Adaptation for hypoxia tolerance. Medical search. Frequent questions

Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)
I am interested in the physiological and related molecular mechanisms that underlie natural metabolic adaptations to low oxygen stress and enable central nervous system function and viability in hypoxia and ischemia. (weebly.com)
Adaptation to chronic hypoxia increases myocardial resistance to acute ischemia/reperfusion (I/R) injury, similarly to application of exogenous erythropoietin (EPO). (nusl.cz)

C) is involved in individual chemosensitivity to acute hypoxia, as assessed by ventilatory responses, in European individuals. (frontiersin.org)
In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O 2 sensor ≫ - heme oxygenase-2 - in the chemosensitivity of carotid bodies in Humans. (frontiersin.org)

The overall interest of Dr. Haddad's laboratory is the effect of hypoxia (and hypercapnia) on cell function and development. (ucsd.edu)

His work included studies of enzyme adaptation to temperature and pressure, the mechanisms underlying tolerance to hypoxia in animals, the bioenergetics of exercise, metabolism during diving in seals, allometric scaling, and human adaptations to high-altitude hypoxia. (wikipedia.org)
When exposed to low oxygen or hypoxia, animals must alter their metabolism and physiology to ensure proper cell-, tissue- and whole-body level adaptations to their hypoxic environment. (thegallolab.com)

Before and after the training intervention, subjects completed a test protocol consisting of a bout of submaximal constant-work-rate exercise, a 24-s high-intensity exercise bout to quantify the phosphocreatine recovery time constant, and an incremental test to the limit of tolerance.The tests were completed in normoxia and hypoxia in both INT and IHT legs. (altitudecentre.com)

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. (cas.cz)

In the Richalet's test, in healthy subject, the intensity and duration (30% maximal oxygen uptake, ~4 min) of exercise in hypoxia appear to be too low to modify the muscular metabolic balance, and to generate a ventilatory fatigue or to set up the hypocapnic inhibition mechanisms of hypoxic hyperventilation. (frontiersin.org)
The tolerance of an organism to low oxygen is inversely related to the extent of their metabolic. (uri.edu)
Total ATP production (metabolic rate) was compared in specimens subjected to night time surface conditions (oxygenated) and day time conditions (hypoxia). (uri.edu)
One adaptation for living in hypoxia is metabolic depression. (uri.edu)
Tolerance to thermal stress requires compensation for the metabolic energy used through molecular regulatory processes. (biomedcentral.com)

2022). Key discoveries include genetic evidence that this small forest mammal has survived in high-latitude "northern" glacial refugia near the Carpathians, in areas previously considered uninhabitable for forest species, or haemoglobin genes that confer resistance to oxidative stress, which is important for adaptation to climate change. (cas.cz)

We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. (cas.cz)
Nevertheless, it is not known if EPO induced by chronic hypoxia plays a role in its cardioprotective mechanism. (nusl.cz)
The aim of this study was to find out if protective effect of exogenous EPO adds up to protection offered by chronic hypoxia. (nusl.cz)
The results indicate that exogenous EPO employs the same cardioprotective mechanisms as adaptation to chronic intermittent hypoxia. (nusl.cz)
This tolerance often links biofilms with persistent and chronic infection, and provides ideal conditions for the acquisition or evolution of AMR. (southampton.ac.uk)
Further studies on cross-adaptation between chronic cold stress and heat tolerance are needed. (biomedcentral.com)

