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  • protein
  • NOVO CIB 's human adenosine kinase is an active and purified, 345-aa short form (14,2) ADK protein ( 39kDa) cloned by RT-PCR amplification of mRNA extracted from human hepatoma cells and expressed in E.coli . (novocib.com)
  • The data provide strong evidence that double-strand DNA ends capable of recruiting the DNA-dependent protein kinase complex are important intermediates in Ig V gene conversion. (cutelevision.org)
  • We used genetic inactivation of a double-strand break restoration protein (DNA-dependent protein kinase) inside a chicken B cell collection to indirectly test whether AID induces double-strand breaks in the antibody V genes. (cutelevision.org)
  • We conclude that physiological manifestation of AID causes the formation of double-strand DNA ends in antibody V genes, which look like prevented from participating in homologous recombination if they recruit DNA-dependent protein kinase. (cutelevision.org)
  • This effect is mediated by adenosine but not by changes in protein kinase C activity or its translocation. (ovid.com)
  • Upregulation
  • We therefore conclude that therapeutic strategies that augment the adenosine system after astrogliosis-induced upregulation of ADK constitute a neurochemical rationale for the prevention of seizures in epilepsy. (sigmaaldrich.com)
  • purine
  • The preparation was free of purine-metabolizing enzymes that could interfere in the assay of the kinase. (biochemj.org)
  • These innovative findings link radiation-induced changes in cognition and CNS functionality to altered purine metabolism and astrogliosis, thereby linking the importance of adenosine homeostasis in the brain to radiation injury. (frontiersin.org)
  • anti-inflammatory
  • ADK is also a validated target for Drug Discovery: adenosine-regulating drugs have been extensively tested(1) as new analgesic and anti-inflammatory agents(4) to treat schizophrenia(7) or to limit brain injury after an ischemic stroke(8). (novocib.com)
  • salvage
  • It can serve as a salvage mechanism for returning adenosine to nucleic acids. (curehunter.com)
  • An alternative way to produce dNTPs is via salvage biosynthesis where deoxyribonucleosides are taken up from outside the cell and phosphorylated by deoxyribonucleoside kinases. (diva-portal.org)