Addition of adjuvant radiotherapy for patients radiotherapy adjuvant. Medical search. Frequent questions

In addition to surgical resection, some cases of SAC tumors have been treated with adjuvant therapy that includes radiotherapy and/or chemotherapy. (wikipedia.org)
Similar to adjuvant RT, the indication for ADT is based on tumour-related factors such as PSA levels, tumour stage, and surgical margins. (wjgnet.com)
in the imaging control 3.5 years after the surgical resection, local recurrence was identified, and the patient was submitted to a local radiation protocol. (thieme-connect.de)
With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
The merits of surgical resection (vs. open biopsy, to confirm recurrence via histology) in addition to conventional adjuvant chemotherapy have been the subject of longstanding debate. (biomedcentral.com)
Standard therapy for newly diagnosed patients with GB involves maximal surgical resection, followed by radiotherapy (RT, typically 60 Gray, given in 30 fractions) with concomitant and adjuvant temozolomide (TMZ) for at least 6 months. (biomedcentral.com)
Stents usually are used if the tumor is unresectable or if the patient is not a surgical candidate. (medscape.com)
Cases that were managed by early surgical intervention in addition to neoadjuvant radiotherapy reported the best outcome. (surgicalneurologyint.com)
With the development of new surgical techniques in breast cancer, such as oncoplastic breast surgery, increased knowledge of risk factors for poor satisfaction with conventional breast-conserving surgery (BCS) is needed in order to determine which patients to offer these techniques to. (springer.com)
Guidelines recommend adjuvant treatment when positive lymph nodes are found after surgical treatment for squamous cell cancer of the vulva except for cases with a single occult intranodal metastasis. (dermatoljournal.com)
Despite recent advances in chemotherapy and radiotherapy for CC, surgical resection remains the primary treatment, but there are gender differences in CC treatment choices [ 3 , 4 ]. (hindawi.com)
Treatment is primarily surgical, but in patients with lymph node metastasis, postoperative radiotherapy is recommended as well. (medscape.com)

In 2004, a randomised phase III trial by the European Organisation for Research and Treatment of Cancer (EORTC) and National Cancer Institute of Canada Clinical Trials Group (NCIC) reported improved median and 2-year survival for patients with glioblastoma treated with concomitant and adjuvant temozolomide and radiotherapy. (nih.gov)

Spiradenoma tumors occur in individuals of various ages but tend to develop in middle-aged and elder adults (e.g. in a study of 27 patients, the median age at diagnosis was 62 years). (wikipedia.org)
All patients underwent hysterectomy, met stage I GOG-99 high-risk criteria, and had stage II, or stages I-II serous or clear cell tumors. (medpagetoday.com)
Former series of long-term survivors are commonly enriched for patients with IDH -mutated tumors. (cancernetwork.com)
The study reveals an overall delay in diagnosis and treatment of pediatric bone tumors and highlights the need for general practitioners to further consider sarcomas in the differential diagnosis when patients present with chronic localized pain, especially when patients are in the at-risk age group and the pain is localized to one of the common sites. (bcmj.org)
It has been said that African patients present late with aggressive tumors and face a lack of therapeutic options, resulting in short survival duration. (karger.com)
Adjuvant and preoperative radiation therapy has been used to reduce tumors in an effort to make them resectable. (medscape.com)
In patients with medially inoperable or unresectable tumors, primary radiotherapy, with or without chemotherapy, has provided a survival advantage and significant palliation over stent placement or bypass surgery alone. (medscape.com)
Thanks to the power of naturally occurring canine tumors as predictive models for cancer immunotherapy response, these data may represent a basis for the translation of this approach to the treatment of human patients with CSPG4-positive melanoma subtypes. (bmj.com)
It is known that the rare occurrence of malignant peripheral nerve sheath tumors (MPNSTs) in the background of NF1 is associated with a lifetime risk of developing MPNST in up to 13% of NF1 patients. (surgicalneurologyint.com)
Brachytherapy as a form of treatment for gynecological tumors has been used for a long time in Brazil (since 1991) and can be considered as a form of radiotherapy treatment. (biomedcentral.com)
Over time, brachytherapy has been consolidated and has become a safe technique for patients with cervical tumors and with very satisfactory results of regression and even cure of the tumor [ 1 ]. (biomedcentral.com)
Meanwhile, patients with non-primary tumors and no pathologic diagnosis were excluded. (biomedcentral.com)
With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
In addition, these rare cutaneous tumors are often difficult to diagnose based solely on the physical examination findings, and the proper diagnosis relies on excisional biopsy with histologic studies. (medscape.com)
Randomized, Open Label Phase 3 study of SAR408701 versus Docetaxel in Previously Treated metastatic non-squamous Non-Small Cell Lung Cancer patients with CEACAM5 positive tumors. (who.int)
Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. (spandidos-publications.com)
Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
Local recurrence, distant metastasis and disease-specific death occurred in 241 patients (8.5%), 554 patients (19.6%) and 230 patients (8.1%), respectively. (biomedcentral.com)
PB exhibited rare associations in the form of non-smoker status, scalp metastasis, and MYCN and ATM gene mutations on NGS in addition to conventional CTNNB1 gene mutation. (turkjpath.org)
The survival outcome in these patients is very poor due to the high rate of tumour recurrence and distant metastasis, and about two-third of the patients succumb to the disease within 2 years of the diagnosis 7 . (turkjpath.org)
however, one patient suffered from rapid recurrence and metastasis. (surgicalneurologyint.com)
When these variables are taken into account, adjuvant radiotherapy does not seem to result in a better survival for patients with a single occult intranodal metastasis. (dermatoljournal.com)
The conclusion is that adjuvant radiotherapy improves survival of patients with positive groin nodes, with the exception of patients with a single intranodal metastasis. (dermatoljournal.com)
38 patients underwent surgery for primary malignancy, 6 patients for benign tumour, while 5 patients had surgery for metastasis. (biomedcentral.com)
The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)

