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Platelet aggregationCollagenTriphosphateAggregationPhosphateAdrenalineBindsArachidonic acidADAPALENEActivationAccumulationReceptorsActivatesSignificantlyMechanismResponseEnergyBodyEither adenosine diphosphatePlatelet AggregationArachidonicPlateletsSupraventricular tachycardiaNucleosideSVTsHypotensiveFlowReducesNodeOxygenTestHeartEffectsFoundShownMiddleAddition

Platelet aggregation7

• Ac.Cr inhibited platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), platelet-activating factor (PAF), epinephrine and Ca 2+ -ionophore. (jcimjournal.com)
• Effects of betel nut crude and pure compounds on human platelet aggregation Concentration-response curves show the inhibitory effect of (A) betel nut 70% aqueous-methanolic extract and (B) (+)-catechin, against platelet aggregation induced by agonists such as arachidonic acid (AA, 1.7 mmol/L), adenosine diphosphate (ADP, 4.3 μmol/L), platelet-activating factor (PAF, 8 nmol/L), epinephrine (20 μmol/L) and Ca2+-ionophore (10 μmol/L) in human venous blood. (jcimjournal.com)
• Epinephrine and adenosine-diphosphate induced platelet aggregation was determined … by optical aggregometry. (semcs.net)
• Results from weighted models indicated that platelet aggregation response to adenosine diphosphate 1.0 µmol/L was independently and positively associated with dementia risk, and it was preceded in importance only by age and hypertension. (nyu.edu)
• Platelet aggregation tests assess the ability of platelets to clump in response to the addition of various activators (eg, collagen, epinephrine , ADP, ristocetin). (msdmanuals.com)
• The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. (revespcardiol.org)
• Literature investigating prolactin's effect on adenosine diphosphate-mediated platelet aggregation along with clinical scenarios in which elevated prolactin is the only sound explanation for a venous thrombosis may make it a risk factor which should be checked following a patient history indicative of a prolactin derangement. (journalmc.org)

Collagen4

• Platelets in patients with the syndrome have abnormal aggregation with collagen, thrombin, epinephrine, and adenosine diphosphate (ADP). (medscape.com)
• The membrane of the cartridges are coated with collagen and adenosine diphosphate (ADP) or collagen and epinephrine inducing a platelet plug to form which closes the aperture. (wikipedia.org)
• Platelet function tests showed a decreased response to adenosine diphosphate (ADP), collagen, ristocetin and epinephrine - induced aggregation. (org.pk)
• This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)

Triphosphate7

• Approximately 40 percent of energy yielded from catabolic reactions is directly transferred to the high-energy molecule adenosine triphosphate (ATP). (bccampus.ca)
• Adenosine triphosphate (ATP) is the energy molecule of the cell. (bccampus.ca)
• a component of adenosine triphosphate and adenosine diphosphate. (adxs.org)
• This pump is driven by the energy stored in ATP (Adenosine TriPhosphate) molecules manufactured in the mitochondria. (benbest.com)
• adenosine diphosphate (ADP): a product of adenosine triphosphate (ATP) breakdown. (studygate.com)
• adenosine triphosphate (ATP): the chemical substance that serves as the currency of energy in cells. (studygate.com)
• Along the way, some of the energy stored in glucose is transferred to other molecules, such as ATP (adenosine triphosphate) and NADH (nicotinamide adenine dinucleotide). (stemcelldaily.com)

Aggregation2

• Out of the tested compounds, none of the compounds in betel nut showed any antiplatelet effect except for catechin that was the most potent against epinephrine-induced aggregation. (jcimjournal.com)
• RESULTS: Epinephrine-induced aggregation was completely inhibited in all ASA and MET concentrations in vitro. (semcs.net)

Phosphate3

• The products of this reaction are a molecule of adenosine diphosphate (ADP) and a lone phosphate group (P i ). (bccampus.ca)
• The liberation of phosphate from ATP is a source of cellular energy that results in ADP (Adenosine DiPhosphate) and hydrogen ion (acid). (benbest.com)
• The net breakdown of ATP from glycolysis results in ADP, AMP (Adenosine MonoPhosphate), phosphate, lactate and acid accumulation (acidosis). (benbest.com)

