• Shown in A) are five nuclear proteins ( LIN-1 , SUR-2 , LIN-25 , EOR-1 , EOR-2 ) that are jointly important for vulval, excretory duct and P12 cell fates. (wormbook.org)
  • In theory, malignant cells that express protein antigens that either are unique to the tumor, vastly over-expressed by the tumor, or whose expression is at least restricted to a narrow range of self-tissues provides a potential immunologic handle whereby tumors may be specifically recognized and destroyed. (aacrjournals.org)
  • The presence of killed bacteria in the adjuvant clearly enhances immunity against vaccine proteins, but whether this effect occurred primarily through an activation of unknown innate immune mechanisms, or through bystander activation of lymphocytes via strong bacterial antigens, is a subject for discussion. (aacrjournals.org)
  • However, despite this sequence specificity, the Tsg101 UEV domain presumably did not evolve to bind viral P(S/T)AP sequences, and it is therefore reasonable to speculate that the Tsg101 UEV domain may bind P(S/T)AP elements found in cellular proteins. (rupress.org)
  • The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. (ebi.ac.uk)
  • CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. (abnova.com)
  • However, breast tumors also rely on the ShcA PTB domain to bind numerous negative regulators that limit activation of secondary mitogenic signaling networks. (aacrjournals.org)
  • Although certain cytosolic Smad proteins transduce signals from an activated transforming growth factor-β (TGF-β) receptor at the cell surface to the nucleus, other Smads such as Smad7 negatively regulate TGF-β signaling when they bind to the receptor. (sciencemag.org)
  • Using an antiserum to the vesicular acetylcholine transporter (VAChT), a marker for cholinergic neurons, many unusually large VAChT-immunoreactive (-ir) nerve terminals, identified by colocalization with the synaptic vesicle protein synaptophysin, were demonstrated in the hypothalamic arcuate nucleus of obese tub/tub mice. (strategian.com)
  • To date, analysis of the role of mammalian Nck proteins in neuronal development has been limited by the observation that mice homozygous for null alleles of either Nck1 or Nck2 alone appear normal, whereas mice lacking both Nck1 and Nck2 die at embryonic day 9.5 ( 12 ). (pnas.org)
  • Mice Lacking Nck Protein in the Developing Nervous System Exhibit Locomotor Defects. (pnas.org)
  • This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met. (novusbio.com)
  • Mice lacking NF-κB p50 and p52 proteins have been shown to be osteopetrotic. (wikipathways.org)
  • Apart from their role in osteoclast differentiation and function, RANKL-RANK signaling is also required for development of lymph node and lactating mammary glands in mice and in the establishment of thymic microenvironment. (wikipathways.org)
  • Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (nih.gov)
  • Although in vivo adiponectin overexpression reduced MKP1 protein levels, the stimulative effects of adiponectin on mitochondrial biogenesis vanished in skeletal muscle of PGC-1α knockout mice. (diabetesjournals.org)
  • RESEARCH DESIGN AND METHODS We used RNA and chromatin from insulin-treated rat hepatic tumor cell line expressing human insulin receptor (HTC-IR) and livers from lean and insulin-resistant ob/ob glucose-fed mice in quantitative RT-PCR and chromatin immunoprecipitation studies to determine gene expression levels and associated recruitment of RNA polymerase II (Pol II), insulin receptor, and cognate signaling proteins to gene loci, respectively. (diabetesjournals.org)
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • Adiponectin mRNA and blood protein levels are inversely associated with obesity ( 7 ), which is a common cause of insulin resistance in humans. (diabetesjournals.org)
  • Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation. (nih.gov)
  • It has been reported that hematopoietic stem and progenitor cells (HSPC) are targets of pathogen products and danger signals. (ashpublications.org)
  • Interestingly, an enhanced p53 protein induction response was observed in HCT116 3-6 (MLH1+) compared with HCT116 (MLH1-) cells after IR or 6-TG. (biomedsearch.com)
  • Retroviral vector-mediated expression of the E6 protein did not, however, affect the enhanced G2-M cell cycle arrest observed in HCT116 3-6 compared with MLH1-deficient HCT116 cells. (biomedsearch.com)
  • MLH1-mediated G2-M cell cycle delay (caused by either MMR proofreading of DNA lesions or by a direct function of the MLH1 protein in cell cycle arrest) may be important for DNA damage detection and repair prior to chromosome segregation to eliminate carcinogenic lesions (possibly brought on by misrepair) in daughter cells. (biomedsearch.com)
  • Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. (semanticscholar.org)
  • However, a preliminary awakening of APC by exogenous or endogenous alarm signals from distressed/injured cells is critical to recruit and drive an efficient T cell activation. (frontiersin.org)
  • How can it be that proteins, describable by the laws of physics, assemble themselves into cellular machines and structures, these into complete living cells, and the latter into whole organisms that require a whole new language for their description? (genomicglossaries.com)
  • These uterine NK cells secrete IL-8, vascular endothelial growth factor (VEGF), stromal cell-derived factor-1, and interferon gamma-inducible protein-10 (IP-10) which help in tissue building, remodeling, and angiogenesis ( 4 ). (frontiersin.org)
  • Multiple factors such as cell-intrinsic signals (transcription factors) and external signals (cytokines and growth factors) govern the development of NK cells. (frontiersin.org)
  • Knockdown of endogenous A20 in Raji cells by expression of A20 short hairpin RNA (shRNA) vectors increases endogenous IRF7 activity and ubiquitination, as well as the protein level of LMP1, a target of IRF7. (pubmedcentralcanada.ca)
  • LMP1 is the only EBV protein that also has oncogenic potential in non-B cells. (pubmedcentralcanada.ca)
  • Indeed, STAP-2 associated with LMP1 through its PH and SH2-like domains, and these proteins interacted with each other in EBV-positive human B cells. (environmental-expert.com)
  • These results suggest that STAP-2 acts as an endogenous negative regulator of Epstein-Barr virus LMP1-mediated signaling through TRAF3 and TRADD. (nih.gov)
  • These results suggest that STAP-2 acts as an endogenous negative regulator of EBV LMP1-mediated signaling through TRAF3 and TRADD. (environmental-expert.com)