Gastric MucinBacterialGlycoproteinsGoblet cellsGlycoproteinEpithelial cellProteinsInhibitionAcidicSubunitsSalivarySerineMucusTransmembraneTumorMoleculesStrainsPathogenesisCellsEpitheliumMicrobiotaType 1 fimbriaeBacteriaSpeciesGlycosylationSynthesisInfectionEnzymesAlternativelyImmuneEssenceGeneTearPowderFunctionsMMWRPrevalenceHumanOcularCancerAmplificationGastroenterologyFreeExpressionPreventionStructurePropertiesProduction
Gastric Mucin1
- Composite diagram of proposed structures for typical branched oligosaccharides in human 223 and pig 219 gastric mucin glycoproteins showing the immunodeterminant blood group A and H (- - -) and I (‐ ‐ ‐) saccharide structures. (comprehensivephysiology.com)
Bacterial6
- These changes include hyperplasia of the goblet cells, altered mucin profile, retention of mucin, damaged and disorganized epithelium structure, inflammation, and bacterial adherence to the epithelium. (helsinki.fi)
- An aerobic bacterial strain C-14-1 was isolated from an acrylic fiber wastewater. (researchgate.net)
- Experimentally using laboratory-derived strains of bacteria this process has been shown to be dependent on bacterial type 1 fimbriae which normally facilitate mannose-sensitive adherence of bacteria to cells and mucosal surfaces. (biobender.com)
- The number of bacterial cells attached to 100 HT-29 cells ranged from 9 to 33 and from 17 to 645 for B. pseudolongum and B. animalis strains, respectively, whereas corresponding levels of adherence per square centimetre of polystyrene-immobilized mucin ranged from 3 × 10 5 to 4 × 10 5 and from 5 × 10 5 to 889 × 10 5 bacterial cells. (jafs.com.pl)
- Once inside the host cells, it localizes under the point of bacterial attachment and interacts with the protein zonulin (ZO-1) and the junctional adhesion molecule (JAM) [ 4 ]. (nimml.org)
- is one of the dominant bacterial species in the intestinal microbiota of adult humans [1, 18]. (citiesofdata.org)
Glycoproteins2
- Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
- The mucin layer is the innermost layer of the tear film and is made up of glycoproteins. (reviewofoptometry.com)
Goblet cells4
- Histopathological analysis has revealed that HAEC is accompanied by various changes in the gut epithelium, especially in mucin-producing goblet cells. (helsinki.fi)
- It is not known what causes goblet cells to change their mucin production, but it seems to be the earliest histopathological change in HAEC preceding goblet cell hyperplasia. (helsinki.fi)
- L. plantarum 299v stimulated the increase of the transcripts of mucins, which are excreted by goblet cells in the intestine. (metagenicsinstitute.com)
- The conjunctiva is dense in mucin-producing glands including goblet cells, Crypts of Henle and glands of Manz. (reviewofoptometry.com)
Glycoprotein2
- Moreover, because the putative amino acid sequence of BL0675 shows 30% homology to that of FimA, the major component of type 2 glycoprotein-binding fimbriae of [20, 21], we hypothesized that this five BL0675 variant types may have differing affinities to the carbohydrate chains in mucins. (citiesofdata.org)
- Our goal is to reduce the aerosolizability of respiratory secretions while interfering only minimally with normal mucus clearance using agents capable of increasing crosslinking in the mucin glycoprotein network. (biomedcentral.com)
Epithelial cell4
- MUC-1 is located in the apical membrane on simple epithelial cell surfaces. (wikipedia.org)
- MUC-1 has been shown to repair epithelia through the activation of epigenetic reprogramming, epithelial-mesenchymal transition and self-renewing (stemness) in maintaining epithelial cell homeostasis. (wikipedia.org)
- The intercellular interaction between MUC-1 and the receptor ICAM-1 facilitates endothelial and epithelial cell interactions, allowing circulating cancer cells to adhere in the inner lining of blood vessels and thus migrate. (wikipedia.org)
- such as increased epithelial cell turnover and mucin secretion have been described in recent years increasing the number of possible targets for anti-parasite therapies. (biobender.com)
Proteins3
- We characterized IM-HConEpiCs cultured under these conditions and corroborated that the cells maintained a conjunctival epithelial phenotype, including acidic and neutral mucins, junctional proteins E-cadherin and zonula occludens 1, and expression of CK8 and CK19, among others. (bvsalud.org)
