Adaptation pluripotent cells. Medical search. Frequent questions

Use Vitronectin XF™ with mTeSR™1 , mTeSR™ Plus , TeSR™-E8™ , or TeSR™-AOF medium to provide a defined culture system for the maintenance of human embryonic stem (ES) cells and human induced pluripotent stem (iPS) cells under feeder-free conditions. (stemcell.com)
Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)
The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
Applications of induced pluripotent stem cell (iPSC) technology, capable of reprogramming somatic tissue of different species and generating species-specific neuronal phenotypes, for the first time offer an opportunity to test specific evolutionary hypotheses in a field of inquiry that has been long plagued by the limited availability of research specimens. (ca.gov)
Robust strategies for developing patient-specific human induced pluripotent stem cell (iPSC)-based therapies of the brain require an ability to derive large numbers of highly defined neural cells. (biospraysehatalami.com)
The use of cardiac myocytes derived from human induced pluripotent stem cells (Hu-iPSC-CM), molecular reporters and advances in gene editing provides diverse unprecedented opportunities to rigorously study these fundamental processes in human cardiac cells. (upenn.edu)
These inquiries involve utilization of several core capabilities in the Prosser and Margulies laboratories including: super-resolution live-cell microscopy, advanced primary human cardiac myocyte mechanical characterization, and an engineered myocardial microtissue model derived from human induced pluripotent stem cells, and murine models currently being developed. (upenn.edu)
The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. (nature.com)
Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens. (ox.ac.uk)
Here we explore the potential of human induced pluripotent stem cell derived macrophages (iPSDMs) to study such pathogen interactions. (ox.ac.uk)
Researchers will explore the link between genetic variations associated with RPD and changes in underlying biology using in vitro induced pluripotent stem cell technology and in vivo preclinical models of disease. (cera.org.au)
Uninterrupted monitoring of drug effects in human-induced pluripotent stem cell-derived cardiomyocytes with bioluminescence Ca2+ microscopy. (ox.ac.uk)
OBJECTIVE: Cardiomyocytes derived from human-induced pluripotent stem cells are a powerful platform for high-throughput drug screening in vitro. (ox.ac.uk)
Human induced pluripotent stem cells (hiPSCs) provide an in vitro system to identify the impact of cell behavior on the earliest stages of cell fate specification during human development. (biomedcentral.com)
Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are widely used in regenerative medicine and experimental models for studying development and diseases because of their pluripotent potential to differentiate into all cell lineages: endoderm, ectoderm, and mesoderm germ layers [ 1 , 2 , 3 ]. (biomedcentral.com)
To investigate underlying disease mechanisms, induced pluripotent stem cells (iPSCs) allow the generation of patient-derived neuronal cells in a dish. (biomedcentral.com)
Basic research utilizing immune-related disease patient-derived induced pluripotent stem (iPS) cells is expected to be a promising platform for elucidating the pathogenesis of the diseases and for drug discovery. (biomedcentral.com)
Investigating human immune-related diseases using induced pluripotent stem (iPS) cells presents a novel and promising field of study. (biomedcentral.com)
We propose that induced pluripotent stem cells are a unique biological resource to study relevant differences between human and non-human primates, and that those differences could have potential adaptation and speciation value. (anthropogeny.org)
To test this hypothesis, we generated induced pluripotent stem cells from chimpanzees and bonobos as new tools to explore factors that may have contributed to great ape evolution. (anthropogeny.org)
We study ubiquitination and autophagy in induced pluripotent stem cell-derived brain-capillary endothelial cells, pericytes, astrocytes, microglia, and neurons. (uniklinikum-jena.de)
We established LOAD-specific induced pluripotent stem (iPS) cell models for microglia and BBB cultures. (uniklinikum-jena.de)
Thus, we will address the question, whether in our induced pluripotent stem cell-derived BBB models these processes are affected by age and/or genetic preposition that are associated with Alzheimer's disease. (uniklinikum-jena.de)
Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease. (cornell.edu)
Characterization of hematopoietic stem and progenitor cells generated by teratoma formation with human induced pluripotent stem cells. (fraunhofer.de)
Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts' (2007), by Masato Nakagawa et al. (asu.edu)
In November 2007, Masato Nakagawa, along with a number of other researchers including Kazutoshi Takahashi, Keisuke Okita, and Shinya Yamanaka, published "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (abbreviated "Generation") in Nature. (asu.edu)
Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells. (rndsystems.com)
Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (rndsystems.com)
The scientists took skin cells from the tail of a male mouse and, in a dish, turned them into what are called induced pluripotent stem cells, which can become any type of cell. (iol.co.za)
The URPP AdaBD is establishing four PLATFORMS and P LATFORM S EEDS that support URPP researchers in high-resolution microscopy, high-dimensional data analysis, induced pluripotent stem cell (iPSC)-based models for neuroscience, and in identifying subtypes of developmental deficits as well as in recruiting study participants. (uzh.ch)
while the frequently reported types of biospecimens used in ALS-related grants were induced pluripotent stem cells, brain, blood, and spinal cord. (cdc.gov)

Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor hematopoiesis reconstitution in vivo still exist, mainly attributing to the lack of solid, reproduced, or pursued differentiation system. (biomedcentral.com)
In this study, we established an in vitro differentiation system yielding in vivo hematopoietic reconstitution hematopoietic cells from mouse PSCs through a 3D induction system followed by coculture with OP9 stromal cells. (biomedcentral.com)
Flow cytometry analysis, RNA-seq, and cell cycle analysis were used to detect the in vitro hematopoietic ability of endothelial protein C receptor (EPCR, CD201) cells generated in our induction system. (biomedcentral.com)
Further, we innovatively demonstrated that notch signaling pathway is responsible for in vitro CD201 + hematopoietic cell induction from mouse PSCs. (biomedcentral.com)
The neuronal cells expressed numerous genes associated with sub-regions within the brain thus suggesting the usefulness of our in-vitro model. (biomedcentral.com)
This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)
Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. (rndsystems.com)
This study developed an estimation routine for counting the viable cells in an in vitro fed-batch Chinese hamster ovary cultivation that relies on off-gas information and inlet gas mixture knowledge. (researchgate.net)

This is a critical review of the stem cell field using iPSC technology to model human disease and for evolutionary studies. (ca.gov)
As the typical morphology of pyramidal neurons tends to be compromised in neurological disorders, application of iPSC technology to the analysis of pyramidal neurons could not only bring new insights into human adaptation but also offer opportunities to link biomedical research with studies of the origins of the human species. (ca.gov)
Removal of ring culture system induces collective cell migration at the iPSC colony edge. (biomedcentral.com)
Collective cell migration modulates self-organized fate patterning decisions in iPSC-derived gastrulation-stage meso-endoderm. (biomedcentral.com)

Here, we address the question of mitochondrial adaptation by examining the differentiation of human pluripotent stem cells to cardiac progenitors and further to differentiated mesodermal derivatives, including functional cardiomyocytes. (uib.no)
Cardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) provide a valuable cell source for regenerative therapy, disease modeling, and drug screening. (biomedcentral.com)
Feric, N. T. & Radisic, M. Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. (nature.com)
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. (nature.com)
By combining GmNL(Ca2+) with this adaptation, we could image spontaneous Ca2+ transients in cultured cardiomyocytes and phenotype their response to well-known drugs without accessing the sample directly. (ox.ac.uk)
Particularly, non-hematopoietic cells, such as fibroblasts and cardiomyocytes, differentiated from autoimmune patient-derived iPS cells have shown promising results for further research into the pathogenesis. (biomedcentral.com)

Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
The AD-iPSCs were differentiated into neuronal cells, in order to generate disease-specific protein association networks modeling the molecular pathology on the transcriptome level of AD, to analyse the reflection of the disease phenotype in gene expression in AD-iPS neuronal cells, in particular in the ubiquitin-proteasome system (UPS), and to address expression of typical AD proteins. (biomedcentral.com)
We detected the expression of p-tau and GSK3B, a physiological kinase of tau, in neuronal cells derived from AD-iPSCs. (biomedcentral.com)
Treatment of neuronal cells differentiated from AD-iPSCs with an inhibitor of γ-secretase resulted in the down-regulation of p-tau. (biomedcentral.com)

