• BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene. (wikipedia.org)
  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. (wikipedia.org)
  • The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2. (thermofisher.com)
  • BCL2 and adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a well-known atrogene, was identified as a potential mediator of muscle fiber atrophy in LOPD muscle biopsies. (nih.gov)
  • YKL-1, E1B 55 kDa-deleted recombinant adenovirus vector, capable of harboring a transgene casette of up to 4.9 kb, was newly constructed by reintroducing E1A and E1B 19 kDa into E1/E3-deleted adenoviral vector with a homologous recombination in E. coll. (elsevierpure.com)
  • Gene therapy using a recombinant adenovirus (Ad) encoding secretory human endostatin (Ad-Endo) has been demonstrated to be a promising antiangiogenesis and antitumor strategy of in animal models and clinical trials. (biomedcentral.com)
  • The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
  • The current data suggested that BNIP3 expression is regulated by inhibition of the AKT-mammalian target of rapamycin pathway, leading to phosphorylation of Unc-51 like autophagy activating kinase 1 (ULK1) at Ser317 by AMP-activated protein kinase. (nih.gov)
  • BNIP3 (Bcl-2/ adenovirus E1B 19-kDa-interacting protein 3) is a receptor accounting for priming damaged mitochondria for autophagic removal. (chinaphar.com)
  • Mechanistically, OA dose-dependently induced the expression of Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3), while knockdown of BNIP3 expression reversed the protection of OA against HR-mediated mitochondrial injury. (figshare.com)
  • BNIP3 and NIX are related multi-functional outer mitochondrial membrane proteins. (1library.net)
  • Here, after a general discussion of mitophagy, we will review and discuss two related outer mitochondrial membrane (OMM) proteins, BNIP3 and BNIP3L (NIX). (1library.net)
  • These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
  • The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. (utsouthwestern.edu)
  • In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. (utsouthwestern.edu)
  • Protein level and Gene expression were tested by Western blotting analysis and by the Applied Biosystems® Tagman® Array Plates, respectively. (longdom.org)
  • 1278\1278\BAD35103.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:1998-4439. (or.jp)
  • 1278\1278\BAD35104.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:TC-18040. (or.jp)
  • 1278\1278\BAD35105.1\Human adenovirus type 4\Human adenovirus type 4 gene for fiber protein, complete cds,isolate:TC-18465. (or.jp)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
  • The mRNA expression of HIF target genes, namely glucose transporter-1, carbonic anhydrase-9, vascular endothelial growth factor, B-cell lymphoma 2/adenovirus E1B 19-kDa protein-interacting protein 3, prolyl hydroxylase domain-2, and prolyl hydroxylase domain-3, was not significantly altered in NVVs and VVs exposed to hypoxia and treated with doxycycline or MPFF compared with those untreated. (ox.ac.uk)
  • Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector. (wikipedia.org)
  • NAC-type plant-specific transcription factor genes encode proteins that play important roles in abiotic stress responses, as well as regulation of plant development. (metu.edu.tr)
  • The steady-state concentrations of p53 were significantly higher in cells infected by the E1B 55 kDa null mutant Hr6 or three mutants carrying small insertions in the E1B 55 kDa protein coding sequence than in Ad5-infected cells. (princeton.edu)
  • 884\684\AAN64737.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 1205\321\AAN64738.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 1791\633\AAN64739.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • 2297\525\AAN64740.1\Human adenovirus type 4\Human adenovirus type 4 early region 3, complete sequence. (or.jp)
  • FIP-1 has regions of homology with other Ras-related small GTP binding proteins but has a unique carboxyl terminus. (yu.edu)
  • TNF-{dollar}\alpha{dollar} induced rapid but transient phosphorylation and association of FIP-1 with other cellular proteins. (yu.edu)
  • Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. (utsouthwestern.edu)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • It is well established that the human subgroup C adenovirus type 5 (Ad5) E1B 55 kDa protein can regulate the activity and concentration of the cellular tumor suppressor, p53. (princeton.edu)
  • The microvessel density and Ad replication in tumor tissue were evaluated by checking the expression of CD34 and hexon proteins, respectively. (biomedcentral.com)
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
  • Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. (biomedcentral.com)
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
  • Mutagenesis analysis has shown that the GTP-binding domain of FIP-1 is indispensable for its interaction with E3-14.7K. FIP-1 is very similar to two proteins: (1) an S. cerevisiae GTP-binding protein that presumably has a role in phosphate transport and (2) a C. elegans protein of unknown function. (yu.edu)
  • Rather, the localization of p53 to E1B containing nuclear sites observed during infection by Ad5 was prevented by mutations that impair interaction of the E1B protein with p53 and/or with the E4 Orf6 protein. (princeton.edu)
  • Subsequently, the interaction of E4orf3 with four different proteins, DNA-PK, Aup1, E1B-55 kDa and E4orf6 was analyzed in detail by GST-pulldown technique. (metu.edu.tr)
  • RESULTS: Treatment of NVV organ cultures exposed to hypoxia with doxycycline or MPFF did not significantly alter the expression of HIF-1α and HIF-2α messenger (m)RNA and protein compared with untreated. (ox.ac.uk)
  • Doxycycline also did not significantly affect the expression of HIF-1α and HIF-2α mRNA and protein in VVs exposed to hypoxia compared with untreated VVs. (ox.ac.uk)
  • In this study, structural and functional aspects of adenovirus type 5 (Ad5) E4orf3 protein were analyzed by biophysical and biochemical methods. (metu.edu.tr)
  • daughter of AQ-1, had a febrile respiratory infection with Human Adenovirus Type 55 cough. (cdc.gov)
  • Transverse chest CT images demonstrated in- We identified a case of fatal acute respiratory disease creased areas of patchy shadows and consolidation in both from household transmission of human adenovirus type lungs compared to CT images from April 22, indicative of 55 (HAdV-55) in Anhui Province, China. (cdc.gov)
  • All four FIPs are novel proteins and are expressed in all major human tissues assayed. (yu.edu)
  • To investigate this issue, we examined properties of p53 in normal human cells infected by E1B mutant viruses that display defective entry into the late phase or viral late mRNA export. (princeton.edu)
  • These results indicate that the E1B protein fulfills an early function that correlates efficient entry into the late phase with the localization of E1B and p53 in the nucleus of Ad5-infected normal human cells. (princeton.edu)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
  • Our results also suggest that E3-14.7K is acting at steps or pathways of TNF-{dollar}\alpha{dollar} cytolysis different from the ones affected by E1B-19K or Bcl-2 since none of the FIPs interact with either Bcl-2 or ElB-19K. (yu.edu)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • Through our study of these proteins, we hope to gain a better apprecia-tion of the relaapprecia-tionship between mitochondria and cells. (1library.net)
  • Immunoblot analysis was used to determine relative protein quantities within cells. (biomedcentral.com)
  • Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
  • However, the contribution(s) of these functions of the E1B protein to viral reproduction remains unclear. (princeton.edu)
  • Therefore, understanding the functions of E4orf3 is very important for developing efficient and safe adenovirus vectors. (metu.edu.tr)
  • FIP-2 and FIP-3 are similar proteins containing leucine-zipper domains. (yu.edu)
  • Interestingly, the reduction of the expression of HIF-1α mRNA in VVs by MPFF was not reflected at the protein level. (ox.ac.uk)
  • Therefore, this study focused on the optimization of expression of E4orf3 protein. (metu.edu.tr)
  • Finally, basic structural information about E4orf3 protein was also obtained for the first time by the direct analysis of the fusion protein in glutathione beads with Fourier Transform Infrared (FTIR) spectroscopy. (metu.edu.tr)
  • A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. (utsouthwestern.edu)
  • In these experiments, E4orf3 was shown to associate with Aup1, E1B-55 kDa and E4orf6 in vitro, and the C-terminal of E4orf3 was determined to be responsible for these interactions. (metu.edu.tr)
  • Whether the cargo is a membrane-bound organelle, precipitated protein aggregate, or an intracellular pathogen, the solution is the same: erect a barrier, direct destructive agents into the newly-formed com-partment, and recycle or remove the debris. (1library.net)
  • By the use of the yeast two-hybrid system, four unique clones that code for {dollar}\underline{lcub}14{rcub}{dollar}.7k-interacting proteins or FIPs have been identified. (yu.edu)
  • As a result, full-length E4orf3 was obtained in soluble form as a Glutathione-S-transferase (GST) fusion protein and purified by GST affinity chromatography for the first time. (metu.edu.tr)