Adaptins adaptor protein complex sigma subunits. Medical search. Frequent questions

Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)

Endocytosis and/or vesicular sorting signals for membrane proteins. (eu.org)
Adaptin-binding acidic dileucine motifs and variants thereof occur almost exclusively on the cytosolic side of membrane proteins, mostly integral (transmembrane) proteins. (eu.org)

They serve to initiate clathrin-mediated endocytosis or protein sorting and can work synergistically with the adaptin mu subunit binding YxxPhi-type motifs ( TRG_ENDOCYTIC_2 ). (eu.org)
AP2 is chiefly involved in endocytosis of cell surface proteins and their trafficking to early or late endosomes. (eu.org)
Conditional protein mislocalization combined with high-resolution imaging provides convincing evidence that K13 is involved in the formation of cytostomes, the structures involved in the endocytosis of host cytosol. (elifesciences.org)

AP complex, mu/sigma subunit [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz02g32120.t1","No alias","Chromochloris zofingiensis","B-block binding subunit of TFIIIC [Interproscan]. (ntu.edu.sg)
Protein kinase domain [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz03g18100.t1","No alias","Chromochloris zofingiensis","Spindle assembly checkpoint component Mad1 [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz03g26100.t1","No alias","Chromochloris zofingiensis","Pre-mRNA polyadenylation factor Fip1 domain [Interproscan]. (ntu.edu.sg)

They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. (wikipedia.org)
Artemisinin-resistant parasites contain mutations in the gene encoding the Kelch 13 protein (K13). (elifesciences.org)

In the latter, they are frequently located near the protein N- or C-termini, with relative proximity (within 10-100aa) to a transmembrane segment. (eu.org)

In fungi and plants, dileucine motifs are often responsible for the vacuolar or tonoplast localization of proteins carrying these motifs. (eu.org)

The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Moreover, specific proteins important for this process and the cellular structures involved have not been unambiguously identified. (elifesciences.org)

A subclass of clathrin assembly proteins that occur as monomers. (lookformedical.com)

All these motifs are believed to bind to the sigma subunit of activated adaptin complexes (AP-1, AP-2 and AP-3). (eu.org)

Adaptor complexes medium subunit family status:Partially_confirmed UniProt:P90761 protein_id:CAB0279. (yeastrc.org)
A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size. (lookformedical.com)
A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)

Depending on organism, cell type as well as the nature of the adaptin complex bound, they can target either to cell surface or to specific, internal membrane-bound organelles (endosomes, lysosomes, melanosomes, synaptic vesicles, etc. (eu.org)
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)

Violin plots show distribution of expression levels for AP complex subunit sigma (SMED30008812) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of AP complex subunit sigma (SMED30008812) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for AP complex subunit sigma (SMED30008812) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)

These clathrin-associated complexes are ancient and found in most eukaryotes. (eu.org)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)
They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)

A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)

A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. (nih.gov)

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. (nih.gov)

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene. (wikipedia.org)

The AP-1B clathrin adaptor complex plays a key role in the recognition and intracellular transport of many membrane proteins destined for the basolateral surface of epithelial cells. (rupress.org)
Expression of a constitutively activated GTP hydrolysis mutant selectively inhibited basolateral (but not apical) transport of newly synthesized membrane proteins. (rupress.org)
To a large extent, plasma membrane proteins are delivered to and maintained at the appropriate cell surface domain by distinct targeting signals that control polarized transport on the secretory and endocytic pathways ( Mellman, 1996 ). (rupress.org)

The primary endocytic machinery in neurons utilizes the multimeric adaptor protein complex 2 (AP2), which exhibits differential expression of its α-subunit isoforms in neurons: the α1 isoform localizes to synaptic compartments, whereas the α2 isoform displays considerable extra-synaptic expression 15 . (nature.com)

Here, we show in Arabidopsis that the AP2 σ subunit mutant ( ap2 σ ) displays various developmental defects that are similar to those of mutants defective in auxin transport and/or signaling, including single, trumpet-shaped and triple cotyledons, impaired vascular pattern, reduced vegetative growth, defective silique development and drastically reduced fertility. (biologists.com)

The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). (innatedb.org)
This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. (nih.gov)

The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (innatedb.org)

Rab8-GFP was localized to membranes in the TGN-recycling endosome, together with AP-1B complexes and the closely related but ubiquitously expressed AP-1A complex. (rupress.org)

A family of small adaptin protein complex subunits of approximately 19 KDa in size. (nih.gov)

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [Interproscan]. (ntu.edu.sg)

However, the function of the AP2 complex in plants remains largely unexplored. (biologists.com)

Vesicular Transpor1

Membrane proteins2

Endocytosis3

Interproscan5

Peptides1

Gene2

Transmembrane1

Localization1

Clathrin coat1

Cellular2

Occur1

Bind1

Family5

Cell4

Structural1

Class1

Expression3

Found4

Formation1

Transport1

Clathrin-associated1

Golgi1

AP3S21

Membrane Proteins3

Isoforms1

Arabidopsis1

Heterotetramer2

Cytoplasmic1

Endosome1

Small1

Specific1

Function1