Building on our work on haemoglobin, this line of research aims to unravel genes and regulatory networks involved in adaptation of resistance to oxidative stress. (cas.cz)

image: Model of the cooperative regulation of putrescine synthesis by ABFs and CBFs to promote cold tolerance in melon seedlings. (eurekalert.org)
Virus-induced gene silencing (VIGS) assays further demonstrated that CmABF1 and CmCBF4 played positive roles in the cold tolerance of melon seedlings by promoting Put synthesis. (eurekalert.org)
Background: The aim of this work was to investigate the serum amino acid (AA) changes after a breath-hold diving (BH-diving) training session under several aspects including energy need, fatigue tolerance, nitric oxide (NO) production, antioxidant synthesis and hypoxia adaptation. (daneurope.org)
The changes in haemolymph flow rates paralleled those in previous reports on reductions in protein synthesis in the hepatopancreas during hypoxia. (silverchair.com)
We also found that hypoxia suppresses the expression of genes involved in ribosome synthesis and egg production, and we showed that hypoxia suppresses tRNA synthesis and mRNA translation and reduces female fecundity. (thegallolab.com)

Hochachka did extensive field and laboratory work studying the biochemical basis for mechanisms of adaptation in multiple species and environments, including water (trout, tuna fish, squid, oysters), air (locusts, hummingbirds) and land (turtles, seals, and humans). (wikipedia.org)
Phenotypic traits of climate stress tolerance rely on a complex and intertwined set of physiological, molecular, and biochemical mechanisms. (cas.cz)

These responses were obtained at rest and during submaximal exercise, using a standardized and validated protocol for exposure to acute normobaric hypoxia. (frontiersin.org)
We discovered that hypoxia exposure led to a FOXO-dependent increase in genes involved in cell signaling, such as kinases, GTPase regulators, and regulators of the Hippo/Yorkie pathway. (thegallolab.com)

We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. (cas.cz)
and altered cardiac tolerance associated with various pathological states. (cas.cz)
We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. (cas.cz)
We study the effects of various forms of hypertension on cardiac ischemic tolerance. (cas.cz)
Digestion during hypoxia was associated with a decrease in both stroke volume and cardiac output. (silverchair.com)

One aspect of our work focuses on identifying genes and biological processes underlying physiological adaptation to different environmental conditions in bank vole populations that have occupied new habitats as a consequence of end-glacial climate change. (cas.cz)

How do PA, ABA, and CBF pathways synergistically regulate melon cold tolerance? (eurekalert.org)
However, whether the PA, ABA, and CBF pathways synergistically regulate melon cold tolerance has been largely unknown. (eurekalert.org)
The long-term aim of my research is to discover cellular pathways and molecular candidates that enable endogenous systemic tolerance to low oxygen stress in hypoxia-adapted species, and to translate these mechanisms to hypoxia-intolerant mammals in order to reduce or reverse brain cell injury caused by pathological conditions that compromise oxygen supply to the tissue (e.g. stroke, heart attack, COPD, etc). (weebly.com)
mRNA targets of these altered miRNAs identify possible protective mechanisms in individual tissues, particularly relevant to hypoxia tolerance, anti-apoptotic pathways, and nitric oxide signal transduction. (uea.ac.uk)

There has been a growing interest in the study of PAs involved in plant stresses, including drought, hypoxia, high temperature, low temperature, salinity, and metal toxicity. (eurekalert.org)

Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude and long-term outcome of the hypoxic consequences are species-specific. (researchgate.net)
Variable tolerance of wetland tree species to combined salinity and waterlogging is related to regulation of ion uptake and production of organic solutes. (arccjournals.com)

Does feeding limit cardiovascular modulation in the Dungeness crab Cancer magister during hypoxia? (silverchair.com)

Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. (nature.com)

An interesting finding was the possibility of positive cross-adaptation which might be supported by greater heat tolerance and cutaneous warm perception thresholds of older haenyeos who adapted to cold water. (biomedcentral.com)

By adding the stress of hypoxia during 'aerobic' or 'anaerobic' interval training, it is believed that IHT would potentiate greater performance improvements compared to similar training at sea level. (bmj.com)

Preliminary results suggest a role for genes previously implied in adaptation to hypoxia at high altitudes. (cas.cz)

Background: The Weddell Seal (Leptonychotes weddelli) represents a remarkable example of adaptation to diving among marine mammals. (uea.ac.uk)

