• Association analysis of the pituitary adenylate cyclase-acti. (lww.com)
  • The pituitary adenylate cyclase-activating polypeptide/adenylate cyclase-activating polypeptide 1 (pituitary) ( PACAP/ADCYAP1 ) gene maps to this region. (lww.com)
  • Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in this website by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles. (childrensmercy.org)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP) is a naturally occurring peptide found in the central nervous system that plays a role in somatosensory processing and activation of protein kinase A (PKA) and protein kinase C (PKC). (uky.edu)
  • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are hypothalamic peptides sharing considerable sequence homology which are postulated to be hypophysiotrophic releasing factors. (ox.ac.uk)
  • Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas / L. Vallar, A. Spada, G. Giannattasio. (unimi.it)
  • Effect of pituitary adenylate cyclase-activating polypeptide supplementation, applied during or after vitrification on mouse embryo. (bvsalud.org)
  • Pituitary adenylate cyclase-activating polypeptide ( PACAP ) is a neuropeptide with widespread occurrence and diverse functions. (bvsalud.org)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal peptide/secretin/glucagon family , has an amino acid sequence identity of 68% with vasoactive intestinal polypeptide (VIP). (eurogentec.com)
  • The ability of a series of compounds to compete for [3H]LSD binding sites correlated closely with their ability to inhibit 5-HT stimulation of adenylate cyclase. (erowid.org)
  • Particulate fractions prepared by exhaustive washing with EDTA and ethylene glycol bis(β-aminoethyl ether)N,N,N',N'-tetraacetic acid (EGTA) (in an attempt to deplete the membranes of calmodulin) exhibited no stimulation of adenylate cyclase by Ca 2+ but did show the Ca 2+ -dependent inhibitory phase (halfmaximal inhibition=0.5 μM). (uky.edu)
  • Addition of manganous ion, which activates adenylate cyclase, markedly enhances the inhibition by adenosine analogues. (docksci.com)
  • Gas activates adenylate cyclase, while Gai/o inhibits adenylate cyclase activity. (genengnews.com)
  • Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. (cyverse.org)
  • Link to all annotated objects annotated to negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway. (cyverse.org)
  • The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. (yeastrc.org)
  • Measurements of adenylyl cyclase activity in membranes from cells expressing m5-HT1B receptors showed that serotonergic agonists mediated the inhibition of adenylyl cyclase activity with a rank order of potency comparable to their affinity constants. (nih.gov)
  • Adenylate cyclase activity was higher in the glial cells than in the neuronal fraction, while guanylate cyclase activity was equally detected in both cell fractions. (fluoridealert.org)
  • Adenylate cyclase was mainly derived from the particulate fraction of both brain cell homogenates, whereas the major portion of guanylate cyclase activity was found in their soluble rather than in the particulate fractions. (fluoridealert.org)
  • G(s) and G(i) are guanine nucleotide-binding, heterotrimer proteins that regulate the activity of adenylate cyclase, and are responsible for transferring stimulatory and inhibitory hormonal signals, respectively, from cell surface receptors to the enzyme catalytic unit. (unimi.it)
  • Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G ( G i )-protein-coupled receptors. (wikipedia.org)
  • This altered pattern of adenylate cyclase regulation was reproduced when a cholate extract of the tumour membranes (which contains G proteins) was reconstituted with G(s)-free, cyc- S49 cell membranes. (unimi.it)
  • We show that the posttranslationally fully processed Ki- and Ha-ras p21s activate yeast adenylate cyclase far more effectively than do the unprocessed proteins. (fujita-hu.ac.jp)
  • Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein. (wikipedia.org)
  • Mammalian ras genes substitute for the yeast RAS gene, and their products activate adenylate cyclase in yeast cells, although the direct target protein of mammalian ras p21s remains to be identified. (fujita-hu.ac.jp)
  • [1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G ( G s )-protein-coupled receptors. (wikipedia.org)
  • The results indicate that [3H]LSD can be used to label the 5-HT receptors coupled to adenylate cyclase activity. (erowid.org)
  • Studies on histamine H.sub.2 receptors coupled to cardiac adenylate cyclase", Mol. (everypatent.com)
