PeptidesMetabolismPathwayPathwaysPhosphorylationMitogen-ActivatCarrier ProteinsKinaseMeSHMoleculesDownstreamTransductionMoleculeCytokinesKinasesIntracellularCanonicalHomologCytoplasmicReceptorsTumor2002InducesRhoAIntrinsicCellsGroup of proteinsComplexesAssaysMTOREnzymatic activityMotifsGPCRRegulatesDomainsFactorSpecificityInteractionsCell
Peptides2
- Identified MWCNT-responsive peptides depicted a mechanism involving aberrant fibrinolysis (fibrinopeptide A), blood-brain barrier permeation (homeobox protein A4), neuroinflammation (transmembrane protein 131L) with reactivity by astrocytes and microglia, and a pro-degradative (signal transducing adapter molecule, phosphoglycerate kinase), anti-plastic (AF4/FMR2 family member 1, vacuolar protein sorting-associated protein 18) state with the excitation-inhibition balance shifted to a hyperexcited (microtubule-associated protein 1B) phenotype. (cdc.gov)
- Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. (wikidoc.org)
Metabolism4
- We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
- Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. (geneticsmr.com)
- Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. (edu.au)
- Receptors transduce these signals to alter intracellular metabolism and cellular responsiveness through heterotrimeric G protein/second messenger pathways or through small GTP-binding protein/protein kinase cascades. (duke.edu)
Pathway13
- Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway. (wikipedia.org)
- TAB2 is an adaptor protein involved in the IL-1 signal transduction pathway: Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (April 2000). (wikipedia.org)
- Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
- Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
- As part of the innate immune system the Toll-like receptor (TLR) signaling pathway contributes to the first line of defense against microbial pathogens. (antibodies-online.com)
- Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. (antibodies-online.com)
- Blocking HMGB1, ROS, or the JNK pathway may attenuate VEGF-A production, suggesting HMGB1 and related signaling molecules play a role in diabetic retinopathy. (molvis.org)
- The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. (geneticsmr.com)
- Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. (uchicago.edu)
- Here, we report that C. elegans LIN-28 represses the expression of LIN-46, a downstream protein in the heterochronic pathway. (stanford.edu)
- Additionally, tumor growth, pathological changes, serum lipid profiles, expression of Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway and its key targets including inflammatory factors, cell cycle and epithelial-mesenchymal transition (EMT) markers were investigated. (bvsalud.org)
- GIT1 only affects the function of G protein-coupled receptors that are internalized through the clathrin-coated pit pathway in a beta-arrestin- and dynamin-sensitive manner. (duke.edu)
- Thus, GIT1 is a protein involved in regulating the function of signaling receptors internalized through the clathrin pathway and can be used as a diagnostic tool for defining the endocytic pathway of a receptor. (duke.edu)
Pathways10
- What pathways are this gene/protein implicaed in? (cancerindex.org)
- Downstream, TLR signaling engages two distinct pathways in which either TRIF (TICAM2) or MyD88 are the key component. (antibodies-online.com)
- https://doi.org/10.1083/jcb.201607098 ) explore the evolutionary origins of these cues and report that in Drosophila melanogaster pro- and mature neurotrophins are capable of inducing death and survival pathways, respectively, by binding Toll receptor family members, which then recruit distinct sets of effector proteins. (rupress.org)
- We now appreciate that the decision to survive or die can often times be represented by two antagonistic signaling pathways. (rupress.org)
- Although the molecular logic for how antagonistic constructive and destructive signaling pathways tune the number of axons, synapses, and neurons is becoming established for vertebrates, the evolutionary history of these pathways is less clear. (rupress.org)
- Multiple signalling pathways can affect the normal function of stromal fibroblasts in tumours, but how these events are coordinated to generate tumour-promoting cancer-associated fibroblasts (CAFs) is not well understood. (icr.ac.uk)
- It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION. (ucdenver.edu)
- Weyant MJ, Carothers AM, Bertagnolli ME, Bertagnolli MM. Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. (ucdenver.edu)
- The aim of these studies is to understand how these molecules participate in TCR mediated signaling and to determine what roles they and the signaling pathways they regulate play in T cell maturation, thymocyte selection and T cell activation. (nih.gov)
- Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. (duke.edu)
