Adenoviral infection adenovirus infections human. Medical search. Frequent questions

Bacterial infections of the middle ear and sinuses A) Very common, often occur together B) Frequently have the same causative agent 2. (slideserve.com)
In most patients the treatment is symptomatically with artificial tears and antibiotic eye drops in cases accompanied by secondary bacterial infections, not prophylactically. (thieme-connect.de)
Do They Mimic Bacterial Infections? (webmedcentral.com)
Respiratory adenovirus (ADV) infections activate acute phase proteins, so they are often interpreted as bacterial infections. (webmedcentral.com)
ADV and bacterial infections may be indistinguishable clinically, necessitating additional and specific diagnostic investigation. (webmedcentral.com)
Next to viral infection, also bacterial infections can be involved in the development of acute exacerbations. (biomedcentral.com)
Persistent clinical symptoms were more commonly associated with atypical bacterial infections. (bmj.com)

Lion T . Adenovirus infections in immunocompetent and immunocompromised patients. (cdc.gov)
In immunocompetent individuals, adenovirus infections often manifest as upper respiratory tract infections, pharyngoconjunctival fever, or diarrhoea. (biomedcentral.com)
In immunocompetent hosts, most adenovirus infections are asymptomatic. (msdmanuals.com)

Other viruses that can be responsible for conjunctival infection include herpes simplex virus (HSV), varicella-zoster virus (VZV), picornavirus (enterovirus 70, Coxsackie A24), poxvirus (molluscum contagiosum, vaccinia), and human immunodeficiency virus (HIV). (medscape.com)
Acute respiratory infections are frequently attributable to respiratory syncytial (RSV) or influenza viruses or rhino-, entero- and adenoviruses. (webmedcentral.com)
Infections with respiratory viruses are known triggers of exacerbations of these diseases. (biomedcentral.com)
Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortality in humans, a universal influenza vaccine is needed to provide comprehensive protection against a wide range of influenza viruses. (cdc.gov)
1 In that study picornaviruses (mostly rhinoviruses) accounted for two thirds of the viral infections, with coronavirus causing less severe asthma exacerbations than other respiratory viruses. (bmj.com)
These most probably result from coronavirus infections, such as MERS-CoV, SARS-CoV, and SARSCoV-2, and other RNA viruses, such as influenza (H1N1, H5N1) and Ebola viruses, which have animal reservoirs and can cross species barriers to adapt to new environments and/or new hosts. (ukdiss.com)
Such an assumption is indeed a global human issue, but are viruses causing diseases in most if not all instances or are viruses just the consequences of human overexploitation of all resources resulting in many negative impacts such as global warming, pollution, and reduction of biodiversity. (biomedcentral.com)
Adenoviruses are DNA viruses classified according to 3 major capsid antigens (hexon, penton, and fiber). (msdmanuals.com)

Lewis PF , Schmidt MA , Lu X , Erdman DD , Campbell M , Thomas A , A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. (cdc.gov)
Adenovirus serotype 14 (Ad14) is a rarely reported but emerging serotype of adenovirus that can cause severe and sometimes fatal respiratory illness in patients of all ages, including healthy young adults. (cdc.gov)

Phylogenetic analysis of human adenovirus 7 genome type d (HAdV-B7d), Oregon, USA, 2014. (cdc.gov)
Gerber SI , Erdman DD , Pur SL , Diaz PS , Segreti J , Kajon AE , Outbreak of adenovirus genome type 7d2 infection in a pediatric chronic-care facility and tertiary-care hospital. (cdc.gov)
Zhao S , Wan C , Ke C , Seto J , Dehghan S , Zou L , Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence. (cdc.gov)
The adenoviral vectors provided by Genemedi are based on human adenovirus type 5 (Ad5), which is replication-incompetent (-E1/-E3) and can't be integrated into host genome, guaranteeing the security for subsequent operations. (9lb.cc)
It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)

