AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AdenocarcinomaNeoplastic Stem CellsPancreatic NeoplasmsGliomaEsophageal NeoplasmsNeoplasmsCell Line, TumorLung NeoplasmsStomach NeoplasmsTumor Markers, BiologicalImmunohistochemistryIncidenceMammary Neoplasms, ExperimentalCarcinogensAdenocarcinoma, Mucinous9,10-Dimethyl-1,2-benzanthraceneColonic NeoplasmsNeoplasms, ExperimentalAdenocarcinoma, PapillaryCarcinoma, Pancreatic DuctalBarrett EsophagusAdenocarcinoma, Bronchiolo-AlveolarMethylnitrosoureaCardiaCocarcinogenesisCarcinogenicity TestsTumor BurdenAnticarcinogenic AgentsRats, Inbred F344Intestinal NeoplasmsAzoxymethaneCarcinoma, Squamous CellPrecancerous ConditionsNeoplasm StagingGene Expression Regulation, NeoplasticSkin NeoplasmsTumor Suppressor Protein p53PapillomaCell Transformation, NeoplasticPrognosisAdenomaTime FactorsGenes, rasMammary Neoplasms, AnimalCecal NeoplasmsNeoplasm MetastasisTumor Necrosis Factor-alphaCell ProliferationNeoplasm TransplantationEsophagogastric JunctionDisease ProgressionDNA, NeoplasmRetrospective StudiesNeoplasms, Multiple PrimaryMice, NudeSurvival RateImmunoenzyme TechniquesCell DivisionGenes, Tumor SuppressorKeratin-7RNA, MessengerEndometrial NeoplasmsLiver Neoplasms1,2-DimethylhydrazineTransplantation, HeterologousCarcinoid TumorReverse Transcriptase Polymerase Chain ReactionMice, TransgenicTreatment OutcomeSurvival AnalysisNeoplasm ProteinsProstatic NeoplasmsMutationMice, Inbred BALB CNeoplasms, Radiation-InducedTumor Suppressor ProteinsNitrosaminesMice, Inbred C57BLDisease Models, AnimalBrain NeoplasmsLiver Neoplasms, ExperimentalAntigens, NeoplasmCroton OilDimethylnitrosamineTumor Cells, CulturedDose-Response Relationship, DrugNeovascularization, PathologicLymphatic MetastasisDuodenal NeoplasmsApoptosisRisk FactorsAntineoplastic AgentsDimethylhydrazinesWilms TumorGene Expression ProfilingColorectal NeoplasmsNeuroendocrine TumorsRectal NeoplasmsEsophagusOvarian Neoplasms
MetastaticSolid tumorsMortalityResectionClinicallyBenignTumoursStromalBehaviorMutationsNeoplasmsDiagnosisGastricInfiltrateCarcinomaAngiogenesisTissueLungIntraperitonealClassificationSurvivalPrimaryGrowthApproachesImportantClinicalCellsGradeCommonDiseaseCancerYearsAccountCentralGenerallySignificantEffectsStudies
Metastatic2
  • NT has shown to exert numerous oncogenic effects involved in tumour growth and metastatic spread. (springer.com)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
Solid tumors1
  • In children under 14 years old, CNS tumors are the most frequent solid tumors, and half of the cases occur in infants 0-4 years old [ 1 - 3 ]. (hindawi.com)
Mortality3
  • Colorectal cancer (CRC) is a worldwide health problem that ranks third in incidence and fourth in mortality with an estimated 1.2 million cases and 0.6 million deaths annually. (springer.com)
  • This report details the preventive strategies aimed at reducing the incidence and mortality of large bowel cancer by nutritional manipulation and chemopreventive agents. (aacrjournals.org)
  • This lecture summarizes our approaches to the reduction of the incidence and mortality of colorectal cancer by nutritional manipulation and chemopreventive agents. (aacrjournals.org)
Resection2
  • The classification system establishes guidelines for surgical approaches to tumor resection. (wikipedia.org)
  • All patients underwent curative resection of pancreatic adenocarcinoma without evidence of intraperitoneal disease. (cancernetwork.com)
Clinically3
  • Additionally, genetic analysis of the tumor may yield mutations that may be clinically significant, as described below. (wikipedia.org)
  • However, they are both clinically and histologically heterogeneous, and tumor recurrence or anaplastic progression occurs in some cases [ 6 ]. (hindawi.com)
  • The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)
Benign5
  • Gangliogliomas are generally benign WHO grade I tumors, most commonly located in the temporal lobes of children and young adults. (hindawi.com)
  • Methods: Flow cytometric analysis of DNA pliody and S-Phase Fraction (SPF) was done in 50 fresh tumor tissue sections of SGTs which diagnosed as 15 benign and 35 malignant tumors. (researchgate.net)
  • Results: 93.3% of the benign SGTs tumors were diploid, while only 34% of malignant tumors were diploid and 66% were aneuploid. (researchgate.net)
  • The malignant SGTs had higher SPF than the benign tumors but with no significant difference. (researchgate.net)
  • The 5 year disease-free survival (DFS) per tumor origin was: 94% for PMP-LG, 85% for PMP-HG, 100% for benign multicyst peritoneal mesothelioma (MPM), 37.4% for colonic origin, and 54%(at 3 years) for ovarian origin. (unav.edu)
Tumours2
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
Stromal3
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Gastrointestinal stromal tumors (GISTs) account for less than 1% of GI tumors, but they are the most common mesenchymal neoplasms of the GI tract. (medscape.com)
  • Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
Behavior3
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • S-phase value is correlated with the behavior of the tumors [13, 14]. (researchgate.net)
  • Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)
Mutations3
  • Numerous genes harboring somatic coding mutations and copy number changes in the microsatellite stable (MSS) OGJ adenocarcinomas are also known to be altered with similar predicted functional consequence in other tumour types. (wikipedia.org)
