• Prolactin is a primary factor required for the growth and terminal differentiation of mammary epithelial cells as determined by the induction of transcription of milk protein genes required for lactation [ 2 ], [ 3 ]. (bio-rad.com)
  • In response to Prolactin receptor stimulation activated STAT s translocate into the nucleus and bind to the interferon-gamma activation sequence (GAS) in the promoter region of target genes. (bio-rad.com)
  • In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. (rcsb.org)
  • Genes encoding proteins that are involved in DNA uptake and transformation, as well as virulence, are upregulated. (prolekare.cz)
  • We demonstrate that deletion of genes coding for the flagellar stator complex, which results in non-swimming bacteria that retain an initial flagellar structure, confers resistance to phagocytic binding and ingestion in several species of the gamma proteobacterial group of Gram-negative bacteria, indicative of a shared strategy for phagocytic evasion. (prolekare.cz)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • Schizophrenia is a complex disease, likely to be caused by a combination of serial alterations in a number of genes and environmental factors. (genes2cognition.org)
  • We also demonstrated the occurrence of multiple AP-1 complexes resulting from combinatorial assembly of various gamma (i.e., gamma1 and gamma2) and sigma1 (i.e., sigma1A, sigma1B and sigma1C) subunit isoforms encoded by different genes. (grantome.com)
  • The protein tyrosine kinases encoded by the c- abl and c- fes/fps genes are distantly related to the Src subfamily. (nature.com)
  • Rhodes D, Stammers M, Malcherek G, Beck S, Trowsdale J. The cluster of BTN genes in the extended major histocompatibility complex. (labome.org)
  • Results indicate that AP-2 is not essential for clathrin -coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. (antikoerper-online.de)
  • Under these conditions, the protein partitioned away from markers destined for the late endocytic pathway and colocalized extensively with cointernalized transferrin. (nih.gov)
  • Upon subsequent incubation at 37 degreesC, ultrastructural studies on cryosections failed to detect B-fragment-specific label in multivesicular or multilamellar late endosomes, suggesting that the protein bypassed the late endocytic pathway on its way to the Golgi apparatus. (nih.gov)
  • How precisely PI(4,5)P(2) metabolism is controlled spatially and temporally is still uncertain, but recent data indicate that direct interactions between type I PIPK and components of the endocytic machinery, in particular the AP-2 adaptor complex, are involved. (rcsb.org)
  • organelles involved in protein sorting to the endocytic and secretory pathways, respectively. (biologists.org)
  • Aberrant endocytic processing through disruption of adaptor protein complexes is likely to result from the AP1S2 mutations identified in the three XLMR-affected families, and such defects may plausibly cause abnormal synaptic development and function. (ox.ac.uk)
  • AP1S2 is the first reported XLMR gene that encodes a protein directly involved in the assembly of endocytic vesicles. (ox.ac.uk)
  • This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. (genecards.org)
  • ADP ribosylation factors (Arfs) constitute a family of GTP binding proteins that regulate membrane trafficking pathways. (bioscience.org)
  • different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. (mybiosource.com)
  • OBJECTIVES: Since mechanotransduction coordinates heart function, we evaluated the underlying mechanism implicated in the mechanical changes, focusing especially in mechanosensitive proteins and related signalling pathways during infection of cardiac cells by T. cruzi. (bvsalud.org)
  • As in other multicellular organisms, RAS proteins play a key role in the signaling pathways that regulate cell growth and differentiation in Drosophila . (springer.com)
  • We review evidence on the formation of a macromolecular complex between RGS proteins and other components of striatal signaling pathways, their molecular regulatory mechanisms and impacts on GPCR signaling in the striatum obtained from biochemical studies and experiments involving genetic mouse models. (frontiersin.org)
  • Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal transduction pathways that govern cellular survival, proliferation, differentiation and apoptosis. (nature.com)
  • A collection of articles that focus on an array of different scientific topics such as pathways, cancer, transmembrane proteins. (cusabio.com)
  • It is known that these complex cell shape changes involve the polymerization of F-actin, but the upstream signals regulating these pathways have yet to be determined. (rupress.org)
  • Structural similarities between Ruk, CIN85 and CD2AP/CMS suggest that these proteins form a novel family of adaptor molecules that are involved in various intracellular signalling pathways. (embl-heidelberg.de)
