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  • stabilize
  • Evidence suggest that N-Cadherins stabilize the connection between the presynaptic terminal and postsynaptic spine and that this stabilization increases the likelihood that released glutamate will bind receptors on the postsynaptic neuron. (wikipedia.org)
  • disassembly
  • Thus, the PS1/γ‐secretase system stimulates disassembly of the E‐cadherin- catenin complex and increases the cytosolic pool of β‐catenin, a key regulator of the Wnt signaling pathway. (embopress.org)
  • phosphorylation
  • NMDAR activity reduces phosphorylation of β-catenin at tyr-654, thereby inhibiting N-cadherin endocytosis and facilitating surface retention and expression. (wikipedia.org)
  • puncta
  • Additionally, KCl depolarization of the presynaptic axon both confers protease resistance to N-cadherins and disperses them throughout the PSD from their original clustering in synaptic puncta, thus increasing their efficacy for cell adhesion. (wikipedia.org)
  • Takeichi
  • Cadherins are Ca 2+ -dependent homophilic synaptic CAMs that contribute to spine morphogenesis and synapse assembly and regulation (for review, see Takeichi and Abe, 2005 ). (jneurosci.org)
  • synaptic
  • Among the many mechanisms responsible for the maintenance of synaptic plasticity is the cadherin-catenin complex. (wikipedia.org)
  • N-cadherins are believed to be involved in mediating LTP and the synaptic changes underlying learning and memory. (wikipedia.org)
  • During embryonic development, cadherins are initially widely distributed, but they become gradually more localized to pre- and post-synaptic sites while synapses are being formed. (wikipedia.org)
  • thus
  • Thus, NPRAP may be a key adaptor that enables diverse components of the postsynaptic signaling machinery to anchor at the sites of cadherins. (jneurosci.org)
  • mice
  • Second, we showed that cAMP levels and E-cadherin expression decreased in Rac1-CKO mice, and each was restored by mutation of NF2/merlin. (jneurosci.org)
  • expression
  • Cadherin expression is also regulated by activity-induced internalization, which occurs much later than surface stabilization (an average of 4 hours after the stimulus). (wikipedia.org)
  • Ectopic CD97 expression upregulates the expression of N-cadherin and β-catenin in HT1080 fibrosarcoma cells leading to enhanced cell-cell aggregation. (wikipedia.org)