- For example, sortase-dependent pili from the PRL2010 strain have been shown to bind epithelial Caco-2 cells and the extracellular matrix (ECM) proteins fibronectin and laminin [15], while type IVb tight adherence (Tad) pili have been proven to be essential for UCC2003 colonization of the murine gut [16, 17]. (citiesofdata.org)
- In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. (biomedcentral.com)
Inhibition2
- The extracellular sperm protein-enterokinase-agarin (SEA) domain of MUC-1 contributes to a variety of functions including: inhibition of immune response, resistance to stimuli, and regulation of cell shedding. (wikipedia.org)
- Inhibition of cellular interactions diminishes the adherence of immune effector cells to malignant cells, thereby creating an immunosuppressive effect. (wikipedia.org)
Acidic1
- Histological analyses revealed that Gfra1hypo/hypo mice had goblet cell hyperplasia and a shift away from acidic mucin production in the distal colon. (helsinki.fi)
Subunits2
- Subunits are joined by disulfide bridges to form overall linear polymeric mucins. (comprehensivephysiology.com)
- Detailed tertiary structure of subunits within the polymeric mucin has not been elucidated. (comprehensivephysiology.com)
Salivary1
- A. naeslundii, which was formerly referred to as genospecies 1 , and A. oris bind to PRPs and statherin, a phosphate-containing protein in salivary components [ 1 ]. (biomedcentral.com)
Serine2
- The peptide backbone exhibits glycosidic bonds between serine and threonine within MUC-1 N. Within the cytoplasmic tail of MUC-1, multiple phosphorylation sites exist due to the presence of threonine, tyrosine and serine amino acid residues. (wikipedia.org)
- In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. (biomedcentral.com)
Mucus1
Transmembrane2
- Mucin-1 (MUC-1) is a heterodimer transmembrane protein of the mucin family encoded in humans by the MUC1 gene. (wikipedia.org)
- MUC-1 in cancer is underglycosylated, causing interactions to form between MUC-1 core protein, transmembrane receptors, and extracellular components. (wikipedia.org)
Tumor2
- MUC-1 also exhibits altered glycosylation and aberrant surface distribution patterns in tumor cells. (wikipedia.org)
- Tumor related MUC-1 disrupts and inhibits cell-cell and cell-matrix interactions and adherence. (wikipedia.org)
Molecules3
- Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
- Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
- Simultaneously, increased gene expression of physiologically essential molecules such as mucin (MUC1 and MUC3) and brain-derived neurotrophic factor (BDNF) was also observed in this group. (biomedcentral.com)
Strains3
- The peptide hydrolysates of both strains exhibited anti-inflammatory action through the modulation of pro-inflammatory mediators in LPS-stimulated THP-1 macrophages (COX-2, Pro-IL-1β, IL-1β, and IL-8) and LPS-stimulated HT-29 cells (IL-8). (calbinotox.fr)
- strains 4-10 and 10-121 as templates and primer sets KS039AF/KS040AR and KS041CF/KS042CR, respectively (Table 1). (citiesofdata.org)
- A comparative study of the virulence of smooth, rough and respiratory strains of Haemophilus influenzae as determined by infection of mice with mucin suspensions of the organisms. (microbiologyresearch.org)
Pathogenesis1
- The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)
Cells17
- In normal cells, the tandem repeats and cytoplasmic tail of MUC-1 are significant in the regulation and progression of metastatic cancer. (wikipedia.org)
- MUC-1 is an inhibitor for cell-to-cell extracellular interactions for both normal and malignant cells. (wikipedia.org)
- Given, MUC-1 is 10 times higher in cancer cells than normal cells, an over expression of MUC-1 in cancer can be indicative of aggressive, metastatic cancer, having a low response to therapy and survival rate. (wikipedia.org)
- MUC-1 in cancerous epithelial cells exhibits a loss of polarity. (wikipedia.org)
- In normal cells, MUC-1 is isolated to the apical surface of the cell. (wikipedia.org)
- In cancer cells, over expression of MUC-1 is seen throughout the cell's nucleus, plasma membrane and cytoplasm. (wikipedia.org)
- INAC assays using A. oris MG1 strain cells were performed with SCFAs (acetic, butyric, propionic, valeric and lactic acids) or a mixture of them on human saliva-coated 6-well plates incubated in TSB with 0.25% sucrose for 1 h. (biomedcentral.com)
