Addition adipose. Medical search. Frequent questions

The functional importance of different adipose depots in energy metabolism and nutritional homeostasis mainly depends on the composition of the various types of adipocytes, classified as white, beige or brown ( Table 1 ). (degruyter.com)
Spectral imaging of adipose tissue provides high-quality information involving molecular compositional, structural, and functional alterations for characterization and differentiation of adipocytes (brown, white) in different adipose tissue regions (visceral, subcutaneous, etc. (intechopen.com)
Adipocytes are the cells that primarily constitute adipose tissue. (intechopen.com)
Besides adipocytes, adipose tissue also includes the stromal vascular fraction (SVF) of cells including fibroblasts, vascular endothelial cells, and a variety of immune cells such as macrophages. (intechopen.com)
It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue. (cambridge.org)
This study examined adipose and muscle inflammatory markers after treatment of humans with FOs and measured the effects of ω-3 fatty acids on adipocytes and macrophages in vitro. (diabetesjournals.org)
Recent data in mice from several laboratories have shown that in addition to brown adipocytes in the interscapular region that share an origin with myocytes and are present constitutively from the embryonic period, brown adipocytes can be induced in subcutaneous white adipose depots in response to cold, chronic administration of B3-adrenergic receptor agonists and exercise. (nih.gov)
Brown adipose tissue is a form of fat that is stored in adipose tissue which is made up of cells called adipocytes. (spts.org)
Brown adipose tissue also known as brown fat produces heat, beige adipose tissue, is located in the white adipose tissue and its adipocytes resemble brown adipocytes. (spts.org)
Presenters addressed the role of adipocytes and adipose tissue metabolism in the heterogeneity of obesity, metabolically healthy (MHO) and unhealthy obesity (MUO) and their relationship to cardiovascular disease (CVD) risk, genetic subclassification of obesity and its role in precision health, and use of machine learning to inform intervention targets that address the heterogeneity of obesity in children from diverse households. (nih.gov)
Philipp E. Scherer, Ph.D., University of Texas Southwestern Medical Center's Touchstone Diabetes Center, highlighted the heterogeneity of adipocytes and adipose tissue. (nih.gov)
Further, dysfunctional adipocytes and adipose tissue are the target for several parasites and viruses, including SARS-CoV-2. (nih.gov)
We also examined whether the addition of walnuts ameliorates HFD-induced adipocytes inflammation and apoptosis. (nih.gov)

It is suggested that these events reflect hypoxia in parts of the growing adipose tissue mass in advance of angiogenesis, and involve the key controller of the cellular response to hypoxia, the transcription factor hypoxia inducible factor-1. (cambridge.org)

The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. (degruyter.com)

The results demonstrated that PDX caused differential metabolite patterns in blood and adipose tissues and that one-carbon metabolism, associated with glycine betaine and l -carnitine, and bile acid and tryptophan metabolism are associated with the hypolipidemic effects observed in mice that were given PDX. (nature.com)
Due to its unique metabolic function, brown adipose tissue (BAT) has recently been in the focus of metabolism research. (degruyter.com)
In this chapter, applications of spectroscopic and spectral imaging techniques for characterization and differentiation of various adipose tissues will be discussed, which will shed light to better understand adipose tissue metabolism and provide new insight into diagnosis and treatment of some metabolic diseases such as obesity. (intechopen.com)
Though studies have shown that brown adipose tissue may be present in some adults as a result of constant exposure to cold which thereby helps in the activation of this brown fat for protective mechanism and for other functional medical importance for regulating glucose metabolism in general and diabetes in particular. (spts.org)
Characterization and influences of the absence of maternal melatonin on the glycemic, hepatic and adipose metabolism of male offspring subjected to different environmental challenges. (usp.br)
FGF21 is currently considered as a myokine and adipokine, which mediates the cross talk between skeletal muscle and adipose tissue in energy metabolism [ 34 , 35 ]. (hindawi.com)

In total, 485,577 CpG sites were profiled in matched, before and after weight loss, subcutaneous and omental adipose tissue. (biomedcentral.com)
Recently, rapid oscillations in lipolysis have been observed in omental adipose tissue in dogs ( 4 ). (diabetesjournals.org)

The high expression of proinflammatory genes in visceral adipose tissue of the HFD group was significantly attenuated by PM. Treatment with PM partially prevented HFD-induced mild vascular dysfunction. (nih.gov)

Metabolic risk is affected by both the distribution of body fat between different adipose tissue depots within an individual and the differing natures of the depots themselves [ 9 - 11 ]. (biomedcentral.com)

There is currently increasing interest in epicardial adipose tissue (EAT) as a marker of cardiovascular disease. (revespcardiol.org)
Here, we obtained samples of epicardial adipose tissue (EAT) from neonates, infants, and children in order to evaluate changes in their transcriptional landscape by applying a systems biology approach. (jci.org)