Adult patients with newly diagnosed glioblastoma were randomly assigned to receive either standard radiotherapy or identical radiotherapy with concomitant temozolomide followed by up to six cycles of adjuvant temozolomide. (nih.gov)
Patients in both groups could receive up to four cycles of adjuvant chemotherapy, radiotherapy, or both. (ascopost.com)

One week later, the patient was submitted to subtotal tumor resection, and remained asymptomatic in the post-operative period. (thieme-connect.de)
Gross total resection followed by radiotherapy is the current standard of care. (thieme-connect.de)
The patient was subjected to right upper lobe resection with lymph node dissection at the end of March 2020 at a local hospital. (spandidos-publications.com)
Fifty-four (82%) received SoC, 7 (11%) resection only, and 5 (8%) radiotherapy only. (bvsalud.org)
All patients would be considered potentially eligible for enrollment (unless the decision regarding resection was already clear-cut in view of other factors). (biomedcentral.com)
Adjuvant radiotherapy has been to improve local control, with variable effect on overall survival after complete resection. (medscape.com)
Pelvic resection is challenging and can have significant functional, social and psychological impact on the patient. (biomedcentral.com)
Methods As many as 246 TSCC people which experienced operative resection were retrospectively reviewed, in addition to their muscle examples had been purchased for TRPC1 necessary protein along with mRNA discovery. (trpv-antagonist.com)

A benefit of combined therapy was recorded in all clinical prognostic subgroups, including patients aged 60-70 years. (nih.gov)
Although there are clear criteria (pT3-pT4 disease and/or positive margins) for the use of adjuvant radiotherapy, no specific clinical or tumour-related criteria have yet been defined for SRT. (wjgnet.com)
It also suggests that the trend in our field of abandoning pelvic radiation in favor of chemotherapy-brachytherapy combinations for high-risk patients is premature and not supported by clinical evidence. (medpagetoday.com)
NEW ORLEANS - For patients with resectable non-small cell lung cancer (NSCLC), further clinical data continue to show benefit from preoperative treatment with the immune checkpoint inhibitor nivolumab (Opdivo) with chemotherapy. (medscape.com)
This will potentially be of benefit in opening up appropriate clinical trial opportunities for this subset of patients in the future. (cancernetwork.com)
Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
The Netherlands Cancer Institute is among the world's best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. (nki.nl)
The clinical picture of BC differs from that of Western countries due to the high proportion of young patients (on account of the African population with a high proportion of young people) and late presentation. (karger.com)
Conventional therapies have limited efficacy, and overall response is still unsatisfactory considering that immune checkpoint inhibitors induce lasting clinical responses only in a low percentage of patients. (bmj.com)
Estimation of accurate clinical course using these factors will enable clinicians to select appropriate patients who can gain benefit from invasive treatment and may improve prognosis for patients. (biomedcentral.com)
In these stages, if the patient has a clinical contraindication or if she does not accept the surgery, the choice becomes exclusive radiotherapy, using teletherapy supplemented by brachytherapy. (biomedcentral.com)
As a result the patients studied in clinical trials represent a heterogeneous population. (touchoncology.com)
The current standard care for locally advanced prostate cancer is a combination of radiotherapy (RT) and androgen deprivation therapy (ADT) and this is supported by several large randomized clinical trials. (touchoncology.com)
As a result, the patients studied in clinical trials of high-risk prostate cancer represents a heterogeneous group, including those with clinically organ-confined disease (cT1/T2) with Gleason score 8-10 and/or PSA >20 ng/ml, and those with locally advanced disease (cT3/T4). (touchoncology.com)
However, to date, the contribution of these scientific advances to the clinical management of GBM patients remains insufficient. (biomedcentral.com)
Clinical and functional information on all 49 patients were available for review. (biomedcentral.com)
Emphasis on screening for colon cancer in women and additional clinical care should be paid for, especially for patients with FCC with metastatic liver cancer. (hindawi.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Neuropathic pain (NP) originates as a In non-oncological patients, chronic NP is The authors declare there are direct consequence of a lesion or disease common in clinical practice and consider- no conflict of interests. (bvsalud.org)

