Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. (wikipedia.org)
This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. (wikipedia.org)
The SH2 domain binds to phosphotyrosine residues in RTKs such as PDGF and EGF, non-RTKs such as Bcr/Abl and FAK, and docking proteins such as FRS-2 and Gab1. (rndsystems.com)
SH2 domains are phosphotyrosine recognition domains, often mediating transient interactions with target proteins. (eu.org)
The growth factor receptor-binding protein Grb2, composed of one SH2 and two SH3 domains, acts as an adaptor protein in transduction of signals from tyrosine-phosphorylaled proteins (EGF-receptor, or SHC), to the Ras dependent pathways. (elsevierpure.com)
loop_ _audit_author.name _audit_author.pdbx_ordinal 'Hu, J.' 1 'Hubbard, S.R.' 2 # _citation.id primary _citation.title 'Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. (rcsb.org)
A significant system of transmitting indicators is certainly by phosphorylation and dephosphorylation of tyrosine residues on essential proteins such as for example development aspect and cytokine receptors adapter proteins and enzymes such as for example non-receptor tyrosine kinases. (biospraysehatalami.com)
Phosphorylation creates sites for protein-protein connections between your phosphorylated proteins and signaling substances formulated with SH2 and phosphotyrosine binding domains that recognize phosphotyrosine [13]. (biospraysehatalami.com)
SH2 domains are around 100 amino acidity subunits that mediate the transduction of indicators via development of multiprotein complexes initiated by reputation and binding to choose phosphotyrosine residues on receptors and various other proteins [13]. (biospraysehatalami.com)
Adaptor proteins contain a series of protein-binding sites that link respective interaction partners to each other and facilitate the generation of larger signaling complexes (1). (ufoscience.org)
The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. (bvsalud.org)
Homology7
The VEE is a heterogeneous compartment containing the Adaptor Protein Phosphotyrosine Interacting with Pleckstrin homology Domain and Leucine Zipper 1 (APPL1) with distinct functions in regulating endosomal Gαs/cAMP signaling and rapid recycling. (frontiersin.org)
SH2 Homology Protein B (SHB) is a cytoplasmic adaptor protein that serves as a link between phosphotyrosine residues on multiple receptor tyrosine kinases and downstream signaling pathways. (rndsystems.com)
The tensin family member cten (C-terminal tensin like) is an Src homology 2 (SH2) and phosphotyrosine binding domain-containing focal adhesion molecule that may function as a tumor suppressor. (rupress.org)
Activated receptor tyrosine kinases bind the Shc adaptor protein through its N-terminal phosphotyrosine-binding (PTB) and C-terminal Src homology 2 (SH2) domains. (elsevierpure.com)
The protein expression of key genes in the pathway, including adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif 1 (Appl1), Sortilin and Syndecan-1, was examined by immunohistochemistry (IHC) in a pilot study of 29 patients with prostate cancer, using monoclonal antibodies designed against unique epitopes. (edu.au)
IRS-1 contains no transmembrane domain but an amino-terminal pleckstrin homology (PH) and a phosphotyrosine-binding domain (PTB), followed by a carboxyl-terminal region which is enriched in Ser and Thr residues 28 . (nature.com)
In addition to a C-terminal Src homology 2 (SH2) domain, dShc contains an N-terminal phosphotyrosine-binding (PTB) domain, which associates in vitro with the autophosphorylated DER receptor tyrosine kinase and with phosphopeptides containing an Asn-Pro-X-pTyr motif, where pTyr stands for phosphotyrosine. (elsevierpure.com)
Binds1
It binds to phosphotyrosine in the cytoplasmic tail of cell surface receptors via its central SH2 domain, and to its immediate downstream target. (elsevierpure.com)
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. (wikipedia.org)
P85 is an Rifamdin adapter molecule harboring an SH3 domain and two SH2 domains. (edrc2013.org)
Leucine1
We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). (phoenixpeptide.com)
Protein involved3
GRB2 (growth factor receptor-bound protein 2), an adaptor protein involved in signal transduction, contains a central SH2 domain flanked by two SH3 domains. (rndsystems.com)
NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)
Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. (biomedcentral.com)
Interaction1
The interaction between the adaptor protein APS and Enigma is involved in actin organisation. (genscript.com)
Clathrin-mediated endocytosis1
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. (sdbonline.org)
Domain3
Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. (sdbonline.org)
The engulfment adaptor phosphotyrosine-binding domain-containing 1 (GULP1) regulates intracellular trafficking of glycosphingolipids and cholesterol, suggesting its close association with lipid metabolism. (bvsalud.org)
The results reveal larger phosphotyrosine-binding domain fluctuations and more structural flexibility of unphosphorylated Shc compared with phosphorylated Shc. (elsevierpure.com)
