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  • genetic
  • A stem cell line is a mass of cells descended from the original, sharing its genetic characteristics. (archives.gov)
  • Because few studies exist to describe the unique molecular network regulation behind pig pre-implantation embryonic development (PED), genetic engineering in the pig embryo is limited. (biomedcentral.com)
  • Nobel Prize-winning geneticist Joshua Lederberg advocated cloning and genetic engineering in an article in The American Naturalist in 1966 and again, the following year, in The Washington Post . (wikipedia.org)
  • Unlike sexual reproduction, during which a new organism is formed when the genetic material of the egg and sperm fuse, in nuclear transplantation cloning there is a single genetic "parent. (stemcellclinic.net)
  • Researchers working with clones of a Holstein cow say genetic programming errors may explain why so many cloned animals die, either as fetuses or newborns. (stemcellclinic.net)
  • Likewise, the definitions of terms such as "gametes", or "diploid cells" could also defer to those used in the Congressional cloning "bans", thus allowing much human cloning and human genetic engineering. (lifeissues.net)
  • Such chaos will take on new meaning with human genetic engineering already firmly on track. (lifeissues.net)
  • This course also provides instruction in the fundamentals of human cytogenetics with discussions of chromosomal structure and cell division, as well as both genetic and epigenetic mechanisms of inheritance and different types of mutations and aneuploidies. (evms.edu)
  • This course will also introduce basic molecular biological techniques that are used in current molecular biological research including DNA, RNA isolation and analysis, protein isolation and analysis, genetic engineering, cloning and sequencing, gene expression analysis, PCR and quantitative real-time RCR. (evms.edu)
  • therapeutic
  • Cord blood collection at the time of birth is an easy, non-invasive means of obtaining a young, therapeutic stem cell that can be efficiently induced towards pluripotency for potential treatment of many childhood and adult diseases such as heart disease, diabetes, Parkinson's, stroke, muscular dystrophy, Alzheimer's and spinal cord injury. (chri.org)
  • Formed in 1994, ACT grew from a small agricultural cloning research facility located in Worcester, Massachusetts, into a multi-locational corporation involved in using both human embryonic stem cells (hESC) and human adult stem cells as well as animal cells for therapeutic innovations. (asu.edu)
  • Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of May 2019 [update] . (wikipedia.org)
  • Stem cell research is a promising field with an alluring potential for therapeutic intervention, and thus begs a critical understanding of the long-term consequences of stem cell replacement. (ukessays.com)
  • To evaluate the Italian physicians' knowledge/information level about the therapeutic potential of stem cells, the research choice between embryonic and cordonal stem cells, and the preference between autologous and heterologous storage of cordonal stem cells, we performed a national survey. (hindawi.com)
  • Eighty-seven % of the physicians interviewed proved to have a general knowledge about stem cells and believe in their therapeutic potential. (hindawi.com)
  • thus
  • The chemical-only induction of pluripotency from cord blood stem cells will provide a non-invasive source of pluripotent stem cells, without the need of viruses and permanent changes to the genome, thus reducing the cancer risk and possibly improving the reprogramming efficiency of this technology. (chri.org)
  • Thus, stem cells by definition have two essential properties, i.e. the capacity of self renewal, and the capacity to differentiate into different cell lineages. (ukessays.com)
  • Translational medicine thus represents a stem of scientific research that aims to move "from bench to bedside" or from laboratory experiments through clinical trials to point-of-care patient applications. (hindawi.com)
  • If the definition is used from the Stearns "ban", the product of cloning would just be a "cell" (an oocyte), rather than a single-cell living human organism -- thus protecting no "products" of human cloning techdniques. (lifeissues.net)
  • zygotic
  • Pig zygotic genome activation was confirmed to occur at the 4-cell stage via genome-wide gene expression analysis. (biomedcentral.com)
  • Few interspecies differences do occur, such as time spent at each stage, timing of zygotic genome activation (ZGA) and cell lineage commitment initiation. (biomedcentral.com)
  • Indeed, LIS1 RNA is uniformly distributed in early embryos before the onset of zygotic gene expression, indicating maternal derivation. (sdbonline.org)
  • transplantation
  • First, the researchers performed nuclear transplantation on the egg cell of the cow, during which they removed the nucleus of the egg cell. (asu.edu)
  • In the simplest terms, the technique used to produce Dolly the sheep - somatic cell nuclear transplantation cloning - involves removing the nucleus of an egg and replacing it with the diploid nucleus of a somatic cell. (stemcellclinic.net)
  • destruction
  • In an anti-abortion statement read with Mr. Bush at his side, the Pope spoke of "evils such as euthanasia, infanticide and, most recently, proposals for the creation for research purposes of human embryos, destined to destruction in the process. (theglobeandmail.com)
  • research
  • At the moment, the government would allow stem-cell research using embryos that are less than 14 days old and would otherwise be destroyed. (theglobeandmail.com)
  • The government's draft bill would allow surplus embryos to be used for medical research with the consent of the egg and sperm donors. (theglobeandmail.com)
  • Mr. Rock's draft appeared only after the government received polling data showing that most Canadians would allow the use of donated embryos for stem-cell research. (theglobeandmail.com)
