Adaptor related protein complex 2 subunit sigma. Medical search. Frequent questions

AP1S2: AP-1 complex subunit sigma-2. (wikipedia.org)

Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
It is a member of a group of key signaling molecules that share a carboxyl-terminal domain related to phosphatidylinositol-3-kinase but unlike many family members, it lacks kinase activity. (biomedcentral.com)
In addition, calcofluor white sensitivity of the strain was enhanced by the protein kinase inhibitor staurosporine, a phenotype shared with the Ada components of the SAGA/SLIK complex. (biomedcentral.com)

Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)
120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)
Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
Phylogenetic analysis of 9 concatenated genes showed that this virus was distantly related to cowpox virus, more closely related to to ectromelia virus, and belonged to the same cluster of an OPXV recently isolated from captive macaques in Italy. (cdc.gov)
The interacting genes are involved in a range of cellular processes including gene expression, mitochondrial function, and membrane sorting/protein trafficking. (biomedcentral.com)
Genes involved in transcription, RNA processing, mitochondrial function and membrane sorting/protein trafficking were prevalent. (biomedcentral.com)
On the other hand, TNBC, which is mainly driven through dysregulation of cell-cycle related genes (e.g. (biomedcentral.com)

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
Two well-defined pathological hallmarks of AD have been described: the formation of extracellular amyloid plaques and the development of intracellular neurofibrillary tangles (NFTs) formed by aggregated hyperphosphorylated TAU protein [ 4 ]. (biomedcentral.com)
Inflammasomes are intracellular multiprotein complexes that regulate the activity of caspase-1 and can be activated by various cellular dangers that trigger the processing and release of pro-inflammatory cytokines to engage innate immunity ( 3 ). (spandidos-publications.com)
What started as an informal meeting among a handful of labs involved in intracellular trafficking has grown to include tens of labs, both young and established, all interested in understanding the cytoskeleton and motor proteins in the context of intracellular trafficking. (silverchair.com)

Adaptor protein complex 1 is found on the cytoplasmic face of vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. (wikipedia.org)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)
The heavy chain subunits of clathrin. (lookformedical.com)
A subclass of clathrin assembly proteins that occur as monomers. (lookformedical.com)
The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
These clathrin-associated complexes are ancient and found in most eukaryotes. (eu.org)
They serve to initiate clathrin-mediated endocytosis or protein sorting and can work synergistically with the adaptin mu subunit binding YxxPhi-type motifs ( TRG_ENDOCYTIC_2 ). (eu.org)

Notably, RNA sequencing revealed a role for COMMD3 in copper signalling, via regulation of the Na + /K + -ATPase subunit, ATP1B1 . (biomedcentral.com)

IQSEC2: encodes an exchange factor for the Arf family of small GTP binding proteins, involved in the formation of secretory vesicles. (wikipedia.org)
KDM5C: Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. (wikipedia.org)
on chromosome 19q13.3, which encodes the adaptor-related protein complex 2 sigma (AP2σ) subunit, cause FHH type 3. (ox.ac.uk)
TRA1 is an essential gene in Saccharomyces cerevisiae that encodes a 437 kDa protein product. (biomedcentral.com)

A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size. (lookformedical.com)
A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)
Depending on organism, cell type as well as the nature of the adaptin complex bound, they can target either to cell surface or to specific, internal membrane-bound organelles (endosomes, lysosomes, melanosomes, synaptic vesicles, etc. (eu.org)
All these motifs are believed to bind to the sigma subunit of activated adaptin complexes (AP-1, AP-2 and AP-3). (eu.org)
One should avoid confusing the adaptin sigma-binding classical dileucine motifs discussed here, and the GGA-binding lysosomal targeting motifs (sometimes also called dileucine motifs). (eu.org)
They have a range of adaptin complexes they can associate with (AP-1, AP-2 and/or AP-3). (eu.org)
Adaptin-binding acidic dileucine motifs and variants thereof occur almost exclusively on the cytosolic side of membrane proteins, mostly integral (transmembrane) proteins. (eu.org)
Due to the similarity of the adaptin sigma subunits, variant dileucine motifs may have overlapping specificities, being capable of binding multiple adaptins. (eu.org)

Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
The citric type, pin-pointed a available interface( complex), describes an Second subcellular transcription within a receptor path-finding. (evakoch.com)
however, the rules guiding receptor subunit assembly are unclear. (jneurosci.org)
What is the subunit composition of native subtypes of receptor? (jneurosci.org)

Endocytosis and/or vesicular sorting signals for membrane proteins. (eu.org)
AP2 is chiefly involved in endocytosis of cell surface proteins and their trafficking to early or late endosomes. (eu.org)

The 2019 edition of the meeting, held from 18-20 October at the National Brain Research Centre (NBRC), Manesar, India and organised by Mahak Sharma (Indian Institute of Science Education and Research, Mohali) and Anindya Ghosh Roy (NBRC), was witness to stimulating research on a range of topics related to the cytoskeleton, including cytoskeletal organization, motor protein function and regulation, mechanical forces and vesicular transport, and trafficking in health and disease. (silverchair.com)

These small highly conserved actin-binding proteins are essential regulators of actin dynamics in living cells. (rupress.org)

ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)
A major modulator of actin filament disassembly is the actin-depolymerization factor/cofilin family of proteins (hereafter referred to as cofilin). (rupress.org)
Cofilin binds preferentially to ADP-actin subunits within actin filaments. (rupress.org)
This binding induces a twist in the filament, accelerates the release of Pi from ADP-Pi subunits, and severs actin filaments ( Pollard and Borisy, 2003 ). (rupress.org)
Severing increases the number of actin filament pointed ends and, in conjunction with capping of barbed ends by capping proteins, stimulates filament disassembly ( Andrianantoandro and Pollard, 2006 ). (rupress.org)
This localization was found to be unaffected by manipulations that were expected to change polymerization rates at the leading edge, which should alter the relative abundance of ATP-, ADP-Pi-, and ADP-actin subunits within the filaments. (rupress.org)

TM4SF2: is a member of the 4 transmembrane domains family of proteins (tetraspanins, see TSPAN7). (wikipedia.org)
In the latter, they are frequently located near the protein N- or C-termini, with relative proximity (within 10-100aa) to a transmembrane segment. (eu.org)

The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)

subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)

They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)
preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)

The δ subunit mRNA was present at wild-type levels in the mutant granule cells, indicating a post-translational loss of the δ subunit. (jneurosci.org)

We tested temozolomide, camptothecin, and DNA methylation inhibitor 5-aza-2-deoxycytidine. (immune-source.com)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)

We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. (nature.com)

ZNF41: Zinc finger protein 41 is a likely zinc finger family transcription factor. (wikipedia.org)
MECP2: methyl CpG binding protein 2 is a transcription regulator, which represses transcription from methylated gene promoters. (wikipedia.org)
The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. (wikipedia.org)
Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)

A constitutively expressed subfamily of the HSP70 heat-shock proteins. (lookformedical.com)
family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus ) are complex, double-stranded DNA viruses with ongoing interest because of their potential use as bioterrorism agents and in gene therapy. (cdc.gov)

Violin plots show distribution of expression levels for AP complex subunit sigma (SMED30008812) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of AP complex subunit sigma (SMED30008812) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for AP complex subunit sigma (SMED30008812) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
We performed immunohistochemical analysis of an independent tumour cohort to investigate relationships between COMMD3 protein expression, phenotypic markers and disease-specific survival. (biomedcentral.com)

Because in α 6 −/− neurons the remaining α 1 , β 2/3 , and γ 2 subunits cannot rescue the δ subunit, certain potential subunit combinations may not be found in wild-type cells. (jneurosci.org)
Neurons from patients with fAD and patients with sAD showed increased phosphorylation of TAU protein at all investigated phosphorylation sites. (biomedcentral.com)
To our knowledge, this is the first study in which the hyperphosphorylation of TAU protein has been compared in fAD and sAD iPSC-derived neurons. (biomedcentral.com)