The authors begin the paper by noting their desire to find a method for inducing somatic cells of patients to return to a pluripotent state, a state from which the cell can differentiate into any type of tissue but cannot form an entire organism. (asu.edu)
In "Generation," the authors point to dedifferentiation of somatic cells as an avenue for generating pluripotent stem cells useful for treating specific patients and diseases. (asu.edu)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

Recognizing shortcomings of 2D formats for inducing cardiac cell maturation or modeling pathological processes, we have increasingly employed a 3D heterocellular model in which cardiac myocytes and fibroblasts self-assemble into contracting cardiac microtissues (CMT) mounted on flexible cantilevers. (upenn.edu)
Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. (rndsystems.com)
You can record from neuronal or cardiac cultures, stem cells, or brain or cardiac slices. (multichannelsystems.com)

In other words, as a single fertilized egg cell - the zygote - continues to divide, the resulting daughter cells change into all the different cell types in an organism, including neurons, muscle cells, epithelium, endothelium of blood vessels, etc., by activating some genes while inhibiting the expression of others. (wikipedia.org)
Unlike many other kinases, GSK3B is believed to be permanently active in resting cells and in neurons without extracellular stimulation and can be inactivated by Ser9 phosphorylation [ 14 ]. (biomedcentral.com)
Ubiquitination and autophagy target proteins via post-translational modifications for regulating the protein homeostasis of amyloid precursor protein (APP) and its harmful byproduct amyloid beta (Aβ) in neurons, but also in other cells of the neurovascular unit including the BBB. (uniklinikum-jena.de)
Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. (plos.org)
Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. (rndsystems.com)

File photo: The technique pioneered in the proof-of-concept experiment is a long way from potentially being used in humans, with obstacles including a low success rate, adaptation concerns and wide-ranging ethical considerations. (iol.co.za)

In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Data on cell proliferation were obtained by labelling replicating cells, and by careful assessment of cell viability for each experimental sample. (altex.org)
The role of cell proliferation as an experimental confounder was tested experimentally by performing the cMINC in the presence of the proliferation-inhibiting drug cytosine arabinoside (AraC), and by a careful evaluation of mitotic events over time. (altex.org)
An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. (ucsf.edu)

In particular, iPS cell-derived monocytic cells and macrophages can be used for functional experiments, such as inflammatory cytokine production, and are often employed in research on patients with autoinflammatory diseases. (biomedcentral.com)

This system allows complete control over the culture environment, resulting in more consistent cell populations and reproducible results in downstream applications. (stemcell.com)
Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
We used two methodological approaches to detect different levels of positive selection, namely episodic positive diversifying selection (i.e., past selection) in the human lineage within primate phylogeny, potentially driven by sperm competition, and recent positive directional selection in contemporary human populations, which would indicate adaptation to different environments. (biomedcentral.com)
In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)

Many of our inquiries are initiated by multilevel examinations of explanted human heart tissues obtained at the time of transplantation or organ donation to permit insights into both the heterogeneity of myocardial adaptations to disease and identification of dominant mechanisms and responses. (upenn.edu)
The mechanisms underpinning such host-restricted intracellular adaptations are poorly understood, in part, due to a lack of appropriate model systems. (ox.ac.uk)
Mechanisms of bronchocontriction mediated by mast cell nerve interaction in human atopic lung tissue. (fraunhofer.de)
Besides revealing physiological processes, we aim to establish causal links between learning deficits or developmental delay and impaired mechanisms of brain circuit adaptation. (uzh.ch)

Functional CMs derived from human pluripotent stem cells (hPSCs) would provide an unprecedented cell source for disease modeling, drug discovery, and cell transplantation therapy for CVD patients [ 3 ]. (biomedcentral.com)
The in vivo hematopoietic reconstitution potential of c-kit + cells derived from the mouse PSCs was evaluated via m-NSG transplantation assay. (biomedcentral.com)

After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
We also show the presence of normal lamellar bodies and the secretion of surfactant into the cell culture medium in the organoids of lentiviral infected cells. (nature.com)
Organoids are tiny, self-organized three-dimensional tissue cultures that are derived from stem cells. (openpr.com)
Organoids grow from stem cells-cells that can divide indefinitely and produce different types of cells as part of their progeny. (openpr.com)

reported a protocol to selectively differentiate hPSCs into CMs with nodal-type characteristics, which relies on co-culture with visceral endoderm-like cells and subsequent culture in a serum-enriched medium [ 12 ]. (biomedcentral.com)

