• In this test, physical exercise or intravenous medication (adenosine/dobutamine) is used to increase the workload and oxygen demand of the heart muscle, and ischemia is detected using ECG changes or nuclear imaging. (wikipedia.org)
  • Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine and contrast medium to assess fractional flow reserve in humans. (rsyd.dk)
  • 800mg 36 sp1998 adapalene + benzoyl peroxide cream 37 sp19171 adapalene + clindamycin gel 38 sp19177 adaplene gel 39 d11 adenosine 3mg / ml inj. (chhattisgarhtenders.net)
  • Erowid.org: Erowid Reference 3068 : Adenosine Cyclic 3',5'-Monophosphate in the Liver Fluke, fasciola hepatica. (erowid.org)
  • The enhanced levels of cyclic AMP were preserved by both caffeine and papaverine, and NaF up to 5 mM caused a specific stimulation of AC. (erowid.org)
  • In the presence of O.i mM 5HT, AC activity in the fluke particles was inhibited by 0.5 mcM LSD, and LSD also antagonized the 5HT stimulated increase in cyclic AMP levels, Adenine, adenosine, histamine (Calbiochem), adrenaline (Mann), tryptophan, dopamine, GTP (Sigma - Chem. (erowid.org)
  • Fertel and Weiss, 1976) therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). (biomedjournal.com)
  • and adenosine response curves were obtained with and without the adenosine uptake blocker, dipyridamole, and the adenosine-deaminase inhibitor, erythro-9,2-hydroxyl-3-nonyl-adenine (EHNA), in the incubation medium. (cdc.gov)
  • Adenosine effects were comparable in intact and epithelium stripped preparations in the absence of dipyridamole and EHNA. (cdc.gov)
  • It was recognised that papaverine and pentoxifylline mediated vasorelaxation by a number of mechanisms including non-selective PDE inhibition and these drugs can be considered as forerunners to the clinically successful PDE5 inhibitors used today for the treatment of erectile dysfunction. (biomedjournal.com)
  • [19] Pentoxifylline is also an antagonist at adenosine 2 receptors. (mdwiki.org)
  • The current examine was undertaken to find out the potential neuroprotective results and the related mechanism of papaverine (PAP), a PDE10A isoenzyme inhibitor, towards quinolinic acid (QUIN)-induced excitotoxicity utilizing human major cortical neurons. (aabioetica.org)
  • The drug works by irreversibly inhibiting a receptor called P2Y12, an adenosine diphosphate (ADP) chemoreceptor on platelet cell membranes. (imexoverseas.in)
  • This is done during maximal blood flow (hyperemia), which can be induced by injecting products such as adenosine or papaverine. (wikipedia.org)
  • Invasive hemodynamic measurements were obtained using the Navvus microcatheter at baseline and before and after each specific intervention (angioplasty and/or directional atherectomy) without and then with hyperemia using intra-arterial adenosine. (clijournal.com)
  • It is measured during medically induced maximal hyperemia with adenosine [3] Due to the need for maximal hyperemia to measure FFR, it has been developed measurement without the need for adenosine like instantaneous wave free ratio(iFR), that can be calculated without the need for medication. (rsyd.dk)
  • The sensitivity of denuded lung trachealis compared to intact trachealis to adenosine was increased significantly in the presence of the adenosine uptake and degradation inhibitors. (cdc.gov)
  • Figure 1 illustrates the data for the mitochondrial toxicant, papaverine (A), and the non mitochondrial toxicant, tamoxifen (B). A 7.91 fold increase in IC 50 value is observed for papaverine in galactose media compared with glucose media (table 1). (cyprotex.com)
  • Epithelium removal had no effect on the sensitivity of tracheal strips to papaverine or salbutamol, but significantly enhanced sensitivity to isoproterenol and sodium- nitroprusside. (cdc.gov)
  • Corticosterone pretreatment enhanced tissue sensitivity to isoproterenol but had no effect on tissue responses to either salbutamol or papaverine. (cdc.gov)
  • Effect of papaverine (A) and tamoxifen (B) on HepG2 cell loss when cells are grown in glucose or galactose media. (cyprotex.com)
  • Dit 'Founders Effect' verklaart wellicht het relatief hoog aantal afwijkingen bij pasgeborenen en jonge kinderen [3]. (cybele.be)
  • Spinal cord injury (SCI) is an inflammatory condition, and excessive adenosine triphosphate (ATP) is released into the extracellular space, which can be catabolized into adenosine by CD73. (biomedcentral.com)