Adrenaline3

• The augmented glycolysis of sepsis (and during adrenergic therapy such as epinephrine/adrenaline or albuterol/salbutamol) is one of the causes of a raised lactate to consider when applying the LACTATES mnemonic I like to use. (resus.me)
• When faced with stressful and threatening situations, the body secretes the hormone adrenaline otherwise known as epinephrine. (sabongdepot.com)
• This is how naturally produced adrenaline or epinephrine revs up the body engine, for enhanced performance The major physiologic triggers of adrenaline release center upon stresses such as physical threat, excitement, noise, bright lights, and high ambient temperature. (sabongdepot.com)

Binds2

• Adenosine diphosphate binds to several G-protein receptors, including P2Y12 and P2X1 [7]. (eotp.org)
• Part of this adenosine is discharged from the cell and binds to adenosine receptors of neighboring cells, which is supposed to compensate for the disturbed balance between energy consumption and energy supply. (adxs.org)

Arachidonic acid1

• Activation involves release of adenosine diphosphate (ADP) from platelet storage granules and conversion of arachidonic acid to thromboxane A2 via a cyclooxygenase-mediated reaction. (msdmanuals.com)

ADAPALENE1

• 800mg 36 sp1998 adapalene + benzoyl peroxide cream 37 sp19171 adapalene + clindamycin gel 38 sp19177 adaplene gel 39 d11 adenosine 3mg / ml inj. (chhattisgarhtenders.net)

Activation1

• Epinephrine triggers the activation of a war machine in the body. (sabongdepot.com)

Accumulation1

• It is possible that elevated glucose and lactate levels in sepsis both may be measures of the same phenomenon: glucose accumulates due to the sympathomimetic response to a systemic infection with increased catecholamine levels leading to increased activity of the Na+K+-ATPase, resulting in accumulation of adenosine diphosphate (ADP). (resus.me)

Receptors3

• Adenosine receptors are closely associated with dopamine receptors and form heteromer s with them. (adxs.org)
• At the same time, adenosine modulates striatal DA release by stimulating glutamate release at adenosine receptors in the striatum , which increases dopamine levels. (adxs.org)
• Other receptors present in the muscles when activated by epinephrine cause the widening of blood vessels so that more blood can reach the muscles for efficient operation. (sabongdepot.com)

Activates1

• When epinephrine reaches the liver cells, it activates a receptor there which initializes a chain reaction that culminates into breaking down glycogen, releasing glucose into the bloodstream. (sabongdepot.com)

Significantly1

• Puerarin extract, daidzein and puerarin have obvious anti-arrhythmic effects on aconitine and barium chloride-induced arrhythmia, and puerarin can also significantly shorten the arrhythmia time induced by chloroform and epinephrine in rabbits. (sanxinherbs.com)

Mechanism1

• Through this mechanism, the increased level of adenosine after sleep deprivation could affect the light sensitivity of the circadian clock. (adxs.org)

Response1

• Sensitivity analyses showed associations with the same directionality for participants defined as adenosine diphosphate hyper-responders, as well as the platelet response to 0.1 µmol/L epinephrine. (nyu.edu)

Energy1

• Among other things, adenosine is used for autoregulation in the event of an imminent lack of energy in the cell (e.g. when the cell's performance is overloaded or when there is a lack of oxygen): If the ATP content in a cell drops, more adenosine is produced as a hydrolysis product. (adxs.org)

Body2

• Adenosine is found in almost all body cells. (adxs.org)
• Once epinephrine is secreted by the body in the endocrine glands, it flows in the bloodstream reaching various organ centers. (sabongdepot.com)

Either adenosine diphosphate2

• In vitro platelet responsiveness to either adenosine diphosphate (ADP) or epinephrine was lower at 6 a.m. (before the subjects arose) than at 9 a.m. (60 minutes after they arose). (nih.gov)
• In this phosphagen system, phosphate can be added to spent ATP-breaking the bonds cleaves off phosphate(s) and leaves either adenosine diphosphate (ADP) or adenosine monophosphate (AMP)-to quickly restore this energy molecule. (naturalproductsinsider.com)

Platelet Aggregation5

• The lowest concentration of these agents required to produce biphasic platelet aggregation decreased (i.e., aggregability increased) from a mean +/- SEM of 4.7 +/- 0.6 to 3.7 +/- 0.6 microM (P less than 0.01) for ADP and from 3.7 +/- 0.8 to 1.8 +/- 0.5 microM (P less than 0.01) for epinephrine. (nih.gov)
• Cr inhibited platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), platelet-activating factor (PAF), epinephrine and Ca 2+ -ionophore. (aku.edu)
• Results from weighted models indicated that platelet aggregation response to adenosine diphosphate 1.0 µmol/L was independently and positively associated with dementia risk, and it was preceded in importance only by age and hypertension. (nih.gov)
• 4. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. (nih.gov)
• 5. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. (nih.gov)

