• Using initial exchange rates, adenine nucleotide translocase activities of mitochondria from the LAD and control regions were not significantly different. (utmb.edu)
  • A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. (nih.gov)
  • They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization. (nih.gov)
  • The translocase is among the most abundant proteins in the mitochondrial internal membrane.2 Its abundance as well as the need for this transporter possess rendered it one of the better characterized members from the mitochondrial carrier (MC) family members which facilitate the motion of a variety of metabolites in and out of mitochondria.3 The translocase comes with an intimate relationship with an integral lipid in mitochondrial membranes cardiolipin (CL). (hiv-proteases.com)
  • Electron cryoEM structures of mitochondrial, chloroplast, and bacterial ATP synthases have revealed the architecture of the FO region, helping to explain the mechanisms of proton translocation, dimerization of the enzyme in mitochondria, and cristae formation. (tcdb.org)
  • compared the structural and functional properties of F-ATP synthases in plant mitochondria with those of yeast and mammals. (tcdb.org)
  • All eukaryotic F-type ATPases pump 3-4 H + out of mitochondria, or into thylakoids of chloroplasts, per ATP hydrolyzed. (tcdb.org)
  • Amyloid β, α-synuclein and the c subunit of the ATP synthase: Can these peptides reveal an amyloidogenic pathway of the permeability transition pore? (nyu.edu)
  • Although the abnormally low levels of AdN persist in the mitochondrial compartment during the early reperfusion period, postischemic contractile dysfunction cannot be explained by depressed mitochondrial respiratory activity. (utmb.edu)
  • Neuroinflammation and oxidative stress, mitochondrial dysfunction, dysregulation of the expression of histone deacetylases, and aggregation of pathogenic forms of proteins are among the most common and significant pathological features of neurodegenerative diseases. (actanaturae.ru)
  • One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
  • V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
  • Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)
  • The F 1 portion of the bovine mitochondrial F-type ATPase has been solved to 2.8 Å resolution. (tcdb.org)
  • pH-dependent 11 degrees F1FO ATP synthase sub-steps reveal aspects of the FO torque generating mechanism ( Yanagisawa and Frasch 2021 ). (tcdb.org)
  • The rotor (which consists of the c, ε and γ subunits) is believed to rotate relative to the stator in response to either ATP hydrolysis by F 1 or proton transport through F 0 . (tcdb.org)
  • The mitochondrial adenine nucleotide translocase (ANT also called the ADP/ATP carrier AAC) facilitates export of ATP outward over the internal membrane in to the cytoplasm in trade for import of ADP back to the matrix.1 That is driven with the electrochemical gradient over the internal membrane. (hiv-proteases.com)
  • The lipids of the Pralatrexate energy-minimized concatenated Personal computer membrane were then exchanged for any model mitochondrial membrane as explained above.34 The resultant system sizes were 65 nm × 65 nm × 14 nm containing 25 proteins and ~11000 lipids solvated by standard MARTINI water and neutralized by ~0.15 M NaCl. (hiv-proteases.com)
  • The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
  • Simulation of huge patches of the model mitochondrial membrane filled with multiple copies from the translocase implies that CL connections persist in the current presence of protein-protein connections and suggests CL may mediate connections between translocases. (hiv-proteases.com)
  • In contrast, pharmacological inhibition of OXPHOS expression and function inhibits ANT-dependent ADP/ATP exchange. (elsevierpure.com)
  • As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
  • this restoration is preceded by recovery of respiratory and adenine nucleotide translocase functions. (utmb.edu)
  • Adenine nucleotides (AdNs) are lost from the mitochondrial fraction of the heart cell during ischemia. (utmb.edu)
  • Bacterial F-type ATPases pump 3-4 H + and/or Na + (depending on the system) out of the cell per ATP hydrolyzed. (tcdb.org)
  • Thus ANTs and the OXPHOS machinery physically interact and functionally cooperate to enhance ANT transport capacity and mitochondrial respiration. (elsevierpure.com)
  • H + transport and ATP synthesis may therefore be coupled mechanically. (tcdb.org)
  • The Pralatrexate current presence of CL is vital for maximal stability of the translocase (i.e. ?1per phosphate group) based on Pralatrexate experimental estimations.36 The acyl tails of PC and PE lipids were modeled as 1-palmitoyl-2-oleoyl-tool to concatenate a system containing a single ANT1 molecule inlayed inside a PC bilayer onto a 5 × 5 grid (Figure S1). (hiv-proteases.com)
  • Creatine kinase is known to interact with mitochondrial adenine nucleotide translocase (ANT) in the transfer of ADP and ATP into and out of the mitochondria. (scirp.org)
  • Thus ANTs and the OXPHOS machinery physically interact and functionally cooperate to enhance ANT transport capacity and mitochondrial respiration. (elsevierpure.com)
  • In contrast, pharmacological inhibition of OXPHOS expression and function inhibits ANT-dependent ADP/ATP exchange. (elsevierpure.com)
  • The myofibrillar ANT may represent a unique adaptation in the muscles that require efficient exchange of nucleotides between mitochondria and myofibrils. (scirp.org)
  • E. Pebay-Peyroula and G. Brandolin, "Nucleotide Exchange in Mitochondria: Insight at a Molecular Level," Current Opinion in Structural Biology, Vol. 14, No. 4, 2004, pp. 420-425. (scirp.org)
  • Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the mitochondrial inner membrane, an activity that is essential for oxidative phosphorylation (OXPHOS). (elsevierpure.com)