The presence of brown adipose tissue in adult humans was discovered in 2003 during FDG-PET scans to detect metastatic cancers. (wikipedia.org)
Characteristics of white, beige and brown adipose tissue in rodents and humans. (degruyter.com)
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass provides a model to investigate obesity and weight loss in humans. (biomedcentral.com)
Brown adipose tissue (BAT) is an organ recently discovered to be functional in adult humans. (nih.gov)
This Funding Opportunity Announcement (FOA) invites applications for Research Project Grants (R01) to investigate the biological functions of brown and beige adipose tissue in humans, other than heat production and maintenance of body temperature, and to explore their impact on human health. (nih.gov)
BAT is a variable mass of metabolically active, highly innervated and vascularized adipose tissue found in the neck and subclavicular region of humans. (nih.gov)
In the case of humans, brown fat is particularly abundant in the fetus and newborn, in whom brown adipose tissue accounts for approximately 5% of birth weight. (spts.org)
In humans, it is mainly present in the fetus and newborn, brown adipose tissue is made up of cells that burn glucose by producing heat, this type of fat as said earlier is very present in babies and helps protect them from cold. (spts.org)
Brown adipose tissue could play a role in the fight against diabetes in humans. (spts.org)
Maintaining constant body temperature is an important factor that determines most physiological functions in humans, and thus the major component function of brown adipose tissue, it is therefore pertinent for an individual to take sensitive measures to keep brown fat in the body healthy through regular exercise and eating balanced diets. (spts.org)
We conclude that release from adipose tissue of the products of lipolysis is pulsatile in humans. (diabetesjournals.org)
In humans, adipose tissue lipolysis, as measured by microdialysis of interstitial glycerol, is not affected by propranolol after an overnight fast. (diabetesjournals.org)
Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. (jci.org)
In addition, circulating FGF21 was also increased in several pathological statuses including obesity, diabetes, and other metabolic syndromes in rodents and humans [ 16 - 18 ]. (hindawi.com)

Collectively, these data provide new results of the protective effects of walnuts on preventing HFD obesity-related hepatic and adipose tissue injuries via mechanisms independent of insulin resistance. (nih.gov)

Numerous scientific articles have highlighted the role of cold in the activation of brown adipose tissues. (spts.org)
FGF21 can be induced in multiple tissues including liver, pancreas, adipose tissue, and skeletal muscle [ 8 - 12 ]. (hindawi.com)
[ 4 ] In addition, insulin negatively regulates the synthesis of the major carrier protein of androgens, the sex-hormone-binding globulin, and therefore reduces circulating sex-hormone-binding globulin levels that, in turn, increase the availability of free testosterone in peripheral tissues and cells. (medscape.com)

White adipose tissue (WAT) depots, however, also possess the capacity to acquire brown fat characteristics in response to thermogenic stimuli. (degruyter.com)
Adipose tissue depots exert distinct local and systemic effects. (degruyter.com)
Notably, promoting brown fat function or the acquisition of BAT characteristics within white adipose depots (referred to as "browning" or "beiging") has been shown to protect against obesity and related metabolic complications in animal studies [9-15]. (degruyter.com)
The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. (cambridge.org)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) encourages applications that primarily focuses on HIV-1 reservoirs in anatomical sites relevant to its mission, particularly the gastrointestinal mucosa, liver, kidney, male genital tract, and adipose tissue depots including those at ectopic sites. (nih.gov)

A paired analysis revealed significant differential methylation in omental and subcutaneous adipose tissue. (biomedcentral.com)
We identify robust correlations between changes in methylation and clinical trait, including associations between fasting glucose and HDAC4 , SLC37A3 and DENND1C in subcutaneous adipose. (biomedcentral.com)
We sought evidence for pulsatility of lipolysis in human subcutaneous adipose tissue in vivo. (diabetesjournals.org)

The adipose (but not muscle) of FO-treated subjects demonstrated a decrease in macrophages, a decrease in MCP-1, and an increase in capillaries, and subjects with the most macrophages demonstrated the greatest response to treatment. (diabetesjournals.org)
Macrophages and dendritic immune cells, in addition to pancreatic islets were investigated in vitro with respect to NEFA-induced cytokine production. (nih.gov)

In addition to weight, brown fat could influence obesity-related disorders, such as type 2 diabetes or fatty liver disease. (spts.org)
Adipose, liver, muscle and islet pathology and inflammation were examined using molecular approaches. (nih.gov)
Type 2 diabetes (T2D) is a metabolic disorder characterized by a combination of insulin resistance, (especially in adipose tissue, skeletal muscles and the liver), and relative insulin secretion deficiency ( 1 ). (frontiersin.org)
In rodents, the liver tissue is the major source of FGF21 in the conditions of fasting and ketogenesis [ 13 , 14 ], while under cold exposure, brown adipose tissue becomes an important organ of FGF21 generation [ 15 ]. (hindawi.com)