  • Retargeting of the mitochondrial protein p32/gC1Qr to a cytoplasmic compartment and the cell surface. (biomedsearch.com)
  • As examined by electron microscopy, HCV proteins induced formation of large electron-dense cytoplasmic structures derived from the ER and containing HCV proteins. (biomedcentral.com)
  • 1999). The amyloid precursor protein (APP), implicated in Alzheimer's disease, contains such a signal in its cytoplasmic tail. (reactome.org)
  • The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division , cell adhesion , and stress response. (wikidoc.org)
  • While it is likely that activation of STAT proteins may be an important function attributed to the JAK kinases, it is certainly not the only function performed by this key family of cytoplasmic tyrosine kinases. (nature.com)
  • We show here that the previously characterized cytoplasmic retention sequence of Cyclin B1, responsible for its interphase cytoplasmic localization, is actually an autonomous nuclear export sequence, capable of directing nuclear export of a heterologous protein, and able to bind specifically to the recently identified export mediator, CRM1. (duke.edu)
  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. (genecards.org)
  • Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells. (nih.gov)
  • The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). (genecards.org)
  • Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. (genecards.org)
  • B-fragment sorting at the level of early/recycling endosomes seemed to involve vesicular coats, since brefeldin A treatment led to B-fragment accumulation in transferrin receptor-containing membrane tubules, and since B-fragment colocalized with adaptor protein type 1 clathrin coat components on early/recycling endosomes. (nih.gov)
  • Typically, the dense fractions contained the clathrin light chain, the γ- and α-adaptins, as well as transmembrane proteins like the transferrin receptor and the CI-MPR, as determined by Western blotting. (nih.gov)
  • Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. (wikipathways.org)
  • Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells. (wikipathways.org)
  • STAT5 transcriptional activation can be cooperatively enhanced by the alpha form of Nuclear receptor subfamily 3 group C member 1 ( GCR-alpha ) and CCAAT/Enhancer binding protein-beta (C/EBPbeta ) to induce the transcription of Beta-casein gene [ 17 ]. (bio-rad.com)
  • Prolactin stimulation of mammary cells leads to the nuclear translocation of Tyrosine phosphatase non-receptor type 11 ( SHP-2 ) as a complex with STAT5A and binding of this complex to DNA, determining the milk protein gene transcription [ 3 ], [ 18 ]. (bio-rad.com)
  • Arf6 is differentiated from the other Arf proteins due to its plasma membrane association and its involvement in the regulation of receptor mediated endocytosis and remodeling of the actin cytoskeleton. (thermofisher.com)
  • The receptor-mediated activation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) P 2 ] with the resultant production of inositol 1,4,5-trisphosphate (InsP 3 ) and diacylglycerol (DAG), the two second messengers linked to Ca 2+ signaling and protein-kinase-C-mediated phosphorylations, respectively, had become textbook knowledge by the early 90s. (biologists.org)
  • Other domains encoded in p62 are the ZZ-type zinc finger domain that binds receptor-interacting protein-1 (RIP1) and the TRAF6 binding site (TBS), which both have been shown to activate the NF-κB signaling pathway ( 21 ). (pubmedcentralcanada.ca)
  • The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. (bioon.com.cn)
  • Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. (bioon.com.cn)
  • Thus, TBC1D16 is a GTPase activating protein for Rab4A that regulates transferrin receptor recycling and EGFR trafficking and signaling. (pnas.org)
  • Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila . (springer.com)
  • G protein-coupled receptor associated sor. (broadinstitute.org)
  • The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. (cusabio.com)
  • Studies indicate that in response to stimulation with antigen, PHB1 translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase Syk. (cusabio.com)
  • Prostaglandin D 2 receptor 2 ( DP 2 or CRTH2 ) is a human protein encoded by the PTGDR2 gene and GPR44. (wikipedia.org)
  • It consists of two introns and three exons and codes for a G protein coupled receptor (GPCR) composed of 472 amino acids. (wikipedia.org)
  • Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network. (nih.gov)
  • The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. (wikipedia.org)
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (embl.de)
  • In the course of HCV protein production, there is disruption of the Golgi apparatus, loss of spatial organization of the ER, appearance of some "virus-like" structures and swelling of mitochondria. (biomedcentral.com)
  • Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking. (naver.com)
  • Class I and II Arfs are associated with trans-Golgi network (TGN) and are involved in recruiting effector proteins to the Golgi membrane and forming vesicles. (thermofisher.com)
  • Arf1 recruits its effectors, including coatomer and clathrin adaptor complex (AP), to the Golgi for vesicle formation and budding. (thermofisher.com)
  • The Golgi-localized gamma-ear-containing Arf (GGA) binding proteins make up another class of effector proteins. (thermofisher.com)
  • The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. (embl.de)
  • We are calling this complex AP-3, a name that has also been used for the neuronalspecific phosphoprotein AP180, but we feel that it is amore appropriate designation for an adaptor-related heterotetramer.Immunofluorescence using anti-delta antibodies reveals that the AP-3 complex isassociated with the Golgi region of the cell as well as with more peripheralstructures. (embl.de)
  • Adaptor proteins (AP) play important roles in the sorting of proteins from the trans-Golgi network, but how they function in the sorting of various melanosome-specific proteins such as Pmel17, an essential structural component of melanosomes, in melanocytes is unknown. (biologists.org)
  • The family of heterotetrameric adaptor protein (AP) complexes function as vesicle coat components, involved in targeting cargo proteins from post-Golgi compartments to the endosomal-lysosomal system. (reactome.org)
  • TBC1D20 inactivates Rab1 and causes collapse of the Golgi complex ( 6 , 7 ), TBC1D10 A-C acts on Rab35 ( 8 , 9 ), TBC1D30 acts on Rab8A ( 10 ), and RUTBC1 is a GAP for Rab32 ( 11 ). (pnas.org)
  • We showed that the molecular function of this complex is to promote tethering and fusion of endosome-derived transport carriers to the trans-Golgi network. (grantome.com)
  • Interference with any of the GARP subunits blocks the delivery of many cargos to the trans-Golgi network, leading to global defects in lysosomal function, lipid traffic and autophagy. (grantome.com)
  • Hardwick K, Pelham H. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. (labome.org)
  • In contrast to other glycosylphosphatidylinositol-anchored proteins, HM1.24 was internalized from lipid rafts on the cell surface by clathrin-mediated endocytosis. (genes2cognition.org)
  • Accordingly the ability of overexpressed PIPKI gamma tail to impair endocytosis of SVs in primary neurons largely depends on its association with AP-2 beta and AP-2mu. (rcsb.org)
  • There are three classes of mammalian Arf proteins, distinguished by size and homology ( 1 ). (bioscience.org)
  • The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps [ PMID: 3025655 ]. (ebi.ac.uk)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The ear like domains of GGA 1-3 display significant structure and sequence similarities to that of gamma-adaptins 1 and 2. (eu.org)
  • Biochemical and X-ray crystallographic analyses revealed that the properties of the APP sequence and the location of the binding site on mu4 are distinct from those of canonical tyrosine-based signals binding to the mu subunits of other AP complexes. (grantome.com)
  • Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)
  • The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. (ebi.ac.uk)
  • Mammalian target of rapamycin (mTOR) complex is a key regulator of autophagy, cell growth and proliferation. (jove.com)
  • Among these substrates is the tuberin protein, the product of the tuberous sclerosis complex 2 gene ( TSC2 ) that upon activation by AMPK represses the activity of the mammalian target of rapamycin, mTOR . (atlasgeneticsoncology.org)
  • Using immunofluorescence, we showed surface expression of BTN-green fluorescent protein fusions in mammalian cell transfectants. (labome.org)
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • Mammalian RGS proteins: Barbarians at the gate. (springer.com)
  • Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/ TNFAIP3 ubiquitin-editing complex (composed of A20/ TNFAIP3 , TAX1BP1 , and the E3 ligases ITCH and RNF11 ). (rcsb.org)
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. (bvsalud.org)
  • The analysis resulted in the identification of 1,261 proteins, 84 of which showed statistically significant differential expression, reinforcing previous data supporting the involvement of the immune system, calcium homeostasis, cytoskeleton assembly, and energy metabolism in schizophrenia. (genes2cognition.org)
  • Current work in our laboratory is aimed at elucidating the structure, regulation and physiological roles of coat proteins and vesicle tethering factors, and investigating human diseases that result from genetic defects (e.g. (grantome.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)