adhesin protein 3 (Cytadherence accessory. (joplink.net)
Cloning structural genes for Treponema pallidum immunogens and characterisation of recombinant treponemal surface protein, P2 (P2 star). (bmj.com)
The recombinant protein in Escherichia coli lysates was labelled P2 (P2 star) to differentiate it from the comigrating adhesin protein called P2. (bmj.com)
We have covalently conjugated cas9 protein with CQD's using EDC/NHS chemistry and targeted papG gene by synthesizing sequence specific complimentary gRNA. (microbiologyresearch.org)
Expression and Purification of Human Bcl-2 Residues 1-218 of the Bcl-2 gene (UniProt entry "type":"entrez-protein","attrs":"text":"P10415″,"term_id":"231632″P10415) were optimized for expression in (GeneArt, Life Technologies) and cloned into a pET28a vector with an N-terminal His6-MBP solubility tag with a TEV cleavage site to remove the tag. (immune-source.com)
Nucleotide sequence analysis of the p40 * gene in M. bovis revealed the presence of a large deletion involving a frameshift that causes premature truncation of the translated protein, indicating that p40 * exists as a pseudogene in M. bovis. (uthscsa.edu)
and tbpA and hgbB, transferrin-binding protein and hemoglobin-binding protein genes involved in iron acquisition. (biomedcentral.com)

this getting suggests that the 88 MDa plasmid offers afimbrial adhesin genes. (immune-source.com)

saa , STEC autoagglutinating adhesin. (cdc.gov)

In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. (embrapa.br)

For each of these factors we will construct isogenic non-polar mutations in the structural gene and test the mutants for decreased adherence in differential intestinal epithelial cell lines, freshly harvested human intestinal epithelial cells, and in a gnotobiotic piglet model of disease. (usda.gov)

An analogue of the adhesin gene p40 of Mycoplasma agalactiae was found in Mycoplasma bovis. (uthscsa.edu)

The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. (embrapa.br)
PCR for the gene pfh A was positive for all five HP isolates. (biomedcentral.com)

Investigators showed higher rates of infection in experimental mice deficient in the genes that control expression of these 2 agents. (medscape.com)
Through the transposon-directed insertion-site sequencing approach, our previous study identified nhaA, the gene encoding a Na+/H+ antiporter, as a crucial factor for infection in vivo. (bvsalud.org)

A putative function has been assigned, using the gene ontology approach, to the set of genes harboring at least one SSR. (researchgate.net)

Importantly, strain NI1060 strongly stimulates Nod1, an innate immune receptor, but is defective in two peptidoglycan recycling genes due to a frameshift mutation . (bvsalud.org)

Our investigation enables further studies of the functionality of important identified genes contributing to the pathogenicity of A. xylosoxidans and thereby improves our understanding and ability to treat this emerging pathogen. (ku.dk)

However, the network and relationships between the various adhesins of a single bacterial species are less well understood. (nih.gov)

Additionally, the metatranscriptomic data indicate that Methanobacterium was significantly more active in the reduction of CO 2 to CH 4 and in the expression of class(III) signal peptide/type-IV pilin genes following repeated fast oxygenation compared to slow oxygenation. (biomedcentral.com)

The first step in the colonization of the human urinary tract by pathogenic Escherichia coli is the mannose-sensitive binding of FimH, the adhesin present at the tip of type 1 pili, to the bladder epithelium. (rcsb.org)

Our data demonstrate that the H7 flagellum acts as an adhesin to bovine intestinal epithelium and its involvement in this crucial initiating step for colonization indicates that H7 flagella could be an important target in intervention strategies. (hw.ac.uk)

Here, we report an efficient gene editing strategy based on direct delivery of Cas9 and gRNA into Uropathogenic E. coli (UPEC) isolate. (microbiologyresearch.org)
Thus, resident E. coli in these children may constitute reservoirs of virulence- and resistance-associated genes. (peerj.com)

P-fimbriae plays major role in bacterial adherence to the uroepithelium through the Galα1-4Gal-binding PapG adhesin. (microbiologyresearch.org)

The clue to pathogenicity might be in specially tuned gene regulation together with a set of adhesin genes and increased thermo- and starvation tolerance. (boku.ac.at)
The main differences seem to include an extended repertoire of adhesin genes, high drug resistance, an enhanced ability to sustain prolonged starvation and adaptations of the transcriptional wiring of key stress response genes. (boku.ac.at)

The method put forth to rank genes by their importance for the comorbid condition of ADHD and dyslexia was employed to predict genes that play key roles in the development of the comorbid condition. (biomedcentral.com)

There was evidence of considerable horizontal transfer of genes on a background of clonality. (ox.ac.uk)