  • Although bulk-separated neurons and glial cells almost failed to change intracellular cyclic nucleotide levels in response to some putative neurotransmitters, activation of adenylate cyclase by NaF was found to be greater in neuronal than in glial cell fractions, and was observed more clearly in the soluble than in the particulate fractions. (fluoridealert.org)
  • Sodium azide greatly increased guanylate cyclase in the particulate fraction, but did not affect it considerably in the soluble one. (fluoridealert.org)
  • Addition of catalase to the reaction mixture together with NaN3 further stimulated guanylate cyclase both int he soluble and the particulate fractions. (fluoridealert.org)
  • Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. (rcsb.org)
  • The adenylate cyclase (AC) domain is then translocated across the cytoplasmic membrane into the cytoplasm. (wikipedia.org)
  • In the current study, rats were exposed to dexamethasone or terbutaline during late gestation and the development of beta-receptor binding capabilities and adenylate cyclase activity evaluated in membrane preparations from kidney and lung. (rti.org)
  • Adenosine and certain adenosine analogues inhibit beef thyroid membrane adenylate cyclase. (docksci.com)
  • We also compare membrane-bound and solubilized adenylate cyclase in an effort to localize this site. (docksci.com)
  • Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)
  • This site appears to be associated with the catalytic unit since it persists in solubilized adenylate cyclase. (docksci.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Cyclase 5 (ADCY5) in Tissue homogenates, cell lysates and other biological fluids. (therabio.org)
  • Thus, our results show that there is an inverse relationship between adenylate cyclase activity and phosphodiesterase activity and suggest that intracellular calcium may indicate a coordinated regulation of the rates of synthesis and degradation of cyclic nucleotides. (uky.edu)
  • Adenylate Cyclase Assay", Adv. Cyclic Nucleotide Res. (everypatent.com)
  • Adenylate cyclase toxin is a virulence factor produced by some members of the genus Bordetella. (wikipedia.org)
  • Bordetella bronchiseptica and Bordetella parapertussis, also able to cause pertussis-like symptoms, also produce adenylate cyclase toxin. (wikipedia.org)
  • Adenylate cyclase toxin binds to target cells by the complement receptor 3 (CD11b/CD18, or Mac-1). (wikipedia.org)
  • The transiently opened pores do, however, contribute to AC domain function by potassium leakage and calcium influx into the target cell, which slows endocytosis of CR3/adenylate cyclase toxin clusters, also, the CR3/toxin complex is mobilized by detachment from the cytoskeleton. (wikipedia.org)
  • The above described effects of the adenylate cyclase toxin, mainly the cAMP overproduction, have a profound effect on target cells. (wikipedia.org)
  • Intoxication with the adenylate cyclase toxin leads to shift in polarization of macrophages from M1 (proinflammatory) phenotype to M2 (immunoregulatory) phenotype and may lead to macrophage apoptosis. (wikipedia.org)
  • The adenylate cyclase domain has intrinsic enzymatic activity. (wikipedia.org)
  • In the membranes from these tumours no stimultion of adenylate cyclase activity by growth hormone-releasing hormone, by GTP or by fluoride was observed. (unimi.it)
  • The first was a 2-fold stimulation of basal cyclase activity (half-maximal =0.08 μm). (uky.edu)
  • These mutations are thought to enhance adenylate cyclase 5 enzyme activity and lead to higher levels of cAMP within cells, so they are described as "gain-of-function" mutations. (medlineplus.gov)
  • Any process that modulates the frequency, rate or extent of cyclase activity. (mcw.edu)
  • Description: A competitive ELISA for quantitative measurement of Human Adenylate cyclase type 5(ADCY5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (therabio.org)
  • The ADCY5 gene provides instructions for making an enzyme called adenylate cyclase 5. (medlineplus.gov)
  • Other ADCY5 gene mutations prevent production of adenylate cyclase 5. (medlineplus.gov)
  • Although dexamethasone and terbutaline also caused significant changes in development of beta-receptor binding capabilities, in neither tissue could these effects account for the direction or magnitude of the changes in adenylate cyclase reactivity. (rti.org)
  • Hypoxia and glucose independently regulate the B-adrenergic receptor-adenylate cyclase system in cardiac myocytes", J. Clinical Investigation, 88, 204 (1991). (everypatent.com)