This report documents the case of a 57‑year‑old male patient initially diagnosed with non‑metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. (spandidos-publications.com)
A large proportion of patients are diagnosed with locally advanced or metastatic disease at the time of presentation [ 3 ]. (biomedcentral.com)
The purpose of this study was to compare the metastatic pattern and prognosis of female colon cancer (FCC) to that of male colon cancer (MCC) to ascertain the independent factors impacting the prognosis of patients with FCC. (hindawi.com)
Compared to patients with nonmetastatic FCC, a greater proportion of metastatic FCC patients was less than 60 years of age, black race, and grade III-IV. (hindawi.com)
Compared to metastatic MCC, a higher proportion of metastatic FCC patients ranged over 60 years of age, black race, treated without chemotherapy, and insurance, while the primary site was located on the right side. (hindawi.com)
Cox multivariate regression analysis showed that the risk ratio was higher in metastatic FCC patients compared to those without metastases. (hindawi.com)
Furthermore, patients with liver metastatic FCC have a worse prognosis than those with MCC. (hindawi.com)
We conducted cross-sectional and longitudinal studies of patients with metastatic FCC to determine their clinicopathological characteristics and differences from patients with metastatic MCC and identify independent factors that affect the prognosis of patients with FCC. (hindawi.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
The study was carried out to exhaust the scientific literature regarding surgery associated with radiotherapy in patients suffering from metastatic spinal cord compression and to assist in the decision of oncology physicians and professionals in choosing the best treatment for the patient. (bvsalud.org)
The researchers carried out a descriptive study using bibliometric and scientometric methods and found that the combination of surgery with postoperative radiotherapy is effective and more efficient than these alone for the treatment of patients affected by metastatic neurological compression. (bvsalud.org)
Adjuvant/neoadjuvant treatment for a patient who had a relapse with metastatic disease during or within 6 months of completion of treatment will be considered as first line treatment. (who.int)

It is not clear that these adjuvant treatments improve patient prognoses. (wikipedia.org)
Among the treatments for improving survival in women with high-risk and early-stage endometrial cancer are radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)
The standard adjuvant treatments of RT and TMZ lead to pseudo-progression on follow-up imaging in 20-30 % of patients imaged at 2 months [ 5 ]. (biomedcentral.com)
Therefore, adjuvant treatments (chemotherapy, radiotherapy etc.) are necessary and critical for management of patients with advanced disease. (biomedcentral.com)
However, further studies are required to evaluate the benefit from adjuvant treatments in this group of patients. (biomedcentral.com)
In addition to the limited benefit in survival, SOC treatments cause significant morbidity involving neurological deficits. (biomedcentral.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
AND c) Participant with EGFR sensitizing mutation or BRAF mutation or ALK/ROS alterations must be able to demonstrate progression of the disease on approved treatments for these conditions, in addition to platinum-based chemotherapy and immune checkpoint inhibitor. (who.int)

Twenty-eight patients were identified who received SBRT after a median prior external beam radiotherapy dose of 50.4 Gy. (ku.edu)
Shown here is the display for planning external-beam radiotherapy to the cholangiocarcinoma (green structure). (medscape.com)
A biliary catheter (red tube) runs through the tumor volume and was used to deliver brachytherapy, which was given in addition to external-beam radiotherapy. (medscape.com)

As the patient could not tolerate anti‑tumor therapy, only symptomatic treatment was provided. (spandidos-publications.com)
There is a growing evidence that genomic and immune features of pre-treatment tumor biopsies may correlate with response in patients with melanoma and other cancers, but they have yet to be fully characterized and implemented clinically. (nki.nl)
Multiple treatment options may contribute to the long-term survival of patients with this intractable tumor. (bvsalud.org)
This study retrospectively extracted 2827 patients with primary trunk and extremity STSs after definitive surgery using the Bone and Soft Tissue Tumor Registry, which is a nationwide sarcoma database in Japan. (biomedcentral.com)
In general, gender may be the first patient characteristic to be considered when discussing tumor differences between patient subgroups. (hindawi.com)
Gender differences in tumor behavior exist in patients with colon cancer [ 5 ], but the exact mechanisms are unknown. (hindawi.com)
Conclusion TRPC1 fits along with very poor tumor thyroid cytopathology features along with undesirable survival inside TSCC patients.Any graphic analysis of equally medicine along with chronic otitis media coformer concentrations led simply by dissolving cocrystals will be presented in the context of a simplified cocrystal stage diagram. (trpv-antagonist.com)
Patient PBMCs are collected by leukapheresis followed by enrichment approaches to isolate T cells while removing other cells such as B cells, monocytes, neutrophils, dendritic cells and contaminating tumor cells. (bdbiosciences.com)
In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
Some factors such as individual treatment strategy, according to the histology of the primary tumor, plan of treatment strategies carried out in a multidisciplinary manner, risk-benefit of radiotherapy, assessment of the degree of spinal instability, improvement in communication and referral between specialists in oncology showed an increase in the survival of these patients. (bvsalud.org)