When compared with ADV-negative and influenza-positive patients, those with ADV infections showed significantly elevated serum CRP concentrations and left-shifted leukocyte counts. (webmedcentral.com)
In order to determine the degree and frequency of inflammatory marker elevation with ADV Infection, we monitored blood levels of C-reactive protein (CRP) and IL-6 in children with viral symptoms.Children with provend influenza and other nonspecific viral respiratory infections served as controls. (webmedcentral.com)
Ultimately, the goal of our study was to evaluate the diagnostic relevance of CRP and IL-6 for ADV infection in a pediatric setting compared with influenza and non-ADV viral illness. (webmedcentral.com)
The study population ranged from one month to 16 years of age.Children with ADV infections had been routinely examined and treated in the interval of November 2003 to June 2007, while those with Influenza virus were seen between February and May 2005. (webmedcentral.com)
Bronchial epithelial cells (BEAS-2B cells and primary bronchial epithelial cells) were exposed to heat-inactivated Haemophilus influenzae , Pseudomonas aeruginosa or Streptococcus pneumoniae and subsequently infected with respiratory syncytial virus (RSV), type 2 human adenovirus or influenza B. Levels of pro-inflammatory cytokines, viral replication and expression of pattern recognition receptors were determined in culture supernatants and/or cell lysates. (biomedcentral.com)
Infection with influenza B on the other hand did not affect cytokine production in BEAS-2B cells exposed to the different bacterial strains. (biomedcentral.com)
In this retrospective case-control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020]. (ukdiss.com)
Although respiratory infections can be classified by the causative virus (eg, influenza), they are generally classified. (msdmanuals.com)

Adenovirus types 3 and 7 cause a distinct syndrome of conjunctivitis, pharyngitis, and fever (pharyngoconjunctival fever). (msdmanuals.com)

In the current study we demonstrated for the first time that human adenovirus (HAdV) type 4, 5 and 7 exhibits tropism for neurons cultured in vitro followed by the extensive replication of all serotypes in the primary culture of murine neurons. (elis.sk)
Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
Human adenovirus (HAdV) infection constitutes a major cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
The incidence of HAdV infection ranges from 5 to 30 %, with pediatric recipients showing the highest rates of infection with up to 83 % lethality [ 1 - 6 ]. (biomedcentral.com)
However, antiviral treatments for HAdV infection with agents like cidofovir and ribavirin are associated with toxicity and may result in delayed immune reconstitution. (biomedcentral.com)
Respiratory tract infections, one of the commonest manifestations of HAdV infections, is frequently due to species B and C. There are considerable geographical variations in the prevalence of various species and serotypes causing respiratory tract infections. (biomedcentral.com)

Thumerelle et al 2 confirmed the high incidence of viral infections (especially enteroviruses or rhinoviruses) in children admitted to hospital with an asthma exacerbation. (bmj.com)

Laboratory tests typically are unnecessary, but they may be extremely helpful in some cases, particularly when an epidemic of adenoviral keratoconjunctivitis threatens a community or clinic. (medscape.com)
There is clinical evidence that topical ganciclovir is effective against at least Adenovirus serotype 8, thus compelling many clinicians to prescribe this agent off-label for compelling cases of epidemic keratoconjunctivitis (EKC), particularly when corneal lesions are noted. (medscape.com)
As in the case of other viral respiratory pathogens, community outbreaks of adenovirus infections may occur, especially with respiratory tract infections and keratoconjunctivitis. (biomedcentral.com)
For example, adenoviral keratoconjunctivitis is often associated with species D, while enteric infections are often caused by F40 and F41 [ 3 ]. (biomedcentral.com)

Ertl's research centers on developing vaccines for an array of diseases and conditions-including AIDS , chronic viral infections, COVID -19 and some forms of cancer-not typically considered to be treated using this approach. (wistar.org)
These vaccines aim to protect against future infections and look to create new therapies for diseases already affecting people. (wistar.org)
They are applying this platform to develop HIV vaccines and creating new therapeutic vaccines against human papillomavirus (HPV), a leading cause of cervical cancer, and chronic hepatitis B virus infection, a major cause of hepatocellular carcinoma. (wistar.org)
The establishment of robust T cell memory is critical for the development of novel vaccines for infections and cancers. (ox.ac.uk)

Adenovirus infections might cause the acute hepatitis in children observed. (bmj.com)
Adenovirus infections do not normally cause hepatitis in healthy children suggesting that a completely new type of adenovirus might have been introduced into the human population. (bmj.com)
BACKGROUND: The prevalence of hepatitis B virus (HBV) infection in Punjab, India, is unknown. (cdc.gov)

The majority of acute exacerbations of COPD (AECOPD) is associated with an acute respiratory infection, with viral and/or bacterial pathogens being detected in more than half of all exacerbations [ 1 , 2 ]. (biomedcentral.com)
Other recently identified pathogens include the enteric adenoviruses, calicivirus, astrovirus, and the Norwalk family of agents. (cdc.gov)

