• In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
  • Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. (nih.gov)
  • CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
  • Primary mucinous carcinoma of the skin is a rare malignant tumour originating from the sweat glands. (regionh.dk)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Pseudomyxoma Peritonei ( PMP ) is a more common name given to the "jelly belly" syndrome caused by mucinous adenoma and mucinous adenocarcinoma. (cancerindex.org)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • Minimal deviation adenocarcinoma (MDA) of mucinous type (adenoma malignum) is considered an extremely well differentiated variant of GAS and is encompassed within the category of GAS. (nih.gov)
  • Adenoma malignum of uterine cervix also referred as minimal deviation adenocarcinoma is a rare variant of cervical mucinous adenocarcinoma. (planetayurveda.net)
  • Adenoma Malignum is often correlated with Peutz-Jeghers syndrome and mucinous tumours of the ovary. (planetayurveda.net)
  • An adenoma is a tumour of epithelial tissue with or without glandular characteristics. (planetayurveda.net)
  • Adenoma is a tumour of glandular tissue originating from the mucosa of uterus, small intestine or colon, in which tumour cells start to grow, these adenomas may be pedunculated or sessile too. (planetayurveda.net)
  • Rat Muc4, a homologue of human MUC4, has been extensively studied in mammary gland tumours and has been shown to play an important role in epithelial growth, cell differentiation, cell-cell adhesion, metastasis, and tumour apoptosis. (bmj.com)
  • The most frequently encountered neoplastic pancreatic cysts include intraductal papillary mucinous neoplasm (IPMN), serous cystadenoma (SCA), mucinous cystic neoplasm with ovarian stroma (MCN), and solid pseudopapillary epithelial neoplasm. (medscape.com)
  • The histopathological examination of the mass of the ampulla of Vater demonstrated intraductal papillary mucinous neoplasm. (ispub.com)
  • After surgery, the histopathological examination of the mass of the ampulla of Vater demonstrated an intraductal papillary mucinous neoplasm (Figure 2). (ispub.com)
  • Note the smooth external contour typical of a mucinous cystic neoplasm. (medscape.com)
  • Papillary, mucinous and solid types may occur. (wikidot.com)
  • The tumors may be entirely benign, as are mucinous cystadenomas or intraductal papillary mucinous adenomas. (medscape.com)
  • Twelve of 50 malignant salivary gland tumours were aneuploid. (researchgate.net)
  • The most obvious value of DNA flow cytometry in salivary gland tumours is thus its contribution to assist histopathology in identifying potentially malignant lesions. (researchgate.net)
  • No such occupational association has been shown for the sinonasal non-intestinal type adenocarcinomas or salivary gland tumours. (wikidot.com)
  • This study on 279 tumours of the salivary glands was conducted to analyse whether the assessment of DNA ploidy by flow cytometry may assist histopathology in discriminating benign from malignant types of tumours. (researchgate.net)
  • Malignant cystadenocarcinoma and intramedullary mucinous carcinomas may be further subdivided into noninvasive and invasive types. (medscape.com)
  • Lung cancer is the most common cause of global cancer-related mortality, leading to over a million deaths each year and adenocarcinoma is its most common histological type. (nature.com)
  • Postoperative histological examination showed infiltrative mucinous adenocarcinoma of the rectum pT3 N0 M0 L0 V0 R0 G3, Astler - Coller B1. (biomedcentral.com)
  • Most of this classification is based on the histological characteristics of tumours seen in surgical or needle biopsy, and is primarily based on light microscopy, although immunohistochemistry and electron microscopy findings are provided when necessary. (ersjournals.com)
  • Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. (figshare.com)
  • Oncogenic (high-risk) human papillomavirus (HPV) infection is implicated in the development of approximately 90% of all cervical adenocarcinomas. (nih.gov)
  • Its occurrence rate is about 1-3% of all cervical adenocarcinomas. (planetayurveda.net)
  • Primary adenocarcinomas of the vulva are rare and especially the villoglandular mucinous adenocarcinoma of intestinal type is rare variant of vulvar adenocarcinoma. (hindawi.com)
  • In the published articles [ 2 ], intestinal type mucinous adenocarcinoma was also taken as a synonymous with villoglandular mucinous adenocarcinoma. (hindawi.com)
  • Intestinal type sinonasal adenocarcinoma is far more frequent in men, likely due to an occupational aetiology. (wikidot.com)
  • There is a strong association between woodworking and the intestinal type adenocarcinoma. (wikidot.com)
  • Unlike most other sinonasal tumours, the intestinal type and non-intestinal type adenocarcinomas are more frequent in the ethmoid sinus than the maxillary sinus. (wikidot.com)
  • We collected 76 surgically resected primary tumors of invasive lung adenocarcinoma, including 51 IMA and 25 non-mucinous adenocarcinomas (non-IMA). (figshare.com)
  • Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature. (nih.gov)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • Comparison of sFRP4 expression in tumour biopsies revealed a positive trend between sFRP4 expression and tumour grade, with mucinous cyst adenocarcinomas exhibiting significantly decreased sFRP4 levels compared to mucinous borderline tumours. (biomedcentral.com)
  • Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. (nih.gov)
  • It is often misdiagnosed clinically since it has an uncharacteristic and variable presentation, and microscopically because it resembles a cutaneous metastasis from the more frequent mucinous adenocarcinomas of the colon, mammae, lungs and ovaries. (regionh.dk)
  • Although all morphologic variants of IPMN can progress to cancer, invasive adenocarcinoma originating in gastric-type IPMNs is associated with a significantly worse survival rate than that originating from other types of IPMNs. (medscape.com)