Evidence suggests that exogenous ABA can enhance cold tolerance of oriental melon seedlings, and PA accumulation contributes to adaptation to root-zone hypoxia stress, Ca(NO 3 ) 2 stress, and salinity-alkalinity stress in melon seedlings, as well as cold stress in melon fruit. (eurekalert.org)
Does tolerance of wheat to salinity and hypoxia correlate with root dehydrogenase activities or aerenchyma formation? (arccjournals.com)

Specifically, I use hypoxia-tolerant comparative model organisms (African mole rats, western painted turtles, goldfish) and oxygen-sensitive mammalian cells and tissues (mouse, human) to investigate cellular and systemic mechanisms involved in hypoxia-tolerance and neuroprotection. (weebly.com)
Mammalian tissues are extremely sensitive to the stress of hypoxia and can only survive for relatively short periods of time. (ucsd.edu)
Furthermore, we have also been interested in long term hypoxia and in the adaptation of cells and tissues to this stress, in the hope that we can learn enough from the tolerant/adapted cells and tissues to be able to manipulate sensitive tissues to become more tolerant and less likely to be injured during hypoxic stress. (ucsd.edu)

Intermittent hypoxic training (IHT) is sometimes used by athletes to enhance non-hematological physiological adaptations to simulated altitude. (altitudecentre.com)

While extensive work has emphasized the importance of the HIF-1 alpha transcription factor on controlling hypoxia gene expression, less is known about other transcriptional mechanisms. (thegallolab.com)
Here we use an RNA-sequencing approach to identify FOXO-dependent changes in gene expression that are associated with these tolerance effects. (thegallolab.com)
We found that hypoxia altered the expression of over 2000 genes and that approximately 40% of these gene expression changes required FOXO. (thegallolab.com)
This work uncovers a widespread role for FOXO in mediating hypoxia changes in gene expression. (thegallolab.com)

Interestingly, DJ123 is considered tolerant to P deficiency, whereas Nerica4 is sensitive, pointing towards a potential role of aerenchyma in tolerance to P deficiency. (biomedcentral.com)
To date, genotypic differences are not clear and the role of aerenchyma in tolerance to P deficiency has not been addressed. (biomedcentral.com)

Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)
Among these, we identified homeodomain-interacting protein kinase (Hipk) as being required for hypoxia survival. (thegallolab.com)

Significant differences are present between COMT genotypes for oxygen saturation and ventilatory responses to hypoxia at rest. (frontiersin.org)
The physiological responses of decapod crustaceans to hypoxia are well documented. (silverchair.com)
We have been studying the thermoregulatory responses of Korean breath-hold women divers, called haenyeo , in terms of aging and cold adaptation. (biomedcentral.com)

In particular, the laboratory is interested in the genetic and molecular mechanisms of cell death and cell survival in oxygen deprivation as well as the mechanisms of tolerance and susceptibility to low oxygen environment, especially in nerve cells and glia. (ucsd.edu)

Purpose: Hypoxia-inducible factor 1 (HIF-1) promotes cancer cell survival and tumor progression. (lincoln.ac.uk)

Despite the positive molecular adaptations observed after various IHT modalities, the characteristics of optimal training stimulus in hypoxia are still unclear and their functional translation in terms of whole-body performance enhancement is minimal. (bmj.com)

Additionally, if you are traveling to moderate or high elevations, you should know that although the initial, or acute, adaptations take place in the first three to four days, the bulk of the performance-enhancing adaptations take 21 to 28 days to fully manifest. (irunfar.com)
It's because of these system-wide adaptations that we not only can survive at high altitudes, but we can also live, perform well, and thrive overall in them. (irunfar.com)
Second, to critically analyse the results of the studies involving high-intensity exercises performed in hypoxia for sea-level performance enhancement by differentiating IHT and RSH. (bmj.com)

Plant injury and adaptation to oxygen deficiency in the root environment, a review. (arccjournals.com)

