• Exposure of Chinese hamster ovary, mouse adrenal cortex tumor (Y-1), THP-1 and U-937 cells and human erythrocytes to adenylate-cyclase-containing urea extracts of Bordetella pertussis (strain 114) organisms promotes the formation of large concentrations of intracellular cAMP. (mysciencework.com)
  • Inhibitors of the effect of diphtheria toxin, such as NH4Cl, methylamine, chloroquine or monensin, have no inhibitory effect on the accumulation of intracellular cAMP promoted by the internalized adenylate cyclase of urea extracts of B. pertussis organisms. (mysciencework.com)
  • In fact, in striatum serotonin inhibited the dopamine-sensitive adenylate cyclase noncompetitively. (aspetjournals.org)
  • The drugs inhibited the dopamine-sensitive adenylate cyclase in a competitive manner. (aspetjournals.org)
  • Further analysis of genes coordinately regulated with those encoding the TTSS led to the identification of a signaling pathway that originates from a membrane-associated adenylate cyclase and controls TTSS gene expression. (nih.gov)
  • Discover related pathways, diseases and genes to Adenylate Cyclase 3. (novusbio.com)
  • Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. (acris-antibodies.com)
  • Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. (acris-antibodies.com)
  • The bloodstream form of Trypanosoma brucei contains transcripts of at least four genes showing partial sequence homology to the genes for eucaryotic adenylate and guanylate cyclases (S. Alexandre, P. Paindavoine, P. Tebabi, A. Pays, S. Halleux, M. Steinert, and E. Pays, Mol. (asm.org)
  • We show here that ESAG 4-related glycoproteins of about 150 kDa can be found in the trypanosome membrane, that they are detected, by light and electron gold immunocytochemistry, only at the surface of the flagellum, and that the products of at least two of these genes, ESAG 4 and GRESAG 4.1, can complement a Saccharomyces cerevisiae mutant for adenylate cyclase. (asm.org)
  • Therefore these 'upstream' git genes appear to encode a glucose-induced adenylate cyclase activation pathway. (biologists.org)
  • A factor [the feedback regulator (FR)] formed by adipocytes after the stimulation of a cAMP raising hormone has been found to be a potent inhibitor of membrane-bound adenylate cyclase [EC 4.6.1.1. (pnas.org)
  • For example, at low glucose concentrations phosphorylated EIIA accumulates and this activates membrane-bound adenylate cyclase. (wikipedia.org)