  • Metastasis of adenocarcinoma was confirmed histologically, and local excision was performed. (biomedcentral.com)
  • A small 0.5 cm diameter ulcer on the upper lip developed after 42 months following the removal of the primary tumor, and biopsy confirmed metastasis of the colorectal adenocarcinoma (Figure 1a . (biomedcentral.com)
  • Patients who maintained high immunoreactivity for anti-MUC1 antibody had a better prognosis, whereas those with an increase in anti-MUC3 immunoreactivity had a poorer prognosis, as judged by tumour size, serosal invasion, and metastasis. (bmj.com)
  • Low grade tumours have an acinar glandular architecture with minimal stroma. (wikidot.com)
  • In 1994, the WHO adopted the International Association for the Study of Lung Cancer (IASLC) pathology panel to comprise the core membership of the WHO committee, to develop a new revised classification of lung and pleural tumours. (ersjournals.com)
  • These tumours generally demonstrate a cribriform/cystic archictecture and invade extensively through bone, accounting for poor prognosis. (wikidot.com)
  • The group of benign tumours included 164 pleomorphic adenomas, 51 Warthin's tumours, 7 basal cell adenomas, 2 lipomas as well as 5 other different tumours. (researchgate.net)
  • We present a case with regional lymph node metastases five years after excision of the primary tumour. (regionh.dk)
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
  • Smoking is the major cause of lung adenocarcinoma but, as smoking rates decrease, proportionally more cases occur in never-smokers (defined as less than 100 cigarettes in a lifetime). (nature.com)
  • Our efforts focused on comprehensive, multiplatform analysis of lung adenocarcinoma, with attention towards pathobiology and clinically actionable events. (nature.com)
  • We analysed tumour and matched normal material from 230 previously untreated lung adenocarcinoma patients who provided informed consent ( Supplementary Table 1 ). (nature.com)
  • The incidence of these tumours has increased by 54% during the past decade, reaching 0.97 cases per 100,000 population in the USA, probably indirectly related to the higher use of computed tomography (CT) scan that allows early diagnosis in asymptomatic patients [ 1 ]. (karger.com)
  • Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
  • Immunohistochemistry and electron microscopy are invaluable techniques for diagnosis and subclassification, but our intention was to render the classification simple and practical to every surgical laboratory, so that most lung tumours could be classified by light microscopic criteria. (ersjournals.com)
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
  • The ability of a tumour marker to predict response to chemotherapy cannot be determined from a patient series in which some patients were specifically selected for chemotherapy and others were not. (biomedcentral.com)
  • In a patient who had been diagnosed in 2006 with appendiceal adenocarcinoma with peritoneal metastases after an incomplete surgery, palliative chemotherapy was administered. (karger.com)
  • Third-line chemotherapy combining capecitabine plus bevacizumab was started, achieving good control of the tumour growth and a minor response in the second computed tomography scan. (karger.com)
  • GAS has a much poorer prognosis than HPV-associated cervical adenocarcinoma, with propensity for presentation at advanced stage and wide dissemination to unusual sites such as the ovary, omentum and peritoneum. (nih.gov)
  • Skin metastases in the face from colorectal cancer are very rare and may indicate tumour relapse several years after primary resection. (biomedcentral.com)
  • Studies of tumours at relapse have demonstrated expression of a T790M mutation in exon 20 of the EGFR TK domain in approximately 50% of cases. (bmj.com)
  • We further examined sFRP4 expression in human ovarian tumours to assess if its expression could be correlated with clinico-pathological features consistent with a proposed role for loss being a contributor to chemoresistance. (biomedcentral.com)
  • There are a range of different types of tumours and cancers which can start in the appendix. (cancerindex.org)
  • Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)
  • Supplementary Table 3 summarizes molecular estimates of tumour cellularity 16 . (nature.com)
  • High grade tumours have a solid growth pattern with minimal gland formation. (wikidot.com)
  • The exact incidence of the subtypes of adenocarcinoma is difficult to assertain. (wikidot.com)
  • 2 ], who observed an increase in the incidence in the last decades, especially in women, and again mucinous adenocarcinoma being the one with the highest prevalence (48%), pointing to an increased incidence of mucinous adenocarcinoma in men (1.0 per million person-years) and women (1.9 per million person-years). (karger.com)
  • Tumour-associated activating mutations in EGFR can identify patients with NSCLC who are likely to have a good response to TKIs. (bmj.com)
  • A number of techniques have been employed for genotypic assessment of tumour-associated DNA to identify EGFR mutations, each of which has advantages and disadvantages. (bmj.com)
  • 3, 4 Several tumour vaccines directed against MUC1 core protein, oligosaccharides, or MUC1 cDNAs have been shown to stimulate immune reactions in basic clinical trials to confer antitumour activity. (bmj.com)
  • Recent developments in technology may make the monitoring of changes in patients' tumour genotypes easier in clinical practice, which may enable patients' treatment regimens to be tailored during the course of their disease, potentially leading to improved patient outcomes. (bmj.com)
  • DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. (nature.com)
  • Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • An international system of tumour classification is important for consistency in patient treatments and to provide the basis of epidemiological and biological studies. (ersjournals.com)
  • The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
  • Treatment varies according to the type and stage of tumour. (cancerindex.org)
  • These tumours are either low or high grade. (wikidot.com)