• Human diseases that involve abnormalities in purine metabolism include gout, Lesch-Nyhan syndrome, adenosine deaminase deficiency, and purine nucleoside phosphorylase deficiency. (tempsite.ws)
  • Adenylosuccinate is cleaved to form AMP and release fumarate as a byproduct. (picmonic.com)
  • The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of energy from a phosphoanhydride bond in the form of guanosine triphosphate (GTP). (wikipedia.org)
  • GTP is used instead of adenosine triphosphate (ATP), so the reaction is not dependent on its products. (wikipedia.org)
  • Disorders of Purine and Pyrimidine Metabolism Rebecca S. Wappner PURINE AND PYRIMIDINE METABOLISM Purine and pyrimidine nucleotides are important constituents of RNA, DNA, nucleotide sugars, and other high-energy compounds and of cofactors such as adenosine triphosphate and nicotinamide-adenine dinucleotide. (tempsite.ws)
  • Therefore, conversion of IMP to AMP requires the replacement of Oxygen with Nitrogen via the substrate Aspartic Acid to form Adenylosuccinate. (picmonic.com)
  • These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. (ymdb.ca)
  • Adenosine monophosphate, also known as adenylic acid or 5'-AMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. (ymdb.ca)
  • belongs to the class of organic compounds known as purine ribonucleoside monophosphates. (ymdb.ca)
  • Caffeine is an antagonist at adenosine receptors, which tells us that adenosine is important in the regulation of vigilance. (heresy.is)
  • Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine monophosphate (AMP). (wikipedia.org)
  • ADSL is a homotetramer involved in two distinct steps of purine synthesis, namely (1) the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) into aminoimidazole carboxamide ribotide (AICAR), and (2) the conversion of adenylosuccinate (S-AMP) into adenosine monophosphate (AMP) in the inosine monophosphate transformation pathway (fig 1). (bmj.com)
  • This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. (nih.gov)
  • The in vitro antiviral activity of ribavirin appears to be mediated by depletion of intracellular guanosine through inhibition of inosine monophosphate dehydrogenase (a necessary enzyme in purine nucleoside synthesis). (nih.gov)
  • Patients with deficiencies in inosine triphosphatase activity (ITPA variants) are relatively protected against the hemolysis of ribavirin, probably because the increased levels of intracellular ITP provide an alternate source for intracellular guanosine and adenosine triphosphate which are depleted in red cells by ribavirin-triphosphate. (nih.gov)
  • 6 Parents of patients affected by Adenylosuccinate lyase deficiency, Patient's Association 'Our Journey with ADSL deficiency', Rome, Italy. (nih.gov)
  • Towards a suggestive facial dysmorphism in adenylosuccinate lyase deficiency? (bmj.com)
  • Adenylosuccinate lyase deficiency (MIM 103050, ADSL) is a rare autosomal recessive disease causing severe mental retardation and/or autistic features. (bmj.com)