Pathogens' inhibition was mostly mediated by the production of organic acids, but neutralization experiments strongly suggested the presence of additional antimicrobial compounds in probiotic culture supernatants such as the bacteriocin Lantibiotic B, whose gene was detected in the genome of B. longum KABP042. (frontiersin.org)
S-layer, adhesin, and flagellin gene expression), and selective microbial competition (e.g., bacteriocin gene expression) between the slow and fast oxygenation treatments during microbial Fe(III) reduction. (biomedcentral.com)

A total of 4,761 perfect and 6,583 imperfect SSRs were present in 3,781 genes (14.11% of the total), corresponding to an overall density across the gene space of 32,5 and 44,9 SSRs/Mbp for perfect and imperfect motifs, respectively. (researchgate.net)

Genes belonging to proteases, bacterial exporters and DNA stabilization were found to be under strong positive selection, thus facilitating pathogenicity and survival of the outliers. (frontiersin.org)

Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)

These genes are potentially important for host adaption and for the induction of dysbiosis through bacterial competition and pathogenicity . (bvsalud.org)

No virulence factors were detected for any strain and only the non-transferable erm(49) gene, which confers resistance to erythromycin and clindamycin, was identified in the genome of B. longum KABP042. (frontiersin.org)

The approach is based on ten criteria for ranking genes by their importance, including relevance scores of association between disease and genes, standard methods of gene prioritization, as well as original criteria that take into account the characteristics of an associative gene network and the presence of known polymorphisms in the analyzed genes. (biomedcentral.com)

As such, the search for candidate genes related to the comorbid conditions of ADHD and DD can help in elucidating the molecular mechanisms underlying the comorbid condition, and can also be useful for genotyping and identifying new drug targets. (biomedcentral.com)
The application of methods of reconstruction and analysis of gene networks is a powerful tool for studying the molecular mechanisms of comorbid conditions. (biomedcentral.com)

The seven cyanobacterial core PSI genes identified in this study, psaA, B, C, D, E, K and a unique J and F fusion, form a cluster in cyanophage genomes, suggestive of selection for a distinct function in the virus life cycle. (nih.gov)
These factors include sugar transporters and invertases as well as metabolites, including sucrose and glucose, which function as signalling molecules to modulate gene expression. (sun.ac.za)

For example, cells rapidly adjust their gene expression program according to the internal and external environment. (boku.ac.at)
We investigated the mechanism of the anti-proliferative effects of SCFAs on human colorectal cancer cells by examining their effects on gene expression. (iiarjournals.org)

Changing of external physical parameters such as high temperature or osmotic stress elicit immediate activation of signaling pathways leading to changes of enzyme activities and also large scale changes of gene expression patterns. (boku.ac.at)

Clustered regularly interspaced short palindromic repeats (CRISPR)-technology has emerged as an important tool for gene editing based therapeutics. (microbiologyresearch.org)

However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
In addition, the expression of ERG2, ERG24 and ERG11 genes and the ergosterol content had no differences between wild type and the mutant. (ncl.edu.tw)

Therefore, Zcf29p regulates stress response probably through its control of other genes not tested in our study. (ncl.edu.tw)

Here we show evidence for the presence of photosystem I (PSI) genes in the genomes of viruses that infect these marine cyanobacteria, using pre-existing metagenomic data from the global ocean sampling expedition as well as from viral biomes. (nih.gov)

Metatranscriptomic analysis and 57 Fe Mössbauer spectroscopy were used to investigate changes in Fe(III)-reducer gene expression and Fe(III) crystallinity, respectively. (biomedcentral.com)
Using the ANDSystem tool, the reconstruction and analysis of gene networks associated with ADHD and dyslexia was carried out. (biomedcentral.com)

Outcomes A Soluble Type of Full-Duration BECN1 COULD BE Expressed in in Milligram Amounts The full-duration gene was cloned into altered pET21b vectors with different N-terminal solubility tags. (immune-source.com)

Anatomy4

Organisms24

Diseases6

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes21

Information Science4

Proteins13

Bacteria6

Fimbrial2

Virulence-associated genes1

Biofilm9

Adhesion3

Antibiotic resistance genes2

Strains5

Protein7

Plasmid1

STEC1

Operon1

Epithelial Cells1

Mycoplasma1

Isolates2

Infection2

Putative1

Peptidoglycan1

Pathogen1

Species1

Additionally1

Escherichia1

Colonization1

Coli2

Adherence1

Starvation2

Roles1

Horizontal transfer1

Bacteriocin2

Present1

Found1

Selective1

Potentially1

Strain1

Characteristics1

Molecular2

Function2

Cells2

Pathways1

Important1

Differences2

Study1

Evidence1

Analysis2

Type1