In biology, epigenetics are stable heritable traits that cannot be explained by changes in DNA sequence, and the study of a type of stable change in cell function (known as a mark) that does not involve a change to the DNA sequence. (wikipedia.org)
Epigenesis in the context of the biology of that period referred to the differentiation of cells from their initial totipotent state during embryonic development. (wikipedia.org)
Frontiers in Cell and Developmental Biology. (uib.no)

Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
Furthermore, the induction of collective cell migration at the colony edge using an endodermal induction media enhanced endodermal differentiation efficiency in association with cadherin switching, which is involved in the epithelial-mesenchymal transition. (biomedcentral.com)

In addition, even in the absence of exogenous supplements, ectoderm, mesoderm, endoderm, and extraembryonic cells differentiated following the induction of collective cell migration at the colony edge by removing the ring-barrier. (biomedcentral.com)
Our findings suggest that collective cell migration can be an effective way to drive the segregation of mesoderm and endoderm lineages, and cell fate decisions of hiPSCs. (biomedcentral.com)

We have developed a feeder-free, Sendai virus-mediated reprogramming protocol suitable for cell culture processing via a robotic liquid handling unit that delivers footprint-free hiPSCs within 3 weeks with state-of-the-art efficiencies. (frontiersin.org)

2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

In human disease studies, ethical concerns often restrict the collection of patient cells and tissues. (biomedcentral.com)
These antigens are found on red blood cells, plasma glycoproteins, and other cell types in various tissues. (anthropogeny.org)

Thus, our work highlights similarities in mitochondrial remodeling during the transition from pluripotent to multipotent state in ectodermal and mesodermal lineages, while at the same time demonstrating cell-lineage-specific adaptations upon further differentiation. (uib.no)
Here, we developed an hiPSC-based model to study the effect of collective cell migration in meso-endodermal lineage segregation and cell fate decisions through the control of space confinement using a detachable ring culture system. (biomedcentral.com)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

Memory of Inflammation in Regulatory T cells. (ucsf.edu)

Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. (wikipedia.org)
Comparative gene expression analysis of human and non-human primate cells revealed differences in the regulation of a class of transposable elements (Long Interspersed Nuclear Element 1 or LINE1 retrotransposons) between species. (anthropogeny.org)

However, these tissue samples do not fairly represent the distinctive traits of live cell behavior and are not amenable to genetic manipulation. (anthropogeny.org)

Thus, a much higher grade of parallelization, and throughput in the production of hiPSCs is needed, which can only be achieved by implementing automated solutions for cell reprogramming, and hiPSC expansion. (frontiersin.org)
However, when collective cell migration was inhibited by blocking E-cadherin function, this fate decision within an hiPSC colony was altered to an ectodermal fate. (biomedcentral.com)

A range of systemic markers (e.g. lipid profiles and innate immunity) and visual function markers (e.g. dark adaptation) will be used to establish causal links between specific genetic risk factors and functional/systemic changes in those with RPD. (cera.org.au)

Transcriptome analysis of AD-iPS derived neuronal cells revealed significant changes in the expression of genes associated with AD and with the constitutive as well as the inducible subunits of the proteasome complex. (biomedcentral.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Histochem Cell Biol 2023 PMID: 37247072 , DOI: 10.1007/s00418-023-02198-1. (yale.edu)

The c-kit + cells from 3D self-assembling peptide induction system followed by the OP9 coculture system possessed apparently superiority in terms of in vivo repopulating activity than that of 3D induction system followed by the 0.1% gelatin culture. (biomedcentral.com)
Altogether, our findings lay a foundation for improving the efficiency of hematopoietic differentiation and generating in vivo functional HSC-like cells from mouse PSCs for clinical application. (biomedcentral.com)
In fact, only using the OP9 co-culture system combined with hematopoietic related cytokines, we hardly obtained the in vivo functional reconstitution hematopoietic cells from PSCs [ 9 ]. (biomedcentral.com)
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. (rndsystems.com)