Overall, the results revealed a possible HSF1-HSP regulatory relationship in Pacific oyster, providing valuable information on the mechanisms of thermal tolerance in this commercially important oyster. (biomedcentral.com)

Since hypoxia may specifically disrupt the conversion of testosterone to estradiol through aromatase activity, resulting in higher testosterone levels and higher testosterone/estradiol ratio (Shang 2006;Landry et al. (researchgate.net)

Episodes of hypoxia are common in the marine environment, especially in shallow coastal zones. (silverchair.com)
Understanding the adaptations of pelagic amphipods to their current environment will help predict the physiological impacts of global warming for amphipods and their predators. (uri.edu)

Only two CmCBFs, CmCBF1 and CmCBF3, have been identified, and their expression is positively correlated with cold tolerance in melon fruit. (eurekalert.org)
Our findings were that older haenyeos still retain local cold tolerance on the extremities despite their aging. (biomedcentral.com)
Finger cold tests supported more superior local cold tolerance for older haenyeos than for older non-diving females. (biomedcentral.com)

For the past several years, we revisited and explored older haenyeos in terms of environmental physiology, beginning with questionnaire and field studies and later advancing to thermal tolerance tests in conjunction with cutaneous thermal threshold tests in a climate chamber. (biomedcentral.com)

Likewise,ventilation rate also showed effects of addivity, increasing in response to both food intake and hypoxia. (silverchair.com)
Management plans should avoid the generalized assumption that combined stressors will result in multiplicative effects and focus attention on alleviating hypoxia in the region. (copernicus.org)

Individual chemosensitivity to hypoxia can be assessed by the hypoxic exercise test, developed and validated by Prof. Richalet et al. (frontiersin.org)
11 ), which measures the ventilatory response to poikilocapnic hypoxia during submaximal exercise (i.e., simulating the effort of walking to the summit of Mont Blanc) ( 11 ). (frontiersin.org)
This study investigated whether IHT would result in greater improvements in muscle energetics and exercise tolerance compared with work matched intermittent normoxic (sea level) training (INT). (altitudecentre.com)
Improvements in the time-to-exhaustion during incremental exercise were not significantly different between training conditions either in normoxia or hypoxia. (altitudecentre.com)

Michael A Singer: Comparative Physiology, Natural Animal Models and Clinical Medicine - Insight into Clinical Medicine from Animal Adaptations. (pmf.hr)

We previously identified the transcription factor FOXO as a regulator of hypoxia tolerance in Drosophila larvae and adults. (thegallolab.com)

These adaptations have been linked to increased abundance of key proteins, suggesting an important, yet still understudied role for gene reprogramming. (uea.ac.uk)

The present study sought to determine how the Dungeness crab Cancer magister balances the demands of physiological systems when they feed and digest in hypoxia. (silverchair.com)

Furthermore, based on differentially expressed genes and WGCNA analyses, we found that the hypoxia signaling pathway was enriched under heat shock conditions. (biomedcentral.com)

Anatomy22

Organisms18

Diseases21

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology12

Phenomena and Processes98

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Health Care8

Geographicals3

Ischemia4

Acute hypoxia2

Effect of hypoxia1

Metabolism2

Completed in normoxia1

Hypoxic environment1

Metabolic5

20221

Chronic6

Oxidative1

Synthesis5

Biochemical2

Exposure2

Cardiac5

Physiological adaptation1

Pathways4

Temperature1

Species2

Cardiovascular1

Mitochondrial1

Cross-adaptation1

Aerobic1

Preliminary1

Mammals1

Salinity2

Tissues3

Intermittent hypoxic1

Gene expression4

Aerenchyma2

Protein2

Responses3

Molecular mechanisms1

Survival1

Functional1

High3

Deficiency1

Regulatory1

Specifically1

Environment2

Cold tolerance3

Thermal tolerance1

Effects2

Exercise4

Physiology1

Transcription1

Role1

Study1

Conditions1