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  • axin
  • The APC binds to β-catenin, axin and glycogen synthase kinase 3β to form a large protein complex, in which β-catenin is phosphorylated and broken down, resulting in negative regulation of the Wnt signaling pathway. (springer.com)
  • neuronal
  • Through its C-terminus, APC binds to post-synaptic density discs large zonula occludens domain-containing proteins, such as discs large (DLG) and post-synaptic density (PSD)-95, and may play important roles in epithelial morphogenesis, brain development and neuronal functions. (springer.com)
  • amino
  • The APC gene encodes a 300-kD protein, consisting of 2,843 amino acids, which has several structural domains. (rupress.org)
  • The middle part of the protein contains three successive 15-amino acid (aa) repeats, followed by seven related but distinct 20-aa repeats. (rupress.org)
  • This mutation replaces the amino acid isoleucine with the amino acid lysine at position 1307 in the APC protein (written as Ile1307Lys or I1307K). (nih.gov)
  • tumour
  • Consistent with the idea that such dominant effects are normally balanced by interactions within the full-length molecule, protein interactions of N-terminal fragments expressed in tumour cells can be altered by binding to C-terminal regions of APC commonly lost in tumours. (biochemsoctrans.org)
  • Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (ebi.ac.uk)
  • putative
  • In addition, RINGdb offers various user-friendly query functions to answer different questions about RGS proteins and GPCRs such as their possible contribution to disease processes, the putative direct or indirect relationship between RGS proteins and GPCRs. (biomedcentral.com)
  • mutant
  • All mutant proteins lack the COOH-terminal half, suggesting that some growthsuppressing or growth-regulating activity is present in this part of the molecule ( 39 ). (rupress.org)
  • All truncated APC proteins lack most of the 20-aa repeats, but the majority of the somatic mutant APC proteins seem to have retained the 15-aa repeats and β-catenin-binding activity ( 39 ). (rupress.org)
  • vitro
  • In addition to these pioneering works, an intimate relationship between APC protein and MTs (or MT-dependent cell migration) has been suggested from both in vitro and in vivo observations. (rupress.org)
  • cellular
  • The structure of the APC protein provides many hints about its possible cellular function. (rupress.org)
  • The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. (nih.gov)
  • This short protein cannot suppress the cellular overgrowth that leads to the formation of abnormal growths (polyps) in the colon, which can become cancerous. (nih.gov)
  • eukaryotic
  • One key factor that both signals the presence of genotoxic stress and serves to minimize DNA damage is RPA, the eukaryotic single-stranded DNA-binding protein. (nyu.edu)
  • accessory
  • These cytoskeletal systems differ from each other in a variety of fundamental ways, and each is associated with characteristic accessory and regulatory proteins. (keystonesymposia.org)
  • cells
  • We expressed green fluorescent protein (GFP)-fusion proteins with full-length and deletion mutants of Xenopus APC in Xenopus epithelial cells, and observed their dynamic behavior in live cells. (rupress.org)
  • The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (nih.gov)
  • cancer
  • The finding that a protein involved in kinetochore-MT attachment is required for the viability of polyploids has potential implications for cancer therapeutics. (rupress.org)