TriphosphateMonophosphateDerivativesInhibitorReceptorsKinaseDiphosphateNucleoside analogPurineInhibitorsInhibitsInhibitionBroad-spectrumNucleotidesNucleotide analogEnzymeActivatesCofactorSubstrateReceptorPotentTransition-stateIncreasesMechanismBindingBiologicalTermsFoundPresenceAdministrationFormationDrugSeriesResponseResultsStudy
Triphosphate9
- EC 2.7.1.20) is an enzyme that catalyzes the transfer of gamma-phosphate from Adenosine triphosphate (ATP) to adenosine (Ado) leading to formation of Adenosine monophosphate (AMP). (wikipedia.org)
- cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway . (wikipedia.org)
- These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery (Mizuguchi, 2004). (sdbonline.org)
- To counteract constraints imposed by nucleosome structure, cells deploy two major classes of multiprotein enzymes, which covalently modify the nucleosome core histones or catalyze nucleosome mobility in an adenosine triphosphate (ATP)-dependent fashion. (sdbonline.org)
- In the first project, I examined the nucleotide binding reaction of CheA using the fluorescent nucleotide analogue, TNP-ATP [2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate]. (umd.edu)
- Two dissociable phases in the contractile response of the guinea pig isolated vas deferens to adenosine triphosphate. (cdc.gov)
- The effects of ATP (adenosine 5' triphosphate) analogs on gross cochlear potentials and single primary afferent discharge properties were studied by intracochlear perfusion in anesthetized guinea pigs. (edu.au)
- The small molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. (fipdoctor.com)
- Depolymerisation of F-actin to G-actin and its repolymerisation in the presence of analogs of adenosine triphosphate. (mpg.de)
Monophosphate6
- GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. (nih.gov)
- Cyclic adenosine monophosphate ( cAMP , cyclic AMP , or 3',5'-cyclic adenosine monophosphate ) is a second messenger , or cellular signal occurring within cells, that is important in many biological processes. (wikipedia.org)
- Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). (wikipedia.org)
- FUNCTION: ATP dependent phosphorylation of adenosine and other CC related nucleoside analogs to monophosphate derivatives. (linuxfocus.org)
- Dietary nucleotides [inclusion adenosine 5'-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. (foodandnutritionresearch.net)
- The exact mechanism of salivary secretion is not completely understood but is believed to be under the influence of a cyclic AMP (adenosine 3,'5'-cyclic monophosphate) and a calcium-activated phosphorylation mechanism. (medscape.com)
Derivatives1
Inhibitor3
- The ground-state analogue inhibitor purine riboside appears to bind at a rate comparable to that of adenosine. (wustl.edu)
- VIREAD is a nucleotide analog HIV-1 reverse transcriptase inhibitor and an HBV reverse transcriptase inhibitor. (nih.gov)
- GC60899 Hibifolin Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. (glpbio.cn)
Receptors3
- These results suggest that spinal antinociception by adenosine analogs: 1) occurs primarily at a postsynaptic site of action (capsaicin results), and 2) is dependent on release of endogenous noradrenaline and activation of spinal adrenergic receptors (6-hydroxydopamine and phentolamine results). (aspetjournals.org)
- 3 A non-speci®c adenosine receptor agonist 2-chloroadenosine (CAD) resulted in biphasic response with a small contraction at lower concentrations (1079 ±1078 M) followed by a signi®cant relaxation at higher concentration in endothelium-intact SHR tissues suggesting presence of both A1 and A2 adenosine receptors in SHR aorta. (uncg.edu)
- Agonists of adenosine A2A receptors (A2AR) reduce cytokine release from most immune cells. (bvsalud.org)
Kinase6
- AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). (stemcell.com)
- 43, Last annotation update) DE Adenosine kinase (EC 2.7.1.20) (AK) (Adenosine 5'-phosphotransferase). (linuxfocus.org)
- RT "Cloning of human adenosine kinase cDNA: sequence similarity to RT microbial ribokinases and fructokinases. (linuxfocus.org)
- RT "Cloning and characterization of cDNA for adenosine kinase from RT mammalian (Chinese hamster, mouse, human and rat) species. (linuxfocus.org)
- RT "Cloning and expression of the adenosine kinase gene from rat and RT human tissues. (linuxfocus.org)
- RT "Structure of human adenosine kinase at 1.5-A resolution. (linuxfocus.org)
Diphosphate2
- A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. (bvsalud.org)
- This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
Nucleoside analog3
- Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern. (nih.gov)
- Our model correctly predicts for HIV-1 that resistance against nucleoside analog reverse transcriptase inhibitors (NRTIs) can be conferred by decreasing their incorporation rate, increasing their excision rate, or decreasing their affinity for the polymerase enzyme. (plos.org)
- Through mathematical modeling, we assess the mechanisms by which HIV-1 can develop resistance against nucleoside analog reverse transcriptase inhibitors (NRTI). (plos.org)
Purine1
- ADA (adenosine deaminase) is a deaminating enzyme that plays a key role in the purine metabolism. (glpbio.cn)
Inhibitors2
- We have studied the effects of viscosogenic agents, sucrose and ficoll, on (1) the hydrolysis of adenosine and of 6-methoxypurine riboside catalyzed by adenosine deaminase and (2) the rates of association and dissociation of ground-state and transition-state analogue inhibitors. (wustl.edu)