Arachidonic2

• Platelet reactivity in response to the agonists Arachidonic acid, Adenosine-diphosphate, Epinephrine and Thrombin-receptor activating protein was significantly reduced in the IUGR cohort. (bmj.com)
• Activation involves release of adenosine diphosphate (ADP) from platelet storage granules and conversion of arachidonic acid to thromboxane A2 via a cyclooxygenase-mediated reaction. (msdmanuals.com)

Platelets1

• 11. Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. (nih.gov)

Supraventricular tachycardia2

• In individuals with supraventricular tachycardia (SVT), adenosine is used to help identify and convert the rhythm. (mdwiki.org)
• In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. (infogalactic.com)

Nucleoside2

• [5] Adenosine is one of four nucleoside building blocks to RNA . (mdwiki.org)
• Adenosine is a purine nucleoside composed of a molecule of adenine attached to a ribose sugar molecule ( ribofuranose ) moiety via a β-N 9 - glycosidic bond . (infogalactic.com)

SVTs2

• Because of the effects of adenosine on AV node-dependent SVTs, adenosine is considered a class V antiarrhythmic agent . (mdwiki.org)
• Certain SVTs can be successfully terminated with adenosine. (infogalactic.com)

Hypotensive2

• Phenylephrine, a drug without β-1 effects, was associated with decreased ventricular performance and ventriculoarterial uncoupling, whereas epinephrine and norepinephrine improved global hemodynamics and myocardial function in severely hypokinetic and hypotensive experimental septic shock. (asahq.org)
• ANAPHYLACTIC SHOCK� Give 0.5 mg (0.5 ml of 1:1000) epinephrine intramuscular (IM)(given intravenous [IV] if there is no central pulse or if severelyunwell) if any compromise in airway (stridor, tongue swelling),breathing (low oxygen saturations, wheeze) or circulation(hypotensive, pale, clammy). (dokumen.tips)

Flow2

• Adenosine also plays a role in regulation of blood flow to various organs through vasodilation . (infogalactic.com)
• The administration of adenosine also reduces blood flow to coronary arteries past the occlusion. (infogalactic.com)

Reduces1

• Epinephrine increases glycogenolysis, reduces glucose up take by tissues, and inhibits insulin release in the pancreas, resulting in hyperglycemia and increased blood lactic acid. (ncats.io)

Node2

• Fast rhythms of the heart that are confined to the atria (e.g., atrial fibrillation , atrial flutter ) or ventricles (e.g., monomorphic ventricular tachycardia ) and do not involve the AV node as part of the re-entrant circuit are not typically converted by adenosine. (mdwiki.org)
• When it is administered intravenously, adenosine causes transient heart block in the atrioventricular (AV) node . (infogalactic.com)

Oxygen2

• Heart rate, myocardial oxygen consumption, and arrhythmia incidence were furthermore increased in the epinephrine group. (asahq.org)
• Nevertheless, epinephrine was associated with increased myocardial oxygen consumption. (asahq.org)

Test3

• In a lab test called aggregometry, platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP). (wikipedia.org)
• Adenosine is used as an adjunct to thallium (TI 201) or technetium (Tc99m) myocardial perfusion scintigraphy (nuclear stress test) in people unable to undergo adequate stress testing with exercise. (mdwiki.org)
• This feature allows physicians to use adenosine to test for blockages in the coronary arteries, by exaggerating the difference between the normal and abnormal segments. (infogalactic.com)

Heart1

• When adenosine is used to cardiovert an abnormal rhythm, it is normal for the heart to enter ventricular asystole for a few seconds. (mdwiki.org)

Effects1

• Epinephrine also alleviates pruritus, urticaria, and angioedema and may relieve gastrointestinal and genitourinary symptoms associated with anaphylaxis because of its relaxer effects on the smooth muscle of the stomach, intestine, uterus and urinary bladder. (ncats.io)

Found1

• Adenosine is a chemical found in mammals which is also used as a medication. (mdwiki.org)

Shown1

• It has been shown in liver slices that epinephrine and glucagon displace this balance in favor of the active phosphorylase (5, 6). (nih.gov)

Middle1

• Most ideal site to inject IM epinephrine is the middle third of thighon the anterolateral aspect. (dokumen.tips)

Addition1

• In addition, atrial tachycardia can sometimes be terminated with adenosine. (mdwiki.org)