• in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. (wikipedia.org)
  • Whereas this observation strictly concerns parenteral delivery routes, orally-delivered vaccines are also sought, owing to their ease of delivery in humans and other species and their potential to elicit mucosal immunity. (frontiersin.org)
  • To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. (frontiersin.org)
  • Their name derives from their initial isolation from human adenoids in 1953. (wikipedia.org)
  • With the help of cellular microtubules, the virus is transported to the nuclear pore complex, whereby the adenovirus particle disassembles. (wikipedia.org)