  • The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. (silverchair.com)
  • The inhibition is presumably through its effects on the Kir6.0 subunit, but not on the SUR subunit, with the binding site different from adenosine triphosphate at the amino acid level. (silverchair.com)
  • ADENOSINE triphosphate-sensitive potassium (K ATP ) channels, which are widely distributed in many tissues, respond to alterations in the metabolic activity of the cell and thereby act as sensors of glucose and oxygen availability. (silverchair.com)
  • MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. (nih.gov)
  • Extracellular ATP can be catabolized into adenosine monophosphate (AMP) by CD39 rapidly, but the conversion of AMP to adenosine is limited by CD73 (ecto-5′-nucleotidase), the rate-limiting ecto-enzyme in extracellular AMP hydrolysis [ 11 ]. (biomedcentral.com)
  • 12. Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by CD-349, a novel 1,4-dihydropyridine derivative: effect of EGTA on the inhibitory activity. (nih.gov)
  • Adenosine monophosphate for injection can not use together with infusion with calcium as phosphate reacts with calcium ion. (wamin.com)
  • Papaverine (Latin papaver, 'poppy') is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm (especially those involving the intestines, heart, or brain), and occasionally in the treatment of erectile dysfunction. (salvavidaspharmaceutical.com)
  • Allina Vigorousness To the quick Oxygen & Medical Tack is accredited next to the Community Form Accreditation Program, Inc. Gallagher, P M, G Lowe, T Fitzgerald, A Bella, C M Greene, N G McElvaney, and S J O'Neill 2003 buy cialis jelly 20mg cheap erectile dysfunction papaverine injection. (aortolock.com)
  • Although the passage was closed, the entrance and exit of the base were even blocked, But it can be seen Papaverine erectile dysfunction no panic in the explorer base Those who can enter here are all best male enhancement pills in stores the Federation elite No matter how bad the situation is, they have seen too many, just closed Ear ringing and cialis always under construction. (unsoed.ac.id)
  • 9. Papaverine and Ro 20-1724 inhibit cyclic nucleotide phosphodiesterase activity and increase cyclic AMP levels in psoriatic epidermis in vitro. (nih.gov)
  • Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a neuromodulator, is involved in pain transmission and sensitization. (mdpi.com)
  • Extracellular cAMP can besequentially degraded into 50AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenoncalled extracellular cAMP-adenosine pathway. (ulaval.ca)
  • The sensitivity of denuded lung trachealis compared to intact trachealis to adenosine was increased significantly in the presence of the adenosine uptake and degradation inhibitors. (cdc.gov)
  • Using different family‐specific PDE inhibitors, we showed that in cauda epididymal and ejaculated spermatozoa, the major cAMP‐PDE activity was papaverine‐sensitive (44.5% and 57.5%, respectively, at 400 nm, papaverine is a specific inhibitor of the PDE10 family). (ulaval.ca)
  • Furthermore, A2aR and A 2b R inhibitors and A2bR knockdown cells were used to investigate the activated adenosine receptor. (biomedcentral.com)
  • This is further supported by the widespread use of caffeine, an adenosine receptor antagonist, in several headache treatments. (mdpi.com)
  • In vitro experiments, CD73+ hucMSC-EVs increased macrophages/microglia M2:M1 polarization, activated adenosine 2b receptor (A2bR), and then promoted cAMP/PKA signaling pathway. (biomedcentral.com)
  • As cAMP-adenosine pathway is involved in sperm capacitation, we hypothesize thatextracellular PDEs are functionally present in seminal plasma. (ulaval.ca)
  • Epithelium removal had no effect on the sensitivity of tracheal strips to papaverine or salbutamol, but significantly enhanced sensitivity to isoproterenol and sodium- nitroprusside. (cdc.gov)
  • Corticosterone pretreatment enhanced tissue sensitivity to isoproterenol but had no effect on tissue responses to either salbutamol or papaverine. (cdc.gov)
  • Using papaverine, we showed that it promotes tyrosine phosphorylation of sperm proteins, phosphorylation of Erk1 and Erk2, and Ca²+ release from Ca²+ store. (ulaval.ca)
  • Clinical evidence and rodent studies have suggested that adenosine signaling also plays a critical role in migraine headache. (mdpi.com)