  • Our study found that BRAF V600E mutations are moderately frequent in PA and GG and that for these tumor entities, IHC VE1 is suitable for screening purposes, but all negative, equivocal, and weak positive cases should be further tested with molecular biology techniques, of which the Idylla system seems to be a promising tool. (hindawi.com)
  • One of the mutations that has aroused considerable interest in recent years concerns the BRAF (v-raf murine sarcoma viral oncogene homolog B) gene that encodes the protein belonging to a highly oncogenic RAS/RAF/MEK/ERK signaling pathway [ 9 ]. (hindawi.com)
Neoplasms1
  • Brain tumors are a diverse group of neoplasms arising from different cells within the CNS or from primary tumors of other organs that spread to the CNS. (hindawi.com)
Diagnosis2
  • Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
  • This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)
Gastric3
Infiltrate2
  • Siewart described three different categories of OGJ adenocarcinoma, all based upon anatomic location: A Type I tumor, located between 5 and 1cm proximal to the OGJ, is an adenocarcinoma that typically arises from an area of intestinal metaplasia of the esophagus and can infiltrate the OGJ from above. (wikipedia.org)
  • Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)
Carcinoma2
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Angiogenesis1
  • The serine/threonine protein kinase BRAF is an important player in the mitogen-activated protein kinase (MAPK) signaling pathway that transduces mitogenic signals from activated cell-surface growth factor receptors to the cell nucleus and as a result modulates many important cellular processes, such as tumor growth, differentiation, proliferation, and angiogenesis. (hindawi.com)
Tissue4
  • The diagnostic workup for OGJ adenocarcinoma usually involves performing an endoscopy with endoscopic biopsy of suspicious looking tissue. (wikipedia.org)
  • Accurate staging of tumor extent and involvement of surrounding tissue or distant metastases is critical to establishing a prognosis, and is usually guided by endoscopic ultrasound, computed tomography scans, and/or positron emission tomography scans to establish the extent of disease. (wikipedia.org)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
Lung1
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
Intraperitoneal1
  • The laparoscopic approach for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (L-CRS + HIPEC) in highly selected patients was previously reported from the PSOGI registry with a demonstrable reduction in length of stay and post-operative morbidity. (unav.edu)
Classification3
  • There is no standardized system for the classification of OGJ adenocarcinoma. (wikipedia.org)
  • The Siewart classification system is a classification scheme used for OGJ adenocarcinomas that has been adopted by many clinicians. (wikipedia.org)
  • An international system of tumour classification is important for consistency in patient treatments and to provide the basis of epidemiological and biological studies. (ersjournals.com)
Survival2
  • Treatment options for adenocarcinomas involving the oesophagogastric junction are limited and the overall prognosis is extremely poor, with a five-year survival rate of approximately 30% with surgery alone. (wikipedia.org)
  • Notably, up to one third of OGJ adenocarcinomas have been found to have human epidermal growth factor receptor 2 (HER2) overexpression or amplification, which may be targetable with trastuzumab, conferring a modest survival benefit based on initial clinical trials. (wikipedia.org)
Primary1
  • Primary brain tumors include a number of histologic types with distinctly different tumor growth rates [ 4 , 5 ]. (hindawi.com)
Growth3
  • GGs are well-differentiated, rare CNS tumors, which are characterized by a slow, circumscribed growth and a relatively favorable prognosis. (hindawi.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
Approaches1
Important1
  • The BRAF V600E mutation is an important oncological target in certain central nervous system (CNS) tumors, for which a possible application of BRAF-targeted therapy grows continuously. (hindawi.com)
Clinical2
  • The clinical features of OGJ adenocarcinoma are variable depending on the extent of the tumor. (wikipedia.org)
  • Due to the uniqueness of the clinical material, we focused our attention on rare brain tumor types-ganglioglioma (GG) and pilocytic astrocytoma (PA). (hindawi.com)
Cells1
  • In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
Grade2
  • Almost all are generally considered WHO grade I tumors [ 8 ]. (hindawi.com)
  • The 5-year DFS per tumor origin was: 96% for perforated low grade appendiceal mucinous neoplasm (LAMN II) and 68.1% for colon origin. (unav.edu)
Common1
  • It is the most common pediatric brain tumor in children [ 7 ]. (hindawi.com)
Disease1
Cancer1
Years1
  • The 5 years OS per tumor origin was: 98% for LAMN II and 83.5% for colonic origin. (unav.edu)
Account1
  • PAs are a distinct histologic and biologic subset of gliomas that account for approximately 5.1% of all these tumors. (hindawi.com)
Central1
  • Note the submucosal tumor mass with the classic features of central umbilication and ulceration. (medscape.com)
Generally1
  • Whereas pleural mesothelioma is highly associated with asbestos exposure , nonmesotheliomatous cancers have generally not been proven to result from exposure to airborne asbestos. (medscape.com)
Significant1
  • There was no significant correlation of ploidy status or SPF with the tumor grades of mucoepidermoid carcinomas. (researchgate.net)
Effects1
  • Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. (jci.org)
Studies1