Transduction results of various Adenovirus vectors. (9lb.cc)
Selected results of Adenovirus transduction in the adult rat cardiac cells (A), eyes (B), neuron cells (C). (9lb.cc)
Following infection of cell lines homozygous for mutant p53, the apparent transduction efficiency calculated (τ(o) = [P1 - P2]/[1 + P2]) correlated with the level of p21 expression. (elsevierpure.com)
Transduction efficiency in heterozygous wild-type/mutant HUG31 cells increased linearly with multiplicity of infection (MOI) for τ(o) value, in keeping with theoretical predictions. (elsevierpure.com)

Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
We here investigated if pre-exposure to bacteria alters the response of lung epithelial cells to subsequent viral infection. (biomedcentral.com)

Heim A , Ebnet C , Harste G , Pring-Åkerblom P . Rapid and quantitative detection of human adenovirus DNA by real-time PCR. (cdc.gov)
ADV infection was confirmed via quantitative polymerase chain reaction (PCR) testing of nasopharyngeal swabs for human ADV-DNA. (webmedcentral.com)
An accurate and cost-effective quantitative assay is essential not only for laboratory diagnosis of adenoviral infections, but also for monitoring of response to antiviral treatment. (biomedcentral.com)
The analytical sensitivity, specificity, linearity, precision and accuracy of an in-house adenovirus quantitative polymerase chain reaction assay were evaluated against the RealStar® Adenovirus PCR Kit (Altona Diagnostics GmbH, Hamburg, Germany), using 122 clinical specimens and 18 proficiency testing samples. (biomedcentral.com)
A comparison of 52 matched samples showed an excellent correlation between the quantitative viral loads measured by the in-house assay and the RealStar® Adenovirus PCR Kit (R 2 = 0.984), with an average bias of − 0.16 log 10 copies/mL. (biomedcentral.com)
To monitor adenovirus-mediated wild-type p53 gene transfer, we have used a quantitative assay which tests the ability of human p53 to activate transcription in yeast. (elsevierpure.com)

Case clusters of severe respiratory disease, caused by specific adenoviruses (particularly types 7, 14, and 55), have occurred in healthy adults. (msdmanuals.com)
Adenoviral infections are being increasingly recognized as causes of severe respiratory and other clinical disease in immunocompromised adults. (msdmanuals.com)

Human adenoviruses are common causes of community-acquired respiratory tract and enteric infections. (biomedcentral.com)

however, adenovirus is by far the most common cause, and herpes simplex virus (HSV) is the most problematic. (medscape.com)

Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
The levels of adenovirus replication in the above-mentioned cell cultures were determined by real-time PCR. (elis.sk)
We also observed accumulation of nuclear actin within nuclei of infected cells which may indicate that it plays role in adenovirus infection and replication in neurons and A549 cells. (elis.sk)
This effect was sustained even when bacteria were washed away before viral infection and was neither associated with enhanced viral replication, nor linked to increased expression of key pattern recognition receptors. (biomedcentral.com)
Recombinant adenovirus (Adenovirus), a replication-defective adenoviral vector system, is widely used for gene delivery in most cell types. (9lb.cc)
The E1 gene contains E1A and E1B, involved in the replication of adenovirus. (9lb.cc)
E1A is critical to start viral replication by promoting transcription from rep gene promoters, P5 and P19, and facilitate viral replication by activating the early adenovirus promoters. (9lb.cc)

Lebeck MG , McCarthy TA , Capuano AW , Schnurr DP , Landry ML , Setterquist SF , Emergent US adenovirus 3 strains associated with an epidemic and serious disease. (cdc.gov)

Ng OT , Thoon KC , Chua HY , Tan NW , Chong CY , Tee NW , Severe pediatric adenovirus 7 disease in Singapore linked to recent outbreaks across Asia. (cdc.gov)

Autopsy and histologic findings at the Office of the Chief Medical Examiner in New York City included presence in the lung of chronic inflammatory cells with intranuclear inclusions, consistent with adenoviral bronchiolitis and acute respiratory distress syndrome. (cdc.gov)

Pierre Boulanger was the co-author of more than 140 publications and reviews in international journals as well as book chapters on basic and medical virology and human gene therapy. (biomedcentral.com)

Although SARS-CoV-2 is a coronavirus similar to SARS-CoV and Middle East respiratory syndrome (MERS)-CoV, a higher human-to-human transmission rate has been observed in the COVID-19 pandemic than in the SARS and MERS outbreaks, which had shorter incubation periods and higher fractions of severe cases and deaths. (ukdiss.com)