  • The poll suggested that 86 per cent of Canadians would allow use of embryos in research with proper government regulation. (theglobeandmail.com)
  • The federal government does not provide funding for scientific research involving stem cells, but has received patent applications from biotech firms planning to clone embryos for research purposes. (theglobeandmail.com)
  • On Thursday, August 9, 2001, U.S. President George W. Bush's decided to allow federal funding for limited stem-cell research, as provided by the White House. (theglobeandmail.com)
  • Federal funding will apply only to research using existing embryonic stem-cell lines, that is, stem cells already harvested from destroyed embryos. (theglobeandmail.com)
  • want to halt stem-cell research that uses fertilized human eggs. (theglobeandmail.com)
  • In a direct appeal to George W. Bush at the papal summer retreat on July 23rd, the Pope told the visiting U.S. President that the creation of human embryos for research purposes is morally wrong. (theglobeandmail.com)
  • But a Vatican spokesman said later that the Pope opposes any stem-cell research using embryos. (theglobeandmail.com)
  • Each of these issues is discussed as I summarize the past, present, and future bioethical issues in stem cell research. (jci.org)
  • This Review summarizes these and other bioethical issues of the past, present, and future of stem cell research. (jci.org)
  • While public concerns such as these about science and its implications are not in themselves new, hES cell research offered the opportunity for all of these inchoate worries to coalesce around a single, new scientific field. (jci.org)
  • Federal funding of research using existing embryonic stem cell lines is consistent with the President's belief in the fundamental value and sanctity of human life. (archives.gov)
  • The President's decision reflects his fundamental commitment to preserving the value and sanctity of human life and his desire to promote vital medical research. (archives.gov)
  • To create embryonic stem cells for research, a "stem cell line" must be created from the inner cell mass of a week-old embryo. (archives.gov)
  • This report discusses issues regarding stem cell research. (unt.edu)
  • With certain restrictions, the President has announced that federal funds may be used to conduct research on human embryonic stem cells. (unt.edu)
  • The suit was filed because Nightlight Christian Adoptions, a frozen embryo adoption agency, felt that the Guidelines for Research Using Human Pluripotent Stem Cells published by the National Institutes for Health were unlawful and violated the restrictions on human embryo research put into place by the Dickey-Wicker Amendment. (asu.edu)
  • This lawsuit was filed in hopes of gaining injunctive relief against a moratorium on the federal funding of stem cell research. (asu.edu)
  • In 2007, the Human Fertilisation and Embryology Authority in London, UK, published Hybrids and Chimeras: A Report on the Findings of the Consultation, which summarized a public debate about research on, and suggested policy for, human animal chimeras. (asu.edu)
  • According to the US National Institutes of Health (NIH), the standard American source on stem cell research, three characteristics of stem cells differentiate them from other cell types: (1) they are unspecialized cells that (2) divide for long periods, renewing themselves and (3) can give rise to specialized cells, such as muscle and skin cells, under particular physiological and experimental conditions. (asu.edu)
  • Research on stem cells is advancing knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. (ukessays.com)
  • They prefer research on cordonal stem cells rather than on embryo stem cells. (hindawi.com)
  • Stem cells research is recently reproposing the paradigmatic case of the reciprocal influence between science and ideological (e.g., political, religious, economic, and social) issues. (hindawi.com)
  • More specifically, an important question deals with the impact upon national regulation and social behaviours of the scientific community experts' advice regarding stem cells research and its exploitation for health care purposes. (hindawi.com)
  • This technique can also be used to produce an embryo from which cells called embryonic stem (ES) cells could be extracted to use in research into potential therapies for a wide variety of diseases. (stemcellclinic.net)
  • And if, as with Weissman et al, human cloning is not cloning if it is for " research " purposes, then the Dickey Amendment could even be construed to allow human cloning for "research" purposes . (lifeissues.net)
  • The Dickey Amendment would actually allow the use of living human embryos and fetuses sexually reproduced in purely experimental research under certain dubious circumstances and if the Secretary of DHHS says so. (lifeissues.net)
  • NOTE: What we are clearly beginning to see emerge here is the massive contradictions accruing among several major federal research documents interwoven as "authorities" over the years, using erroneous (or no) scientific definitions for "political" purposes now concretized as stare decisis , ultimately rendering them unconstitutional due to vagueness, and impotent in protecting the lives of both sexually and asexually reproduced human beings in research and in reproduction. (lifeissues.net)
  • Under HHS [OHRP federal] regulations at 45 CFR Part 46, human subject means a living individual about whom an investigator (whether professional or student) conducting research obtains (1) data through intervention or interaction with the individual, or (2) identifiable private information . (lifeissues.net)
  • 1. The definition of " human subject research " is the focus of these Guidances, and references are given to both the current OHRP federal regulations (45 CFR 46) and to Public Law 103-43 (the NIH Revitalization Act). (lifeissues.net)