Our results show that FXR is expressed in the white adipose tissue of adult mice and in differentiated 3T3-L1 cells but not in undifferentiated preadipocytes. (aspetjournals.org)

In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. (wikipedia.org)
Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled respiration and heat production (thermogenesis). (degruyter.com)
Gsα, the G protein that transduces receptor-stimulated cAMP generation, mediates sympathetic nervous system stimulation of brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT), which are both potential targets for treating obesity, as well as lipolysis. (nih.gov)
In addition, all the brown adipose tissuely reducing appetite and improve the weight loss of thermogenesis. (atime.org)

In addition, adipogenesis of murine 3T3-L1 and human Simpson-Golabi-Behmel Syndrome preadipocytes was dose- and time-dependently reduced by PM, as demonstrated by Oil Red O staining and reduced expression of adipogenic differentiation genes. (nih.gov)
Indeed, adipose tissue from mice fed the HFD+walnuts showed decreased levels of macrophage infiltration with suppressed expression of inflammatory genes compared to those in HFD-fed mice. (nih.gov)
reduzida expressão do transportador de glicose em tecidos adiposos branco e marrom, aumento de expressão de alguns genes termogênicos e de diferenciação celular no tecido adiposo marrom que, por sua vez, não correponderam à eficiência funcional observadas nas análises de termografia, e maior dificuldade em termorregular pela cauda. (usp.br)

Furthermore, a study revealed that the ectopic expression of UCP1 in skeletal muscle upregulates FGF21 level in both skeletal muscle and circulation system, and increased FGF21 promotes browning of white adipose tissue [ 35 ]. (hindawi.com)

In addition, results from a study that followed 87,253 female U.S. nurses over eight years showed that the group that exercised at least once a week at an intensity sufficient to cause sweating had a relative risk of developing diabetes of 0.84 compared with a group that exercised less than once a week [ 8 ]. (hindawi.com)

Adipose tissue and adipokines play a role in scleroderma and cutaneous fibrosis. (rochester.edu)

It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. (cambridge.org)
Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, and inflammation of adipose tissue. (nih.gov)
Obesity is associated with low grade inflammation, which may adversely impact the biological functions of adipose tissue and consequently of adipose-derived stem cells (ASCs). (biorxiv.org)
In addition, a deeper understanding of the intersection between immune function during aging and susceptibility to systemic inflammatory diseases including mechanisms related to diminished resolution of inflammation is needed. (nih.gov)

Adipose tissue is an endocrine organ [ 5 ] and plays a fundamental role in obesity-related metabolic dysfunction [ 6 ]. (biomedcentral.com)

Adipose tissue is a complicated, crucial, and highly active metabolic and endocrine organ. (intechopen.com)
Adipose tissue is the primary storage location for excess energy but it may also be defined as an endocrine organ. (intechopen.com)
in addition to the central role of lipid storage, it has a major endocrine function secreting several hormones, notably leptin and adiponectin, and a diverse range of other protein factors. (cambridge.org)

To investigate these findings more closely, a non-targeted metabolomics approach, was exploited to determine metabolic alterations in blood and epididymal adipose tissue samples that were collected from C57BL/6 mice fed with a Western diet, with or without oral administration of PDX. (nature.com)
Expression of uncoupling protein 1 (UCP1), retinoic acid receptor α (RARα) and retinoid X receptor α (RXRα) in BAT and levels of Bcl2 and Bax in epididymal white adipose tissue (eWAT) were determined by immunoblotting. (biomedcentral.com)

Very recently, a new weight loss strategy has been proposed that harnesses the energy-dissipating properties of brown adipose tissue (BAT). (medscape.com)
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). (wikipedia.org)
Brown adipose tissue is found in almost all mammals. (wikipedia.org)
Brown adipose tissue is especially abundant in newborns and in hibernating mammals. (wikipedia.org)
Using these scans and data from human autopsies, several brown adipose tissue deposits have been identified. (wikipedia.org)
It remains to be determined whether these deposits are 'classical' brown adipose tissue or beige/brite fat. (wikipedia.org)
More than sixty years of studies in rodent models have shown that the presence and activation of brown adipose tissue (BAT) via cold stimulation or B3-adrenergic treatment provides significant health benefits for the animals. (nih.gov)
Much of the current interest in human brown adipose tissue has been driven by the hope that it represents a novel, easily assessable target for the treatment of obesity. (nih.gov)
Body composition and morphological analysis of brown adipose tissue (BAT) was analyzed. (biomedcentral.com)
Whereas white adipose tissue, which is the body's main fat reserve and accounts for approximately 20% of an adult's weight, it is the main fat composition commonly found in the body of an adult, but there exists an important second type of adipose tissue known as brown adipose tissue, in this article, we are going to review in detail what is known as brown adipose tissue, its functions, and importance. (spts.org)
Brown adipose tissue is present in some mammals, especially those that hibernate. (spts.org)
Brown fat gradually disappears in adulthood ( it is then called beige adipose tissue) to be replaced by white adipose tissue which tends to store fat. (spts.org)
How Does Brown Adipose Tissue Produce Heat? (spts.org)
In brown adipose tissue, heat is possible due to a mitochondrial protein called thermogenin, or UCP1 ( UnCoupling Protein 1). (spts.org)
In adults, brown adipose tissue activity is reduced in obesity. (spts.org)