- However, the slower rates of association (0.16-2.5 μM -1 s -1 ) and dissociation (5 X 10 -6 to 12 s -1 ) of transition-state analogue inhibitors are affected by the viscosity of the medium to approximately the same extent as the encounter-controlled rates of association and dissociation of adenosine. (wustl.edu)
Inhibits1
- Here we show that BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. (flutrackers.com)
Inhibition3
- von Kleist M, Metzner P, Marquet R, Schütte C (2012) HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection. (plos.org)
- The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
- Inhibition of ATPase with a disulfide analog of ATP. (mpg.de)
Broad-spectrum2
- Structure and HPLC chromatograms of cordycepin and the broad-spectrum adenosine-analog. (spandidos-publications.com)
- D) Structure of the broad-spectrum adenosine-analog. (spandidos-publications.com)
Nucleotides1
- Serves as CC a potential regulator of concentrations of extracellular adenosine CC and intracellular adenine nucleotides. (linuxfocus.org)
Nucleotide analog2
- Nucleotide analog interference mapping of the hairpin ribozyme: implications for secondary and tertiary structure formation. (umassmed.edu)
- Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping. (umassmed.edu)
Enzyme1
- A two-step mechanism, a weak prior-equilibrium binding step followed by a viscosity-dependent enzyme conformation change, seems to adequately account for both the low absolute magnitude and the viscosity dependence of the apparent second-order rate constants for transition-state analogue binding. (wustl.edu)
Activates1
- This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA. (emdmillipore.com)
Cofactor1
- The presence of the zinc cofactor and the precise structure of the bound analog were not previously known. (rcsb.org)
Substrate2
- Thus, the bimolecular rate constant, V max /K m = 11.2 ± 0.8 μM -1 s -1 , for the reaction with adenosine is found to be at the encounter-controlled limit while that for the reaction with the poor substrate 6-methoxypurine riboside, 0.040 ± 0.004 μM -1 s -1 , is limited by some other process. (wustl.edu)
- These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. (fipdoctor.com)
Receptor2
Potent1
- Apadenoson is a potent and selective anti-inflammatory adenosine analog that reduces inflammation. (bvsalud.org)
Transition-state1
- The crystal structure of a murine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine ribonucleoside, a nearly ideal transition-state analog, has been determined and refined at 2.4 angstrom resolution. (rcsb.org)
Increases1
- In agreement with previous reports on ATP-gamma-S, it was found that all ATP analogs produced significant increases in the DC potential in scala media (endocochlear potential, EP). (edu.au)
Mechanism1
- To determine the mechanism of action of third generation methylenecyclopropane nucleoside analogs (MCPNAs), DNA sequencing of HSV-1 isolates resistant to third generation MCPNAs resulted in the discovery of G841S and N815S mutations in HSV-1 UL30. (researchgate.net)
Binding1
- Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
Biological1
- Dual computational and biological assessment of some promising nucleoside analogs against the COVID-19-Omicron variant. (cdc.gov)
Terms1
- The reduction in the effect of morphine by capsaicin (removes a source of adenosine release) and phentolamine (antagonizes the action of endogenously released adenosine) can be explained in terms of the adenosine release hypothesis of morphine action within the spinal cord. (aspetjournals.org)
Found2
- For adenosine, V max /K m is found to be inversely proportional to the relative viscosity with sucrose, an agent affecting the microscopic viscosity, while no effect is found with Ficoll, an agent affecting the macroscopic viscosity. (wustl.edu)
- This study has found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. (sdbonline.org)
Presence1
- Here we report the reconstruction using single-particle cryo-electron microscopy of the complex between subunits BchD and BchI of Rhodobacter capsulatus Mg-chelatase in the presence of ADP, the nonhydrolyzable ATP analog AMPPNP, and ATP at 7.5 A, 14 A, and 13 A resolution, respectively. (lu.se)
Administration1
- Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine. (aspetjournals.org)
Formation1
- The 6R isomer of the analog is very tightly held in place by the coordination of the 6-hydroxyl to the zinc and the formation of nine hydrogen bonds. (rcsb.org)
Drug1
- Nucleoside analogs ( NA s) represent an important drug class for the treatment of viral infections and cancer. (plos.org)
Series2
- A Series of Adenosine Analogs as the First Efficacious Anti-SARS-CoV-2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study. (cdc.gov)
- Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study. (cdc.gov)
Response2
- 2 In phenylephrine contracted aortic rings concentration-response curves were constructed by cumulative additions (10711 ±1075 M) of (2S)-N6-[2-endo-Norbornyl] adenosine (ENBA) N6- cyclopentyladenosine (CPA) R-N6-(2-phenylisopropyl) adenosine (R-PIA) 2-p-(-2-carboxyethyl) phenethylamino-5'-N-thylcarboxamido adenosine (CGS-21680). (uncg.edu)
- 8 These data suggest that the contractile response to adenosine analogues in SHR aorta is probably mediated by free radicals which are generated through the increased cyclo-oxygenase ctivity occurring in the vascular endothelium of SHR but not the WKY rats. (uncg.edu)
Results2
- This ddATP analog also contains a 1-Thiotriphosphate which results in a nuclease resistant phosphorothioate linkage. (trilinkbiotech.com)
- Our results, taken together, indicate that astrocyte-derived ATP may be hydrolyzed into adenosine by TNAP, which may in turn act on VLPO neurons to promote sleep. (jneurosci.org)