HspX or α-crystallin, a 16 kDa protein, is one of the dominant antigens expressed during the latent stages of M. tuberculosis infection and under various other conditions like low oxygen tension, nutrient starvation or hypoxia 7 , 8 . (nature.com)

Multiplicity of Infection. (docksci.com)

Content will not include any discussion of the unlabeled use of a product or product under investigational use with the exception of Dr. Elizabeth Moulton, who may discuss off-label use of cidofovir for adenovirus treatment. (cdc.gov)

Treatment of adenoviral conjunctivitis is supportive. (medscape.com)

The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)

Streptococcal pharyngitis Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. (msdmanuals.com)
Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. (msdmanuals.com)
Even severe primary adenoviral pneumonia is not fatal except for rare fulminant cases, predominantly in infants, military recruits, and immunocompromised patients. (msdmanuals.com)

Nonrespiratory adenoviral syndromes include hemorrhagic cystitis, diarrhea in infants, and meningoencephalitis. (msdmanuals.com)
Arad E, Naschitz J, Yeshurun D. [Hemorrhagic cystitis as a presenting symptom of acute infection with Salmonella typhi]. (medscape.com)

Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. (cdc.gov)
Certain species/serotypes are characteristically associated with organ-specific infections. (biomedcentral.com)
Similarly, species C is one of the commonest species involved in infections among the immunocompromised patients [ 3 ]. (biomedcentral.com)
There are 7 human adenovirus species (A to G) and 57 serotypes. (msdmanuals.com)

Kandel R , Srinivasan A , D'Agata EMC , Lu X , Erdman D , Jhung M . Outbreak of adenovirus type 4 infection in a long-term care facility for the elderly. (cdc.gov)
Calder JA , Erdman DD , Ackelsberg J , Cato SW , Deutsch VJ , Lechich AJ , Adenovirus type 7 genomic-type variant, New York City, 1999. (cdc.gov)
In this study the tropism of the human adenoviruses type 4, 5, 7 to primary cultures of murine neurons and the influence of infection on the neuron morphology and actin cytoskeleton was examined. (elis.sk)
In comparison with the Ad14 patients, among the 12 adenovirus non-type 14 patients (i.e., all but three) whose medical charts were reviewed, nine (75%) were male. (cdc.gov)
The R 0 (basic reproduction number) of the original wild type SARS-CoV-2 has been estimated between 2.2 and 3.3 in a non-lockdown population, that is each infected individual, on average, causes between 2-3 new infections 12,33 . (radiopaedia.org)

He identified and characterized cellular receptors of adenoviruses and developed effective capsid modification systems. (biomedcentral.com)

Specimens can be obtained by culture and conjunctival cytology smear if inflammation is severe, in chronic or recurrent infections, with atypical conjunctival reactions, and in patients who fail to respond to treatment. (medscape.com)
Atypical bacteria, Chlamydia pneumoniae , and Mycoplasma pneumoniae infections may precede asthma onset or exacerbate asthma, 3 and these bacteria might be involved in chronic asthma. (bmj.com)

Ison MG . Adenovirus infections in transplant recipients. (cdc.gov)

Adenovirus also was isolated by culture, confirmed by immunofluorescence assay (IFA), and typed as Ad14 by antibody neutralization assay. (cdc.gov)

Case-control studies have shown that the E1A DNA from group C adenoviruses is present in greater amounts in the lungs of patients with COPD than in controls with normal lung function matched for age, sex and smoking history 5 , and that the excess inflammation in the lungs of smokers with severe emphysema is associated with increased numbers of alveolar epithelial cells expressing E1A 6 . (ersjournals.com)
Approximately 1 in 4 patients with acute conjunctivitis have confirmed adenoviral conjunctivitis. (medscape.com)
Isolates from 50 (74%) of these patients were available for further adenovirus typing at either CDC or OSPHL. (cdc.gov)
Infections of the respiratory tract are a major risk to patients with chronic respiratory diseases, such as chronic obstructive pulmonary diseases (COPD). (biomedcentral.com)

The in-house adenovirus assay is a sensitive and reliable assay with lower cost for the detection and quantification of adenoviral DNA when compared to the RealStar® Adenovirus PCR Kit. (biomedcentral.com)