  • genome
  • One of the seminal achievements of mammalian embryology of the last decade is the routine insertion of specific genes into the mouse genome through the use of mouse ES cells. (google.es)
  • germ cell
  • We reveal a link between energy metabolism and epigenetic control of cell state transitions during a developmental trajectory towards germ cell specification, and establish a paradigm for stabilizing fleeting cellular states through metabolic modulation. (embopress.org)
  • mRNA
  • To further define which cell types express Lis1 in the ovary, whole-mount mRNA in situ hybridization was performed using a Lis1 antisense probe. (sdbonline.org)
  • During oogenesis LIS1 mRNA is expressed primarily in germ-line cells. (sdbonline.org)
  • Low levels of LIS1 mRNA can be detected in the germarium in regions 1 and 2 and in both nurse cells and the oocyte in stage 2-4 egg chambers. (sdbonline.org)
  • however, in stage 8-10 egg chambers LIS1 mRNA accumulates at much higher levels in nurse cells. (sdbonline.org)
  • fetus
  • According to US National Institutes of Health (NIH), in humans, the term "embryo" applies to a fertilized egg from the beginning of division up to the end of the eighth week of gestation, when the embryo becomes a fetus. (asu.edu)
  • molecules
  • A niche consists of signalling molecules, intercellular communication and the interaction between stem cells and their neighboring extracellular matrix. (ukessays.com)
  • possibility
  • Most of the physicians involved (67%) were Catholics, and the majority were gynaecologists and paediatricians (43%) who are mainly in charge to inform future mothers about the possibility of cordonal stem cells conservation. (hindawi.com)
  • researchers
  • The researchers extracted the egg cell from the ovary of the domestic cow and the skin cell from the skin of the gaur. (asu.edu)
  • Using wildtype or engineered stem cell lines, researchers may use this technique to uncover the various mechanisms or treatments that may affect early brain infection and resulting microcephaly in Zika virus-infected embryos. (jove.com)
  • development
  • Living in a pluralistic society such as ours, supporters argue, means having to tolerate differences in religious and personal convictions over such personally theoretical matters as when during the course of human biological development moral personhood first appears. (jci.org)
  • Gene-regulation networks of mouse PEDs have been extensively studied and reported [ 15 - 17 ], but scarce information regarding molecular mechanism of pig early embryonic development as well as other large domestic animals has limited our knowledge of developmental biology and aspects of engineering their stem cells. (biomedcentral.com)
  • Primary mouse placental trophoblast cells are a useful tool for studying normal and abnormal placental development, and unlike cell lines, may be isolated and used to study trophoblast at specific stages of pregnancy. (jove.com)
  • Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
  • Diagram of the ways to reprogram cells along with the development of humans. (wikipedia.org)
  • This three-dimensional microenvironment is thought to influence/control genes and properties that define 'stemness' of the stem cells, i.e. self-renewal or development to committed cells. (ukessays.com)
  • An additional concern focuses on whether cellular aging will affect the ability of somatic cell nuclei to program normal development. (stemcellclinic.net)
  • 8 Columbia Center for Translational Immunology & Columbia Center for Human Development, Columbia University Medical Center, New York, New York, USA. (jci.org)
  • Molecular and Cel
  • Barwy Pasażowanie ludzkich embrionalnych komórek macierzystych linii Trypsyna Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard W tym filmie pokazujemy, jak w naszym laboratorium rutynowo fragmenty barwy linii ludzkich zarodkowych komórek macierzystych, z trypsyny. (jove.com)
  • Zamrażanie komórek ES człowieka Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Tutaj pokazujemy, jak w naszym laboratorium zawiesza barwy linii ludzkich zarodkowych komórek macierzystych. (jove.com)
  • Człowieka komórek ES: Kultura Od mrożone komórki Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Tutaj pokazujemy, jak w naszym laboratorium rozpoczyna odcienie ludzkich zarodkowych komórek macierzystych kultury linii mrożonych ręki. (jove.com)
  • Transfer jądra do komórki jajowej myszy Dieter Egli 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Ten film i protokół mają pomóc nauki transfer jądra. (jove.com)
  • Passage TINTEN menselijke embryonale stamcellijnen-lijnen met trypsine Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard In deze video laten we zien hoe onze lab routinematig TINTEN menselijke embryonale stamcellijnen passages met trypsine. (jove.com)
  • Invriezen menselijke embryonale stamcellen Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Hier laten we zien hoe onze lab TINTEN menselijke embryonale stamcellijnen bevriest. (jove.com)
  • Menselijke ES-cellen: Vanaf Cultuur van bevroren cellen Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Hier laten we zien hoe onze lab een TINTEN menselijke embryonale stamcellen lijn cultuur begint met een bevroren voorraad. (jove.com)
  • Nuclear Transfer naar Mouse Eicellen Dieter Egli 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Deze film en het protocol zijn bedoeld om te leren nucleaire transfer. (jove.com)
  • fetal
  • The major cell type of the fetal portion of the placenta is the trophoblast. (jove.com)
  • For example, when the trophoblast cells of the placenta fuse to form the syncytiotrophoblast, the syncytiotrophoblast is better able to transport nutrients and hormones across the maternal-fetal barrier than unfused trophoblasts 1-4 . (jove.com)
  • 78:7634-7638, 1981) or from fetal germ cells (Matsui, et al. (google.es)