Unadjusted median survival with and without adjuvant chemotherapy was 44.0 versus 29.7 months, respectively (P=0.001). (medscape.com)
Among 358 patients in the trial, the median event-free survival (EFS) was 31.6 months for patients randomly assigned to the combination of the immune checkpoint inhibitor nivolumab and platinum-base chemotherapy, compared with 20.8 months for patients assigned to chemotherapy alone. (medscape.com)
In an interim analysis, the median OS rate was 83% at 2 years for patients treated with nivolumab plus chemotherapy, compared with 71% for patients treated with chemotherapy alone. (medscape.com)
The median patient age was 63 years old and the median follow-up was 5.9 months. (ku.edu)
RESULTS: A total of 95 recurrences in 40 patients with a median (interquartile range [IQR]) follow-up of 43 (18-79) months were identified. (bvsalud.org)
The median (IQR) age at the time of diagnosis was 48 (36-62) years, and 55% of patients were male. (bvsalud.org)
The median (range) number of recurrences per patient was 2 (1-8), and the median (IQR) time to the first recurrence was 29 (9-51) months. (bvsalud.org)
Seven patients received systemic therapy, and the median (95% CI) OS of these patients since initiation of systemic therapy was 31 (11-51) months. (bvsalud.org)
The addition of TMZ to RT has increased median overall survival (mOS) from 12.1 months to 14.6 months, and 2-year survival from 10 to 26 % [ 3 ]. (biomedcentral.com)
However, the prognosis of GBM patients remains dismal, with a median survival time of approximately 15 months and a recurrence rate of about 90% [ 3 ]. (biomedcentral.com)

The other study, PORTEC (Post-Operative Radiation Therapy in Endometrial Carcinoma), compared the standard of care with adjuvant chemotherapy during and after radiotherapy for patients with high-risk endometrial cancer. (medpagetoday.com)
The role of radiotherapy is controversial in both the adjuvant (post-operative) and definitive (unresectable localized disease) settings. (ku.edu)
The cohort was comprised of patients with pre- and post-operative MRIs. (bvsalud.org)

The age of the patient is also an important factor, especially in stage III disease, when considering different treatment options, but for now pelvic radiation therapy appears to remain the standard of care for high-risk, endometrial cancer patients. (medpagetoday.com)
Of the 601 patients accrued, 301 were assigned to the pelvic external-beam radiation therapy (PXRT) arm and 300 were assigned to the vaginal cuff brachytherapy and chemotherapy (VCB/C) arm. (medpagetoday.com)
Second, although not mandated for this trial, approximately 20% of the patients received postoperative therapy. (medscape.com)
Is adjuvant therapy necessary? (medscape.com)
What criteria should be used to select patients to receive adjuvant therapy? (medscape.com)
Eligible patients had prior external beam radiation therapy to the pancreas. (ku.edu)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. (nki.nl)
In addition, novel approaches such as adoptive cell therapy, oncogenic viruses, vaccines and different strategies of drug administration including sequential, or combination treatment are being tested. (nki.nl)
Despite the progress in diagnosis of melanocytic lesions, correct classification of patients, selection of appropriate adjuvant and systemic theràapies, and prediction of response to therapy remain real challenges in melanoma. (nki.nl)
A study of 66 patients with unresectable intrahepatic cholangiocarcinoma treated with hypofractionated radiation therapy reported 2-year outcomes of 84% local control and 58% overall survival. (medscape.com)
More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. (bvsalud.org)
The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. (bvsalud.org)
Interdisciplinary Diagnosis, Therapy and Follow-up of Patients with Endometrial Cancer. (thieme-connect.de)
In the no RT group, adjuvant endocrine therapy with tamoxifen was given to 40/53 patients. (biomedcentral.com)
The LR rate as shown in this retrospective study is highly comparable to that of younger patients treated by conventional therapy. (biomedcentral.com)
The benefit of nivolumab was maintained in analysis adjusted for optional receipt of adjuvant therapy (HR = 0.65, 95% CI = 0.47-0.90). (ascopost.com)
But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. (scirp.org)
To the best of our knowledge, our case is the sixth case that primary adenosarcomas arising in vaginal endometriosis and it is the first case living without chemo-therapy or radiotherapy. (scirp.org)
The availability and the use of improved cellular and/or molecular markers to better risk stratify prostate cancer patients will allow us to select the most effective therapy to enhance the overall outcome. (touchoncology.com)
This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with endocrine therapy of physician's choice in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. (roche.com)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
The scientific hypothesis is that this alternative schedule for follow-up will identify the aggressive cancers earlier with less health-care resources and better quality of life for the patients, without increasing the total proportion of patients receiving radical therapy within 5 years. (cancercentrum.se)

Decompression surgery and postoperative radiotherapy was mostly palliative. (bvsalud.org)

As described here, two recent studies have indicated that pelvic radiation following surgery should remain the standard of care for these patients, with some exclusions. (medpagetoday.com)
Two recently published studies suggest that pelvic radiation following surgery should remain the standard of care for this patient population, with some exceptions. (medpagetoday.com)
The overall survival rate was 91% for PXRT versus 88% for VCB/C. While no differences were seen between vaginal or distant failure, pelvic or para-aortic nodal recurrences were more common in the patients receiving VCB/C (25 versus 12). (medpagetoday.com)
Our trial clearly demonstrates that adjuvant pelvic radiation should remain the standard of care for high-risk, early-stage endometrial cancer patients," the lead author of the study, Marcus Randall, MD, of the University of Kentucky College of Medicine in Lexington, said in an ASTRO news release. (medpagetoday.com)
In March 1998, the patient was found to have multiple polys in the vaginal posterior fornix and a fistula that was at the posterior fornix and extended to the pelvic cavity. (scirp.org)
Between 1996-2003, 49 patients (mean age 43 years) underwent pelvic tumour resections- 38 primary malignant tumours, 5 secondary tumours and 6 benign tumours. (biomedcentral.com)
However, given the often poor prognosis of patients with pelvic tumours, the question of whether this type of surgery is justified remains unanswered. (biomedcentral.com)
From 1996 to 2003, 49 patients at St. Vincent's Hospital underwent pelvic tumour resections. (biomedcentral.com)
In the SAMS (SAMS-FU and SAMS-ObsQoL) the quality of life and pelvic symptoms of patients on active surveillance will be investigated and compared to those of patients receiving immediate treatment with curative intent. (cancercentrum.se)