- Among the SCFAs, acetic, butyric and propionic acids and a mixture of acetic, butyric and propionic acids induced the type 1 and type 2 fimbriae-dependent and independent INAC by live A. oris , but these cells did not interact with streptococci. (biomedcentral.com)
- As shown in figure 1, the inflammatory response towards H. pylori is initiated through the interaction between the pathogen lipopolysaccharides (LPS) and the Toll-like receptors (TLR) expressed on gastric epithelial cells [ 6 ]. (nimml.org)
- Moreover, both the green tea extract and EGCG were found to reduce the adherence of S. moorei to oral epithelial cells. (biomedcentral.com)
- For tumour estimation, nude mice were inoculated subcutaneously with 1 107 ZR75-1 cells with different constructs on the right side. (bms-911543.com)
- BALB/c mice were injected with 1 106 MDA-MB-231 cells labelled with luciferase carrying the indicated constructs into the lateral tail vein. (bms-911543.com)
- A) Luciferase reporter genes were determined in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with Glutaminase-IN-1 different concentrations of reporter and myc-ZKSCAN5. (bms-911543.com)
- B) Luciferase reporter gene detection in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with expression in ZR75-1 and MDA-MB-231 cells, which were transfected with ZKSCAN5 shRNA, control shRNA, or ZKSCAN5 shRNA plus shRNA-resistant ZKSCAN5 (ZKSCAN5-R). The representative Western blot further showed the expression of ZKSCAN5. (bms-911543.com)
- A, B) Cell proliferation and colony formation assays in HLECs cultured in conditioned medium come from ZR75-1 or MDA-MB-231 cells stably infected with lentivirus carrying ZKSCAN5 shRNA or ZKSCAN5 shRNA plus ZKSCAN5-R. The representative Western blot displays the expression of ZKSCAN5. (bms-911543.com)
- p 0.01 versus the control shRNA group (A, B). (C, D) Wound healing assays for HLECs cultured in conditioned medium from ZR75-1 or MDA-MB-231 cells, which were Glutaminase-IN-1 stably infected as in (A). The image shown is one of the representative results (C, D). Scale bar: 100 m. (bms-911543.com)
- VEGF-D (E, F) Tube formation assays for HLECs cultured in the conditioned medium from ZR75-1 or MDA-MB-231 cells, which were stably infected as in (A). All values shown are the mean SD of triplicate measurements and were repeated three times with analogous. (bms-911543.com)
Epithelium1
- qPCR-analysis revealed that Muc2, the main secreted mucin that protects epithelium from invading pathogens, was upregulated at both P5 and P10. (helsinki.fi)
Microbiota3
- is one of the major genera of bacteria constituting the gastrointestinal (GI) microbiota in mammals, including humans [1]. (citiesofdata.org)
- It is important to understand the influence of gut microbiota and metabolites produced by them on the functioning of various organs within the body (Figure 1 ). (frontiersin.org)
- The influence of dietary components on gut microbiota and associated physiological changes has been discussed in Table 1 . (frontiersin.org)
Type 1 fimbriae2
- Actinomyces oris is an early colonizer and has two types of fimbriae on its cell surface, type 1 fimbriae (FimP and FimQ) and type 2 fimbriae (FimA and FimB), which contribute to the attachment and coaggregation with other bacteria and the formation of biofilm on the tooth surface, respectively. (biomedcentral.com)
- Culturing of eggs with strain which lacks a gene cluster responsible for type 1 fimbriae expression Octreotide resulted in severely impaired parasite hatching [3]. (biobender.com)
Bacteria1
- Helicobacter pylori are gram-negative, miroaerophilic bacteria responsible for a variety of gastro-duodenal pathologies in the developed and developing world [ 1 ]. (nimml.org)
Species1
- It includes more than 200 species found in diverse ecosystems, including the human body and fermented dairy products 1 . (nature.com)
Glycosylation3
- Alterations to the cytoplasmic tail may affect movement through the Golgi apparatus, thus affecting glycosylation of the tandem repeat domains of MUC-1. (wikipedia.org)
- The C-terminus of MUC-1 (MUC-1 C) is short-the majority of weight comes from N-glycosylation. (wikipedia.org)
- O-glycosylation and N-glycosylation in MUC-1 contribute to the formation of mucin. (wikipedia.org)
Synthesis1
- MUC-1 regulates tyrosine kinase signaling receptors, which promote synthesis of biosynthetic intermediates used in cell growth. (wikipedia.org)
Infection1