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and is divided into three subtypes according to pathogenesis: adenocarcinoma, squamous cell carcinoma and large cell carcinoma [ 2 ]. (oncotarget.com)

The latter dileucine motifs were implicated in membrane protein sorting to vacuoles or tonoplasts. (eu.org)
In fungi and plants, dileucine motifs are often responsible for the vacuolar or tonoplast localization of proteins carrying these motifs. (eu.org)

In complexes, the other enzymes affect cleaved CBF1( or RBPJkappa), while in channels they are required Lag-1, immediately that the m ' CSL ' demonstrates separated been to this produced feature experience breast. (evakoch.com)
RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)

GDI1: RabGDI alpha makes a complex with geranylgeranylated small GTP-binding proteins of the Rab family and keeps them in the cytosol. (wikipedia.org)
The MutS sites possess reviewed to phenotypically avoid sympathetic download Sarkozy, Israël et les, ceasing along the Parental hardware for principles motility-related to a ' special effect ' until they are a IM alpha-H activating a context. (erik-mill.de)

A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)

LBH589 (25?nmol/L) as well as Dox at the number of 0.03 to 2?g/mL induced dramatic cellular number reduction, and reduced the IC50 of Dox from 0.8?g/ml to 0.08?g/ml (Fig. (immune-source.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)

It has therefore been proposed that the oncogenic activity of MLL-fusion proteins depends on chromatin targeting functions exerted by the MLL N-terminus in combination with other functional properties encoded by the fusion partners 6 . (nature.com)

Families of related leukemia fusion proteins that share genomic and biological properties represent unique opportunities to study how the combination of distinct functional protein modules can drive oncogenic transformation. (nature.com)

Sigma subunits of AP complexes differ slightly in their surface charge densities and binding groove geometry, allowing for both generic and selective interactions with protein partners. (eu.org)
The pathway maps illustrate protein interactions and regulation to provide a comprehensive picture of signaling and disease processes. (bio-rad.com)
By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas , the main oyster species exploited worldwide. (nature.com)
Introduced to France in the 1970s, C . gigas suffers mass mortalities associated with complex interactions between the host, the environment and pathogens 5 . (nature.com)
A hierarchal cluster analysis revealed that the pattern of SSL interactions for tra1 SRR 3413 most closely resembles deletions of a group of regulatory GTPases required for membrane sorting/protein trafficking. (biomedcentral.com)

However, it is unclear whether these molecular mechanisms pertain to the entire family of MLL-fusions or if they specifically affect the leukemogenicity of isolated MLL-fusion proteins. (nature.com)

All AFF proteins are localized in the nucleus and have a role as transcriptional activators with a positive action on RNA elongation. (wikipedia.org)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)

FTSJ1: Transfert RNA methyltransferase 1 is a member of the S-adenosylmethionine-binding protein family. (wikipedia.org)
It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. (wikipedia.org)
PHF8: PHD finger protein 8 belongs to the family of ferrous iron and 2-oxoglutarate dependent oxygenases, and is a histone lysine demethylase with selectivity for the di-and monomethyl states. (wikipedia.org)
FMR2: Fragile mental retardation 2 (FMR2: synonym AFF2), the protein belongs to the AFF family which currently has four members: AFF1/AF4, AFF2/FMR2, AFF3/LAF4 and AFF4/AF5q31. (wikipedia.org)
In the current study, we examined the effects of recombinant ERRP on the growth and ligand-induced activation of multiple members of erbB family in three pancreatic cancer cell lines that express varying levels of EGFR and other member(s) of its family, specifically HER-2. (aacrjournals.org)

The objective of the present work was to examine one disease of complex aetiology affecting one of the most utilized invertebrate species in the world, the Pacific oyster Crassostrea gigas , applying a holistic approach to decipher the phenomenon. (nature.com)
The MLH and MutL ketoacyl-CoA species extend with complexes of MutS analyses to exchange signal subsequent effects. (erik-mill.de)
Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
This virus was more closely related to ECTV than to CPXV, putatively representing a novel OPXV species. (cdc.gov)

vps, vacuolar protein sorting. (rupress.org)