Receptors4
c-Met and receptor originated from nantes (RON) are structurally related transmembrane phosphotyrosine kinase receptors. (oncotarget.com)
c-Met and RON form both activated homodimers and heterodimers with themselves and other families of phosphotyrosine kinase receptors. (oncotarget.com)
Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. (abcam.com)
SH2 domains bind to short phosphotyrosine-containing sequences in growth factor receptors and other phosphoproteins. (ufoscience.org)
Receptor2
Las proteínas comparten un DOMINIO DE HOMOLOGÍA PLECKSTRIN, un dominio de unión a fosfotirosina que interacciona con el RECEPTOR DE INSULINA fosforilado y un dominio C-terminal rico en TIROSINA. (bvsalud.org)
Tras la fosforilación de la tirosina, las proteínas sustrato del receptor de insulina interaccionan con proteínas específicas que contienen el DOMINIO SH2 y que participan en la señalización del receptor de insulina. (bvsalud.org)
Kinase2
Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. (genscript.com)
The specific activity of the PI 3-kinase immunoprecipitated with anti-phosphotyrosine antibody was 3-fold higher than that with anti-PI 3-kinase antibody. (edrc2013.org)
Human2
Description: A sandwich ELISA kit for detection of Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
Antibodies to the human Shc adaptor protein were used to isolate a cDNA encoding a Drosophila Shc protein (dShc) by screening an expression library. (elsevierpure.com)
Protein21
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. (wikipedia.org)
Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. (wikipedia.org)
This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. (wikipedia.org)
Here we map the ARH locus to an approximately 1-centimorgan interval on chromosome 1p35 and identify six mutations in a gene encoding a putative adaptor protein (ARH). (nih.gov)
Characterization of a novel neuronal adaptor protein, ShcD. (uoguelph.ca)
6. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. (nih.gov)
13. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. (nih.gov)
19. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. (nih.gov)
Effects of dasatinib administration on microglial and astroglial activation, protein phosphotyrosine levels, active Src kinase levels, Aβ plaque deposition, and spatial working memory were assessed via immunohistochemistry, Western blot, and T maze analysis. (nih.gov)
Dasatinib administration to APP/PS1 mice decreased protein phosphotyrosine, active Src, reactive microglia, and TNFα levels in the hippocampus and temporal cortex. (nih.gov)
APPL1, an adaptor protein containing an NH2-terminal Bin/Amphiphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain and a COOH-terminal phosphotyrosine binding (PTB) domain [1] was originally identified as an interacting partner of Akt in a yeast two-hybrid assay using Akt2 as a bait [2]. (immunodiagnostics.com.hk)
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling. (immunodiagnostics.com.hk)
Cheng KK, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KS, Xu A. The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. (immunodiagnostics.com.hk)
Moreover, we showed that v-Src- transformed cells have elevated levels of phosphotyrosine in protein. (nih.gov)
The loading of GTP onto Ras is stimulated by Sos, a guanine nucleotide exchange factor that is bound to the Grb2 adaptor protein. (nih.gov)
Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface. (expasy.org)
Under steady-state conditions, mice lacking the inhibitory adaptor protein Lnk harbor an expanded HSC pool with enhanced self-renewal. (jci.org)
For example, in the T cell receptor signaling system, linker for activation of T cells (LAT) phosphorylation results in the recruitment of the adaptor protein Grb2 through binding to multiple phosphorylated tyrosine sites on LAT. (elifesciences.org)
Anti-phosphotyrosine1
Phosphopeptides were enriched by either titanium dioxide chromatography or anti-phosphotyrosine immunoaffinity, and analyzed by liquid chromatography-mass spectrometry. (nih.gov)
Peptide1
This sensor consists of an Src substrate peptide from the p130cas molecule and a phosphotyrosine-binding SH2 domain from the c-Src molecule sandwiched between ECFP and EYFP. (encyclopedia.pub)
4G101
Cell lysates were then precipitated with Flag-specific antibodies (left panel) and blotted with antibodies specific for myc (top), phosphotyrosine 4G10 (middle), or Lnk (bottom). (jci.org)
Tyrosine2
1. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. (nih.gov)
We guessed that this might be tyrosine, quickly made some phosphotyrosine, and showed that the product of acid hydrolysis of phosphorylated middle T antigen co-migrated with the synthetic phosphotyrosine. (nih.gov)
Molecules1
There, I studied a unique signalling scaffold in the kidney known as the slit diaphragm, and through a combination of biochemical, cellular and genetic approaches, we were able to demonstrate the importance of several adaptor molecules in kidney development and disease. (uoguelph.ca)