• Nck proteins contain a C-terminal SH2 domain that binds preferentially to pY-D-X-V motifs ( 1 ) and three N-terminal SH3 domains that associate with proteins implicated in the regulation of the actin cytoskeleton, including N-WASP and the Pak serine/threonine kinases ( 2 ). (pnas.org)
  • Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin. (duke.edu)
  • Analysis of how these adapter proteins bind to the Met receptor and what signal transducers they recruit have led to more substantial models of HGF/SF-Met signal transduction and have uncovered new potential pathways that may be involved into Met mediated tumor cell invasion and metastasis. (nih.gov)
  • Fitau J, Boulday G, Coulon F, Quillard T, Charreau B. The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and −2 pathways. (springer.com)
  • XB130's functional domains and motifs enable its interaction with a multitude of proteins involved in several different signaling pathways. (hindawi.com)
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. (duke.edu)
  • Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. (hindawi.com)
  • Ligand-bound GPCRs activate heterotrimeric G proteins, resulting in adenylyl cyclase and phospholipase activation, among other effector systems. (pubmedcentralcanada.ca)
  • Several G-protein coupled receptors, such as the beta1-adrenergic receptor (beta1-AR), contain polyproline motifs within their intracellular domains. (duke.edu)
  • SH2B1, SH2B2, and SH2B3 were originally named as SH2-B [also known as SH2 domain-containing signaling mediator (PSM)], adapter protein with PH and SH2 domains (APS) and Lnk, respectively. (springer.com)
  • To date, analysis of the role of mammalian Nck proteins in neuronal development has been limited by the observation that mice homozygous for null alleles of either Nck1 or Nck2 alone appear normal, whereas mice lacking both Nck1 and Nck2 die at embryonic day 9.5 ( 12 ). (pnas.org)
  • Tsg101 is the mammalian orthologue of a yeast protein, Vps23p, which, along with ≈16 other proteins, is required for MVB formation ( 16 ). (pnas.org)
  • Mammalian homologues of ESCRT-III components, the charged MVB proteins (CHMPs) have not been studied in detail, but CHMP1A and CHMP2A bind to mammalian VPS4 ( 19 ). (pnas.org)
  • A cargo/PACS-1/AP-1A complex is necessary to drive the appropriate transport of several cargo proteins within the regulated secretory pathway. (frontiersin.org)
  • We review the functions of AP-1A, PACS-1, and GGAs in facilitating the retrieval of proteins from immature SGs and review examples of cargo proteins whose trafficking within the regulated secretory pathway is governed by APs. (frontiersin.org)
  • The production of mature SGs requires concentrating newly synthesized soluble content proteins in granules whose membranes contain the appropriate integral membrane proteins. (frontiersin.org)
  • The mechanisms underlying the sorting of soluble and integral membrane proteins destined for SGs from other proteins are not yet well understood. (frontiersin.org)
  • The trafficking of granule membrane proteins can be controlled by both luminal and cytosolic factors. (frontiersin.org)
  • A reduced miR-126 expression and an elevated Crk protein expression, alone or in combination, statistically correlated with aggressive clinicopathological characteristics, such as larger tumor size, deeper local invasion, more lymph node metastasis, advanced TNM stage, and poorer prognosis. (nih.gov)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • In order to determine differences between HPS2 and wild type CTL, the localisation of a range of lysosomal, cytolytic, transmembrane, inhibitory and activation marker proteins is examined. (bl.uk)
  • Several modular domains have been identified that recognize specific sequences on their target acceptor proteins. (sciencemag.org)
  • These sequences, in single-letter code, are indicated for ( A ) SH2 domains, ( B ) PTB domains, ( C ) PDZ domains, ( D ) SH3 domains, ( E ) WW domains, and ( F ) 14-3-3 proteins. (sciencemag.org)
  • The apparent molecular mass of both proteins is 142 kD, and they consist of three structural domains. (rupress.org)
  • Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. (duke.edu)
  • The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (nih.gov)
  • Nef is a crucial viral protein for HIV to replicate at high titers and in the development of AIDS. (jimmunol.org)
  • Expression of the adaptor protein Lnk in leukemia cells. (springer.com)
  • Expression of certain ESCRT-III components as fusion proteins induces a late budding defect that afflicts all three L-domain types, suggesting that ESCRT-III integrity is required in a general manner. (pnas.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)