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. (medscape.com)
  • the effect resulted from increases in the enzyme itself, as both basal adenylate cyclase and forskolin-stimulation of the enzyme were also increased by dexamethasone. (rti.org)
  • Researchers suggest that the polymorphisms associated with increased type 2 diabetes risk may decrease the ability of the adenylate cyclase 5 enzyme to produce cAMP, resulting in the abnormal response to glucose that occurs in type 2 diabetes. (medlineplus.gov)
  • Distribution and different activation of adenylate cyclase by NaF and of guanylate cyclase by NaN3 in neuronal and glial cells separated from rat cerebral cortex. (fluoridealert.org)
  • Distribution of adenylate cyclase and guanylate cyclase activities in neuronal perikarya and glial cells separated from rat brain, and cellular differences in activation between of adenylate cyclase by NaF and of guanylate cyclase by NaN3 have been studied. (fluoridealert.org)
  • The pharmacological properties of a serotonin-sensitive adenylate cyclase (AC) found in the nervous tissue of insects were investigated. (erowid.org)
  • Both the CB1 and CB2 receptors inhibit adenylate cyclase and stimulate potassium channels. (medscape.com)
  • The effect of Ca 2+ on guinea pig brain adenylate cyclase has been studied using metal buffers to regulate the free Ca 2+ concentration. (uky.edu)
  • Description: A sandwich ELISA kit for detection of Adenylate Cyclase 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
  • Similarly, prenatal terbutaline exposure evoked increases in basal, isoproterenol-stimulated and forskolin-stimulated adenylate cyclase in the kidney. (rti.org)
  • In the lung, dexamethasone produced an initial postnatal deficit in basal adenylate cyclase and deficient responsiveness to isoproterenol, but the deficit resolved shortly after birth. (rti.org)
  • At higher [Ca 2+ ], the cyclase was inhibited to -80 to 90% of basal (half-maximal inhibition=0.3 μM). (uky.edu)
  • The Ca 2+ dependence of calmodulin-dependent phosphodiesterase exhibited a half-maximal activation at [Ca 2+ ]=0.3 μM, similar to the half-maximal inhibition of cyclase in the two preparations. (uky.edu)
  • Adenosine interactions with thyroid adenylate cyclase. (docksci.com)
  • Among the many actions of adenosine on cells, a great deal of attention has recently been devoted to the effects of this nucleoside on adenylate cyclase (EC 4.6.1.1. (docksci.com)
  • In an attempt to resolve these paradoxical effects of adenosine on adenylate cyclases, we have compared purine and ribose-modified analogues of adenosine (1). (docksci.com)
  • GPCRs that couple with adenylate cyclase will increase or decrease intracellular cAMP levels. (genengnews.com)
  • Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. (wikipedia.org)
  • Calcium at concentrations above 300 EM signincantly reduced both [3H]LSD binding and 5-HT activation of adenylate cyclase. (erowid.org)
  • These results suggest that adenylate cyclase and guanylate cyclase without intimate coupling to the transmitter-receptor system, but with activation by NaF or NaN3, may be distributed ubiquitously in the cells separated from rat cerebral cortex. (fluoridealert.org)
  • Likewise, Sr 2+ activation of phosphodiesterase (half-maximal stimulation=0.1 mM) occurred over the same [Sr 2+ ] range as did half-maximal inhibition of cyclase (0.3 mM) in EGTA-and Ca-membranes. (uky.edu)
  • The Ca 2+ and Sr 2+ dependence of calmodulin tyrosine fluorescence (an indirect measure of Ca 2+ and Sr 2+ dependence of phosphodiesterase activation and the inhibition of the cyclase. (uky.edu)
  • Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5. (medlineplus.gov)
  • 3H]LSD binding sites were most concentrated in the anterior region of the fluke which was consistent with the higher levels of 5-HT activated adenylate cyclase found in this region. (erowid.org)
  • These results suggest that the Ca 2+ dependent inhibition of adenylate cyclase may be mediated either by calmodulin or by a metal binding site which has binding properties similar to calmodulin. (uky.edu)
  • Histamine-mediated adenylate cyclase stimulation in human myocardium", Mol. (everypatent.com)
  • A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. (jci.org)
  • Erowid.org: Erowid Reference 2857 : Serotonin-sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide. (erowid.org)
  • In this investigation, we have studied whether the posttranslational processing of Ki- and Ha-ras p21s is critical for their stimulation of yeast adenylate cyclase in a cell-free system. (fujita-hu.ac.jp)