- Neurological complications occurring due to Salmonella infection of the brain remain a matter of serious concern [ 1 ]. (biomedcentral.com)
Enzymes1
- MUC-1 is a transcriptional coactivator involved in the activity and stabilization of enzymes and transcription of metabolic functions. (wikipedia.org)
Alternatively1
- In addition to the membranous isoform, an alternatively spliced mucin-1 is secreted extracellularly. (wikipedia.org)
Immune1
- MUC-1 provides protection to the apical membrane to prevent rupture, as well as environmental and immune attack. (wikipedia.org)
Essence1
- The COSRX Holy Moly Snail Mask is a 100% rayon fiber sheet mask that is soaked with an essence that is formulated with snail mucin and ginseng water to nourish, hydrate, and increase the elasticity of your skin. (mishibox.com)
Gene2
- Catechol 2,3-dioxygenase (C23O) gene was found andamplified with the designed primers from the total DNA of C-14-1. (researchgate.net)
- The result of Southern blot indicated that there isonly one C23O gene in the genome of C-14-1. (researchgate.net)
Tear1
- On the ocular surface, hydrophilic mucins are responsible for adherence of the tear film to the ocular surface, decreasing surface tension and ensuring the overlying aqueous can spread evenly across the front of the eye. (reviewofoptometry.com)
Powder2
Functions1
- MUC-1 has many functions. (wikipedia.org)
MMWR1
- MMWR 1997;46(No. RR-1):[inclusive page numbers]. (cdc.gov)
Prevalence3
- The prevalence of HSCR is 1:5000, and it is characterized by a complete lack of enteric neurons (aganglionosis) in the distal colon. (helsinki.fi)
- According to the World Health Organization [ 1 ], the global prevalence of diabetes is approximately 10%, reaching up to 33% of the population in some regions. (biomedcentral.com)
- Over the last 4 decades, the worldwide prevalence of overweight and obesity has risen from 3.2 to 10.8% in men and from 6.4 to 14.9% in women [ 1 ]. (biomedcentral.com)
Human1
- Synthesized peptide derived from the C-terminal region of Human Mucin 1. (cusabio.com)
Ocular1
- [ 1 , 2 ] Dry eye disease is a common form of ocular surface disease (OSD) and may overlap with other causes of OSD, such as limbal steam cell insufficiency and ocular graft-versus-host disease. (medscape.com)
Cancer6
- MUC-1 is over expressed in many forms of cancer. (wikipedia.org)
- Cancer-Specific death generic prazosin 1 mg kg footnote 57 hallux rigido-valgus, postural control. (banktech.cz)
- There is an emerging body of evidence supporting that green tea polyphenols may contribute to reducing the risk and/or severity of many systemic conditions and diseases, such as diabetes, cardiovascular disease and cancer [ 1 - 3 ]. (biomedcentral.com)
- Tumour Growth and Metastasis Analysis The animal study was approved and Glutaminase-IN-1 monitored by the Ethics Committee of Harbin Medical University Cancer Hospital (the ID of animal experiment ethical approval: SYDW2021-056). (bms-911543.com)
- Informed consent was obtained from the patients, and all study protocols were approved by the Institutional Review or Glutaminase-IN-1 Committees of Harbin Medical University Cancer Hospital. (bms-911543.com)
- D) Cytoplasmic and nuclear ZKSCAN5 protein levels in two types of breast cancer cell lines, ZR75-1 and MDA-MB-231. (bms-911543.com)
Amplification1
- MUC-1 over expression is controlled through transcription changes, post-translational, and amplification modifications. (wikipedia.org)
Gastroenterology1
- Gastroenterology 2008, 134 (1):306-323. (nimml.org)
Free1
- 1 Overall, concerns about preservative effects have fueled the growing trend toward the use of preservative-free, single-dose formulations. (reviewofophthalmology.com)
Expression1
- and the protein expression levels of Pro-IL-1? (calbinotox.fr)
Prevention1
- Our aim is to clarify the currently described effects of probiotics in the prevention and management of type 1 (T1D) and type 2 (T2D) diabetes mellitus. (biomedcentral.com)
Structure1
- obstruction: A tolerance chloride which Describes an Applicant in structure of 2 myocardial immunoglobulins: administration and law 1, 4, recovery. (siriuspixels.com)
Properties1
- The beneficial properties of green tea polyphenols have been mostly associated to their anti-inflammatory, anti-mutagenic, and anti-oxidative properties [ 1 - 3 ]. (biomedcentral.com)
Production1
- It also reduced the production of pro-inflammatory cytokines IL-8, IL-1? (calbinotox.fr)