Moura PO , Roberto AF , Hein N , Baldacci E , Vieira SE , Ejzenberg B , Molecular epidemiology of human adenovirus isolated from children hospitalized with acute respiratory infection in São Paulo, Brazil. (cdc.gov)
A simian adenoviral vector termed adenovirus C68 (AdC68) was generated as a molecular clone to express the glycoprotein of rabies virus. (wistar.org)
Pierre Boulanger, born on January 26, 1940, and died on March 30, 2020, was a renowned virologist with more than 30 years of experience in research and teaching in molecular virology and imaging, notably on Adenoviruses and HIV-1. (biomedcentral.com)
Pierre also experienced three lives in molecular virology, investigating the structure of Adenovirus particles and on HIV Gag assembly and at the same time at the forefront of the development of viral vectors for gene transfer and therapeutic purposes. (biomedcentral.com)

These human observations are supported by experiments in guinea pigs, where, in the absence of actively replicating virus but the presence of E1A DNA, adenovirus infection resulted in excess lung inflammation following a single exposure to cigarette smoke 7 , and increased parenchymal and airway wall inflammation with greater emphysematous destruction after chronic exposure 8 . (ersjournals.com)

Adenovirus advances: new diagnostic and therapeutic options. (thieme-connect.de)

Indeed, as the Covid-19 pandemic has taught us, human, animal and environmental health are mutually and inextricably linked to each other, a concept efficiently summarized by the "One Health" principle. (bmj.com)
Lymphocytes were related to the entire course of adenovirus infection, recovery of COVID-19, and disease development of SARS. (ukdiss.com)

acr was able to efficiently boost the BCG induced protection against M. tuberculosis infection in guinea pigs by significantly reducing the pulmonary bacillary load (1.27 log 10 fewer bacilli) in comparison to BCG vaccination alone. (nature.com)

Respiratory infections are well known triggers of asthma exacerbations, but their role in stable adult asthma remains unclear. (bmj.com)

The laboratory developed an adenovirus-based vaccine against rabies virus that can provide rapid immunity following a single administration. (wistar.org)

Adenoviral infections of the central nervous system are rare, but they are characteristic for their high mortality rate. (elis.sk)
Severe disseminated infections with high mortality rates may be seen in immunocompromised individuals. (biomedcentral.com)

When infections are symptomatic, a broad spectrum of clinical manifestations is possible because most adenoviruses that cause mild disease have affinity for a variety of tissues. (msdmanuals.com)

Our optimized custom adenoviral vector production and strict quality control systems provide customers a high titer of functional recombinant adenoviral vectors. (9lb.cc)
T cell memory inflation, as seen for example after CMV infection, is the maintenance of expanded, functional, tissue-associated effector memory cell pools. (ox.ac.uk)

Although inhalation of toxic gases and particles is the major risk factor for COPD 3 , viral infections, particularly childhood infection, add to the risk of developing this condition 1 . (ersjournals.com)

Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991-2007). (cdc.gov)
Through retrospective examination of laboratory reports from the three clinical laboratories in the state that have virology capacity and the Oregon State Public Health Laboratory (OSPHL), OPHD identified 68 persons who tested positive (by culture, PCR, or IFA) for adenovirus during November 1, 2006--April 30, 2007. (cdc.gov)
Both clinical and experimental evidence suggest an important role for respiratory infections as triggers of asthma attacks in adults and in children. (bmj.com)

Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. (docksci.com)
The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have antioncogenic properties. (docksci.com)

Viral conjunctivitis, or pinkeye (see the image below), is a common, self-limiting condition that typically is caused by adenovirus. (medscape.com)

Anatomy8

Organisms13

Diseases10

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes16

Information Science2

Bacterial infections7

Immunocompetent3

Viruses8

Serotype 142

Genome5

Influenza8

Pharyngoconjunctival fever1

HAdV6

Rhinoviruses1

Keratoconjunctivitis4

Vaccines4

Hepatitis3

Pathogens2

Transduction4

Lung epithelial cells2

Quantitative6

Severe respiratory2

Enteric1

Herpes simpl1

Replication7

Strains1

Pediatric1

Bronchiolitis1

Gene therapy1

Coronavirus1

Antigens1

Multiplicity of infect1

Cidofovir1

Supportive1

Occur1

Pneumonia3

Hemorrhagic2

Species4

Type5

Capsid1

Atypical2

Recipients1

Immunofluorescence1

Patients4

Assay1

Molecular4

Inflammation1

Therapeutic1

COVID2

Significantly1

Known triggers1

Laboratory-developed1

High mortality2

Manifestations1

Functional2

COPD1

Clinical3

Papillomavirus2

Typically1