Phosphorylation1
- The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
Mitogen-Activat1
- A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES. (uchicago.edu)
Carrier Proteins1
- A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. (childrensmercy.org)
Kinase7
- Good article about adaptor proteins involved in protein kinase C-mediated signal transduction: Schechtman D, Mochly-Rosen D (October 2001). (wikipedia.org)
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
- The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
- The expression of HMGB1, c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38 MAPK) was assessed with immunofluorescence and western blot analysis. (molvis.org)
- It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity. (bvsalud.org)
- TGF-β- activated kinase 1 and MAP3K7 binding protein 3 (TAB3), calcium/calmodulin-dependent protein kinase type IV (CAMK4) and HemK methyltransferase family member 1 (HEMK1) were significantly upregulated in Ara h 2-specific T cells of PA patients. (kl.ac.at)
- A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)
MeSH4
- Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Nod Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Molecules5
- They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. (childrensmercy.org)
- It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. (umassmed.edu)
- Glycation, the result of a protein or lipid molecule bonding with sugar molecules, is a consequence of the aging process. (molvis.org)
- Second, we have begun to identify and characterize the function of other signal transducing molecules that play an important role in T cell development (CCR9, CD5, TLAP). (nih.gov)
- They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. (edu.au)
Downstream1
- In summary, different sensor TNLs differentially use two groups of hNLRs to transduce downstream defense signals. (ubc.ca)
Transduction3
- Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short-lived active complexes in response to an activating signal such as a growth factor binding to its receptor. (wikipedia.org)
- There are many other types of interaction domains found within adaptor and other signalling proteins that allow a rich diversity of specific and coordinated protein-protein interactions to occur within the cell during signal transduction. (wikipedia.org)
- Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. (expasy.org)
Molecule2
- Our data propose Eps8 as a key molecule involved in the control of the intrinsic invasive behavior of GBM cells, and suggest that this protein might represent a useful target for the design of new drugs for the treatment of these tumors. (nih.gov)
- Animal STAM (signal-transducing adaptor molecule), which interacts with Hrs and may therefore be involved in endocytosis/vesicular transport. (expasy.org)
Cytokines2
- Many studies have reported their regulatory roles in immunity through cytokines and cell signaling. (cancerindex.org)
- A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. (ouhsc.edu)
Kinases4
- This protein initially was identified as an interacting partner for the G protein-coupled receptor kinases, and its overexpression was found to affect signaling and internalization of the prototypical beta(2)-adrenergic receptor. (duke.edu)
- Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. (duke.edu)
- Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. (duke.edu)
- The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate and desensitize agonist-occupied GPCRs. (duke.edu)
Intracellular3
- Subsequent cascades of intracellular signalling then alter cell functions. (wikidoc.org)
- Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
- Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. (edu.au)
Canonical2
- Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. (childrensmercy.org)
- Mechanistically, DKK3 in CAFs acts via canonical Wnt signalling by interfering with the negative regulator Kremen and increasing cell-surface levels of LRP6. (icr.ac.uk)
Homolog2
- This graph shows the total number of publications written about "Discs Large Homolog 1 Protein" by people in this website by year, and whether "Discs Large Homolog 1 Protein" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles. (umassmed.edu)
Cytoplasmic2
- Following dimerization, TLR signals are transduced via a cytoplasmic C-terminal Toll IL-1 receptor (TIR) domain to a set of adapter proteins. (antibodies-online.com)
- Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. (edu.au)
Receptors7
- Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
- Here, we report that GIT1 overexpression regulates internalization of numerous, but not all, G protein-coupled receptors. (duke.edu)
- Furthermore, the GIT1 effect is not limited to G protein-coupled receptors because overexpression of this protein also affects internalization of the epidermal growth factor receptor. (duke.edu)