In recent years, obesity caused by the hypertrophy of white adipose tissue (WAT) has steadily increased worldwide, and has become a serious social problem [ 1 ]. (hindawi.com)
Excess nutrient-derived energy is mainly stored in white adipose tissue (WAT) and leads to the expansion of total body mass [6]. (degruyter.com)

PM inhibited the expansion of adipose tissue and adipocyte hypertrophy in mice. (nih.gov)

The aim of this paper is to describe the methodology of a pilot randomised controlled trial comparing arthroscopic microfracture alone for isolated knee chondral defects versus arthroscopic microfracture combined with postoperative autologous adipose derived mesenchymal stem cell injections. (bmj.com)
40 participants aged 18-50 years, with isolated femoral condyle chondral defects and awaiting planned arthroscopic microfracture will be randomly allocated to a control group (receiving no additional treatment) or treatment group (receiving postoperative adipose derived mesenchymal stem cell treatment). (bmj.com)

In addition, multi-organ physiological coupling to model drug disposition in the whole-body context has demonstrated a potential for these methodologies to guide clinical trial design. (nih.gov)
If human organ chips are found to perform better than existing models, then, in addition to reducing animal testing, they may be used to develop or select therapeutics that are personalized for individual patients, distinct genetic subpopulations, or even subgroups with specific disease comorbidities that could revolutionize clinical trials design. (nih.gov)

In addition, an in vivo model of atherosclerosis was established using Apolipoprotein E (ApoE) knockout (ApoE ‑/‑ ) mice. (spandidos-publications.com)

Beige fat is the adrenergically inducible cell type that is dispersed throughout adipose tissue. (wikipedia.org)

Examining how aging alters communication between other cell types (e.g., platelets, adipose tissue, stromal cells), the microbiome, and immune cells to influence host responses is anticipated. (nih.gov)

Nevertheless, there are no studies investigating the effect of obesity on ASCs from GM, which could constitute a valuable addition to both obesity modelling and adult stem cells investigations. (biorxiv.org)

These results suggest that the protective effects of walnuts against HFD-induced steatohepatitis in mice were mediated, at least in part, by the regulation of adipose tissue macrophage recruitment and apoptosis. (nih.gov)

Adipose-derived stem cells (ADSCs) were isolated and identified from human adipose tissue. (biomedcentral.com)

In addition to its thermogenic role, it is critical to determine if human BAT plays a harmful or protective role in metabolic health unrelated to weight modulation. (nih.gov)

Some metabolites were found in both plasma and adipose tissue, such as the bile acid derivative deoxycholic acid and the microbiome-derived tryptophan metabolite indoxyl sulfate, both of which increased by PDX. (nature.com)
adipose, bile, tissue grinder with acetonitrile. (cdc.gov)

In addition, TUNEL assay revealed that the hepatic apoptosis rates were significantly suppressed in mice fed HFD+walnuts, compared to the corresponding HFD-fed mice. (nih.gov)

Obesity or insulin resistance-induced molecular alterations in adipose tissue can be detected using these techniques. (intechopen.com)

In addition, the TNF-transgenic mouse model has proven a valuable tool in the further understanding of the pulmonary vascular disease in scleroderma and with additional characterization, may provide a mechanism for the pre-clinical investigation of potential targets for treatment. (rochester.edu)

Anatomy31

Organisms12

Diseases27

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology2

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science2

Health Care4

Geographicals1

Adipocytes13

Growing adipose tissue mass1

Understanding of adipose tissue1

Metabolism6

Omental adipose tissue2

Visceral adipose tissue1

Different adipose tissue1

Epicardial adipose tissue2

Humans14

Hepatic and adipose1

Tissues3

Depots5

Subcutaneous3

Macrophages2

Liver4

Expressed in the white adipos1

Thermogenesis4

Genes3

Browning of white adipos1

Diabetes1

Adipokines1

Inflammation4

Obesity-related1

Endocrine3

Epididymal2

Brown15

White2

Adipocyte1

Mesenchymal2

Organ2

Vivo1

Beige1

Stromal1

Adult1

Macrophage1

Stem cells1

Human1

Bile2

Apoptosis1

Alterations1

Treatment1