In the open-label international trial, 358 patients with stage IB to IIIA resectable disease were randomly assigned between March 2017 and November 2019 to receive neoadjuvant treatment with nivolumab at 360 mg plus platinum-doublet chemotherapy (n = 179) or platinum-doublet chemotherapy alone (n = 179) every 3 weeks for three cycles before definitive surgery. (ascopost.com)
The investigators concluded: "In patients with resectable NSCLC, neoadjuvant nivolumab plus chemotherapy resulted in significantly longer event-free survival and a higher percentage of patients with a pathological complete response than chemotherapy alone. (ascopost.com)
9 patients received chemotherapy alone, 6 received radiotherapy alone, and 6 patients received both chemotherapy and radiotherapy. (biomedcentral.com)

A National Cancer Data Base (NCDB) analysis of 1797 patients with vulvar cancer who underwent extirpative surgery with confirmed inguinal nodal involvement treated with adjuvant radiotherapy concluded that the addition of adjuvant chemotherapy resulted in a 38% reduction in mortality risk. (medscape.com)
In March 2020, 2 months after initial symptom development, the patient underwent a computed tomography (CT) scan, which revealed a mass 6.5×6.2×7.2 cm in size in the upper lobe of the right lung ( Fig. 1A ). (spandidos-publications.com)
range: 70 - 87 years) patients (analysed as 93 'patients' due to one patient having bilateral cancers) managed in a dedicated breast clinic and who underwent BCS for invasive carcinoma was carried out. (biomedcentral.com)
001). Among all randomly assigned patients, 149 (83.2%) of those in the nivolumab group and 135 (75.4%) of those in the control group underwent surgery. (ascopost.com)
Among patients who underwent surgery, surgery-related adverse events of any grade occurred in 41.6% vs 46.7% of patients. (ascopost.com)
The patient underwent right thyroid lobectomy and he received adjuvant radiotherapy in combination with chemotherapy. (nigeriamedj.com)

Whether the addition of chemotherapy to the radiotherapy for patients with more than one positive node or extracapsular spread results in a better survival remains uncertain. (dermatoljournal.com)

278 (97%) of 286 patients in the radiotherapy alone group and 254 (89%) of 287 in the combined-treatment group died during 5 years of follow-up. (nih.gov)
the investigators suggested that adjuvant treatment or completion inguinofemoral lymph node dissection be performed for such sentinel lymph nodes. (medscape.com)
In addition, a subgroup of lower-grade gliomas may carry molecular features and signatures similar to glioblastoma, with a similarly aggressive natural course,[4] for which an intensive treatment strategy is advocated. (cancernetwork.com)
Chemotherapy is recommended for patients able to tolerate treatment, but response rates for gross disease are poor. (ku.edu)
Ninety eligible patients will be randomly assigned at a ratio 1:1:1 to one of the following: control group (n = 30), low-cell dose treatment group (n = 30), and high-cell dose treatment group (n = 30). (unav.edu)
Treatment will be administered in a single-dose way and patients will be followed for 12 months. (unav.edu)
Development of novel biomarker platforms may help to improve diagnostics and predictive accuracy for selection of patients for specific treatment. (nki.nl)
Evidence on treatment from prospective randomized trials that address the specific characteristics of African patients is lacking. (karger.com)
Patients would be eligible at the time of first recurrence if they had received conventional treatment until that point and at least 1 month had elapsed since the time of radiation. (biomedcentral.com)
This is reflected, for example, in the Canadian recommendations for the treatment of recurrent or progressive GB, which state: "In the absence of level I evidence, the decision to re-operate should be made according to individual circumstances, in consultation with the multidisciplinary team and the patient" [ 6 ]. (biomedcentral.com)
Three-dimensional treatment planning uses CT scan slices to reconstruct the patient as a volume. (medscape.com)
Herein, we report on the use of osimertinib in patients with EGFR T790M mutation-positive non-small cell lung cancer who had previously received EGFR tyrosine kinase inhibitor (TKI) treatment in Korea. (bvsalud.org)
Numerous studies have shown that HDR for gynecological cancer presents results that can reach up to 85% cure, and with this it is concluded that there are few complications during or after treatment, since adjacent tissues are preserved, making HDR a safe procedure for patients and professionals. (biomedcentral.com)
Adjuvant radiotherapy to the breast after breast conserving surgery (BCS) is the mainstay of treatment to achieve local control in patients with invasive carcinoma. (biomedcentral.com)
However, the benefit from any adjuvant treatment is directly related to the patients overall co-morbidity and life expectancy. (biomedcentral.com)
Searching the patient database identified 92 patients with primary invasive breast carcinoma over the age of 70 during this period who were treated with BCS as the primary treatment. (biomedcentral.com)
As reported in The New England Journal of Medicine by Forde et al, the phase III CheckMate 816 trial has shown improved pathologic complete response rate and event-free survival with the addition of nivolumab to platinum-based chemotherapy in the neoadjuvant treatment of resectable non-small cell lung cancer (NSCLC). (ascopost.com)
Death due to treatment-related adverse events occurred in no patients in the nivolumab group and in 3 (1.7%) in the control group. (ascopost.com)
The aim of this study was to investigate patient satisfaction regarding aesthetic result and skin sensitivity in relation to patient, tumour, and treatment factors, in a consecutive sample of patients undergoing conventional BCS. (springer.com)
If I cannot, my focus is to lead patients and their families through the treatment process, with an emphasis on providing clear, straightforward communication. (stanfordchildrens.org)
Regarding treatment, more SRC patients received surgery, radiotherapy and chemotherapy than non-SRC patients. (biomedcentral.com)
We will also discuss the state-of-the-art emerging technologies using big data analysis and how they will settle the bases on future diagnosis and treatment strategies in GBM patients. (biomedcentral.com)
Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. (biomedcentral.com)
For example, 90 percent of patients who receive treatment before the cancer has spread are alive after five years, compared to only 10 percent who survive if the cancer is widespread and treated conventionally (Dashwood RH 1999). (bioresonancetherapy.com.sg)
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
In addition, SAMS will evaluate prognostic factors, criteria for intervention and the effects of 5-alpha-reductase inhibitors, the outcome after treatment with curative intent, time to symptoms and metastases from prostate cancer, prostate cancer specific survival, and overall survival. (cancercentrum.se)
Hopefully, SAMS will increase our knowledge on active surveillance for low-risk prostate cancer, so that more patients with aggressive cancer will receive curative treatment and fewer patients will receive un-necessary treatment for indolent tumours and thereby maintain their quality of life better. (cancercentrum.se)
A study of new drug comparing with standard chemotherapy treatment (Docetaxel) in previously treated stage 4 lung cancer patients. (who.int)

