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  • tumors
  • In such cases, these biphasic tumors are classified as a form of pulmonary blastoma because the presence of the blastomatous cells dramatically worsens the prognosis. (wikipedia.org)
  • endocrine gland tumors, such as a VIPoma, an insulinoma, or a pheochromocytoma, are typically not referred to as adenocarcinomas but rather are often called neuroendocrine tumors. (wikipedia.org)
  • Typically, women develop DES-related adenocarcinoma before age 30, but increasing evidence suggests possible effects or cancers (including other forms of vaginal glandular tumors) at a later age. (wikipedia.org)
  • Vaginal germ cell tumors (primarily teratoma and endodermal sinus tumor) are rare. (wikipedia.org)
  • The naming issue to a certain extent reflects histological characteristics and development of the tumors, in which the different types of tissues are believed to either develop separately and join into a single mass (the "collision" theory), that an adenocarcinoma stimulates the stroma to create a tumor (the "composition" theory), or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). (wikipedia.org)
  • the "combination" theory is most widely held, and is due to evidence that the tumors develop from a single line of cells, developing in a fashion similar to the fundus of the uterus from the Müllerian duct - first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. (wikipedia.org)
  • There is evidence that some tumors are better explained by the composition theory, due to the aggressive nature of the epithelial cells involved which tend to metastasize much more readily than the sarcomal component. (wikipedia.org)
  • Ovary
  • Histopathological examination revealed an adenocarcinoma, similar to clear cell carcinoma of the ovary, invading the subserosa and no metastasis of lymph nodes. (sages.org)
  • Ho CM, Huang YJ, Chen TC, Huang SH, Liu FS, Chang Chien CC, Yu MH, Mao TL, Wang TY, Hsieh CY: Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxelplatinum-based chemotherapy in pure-type advanced disease. (springermedizin.de)
  • colonic
  • Normal colonic glands tend to be simple and tubular in appearance with a mixture of mucus secreting goblet cells and water absorbing cells. (wikipedia.org)
  • survival
  • Ho CM, Chien TY, Shih BY, Huang SH: Evaluation of complete surgical staging with pelvic and para-aortic lymphadenectomy and paclitaxel plus carboplatin chemotherapy for improvement of survival in stage I ovarian clear cell carcinoma. (springermedizin.de)
  • Another theory holds that although in all cells loss of VHL leads to activation of HIF, in most cells this leads to no advantage in proliferation or survival. (wikipedia.org)
  • atypical
  • It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close proximity to atypical tuboendometrial glands, and microglandular hyperplasia has been seen to arise from these lesions. (wikipedia.org)
  • Biopsy
  • Biopsy of the tumor revealed a well differentiated adenocarcinoma. (sages.org)
  • While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required to rule out biphasic pulmonary blastoma, a mixed tumor of higher aggressiveness, wherein FA occurs admixed with primitive blastoma cells. (wikipedia.org)
  • ovarian
  • PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy with carboplatin and cyclophosphamide followed by bone marrow and peripheral stem cell transplantation in treating patients who have advanced ovarian epithelial cancer. (clinicaltrials.gov)
  • OBJECTIVES: I. Determine the maximum tolerated dose of carboplatin when combined with cyclophosphamide as high-dose therapy followed by autologous bone marrow and peripheral blood stem cell rescue in patients with platinum sensitive ovarian epithelial carcinoma. (clinicaltrials.gov)
  • cervix
  • Bichler, who at 17 had developed clear cell adenocarcinoma of the cervix and vagina requiring the removal of her reproductive organs, had brought a product liability action against the Eli Lilly pharmaceutical company for damages sustained through her mother's use of DES (diethylstilbestrol) while she was pregnant with her. (wikipedia.org)
  • cancerous
  • Cancerous cells are particularly vulnerable to attacks on DNA because of their high rate of division and their reduced abilities to repair DNA damage. (wikipedia.org)
  • Further, clonal pattern of MCV insertions into MCC cell genomes indicates that the virus was present in the Merkel cell before it underwent cancerous transformation. (wikipedia.org)
  • anticancer
  • Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. (qxmd.com)
  • Neural
  • Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. (wikipedia.org)
  • first described a sequence tag corresponding to the NEDD9 3′ untranslated region based on the cloning of a group of genes predominantly expressed in the brain of embryonic, but not adult mice, a group of genes designated neural precursor cell expressed, developmentally down-regulated. (wikipedia.org)
  • colon
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • human
  • overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). (wikipedia.org)
  • In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. (wikipedia.org)
  • Anal cancer is typically an anal squamous cell carcinoma that arises near the squamocolumnar junction, often linked to human papillomavirus (HPV) infection. (wikipedia.org)
  • assay
  • In vitro wound scratch assay revealed that CRE treatment inhibited cell motility and cell migration in a dose-dependent manner. (qxmd.com)
  • induce
  • Several organ-derived cytokines (produced by inflammatory cells) are known to induce expression of IL-8 in normal and transformed cells (83). (americorpshealth.biz)
  • Accumulation of lipid droplets induce the modification of macrophages to foam cells. (wikipedia.org)
  • Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. (wikipedia.org)
  • Protein
  • Perlipin 2 protein around the macrophages and foam cells was found to play important role in formation of atheroma. (wikipedia.org)
  • cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells and hypothesized to play a role in the process of T cell costimulation, designating this gene Cas-L (Crk-associated substrate-related protein, Lymphocyte type). (wikipedia.org)
  • NEDD9 is a noncatalytic scaffolding protein that contains docking sites for proteins involved in multiple signal transduction pathways, regulating magnitude and duration of cell signaling cascades The overall structure of NEDD9 is represented graphically in Figure 1. (wikipedia.org)
  • These antibodies target the protein aquaporin 4 in the cell membranes of astrocytes which acts as a channel for the transport of water across the cell membrane. (wikipedia.org)
  • Both large T and small T oncoproteins are probably needed to transform healthy cells into cancer cells, and they act by targeting tumor suppressor proteins, such as retinoblastoma protein. (wikipedia.org)
  • Antibodies
  • Unlike standard MS, the attacks are not believed to be mediated by the immune system's T cells, but rather by antibodies called NMO-IgG, or simply NMO antibodies. (wikipedia.org)
  • vitro
  • Unlike for other polyomaviruses, MCV small T antigen transforms cells in vitro by activating cap-dependent translation. (wikipedia.org)
  • genome
  • DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. (wikipedia.org)
  • factors
  • The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. (wikipedia.org)
  • DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 10,000 to 1,000,000 molecular lesions per cell per day. (wikipedia.org)
  • cases
  • It seems also clear that lupus can produce NMO-IgG autoantibodies sometimes, leading to some cases of lupus-derived NMO. (wikipedia.org)
  • It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. (wikipedia.org)
  • mutations
  • Daughter cells that inherit these wrong bases carry mutations from which the original DNA sequence is unrecoverable (except in the rare case of a back mutation, for example, through gene conversion). (wikipedia.org)
  • patients
  • In patients the thymus is typically enlarged, and contains many germinal centres with T and B cell areas very similar to those seen in lymph nodes. (wikipedia.org)