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)

Gene Ontology annotations were extended to 16,467 proteins. (biomedcentral.com)

Based upon the nuclear localization of GFP-Tra1 and the finding that deletion of the Ada components of the SAGA complex result in similar phenotypes as tra1 SRR 3413 , we suggest that the effects of tra1 SRR 3413 are mediated, at least in part, through its role in the SAGA complex. (biomedcentral.com)

In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)

Tra1 is an essential 437-kDa component of the Saccharomyces cerevisiae SAGA/SLIK and NuA4 histone acetyltransferase complexes. (biomedcentral.com)

Finally, a survey of the human proteome has allowed us to map a protein-protein network which links the identified immune/MER41/cognition pathway to FOXP2 (Forkhead Box P2), a key TF involved in the emergence of human speech. (biorxiv.org)
240 million paired-end reads were assembled de novo to produce a strictly filtered predicted proteome consisting of over 22,000 proteins. (biomedcentral.com)

2,693 sequences were identified in orthology groups spanning flukes, tapeworms and planaria, with 441 highlighted as belonging to druggable protein families. (biomedcentral.com)

The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. (wikipedia.org)
SYP7 group Qc-type SNARE protein","protein_coding" "MA_10436714g0010","No alias","Picea abies","acyl-CoA thioesterase","protein_coding" "MA_135972g0010","No alias","Picea abies","Acyl-CoA-binding domain-containing protein 3 OS=Oryza sativa subsp. (ntu.edu.sg)
For instance, the CxxC-domain is essential for DNA binding of MLL-fusion proteins 7 . (nature.com)
Furthermore, the MLL-interacting protein Menin links MLL-fusion proteins with LEDGF, and the H3K36me3-binding PWWP domain of LEDGF is critical for the function of MLL-fusions 8 . (nature.com)
The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)

As a component of both SAGA and NuA4 complexes, Tra1 is positioned to play a major role in nuclear processes. (biomedcentral.com)

Other Eukaryotes - 2 (source: NCBI BLink). (ntu.edu.sg)

Similar to protein-coding regulators, recently mounting studies have revealed that lncRNAs are also importantly involved in tumor progression and have great potentials to be clinically applied in the treatment of cancer [ 7 ]. (aging-us.com)

We determined the isobologram index (Ix) of Dox and LBH589 as 0.41 relating to the equation in Strategies and Materials. (immune-source.com)

protein_coding" "AAC73139","fkpB","Escherichia coli","FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73161","apaG","Escherichia coli","protein associated with Co2+ and Mg2+ efflux [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73196","murE","Escherichia coli","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73197","murF","Escherichia coli","UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73288","bamA","Escherichia coli","BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73290","lpxD","Escherichia coli","UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73627","ppiB","Escherichia coli","peptidyl-prolyl cis-trans isomerase B (rotamase B) [Ensembl]. (ntu.edu.sg)

ARX: Aristaless related homeobox, is a protein associated with intellectual disability and lissencephaly. (wikipedia.org)

14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)

Anatomy25

Organisms15

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes72

Disciplines and Occupations3

Information Science7

Health Care1

AP1S21

Kinase4

Genes9

Intracellular4

Clathrin12

ATPase1

Encodes4

Adaptin9

Receptor4

Endocytosis2

Cytoskeletal1

Highly conserved1

Actin6

Transmembrane2

Monomeric1

Signal peptidase1

Preferentially2

Post-translational1

Inhibitor1

Vesicular2

Distantly related1

Transcription4

Subfamily2

Expression5

Neurons3

Subtypes1

Motifs2

Enzymes2

Alpha2

Cytoplasmic1

Cellular2

Chromatin1

Genomic1

Interactions5

Molecular1

Transcriptional2

Family5

Species4

Vacuolar1

Vesicles2

Annotations1

Localization1

Enzyme1

Histone1

Proteome2

Sequences1

Domain5

Nuclear1

Eukaryotes1

Regulators1

0.411

Ensembl8

Aristaless1

Amyloid1