The nomogram, a graphical calculation tool designed to allow prediction of the overall probability of a specific outcome for any individual patient, can provide clinicians with accurate estimates of prognosis for several cancers. (biomedcentral.com)
Patients with SRC of the gallbladder have distinct clinicopathological features with poor prognosis. (biomedcentral.com)
Liver and lung were the two most common sites of solitary metastases in CC, and among patients with solitary metastases in CC, patients who had lung metastases had a better prognosis than those who developed other types of metastasizes. (hindawi.com)
Patients with FCC with metastases of the liver had a worse prognosis than their MCC counterparts. (hindawi.com)

Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up. (nih.gov)
MGMT methylation status identifies patients most likely to benefit from the addition of temozolomide. (nih.gov)

Hence, it is important to identify factors associated with a poor aesthetic outcome after conventional BCS, in order to determine which patients would benefit the most from oncoplastic breast surgery. (springer.com)

During the Melanoma Bridge meeting (December 2nd-4th, 2021, Naples, Italy) discussions focused on the currently approved systemic and local therapies for advanced melanoma and discussed novel biomarker strategies and advances in precision medicine as well as the impact of COVID-19 pandemic on management of melanoma patients. (nki.nl)
CONCLUSIONS: Despite the aggressive nature of recurrent chordoma, 14 of 29 patients (48%) survived for more than 5 years after the initial recurrence using combined therapies. (bvsalud.org)

Combination modalities with other immunotherapy agents, chemotherapy, radiotherapy, electrochemotherapy are also being explored to overcome resistance and to potentiate the immune response. (nki.nl)
Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy-by the use of adjuvants. (mdpi.com)
Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)

Improving survival in women with high-risk, early-stage (stages I-II) endometrial cancer has been the goal of research exploring various modalities such as radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)

Lung cancer is the leading cause of cancer-related death worldwide, with most patients presenting with metastases during diagnosis ( 1 ). (spandidos-publications.com)
Patients with histopathological diagnosis of chordoma were included. (bvsalud.org)
2 the Genitourinary Radiation Oncologists of Canada (GUROC) developed a classification system for patients with localized/locally advanced disease based on T category, prostate specific antigen (PSA) level at diagnosis, and Gleason score. (touchoncology.com)

It would appear that omission of RT following successful BCS in elderly patients with ER positive tumours receiving adjuvant tamoxifen may be acceptable. (biomedcentral.com)
According to the Enneking's classification, one patient had stage 1A tumour, one patient had stage 1B tumour, 6 patients had stage 2A tumours and 30 patients had 2B tumours. (biomedcentral.com)

In addition, other endoscopic forms of palliation, such as brachytherapy and radiofrequency ablation, have been used. (medscape.com)
High Dose Rate brachytherapy (HDR) is a therapeutic modality of radiotherapy in which radioactive sources are used in close contact with the region to be treated. (biomedcentral.com)
Cisplatin-based chemoradiation plus high dose rate intracavitary brachytherapy can prevent locoregional relapse and effect cure in 40-75% of patients [ 4 , 5 ]. (biomedcentral.com)