- Critical physiological events throughout the body are controlled by extracellular signals from neurotransmitters and hormones acting on cell surface receptors. (duke.edu)
- Broadly, my research focuses on the role for G protein-coupled receptors in the pathophysiology of asthma. (duke.edu)
- G protein-coupled receptors figure largely in the pathology and treatment of this disease. (duke.edu)
- Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. (edu.au)
Tumor3
- Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
- Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. (ucdenver.edu)
- Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. (uchicago.edu)
20021
- A good article regarding the role of adaptor proteins involved with the T-cell antigen receptor: Samelson LE (2002). (wikipedia.org)
Induces1
- Furthermore, TLR signaling induces dendritic cell maturation and contributes consequently to the adaptive immune response. (antibodies-online.com)
RhoA1
- Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. (ucdenver.edu)
Intrinsic1
- These proteins tend to lack any intrinsic enzymatic activity themselves, instead mediating specific protein-protein interactions that drive the formation of protein complexes. (wikipedia.org)
Cells3
- The VEGF-A protein and mRNA levels in conditioned medium of RGC-5 cells incubated with AGE-modified BSA (AGE-BSA) were examined with real-time PCR and enzyme-linked immunosorbent assay (ELISA), and BSA-treated cells were used as controls. (molvis.org)
- Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. (molvis.org)
- Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
Group of proteins1
- VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking. (expasy.org)
Complexes1
- Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. (wikipedia.org)
Assays3
- We found that silencing of the protein by small interfering RNAs (siRNAs) abrogated the migratory and invasive capacity of three different human GBM cell lines both in 2-dimensional (2-D) and 3-dimensional (3-D) in vitro assays. (nih.gov)
- In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
- Clinical interest in the measurement of Cereblon (CRBN), the primary target of the IMiDs immunomodulatory drugs lenalidomide and pomalidomide, has been fueled by its essential requirement for antitumor or immunomodulatory activity of both drugs in multiple myeloma (MM). However, limited analyses of clinical samples for CRBN gene expression or protein levels have utilized unvalidated reagents and assays, raising uncertainty about the interpretation of these results. (ox.ac.uk)
MTOR1
- Interactúa directamente con mTOR para incrementar su actividad cinasa y estabiliza la interacción de la PROTEÍNA RPTOR con mTOR en condiciones de escasez de nutrientes, favoreciendo la inhibición que la PROTEÍNA RPTOR ejerce sobre la actividad de mTOR. (bvsalud.org)
Enzymatic activity1
Motifs1
- The first area of research, representing a long-term project in the lab, involves characterization of the role of T cell antigen receptor (TCR) signals, and in particular, individual TCR signal transducing subunits and signal transducing motifs in T cell development. (nih.gov)
GPCR1
- Research in the Marchese lab is directed towards understanding the molecular mechanisms governing G protein-coupled receptor (GPCR) signaling. (mcw.edu)
Regulates1
- Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
Domains7
- Adaptor proteins usually contain several domains within their structure (e.g. (wikipedia.org)
- Src homology 2 (SH2) and SH3 domains) that allow specific interactions with several other specific proteins. (wikipedia.org)
- SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins. (wikipedia.org)
- This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. (uchicago.edu)
- Interestingly, functionally redundant SNIPER1 and SNIPER2 can control the protein levels of diverse sNLRs and the interactions between SNIPER1 and sNLRs appear to be through the common nucleotide-binding (NB) domains of sNLRs. (ubc.ca)
- Avian EAST (epidermal growth factor receptor-associated protein with SH3 and TAM domains), which colocalizes with clathrin in vesicular structure. (expasy.org)
- SMART, a simple modular architecture research tool: identification of signaling domains. (expasy.org)
Factor2
- High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. (molvis.org)
- Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. (duke.edu)
Specificity1
- The specificity of the GIT1 effect is not related to the type of G protein to which a receptor couples, but rather to the endocytic route it uses. (duke.edu)
Interactions1
- Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. (expasy.org)
Cell1
- These chemical signals are similar to hormones and neurotransmitters and are used to allow one cell to communicate with another. (wikidoc.org)