Paris, France - Scientists have created eggs using the cells of male mice for the first time, leading to the birth of seven mice with two fathers, according to research hailed as revolutionary. (iol.co.za)
The cells were then used to create eggs, which were fertilised with the sperm of a different male mouse and implanted into the uteruses of surrogate female mice . (iol.co.za)

We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

Indeed, both the hESc and human neuroprogenitor cell (hNPC) models provide valid and useful tools for studying DNT. (plos.org)

Such cultures can be crafted to replicate much of the complexity of an organ, or to express selected aspects of it like producing only certain types of cells. (openpr.com)

Since autoinflammatory diseases are usually monogenic, genetic mutations affect the cell function and patient-derived iPS cells tend to exhibit disease-specific phenotypes. (biomedcentral.com)
On the other hand, the utilization of disease-specific iPS cells is less successful for research on autoimmune diseases. (biomedcentral.com)
One reason for this is that autoimmune diseases are usually polygenic, which makes it challenging to determine which factors cause the phenotypes of patient-derived iPS cells are caused by. (biomedcentral.com)
In summary, patient-derived iPS cells can provide a promising platform for pathological research and new drug discovery in the field of immune-related diseases. (biomedcentral.com)
We suggest an advantage of utilizing iPS cells for studying human immune-related diseases. (biomedcentral.com)
With iPS cell technology, researchers can readily acquire human cells and investigate these diseases using human-derived samples. (biomedcentral.com)
In this way, investigating human immune-related diseases using iPS cells offers distinct advantages over conventional research methods. (biomedcentral.com)
In this review, we discuss the application of iPS cells in the study of human immune-related diseases, with an emphasis on autoimmune diseases (Fig. 1 ). (biomedcentral.com)
A schematic summary of the investigation of immune-related diseases using patient-derived iPS cells. (biomedcentral.com)
Though age related changes in BBB function may also represent an adaptation for healthy ageing, but results in consequence in a dysfunctional BBB, which often correlate with the progressive cause of brain diseases like the development of neural diseases, including late-onset Alzheimer's disease (LOAD). (uniklinikum-jena.de)

Jonathan Bayerl and Diana Laird, stem cell and reproductive experts at the University of California, San Francisco, said it was not known if the process would even work with human stem cells. (iol.co.za)

Moreover, an AD-related protein interaction network composed of APP and GSK3B among others could be generated using neuronal cells differentiated from two AD-iPS cell lines. (biomedcentral.com)
Alzheimer's disease (AD) is characterized by histopathological changes, designated as senile plaques and fibrillary deposits, which ultimately lead to the death of neuronal cells in particular in the cerebral cortex of the brain [ 1 , 2 ]. (biomedcentral.com)
These articles examine the cytological processes, neuronal and endocrinal controls, and the influence of drugs on the mechanism of cell death observed in pupal muscle structures of the American silkmoth. (asu.edu)

Although hematopoietic stem and progenitor cells (HSPCs) enable autologous treatment of blood disorders, de novo generation of hematopoietic cells from pluripotent stem cells still compromises the unlimited high yield and rich hematopoiesis engraftment potential [ 2 ]. (biomedcentral.com)
Of particular interest is their contribution to Developmental Neurotoxicity (DNT) as well as their potential impact on stem cells. (plos.org)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)

Waddington held that cell fates were established during development in a process he called canalisation much as a marble rolls down to the point of lowest local elevation. (wikipedia.org)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Genomic characterization of lymph node-derived disseminated prostate cancer cells. (fraunhofer.de)

Non-small cell lung cancer primary tumor model generation, characterization and treatment. (fraunhofer.de)

We interestingly found that our 3D+OP9 system enriched a higher percentage of CD201 + c-kit + cells that showed more similar HSC-like features such as transcriptome level and CFU formation ability than CD201 - c-kit + cells, which have not been reported in the field of mouse PSCs hematopoietic differentiation. (biomedcentral.com)
Moreover, CD201 + hematopoietic cells remained in a relatively slow cycling state, consistent with high expression levels of P57 and Ccng2. (biomedcentral.com)

2018. Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. . (cornell.edu)
In Sep-2018, STEMCELL Technologies Signed a partnership agreement with Brigham and Women's Hospital to commercialize a human pluripotent stem cell-derived kidney organoid culture system. (openpr.com)

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