Background/Aims@#Efficacy of proton pump inhibitors is limited in patients with nonerosive reflux disease (NERD). (bvsalud.org)
The aim of this study was to assess the efficacy of BCS without adjuvant RT in this group of patients. (biomedcentral.com)
This retrospective analysis aimed to address the efficacy of BCS without adjuvant radiotherapy in the elderly population. (biomedcentral.com)
In addition, an open-label exploratory substudy will explore the safety and efficacy of giredestrant in combination with abemaciclib in a subset of the primary study population. (roche.com)

The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
However, from 30% to 55% of patients who undergo surgery with curative intent ultimately experience recurrence and die from their disease. (medscape.com)
Twenty-three patients were treated with surgery followed by adjuvant radiation before the first recurrence. (bvsalud.org)
Surgery was performed for 44 recurrences in 25 patients. (bvsalud.org)
These nomograms allowed accurate prediction of LRFS, DMFS and DSS at 2 years after definitive surgery, and can be used as a guide by clinicians for appropriate follow-up and counseling of patients. (biomedcentral.com)
There are data suggesting that radiotherapy (RT) following breast conserving surgery (BCS) for invasive carcinoma may not be necessary in some elderly patients. (biomedcentral.com)
The addition of RT to surgery might constitute an imposition to such patients due to age-related factors. (biomedcentral.com)
The addition of nivolumab to neoadjuvant chemotherapy did not increase the incidence of adverse events or impede the feasibility of surgery. (ascopost.com)
Breast-conserving surgery (BCS), i.e. a partial mastectomy, followed by radiotherapy, is today a common alternative to mastectomy, when treating early breast cancer. (springer.com)
After the surgery, the patient had recurrent vaginal stump polyps for 10 years. (scirp.org)
Soon after the surgery, her dysmenorrhea was aggravating, and the patient was diagnosed as endometriosis. (scirp.org)
Of limb sparing surgery, prosthetic reconstructions were performed in 10 patients, biologic reconstructions in 6, a combination of these in 3 and no reconstruction in others. (biomedcentral.com)
With the introduction of adjuvant chemotherapy and radiotherapy, and improved reconstruction techniques, limb- sparing surgery has largely replaced external hemipelvectomy. (biomedcentral.com)
Radiotherapy can be considered in cases of local disease that is poorly differentiated or for those who are poor candidates for surgery. (medscape.com)
[ 3 ] An endometrial sample can be obtained with office biopsy, hysteroscopy , or D&C. The initial histologic test can differentiate between benign and malignant causes and in case of malignancy may determine the surgery the patient has to undergo. (medscape.com)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

Up to 10% of patients with glioblastoma harbor a mutation in the IDH1 or IDH2 genes, an early event in gliomagenesis. (cancernetwork.com)

Tseng W , Martinez SR , Tamurian RM , Histologic type predicts survival in patients with retroperitoneal soft tissue sarcoma . (jnccn.org)
In addition to the stage of the disease and histologic type, the degree of differentiation influences management. (medscape.com)

In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)

[ 6 ] However, in their review, Perez et al observed only 7% of patients to have regional nodal involvement. (medscape.com)

A total of 686 women were accrued, randomly assigned to either chemoradiotherapy or radiotherapy only. (medpagetoday.com)

The beneficial effect of chemo radiotherapy for subgroups of patients with positive nodes seems likely, although more data are needed before a definite conclusion can be made. (dermatoljournal.com)

No patients in the oestrogen receptor (ER) negative group received tamoxifen. (biomedcentral.com)
Within the ER positive group the LR rate was 0.92% per annum (0.62% per annum in patients treated with adjuvant tamoxifen, regardless of margin status). (biomedcentral.com)

Patients with endometrioid cancer and grade 1 or 2 histology localized to the uterus may undergo hysterectomy only and require no extensive dissection of lymph nodes. (medscape.com)

Most patients are free from local progression, albeit with limited follow-up, but overall survival remains poor. (ku.edu)
Overall survival (OS) and cancer-specific survival (CSS) of patients who had SRC were compared with those of patients who had non-SRC using Cox regression and propensity score methods. (biomedcentral.com)
An increased TRPC1 proteins rating had been adversely associated using overall survival, this also correlation has been substantially apparent within sufferers who acquired adjuvant radiotherapy. (trpv-antagonist.com)

METHODS: A single-center retrospective analysis was conducted on patients seen for recurrent clival chordoma. (bvsalud.org)
Objectives:To determine the pattern of ocular disorders among stroke patients in Federal Teaching Hospital, Lokoja (FTHL).Materials and Methods:Consecutive new stroke patients seen at the Federal Teaching Hospital, Lokoja over a 3-month period were studied. (bvsalud.org)

On Next Generation Sequencing (NGS), in addition to conventional CTNNB1 gene mutation, new pathogenic MYCN and ATM gene mutations were detected. (turkjpath.org)
In all, 297 women completed a study-specific questionnaire 1 year after conventional BCS and radiotherapy. (springer.com)
The aims of this prospective study were to examine patient satisfaction concerning aesthetic result, including symmetry, and skin sensitivity in the breast, in a consecutive sample of patients undergoing conventional BCS at a single institution, and to investigate potential risk factors for low satisfaction. (springer.com)

En ocasiones el carcinoma epidermoide cutáneo se caracteriza por tener un mayor riesgo de desarrollar recurrencia locorregional y ocasionalmente metástasis a distancia. (actasdermo.org)
A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)

Radiation was used to treat 42 recurrences in 28 patients. (bvsalud.org)
Patients with recurrences but without prior radiation had longer PFS than those patients with prior radiation. (bvsalud.org)
Multivariate Cox regression analysis showed that mortality after the first recurrence was significantly associated with no adjuvant radiation (HR 0.149, 95% CI 0.038-0.59, p = 0.0067), older age at the time of the first recurrence (HR 1.04, 95% CI 1.01-1.08, p = 0.021), and total number of recurrences (p = 0.032). (bvsalud.org)

However, cases of MPNST in concomitance with NF1 were found to be resistant to both chemo and radiotherapy and have high recurrence rate. (surgicalneurologyint.com)

However, few effective chemotherapeutic options exist for advanced PDAC patients in the clinic. (biomedcentral.com)

In order to avoid a mutilating approach, multiple excisions with safety margins were performed, and the patient was instructed not to smoke. (bvsalud.org)

Six pediatric patients at BC Children's Hospital who were diagnosed with either osteosarcoma or Ewing sarcoma in 2018 were identified from the oncology database. (bcmj.org)

Patients with this cancer type face significant morbidity and mortality, with over 13,000 deaths per year in the United States. (cancernetwork.com)

Factors associated with less satisfied patients regarding skin sensitivity in the operated breast were an excision of ≥20% of preoperative breast volume, a BMI of 25-30 kg/m 2 , axillary clearance, and radiotherapy. (springer.com)

Other ocular abnormalities included corneal anaesthesia and macular hole in 2(1.2%).Conclusion:Anterior and posterior segments, together with neuro-ophthalmic disorders were found among stroke patients in this study. (bvsalud.org)

The addition of nivolumab to chemotherapy significantly improved pathologic complete response rate. (ascopost.com)

Functional assessment was performed and no patient had metastases at presentation. (biomedcentral.com)
In addition to primary malignancies, the skin can also be a major site for metastases of internal cancers. (medscape.com)

Using Cox's proportional hazards model, we estimate that at least 456 patients would be necessary to demonstrate an increase in the hazard ratio to 1.3 for those undergoing biopsy alone. (biomedcentral.com)

I always find this interesting when seeing studies about hospice and palliative care patients, because opioids have a wide range of therapeutic dosing. (pallimed.org)
This review focuses on the relevance of IEs in GBM biology and their implementation as a potential theranostic target to stratify GBM patients and develop novel therapeutic approaches. (biomedcentral.com)

In one of the largest series to date, Perez et al reported on 88 patients with cutaneous angiosarcoma divided into 4 groups: 38 head and neck, 30 radiotherapy-induced, 13 sporadic trunk/extremity, and 7 Stewart-Treves syndrome related. (medscape.com)

Event-free survival was improved in patients with a pathological complete response compared with those without, suggesting pCR is a surrogate endpoint for long-term outcomes in resectable non-small cell lung cancer, and this is the first time [this has been shown] in a randomized phase 3 study," he said. (medscape.com)
We emphasize the value of contemplating how several types of outgroup clash can easily make diverse assortment challenges in addition to investigating variance inside physical fitness outcomes within just along with involving species. (trpv-antagonist.com)

pain relief in palliative care patients, a case series. (bvsalud.org)

Background: Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. (unav.edu)

However, models for patients with soft tissue sarcomas (STSs) are limited because of the rarity and heterogeneity of such cancers. (biomedcentral.com)
The risk of not treating patients with aggressive cancers early enough, the long-term effects and the impact on quality of life are unknown. (cancercentrum.se)

Anatomy7

Organisms2

Diseases82

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment85

Phenomena and Processes9

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Humanities1

Information Science6

Named Groups1

Health Care35

Surgical12

Concomitant and adjuvant temozolomide1

Tumors17

Metastasis10

Cycles of adjuvant2

Resection8

Clinical21

Metastatic13

Treatments8

External beam radioth3

Tumor10

Median10

Post-operative3

Therapy25

Postoperative radiotherapy1

Pelvic9

Chemotherapy alone3

Underwent6

Extracapsular spread1

Treatment31

Prognosis4

Temozolomide2

Outcome1

Therapies2

Immunotherapy3

Plus chemotherapy1

Diagnosis3

Tumours2

Brachytherapy3

Efficacy4

Surgery16

Glioblastoma1

Histologic2

Unresectable localized1

Nodal1

Randomly assigned1

Subgroups1

Tamoxifen2

Lymph nodes1

Overall survival3

Methods2

Conventional3

Carcinoma3

Recurrences3

Recurrence rate1

Chemotherapeutic1

Margins1

Oncology1

Mortality1

Preoperative1

Conclusion1

Pathologic1

Metastases2

Hazard1

Therapeutic2

Head and neck1

Outcomes2

Palliative care patients1

Limb1

Cancers2